Neuroscience

Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.

Sous-catégories appartenant à la catégorie "Neuroscience"

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BACE1-IN-1
CAS :
- 1310347-50-2
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
Formule :C₁₈H₁₄F₃N₅O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :389.33
Ref: TM-T10450
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Robalzotan
CAS :
- 169758-66-1
Robalzotan is a selective 5-HT1A receptor antagonist.
Formule :C₁₈H₂₃FN₂O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :318.39
Ref: TM-T24721
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CGP 64213
CAS :
- 200402-50-2
CGP 64213 is a GABAb receptor agonist.
Formule :C₂₆H₃₆IN₂O₇P
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :646.45
Ref: TM-T26995
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Afizagabar
CAS :
- 1398496-82-6
Afizagabar, a first-in-class α5-GABAAR antagonist, IC50: 585 nM, Ki: 66 nM, may boost memory.
Formule :C₁₉H₁₂FN₃O₂S
Couleur et forme :Solid
Masse moléculaire :365.38
Ref: TM-T37388
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L-AP4
CAS :
- 23052-81-5
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).
Formule :C₄H₁₀NO₅P
Degré de pureté :98%
Couleur et forme :White To Off-White Crystalline Powder
Masse moléculaire :183.1
Ref: TM-T15692
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(S)-Renzapride
(S)-Renzapride (BRL 24924), 5-HT4 agonist (Ki 115 nM), 5HT2b/5HT3 antagonist, for C-IBS study.
Formule :C₁₆H₂₂ClN₃O₂
Couleur et forme :Solid
Masse moléculaire :323.82
Ref: TM-T72809
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Fosthiazate
CAS :
- 98886-44-3
Fosthiazate is a broad-spectrum nematicide that combats a range of plant parasitic nematodes such as Meloidogyne spp., Globodera spp., and Pratylenchus spp., by
Formule :C₉H₁₈NO₃PS₂
Degré de pureté :97.78%
Couleur et forme :Solid
Masse moléculaire :283.35
Ref: TM-T80625
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GSM-1
CAS :
- 884600-68-4
GSM-1 is a modulator of γ-Secretase.
Formule :C₂₆H₃₁ClF₃NO₂
Couleur et forme :Solid
Masse moléculaire :481.98
Ref: TM-T24116
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L 663581
CAS :
- 122384-14-9
L 663581 is the benzodiazepine receptor partial agonist.
Formule :C₁₇H₁₆ClN₅O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :357.79
Ref: TM-T24317
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Eslicarbazepine
CAS :
- 104746-04-5
Eslicarbazepine (Stedesa) can be used for adjunctive therapy for adults with partial-onset seizures.
Formule :C₁₅H₁₄N₂O₂
Degré de pureté :99.97%
Couleur et forme :Off-White Solid
Masse moléculaire :254.28
Ref: TM-T3285L
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NO-711ME
CAS :
- 127586-66-7
NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.
Formule :C₂₂H₂₄N₂O₃
Degré de pureté :99.54%
Couleur et forme :Solid
Masse moléculaire :364.44
Ref: TM-T24540
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eeAChE-IN-2
CAS :
- 2763366-33-0
eeAChE-IN-2 is a potent inhibitor of eeAChE, exhibiting inhibitory potency with an IC50 of 2 nM.
Formule :C₃₇H₄₀N₈O₅S
Couleur et forme :Solid
Masse moléculaire :708.83
Ref: TM-T72983
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Yhhu-3792 hydrochloride
CAS :
- 2624336-93-0
Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].
Formule :C₂₄H₂₅ClN₄O₂
Couleur et forme :Solid
Masse moléculaire :436.93
Ref: TM-T84890
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Dothiepin
CAS :
- 113-53-1
Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing
Formule :C₁₉H₂₁NS
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :295.44
Ref: TM-T78126
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Lanabecestat camsylate
CAS :
- 1522418-41-2
Lanabecestat camsylate is used as a BACE1 Inhibitor.
Formule :C₃₆H₄₄N₄O₅S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :644.83
Ref: TM-T25610
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LY108742
CAS :
- 150196-69-3
LY108742 is an antagonist of 5-HT2.
Formule :C₂₁H₂₈N₂O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :356.46
Ref: TM-T27929
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Befiradol
CAS :
- 208110-64-9
Befiradol (NLX-112) is an agonist of 5-HT1A receptor.
Formule :C₂₀H₂₂ClF₂N₃O
Couleur et forme :Solid
Masse moléculaire :393.86
Ref: TM-T10495L
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ABT-418 hydrochloride
CAS :
- 147388-83-8
ABT-418 HCl enhances cognition and reduces anxiety as a selective nAChRs agonist, researched for Alzheimer's.
Formule :C₉H₁₅ClN₂O
Couleur et forme :Solid
Masse moléculaire :202.68
Ref: TM-T10224
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FPPQ
CAS :
- 1648745-46-3
FPPQ blocks 5-HT3 and 5-HT6 receptors (Ki: 0.9 & 3 nM) and may improve psychosis and cognition.
Formule :C₂₁H₁₉FN₄O₂S
Couleur et forme :Solid
Masse moléculaire :410.46
Ref: TM-T62082
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Diproqualone
CAS :
- 36518-02-2
Diproqualone, analogous to methaqualone, exhibits sedative, anxiolytic, anti-inflammatory, and analgesic properties [1].
Formule :C₁₂H₁₄N₂O₃
Couleur et forme :Solid
Masse moléculaire :234.255
Ref: TM-T85285
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AChE-IN-44
CAS :
- 2758685-58-2
AChE-IN-44 (Compound Tap4), an AChE inhibitor, is convertible into its thiazole salt form known as Tat2 [1].
Formule :C₃₁H₃₈ClN₃OS₂
Couleur et forme :Solid
Masse moléculaire :568.24
Ref: TM-T83184
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UNC9994 hydrochloride
CAS :
- 2108826-33-9
UNC9994 hydrochloride is a selective β-arrestin-biased D2R agonist, Ki of 79 nM, that stimulates β-arrestin and modulates cAMP.
Formule :C₂₁H₂₃Cl₃N₂OS
Couleur et forme :Solid
Masse moléculaire :457.84
Ref: TM-T62853
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NAD 299 hydrochloride
CAS :
- 184674-99-5
Selective, high affinity 5-HT1A receptor antagonist
Formule :C₁₈H₂₄ClFN₂O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :354.85
Ref: TM-T23050
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Indeloxazine hydrochloride
CAS :
- 65043-22-3
Indeloxazine HCl: Serotonin releaser, NE reuptake inhibitor, NMDA antagonist; antidepressant that boosts acetylcholine in rats.
Formule :C₁₄H₁₈ClNO₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :267.75
Ref: TM-T19629
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Nemonapride
CAS :
- 75272-39-8
Nemonapride is a dopamine D2-like receptor antagonist.
Formule :C₂₁H₂₆ClN₃O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :387.9
Ref: TM-T23063
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5-HT2A&5-HT2C agonist-1
CAS :
- 1640-02-4
5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM.
Formule :C₁₄H₂₀N₂O
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :232.32
Ref: TM-T79806
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DU-125530
CAS :
- 161611-99-0
DU-125530 is a 5-HT1A receptor antagonist.
Formule :C₂₃H₂₆ClN₃O₅S
Couleur et forme :Solid
Masse moléculaire :491.99
Ref: TM-T27215
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TPA 023
CAS :
- 252977-51-8
TPA 023 is a selective agonist of GABAA α2/α3 subtype (Kis = 0.19 - 0.41 nM).
Formule :C₂₀H₂₂FN₇O
Degré de pureté :99.75%
Couleur et forme :Solid
Masse moléculaire :395.43
Ref: TM-T17144
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β-Secretase Inhibitor IV
CAS :
- 797035-11-1
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).
Formule :C₃₁H₃₈N₄O₅S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :578.72
Ref: TM-T13434
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SB 258719
CAS :
- 195199-95-2
SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.
Formule :C₁₈H₃₀N₂O₂S
Degré de pureté :99.73%
Couleur et forme :Solid
Masse moléculaire :338.51
Ref: TM-T12855
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Calmidazolium chloride
CAS :
- 57265-65-3
Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.
Formule :C₃₁H₂₃Cl₇N₂O
Degré de pureté :98.53%
Couleur et forme :Solid
Masse moléculaire :687.7
Ref: TM-T10667
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Osemozotan Free Base
CAS :
- 137275-81-1
Osemozotan Free Base is a 5-HT(1A) receptor agonist.
Formule :C₁₉H₂₁NO₅
Couleur et forme :Solid
Masse moléculaire :343.37
Ref: TM-T70840
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Brasofensine Maleate
CAS :
- 173830-14-3
Brasofensine Maleate inhibits the monoamine re-uptake.
Formule :C₂₀H₂₄Cl₂N₂O₅
Couleur et forme :Solid
Masse moléculaire :443.32
Ref: TM-T26361L
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Cyclophostin
CAS :
- 144773-26-2
Cyclophostin is an irreversible inhibitor of acetylcholinesterase (AChE).
Formule :C₈H₁₁O₆P
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :234.14
Ref: TM-T27105
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NAS-181
CAS :
- 205242-62-2
NAS-181 is a potent and selective rat 5-hydroxytryptamine 1B (r5-HT1B) antagonist (Ki: 47 nM).NAS-181 enhances the accumulation of 5-HTP in rat brain regions.
Formule :C₂₀H₃₀N₂O₇S
Couleur et forme :Solid
Masse moléculaire :442.53
Ref: TM-T62585
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NAS181
CAS :
- 1217474-40-2
rat 5-HT1B receptor antagonist
Formule :C₂₁H₃₄N₂O₁₀S₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :538.63
Ref: TM-T23055
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AMPA receptor modulator-5
CAS :
- 2034182-22-2
AMPA Receptor Modulator-5 (Example 217) serves as an AMPA receptor modulator, utilized in neurological disease research [1].
Formule :C₂₀H₁₂F₄N₆
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :412.34
Ref: TM-T79191
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(+)-Bicuculline methiodide
CAS :
- 40709-69-1
(+)-Bicuculline methiodide is a GABAA receptor blocker that blocks epileptogens and may be used in the study of neurological disorders.
Formule :C₂₁H₂₀INO₆
Degré de pureté :99.24%
Couleur et forme :Solid
Masse moléculaire :509.29
Ref: TM-T22604
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MGS-0039
CAS :
- 569686-87-9
MGS-0039: Group II mGluR2/3 antagonist, non-serotonergic antidepressant-like effect, AMPA involvement, regulates dopamine in NAc.
Formule :C₁₅H₁₄Cl₂FNO₅
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :378.18
Ref: TM-T28034
+ Info
MTPG
CAS :
- 169209-66-9
Group II/group III metabotropic glutamate receptor antagonist
Formule :C₁₀H₁₁N₅O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :233.23
Ref: TM-T23033
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GR 127935 hydrochloride
CAS :
- 148642-42-6
5-HT1B/1D receptor antagonist
Formule :C₂₉H₃₂ClN₅O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :534.05
Ref: TM-T22806
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mAChR antagonist 1
CAS :
- 101491-79-6
Compound 4a, a mAChR antagonist, exhibits K i values of 255 nM for M1 and M5 subtypes, and lower values of 121 nM and 158 nM for M3 and M4 subtypes,
Formule :C₁₉H₂₂N₂O₂
Couleur et forme :Solid
Masse moléculaire :310.39
Ref: TM-T81888
+ Info
ASS234
CAS :
- 1334106-34-1
ASS234 is a multi-target propylamine used in the treatment of Alzheimer's disease.
Formule :C₂₉H₃₇N₃O
Couleur et forme :Solid
Masse moléculaire :443.62
Ref: TM-T30176
+ Info
Muscarine tosylate
CAS :
- 82083-43-0
Muscarine ((+)-Muscarine) tosylate, a prototype mAChR agonist, serves as a parasympathetic nervous system stimulant and is recognized for its toxic properties [1] [2].
Formule :C₁₆H₂₇NO₅S
Couleur et forme :Solid
Masse moléculaire :345.45
Ref: TM-T84726
+ Info
rel-HDMP 28 hydrochloride
CAS :
- 219915-69-2
Rel-HDMP-28 hydrochloride (Compound 2g) is an analogue of methylphenidate, exhibiting selective affinity for the serotonin transporter (SERT) with a binding constant (Ki) of 105 nM [1].
Formule :C₁₈H₂₂ClNO₂
Couleur et forme :Solid
Masse moléculaire :319.83
Ref: TM-T84393
+ Info
(1α,1'S,4β)-Lanabecestat
CAS :
- 1384082-96-5
(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzymel (BACE1) inhibitor, and has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay),
Formule :C₂₆H₂₈N₄O
Couleur et forme :Solid
Masse moléculaire :412.53
Ref: TM-T10014
+ Info
MK-8768
CAS :
- 1432729-22-0
MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized by
Formule :C₂₁H₂₂F₃N₅O₂
Couleur et forme :Solid
Masse moléculaire :433.43
Ref: TM-T79302
+ Info
Abaperidone
CAS :
- 183849-43-6
Abaperidone is an atypical antipsychotic, antagonizes 5-HT2A (IC50=6.2 nM) and D2 receptors (IC50=17 nM), reduces hsp70 mRNA in rat brains.
Formule :C₂₅H₂₅FN₂O₅
Degré de pureté :98.22%
Couleur et forme :Solid
Masse moléculaire :452.47
Ref: TM-T14083
+ Info
UNC9994
CAS :
- 1354030-51-5
UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.
Formule :C₂₁H₂₂Cl₂N₂OS
Couleur et forme :Solid
Masse moléculaire :421.38
Ref: TM-T29065
+ Info
Lanabecestat
CAS :
- 1383982-64-6
Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.
Formule :C₂₆H₂₈N₄O
Degré de pureté :98.55%
Couleur et forme :Solid
Masse moléculaire :412.53
Ref: TM-TQ0238
+ Info
VU6004909
CAS :
- 1860797-76-7
VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.
Formule :C₂₁H₁₅FN₂O₄
Degré de pureté :96.68% - 98.44%
Couleur et forme :Solid
Masse moléculaire :378.35
Ref: TM-T79784
+ Info
γ-Secretase-IN-1
CAS :
- 209986-17-4
γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.
Formule :C₂₇H₂₄F₂N₄O₃
Degré de pureté :99.56%
Couleur et forme :Solid
Masse moléculaire :490.5
Ref: TM-T3521
+ Info
AMPA receptor antagonist-3
CAS :
- 923272-18-8
AMPA receptor antagonist-3 is an AMPA receptor antagonist.
Formule :C₂₀H₁₉N₅O₂S
Degré de pureté :99.79%
Couleur et forme :Solid
Masse moléculaire :393.46
Ref: TM-T61813
+ Info
Osemozotan HCl
CAS :
- 137275-80-0
Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.
Formule :C₁₉H₂₂ClNO₅
Degré de pureté :98.87% - 99.63%
Couleur et forme :Solid
Masse moléculaire :379.84
Ref: TM-T28270
+ Info
R-(+)-EU-1180-453
CAS :
- 2488764-06-1
R-(+)-EU-1180-453 is a novel GluN2C/D selective NMDAR-positive modulator for the study of neurological disorders.
Formule :C₂₂H₂₁FN₂O₃
Degré de pureté :99.63%
Couleur et forme :Solid
Masse moléculaire :380.41
Ref: TM-T69611
+ Info
Tematropium
CAS :
- 113932-41-5
Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.
Formule :C₂₁H₃₁NO₈S
Degré de pureté :99.89%
Couleur et forme :Solid
Masse moléculaire :457.54
Ref: TM-T10732
+ Info
Dalzanemdor
CAS :
- 1629853-48-0
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive
Formule :C₂₇H₄₃F₃O₂
Degré de pureté :98.2% - >99.99%
Couleur et forme :Solid
Masse moléculaire :456.62
Ref: TM-T62839
+ Info
AMPA receptor modulator-1
CAS :
- 2036074-41-4
AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
Formule :C₁₆H₁₁ClF₃NO₂
Degré de pureté :99.93%
Couleur et forme :Solid
Masse moléculaire :341.71
Ref: TM-T10307
+ Info
WAY-607695
CAS :
- 380469-52-3
WAY-607695 is a potential 5-HT1A receptor agonist.
Formule :C₁₃H₁₂FNO₂
Degré de pureté :99.82%
Couleur et forme :Solid
Masse moléculaire :233.24
Ref: TM-T80805
+ Info
JNJ-42253432
CAS :
- 1428327-35-8
JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels
Formule :C₂₈H₃₈N₄O
Degré de pureté :99.98%
Couleur et forme :Solid
Masse moléculaire :446.63
Ref: TM-T27683
+ Info
BuChE-IN-TM-10
CAS :
- 2313524-95-5
TM-10: Potent BuChE inhibitor, IC50 8.9 nM, disaggregates Aβ, antioxidant, BBB penetrant, may treat Alzheimer's.
Formule :C₃₂H₃₈N₂O₃
Degré de pureté :99.54%
Couleur et forme :Solid
Masse moléculaire :498.66
Ref: TM-T10630
+ Info
SB 216641 hydrochloride
CAS :
- 193611-67-5
SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.
Formule :C₂₈H₃₁ClN₄O₄
Degré de pureté :98.06% - 99.23%
Couleur et forme :Solid
Masse moléculaire :523.02
Ref: TM-T23315
+ Info
Philanthotoxin 74 dihydrochloride
CAS :
- 1227301-51-0
Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
Formule :C₂₄H₄₄Cl₂N₄O₃
Degré de pureté :99.75%
Couleur et forme :Solid
Masse moléculaire :507.54
Ref: TM-T16524
+ Info
Gossypolone
CAS :
- 4547-72-2
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
Formule :C₃₀H₂₆O₁₀
Degré de pureté :96.66%
Couleur et forme :Solid
Masse moléculaire :546.52
Ref: TM-T31987
+ Info
Rislenemdaz
CAS :
- 808732-98-1
Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B).
Formule :C₁₉H₂₃FN₄O₂
Degré de pureté :98.18%
Couleur et forme :Solid
Masse moléculaire :358.41
Ref: TM-T12733
+ Info
TZ3O
CAS :
- 2218754-19-7
TZ3O is an anticholinergic compound with neuroprotective activity.TZ3O ameliorates memory impairment in Scopolamine-induced Alzheimer's type model in rats.
Formule :C₁₈H₁₃NO₄S
Degré de pureté :99.84%
Couleur et forme :Solid
Masse moléculaire :339.37
Ref: TM-T77678
+ Info
Didesmethyl cariprazine
CAS :
- 839712-25-3
Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.
Formule :C₁₉H₂₈Cl₂N₄O
Degré de pureté :99.52%
Couleur et forme :Solid
Masse moléculaire :399.36
Ref: TM-T15117
+ Info
Atabecestat
CAS :
- 1200493-78-2
Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.
Formule :C₁₈H₁₄FN₅OS
Degré de pureté :99.21% - 99.77%
Couleur et forme :Solid
Masse moléculaire :367.4
Ref: TM-T14338
+ Info
CGP 78608 hydrochloride
CAS :
- 1135278-54-4
CGP 78608 hydrochloride: NMDA receptor antagonist (IC50=6 nM), anticonvulsant, enhances GluN1/GluN3A currents (EC50=26.3 nM).
Formule :C₁₁H₁₄BrClN₃O₅P
Degré de pureté :99.85%
Couleur et forme :Solid
Masse moléculaire :414.58
Ref: TM-T10781
+ Info
PXS-5120A
CAS :
- 2125955-70-4
PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity.
Formule :C₂₂H₂₅ClFN₃O₄S
Degré de pureté :97.02%
Couleur et forme :Solid
Masse moléculaire :481.97
Ref: TM-T12584
+ Info
Lumateperone
CAS :
- 313368-91-1
Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).
Formule :C₂₄H₂₈FN₃O
Degré de pureté :99.68% - 99.91%
Couleur et forme :Solid
Masse moléculaire :393.5
Ref: TM-T21069
+ Info
SB-616234-A
CAS :
- 908601-49-0
SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.
Formule :C₃₂H₃₆ClN₅O₃
Degré de pureté :99.72%
Couleur et forme :Solid
Masse moléculaire :574.11
Ref: TM-T12847
+ Info
MDR-1339
CAS :
- 1018946-38-7
MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
Formule :C₂₀H₂₂O₄
Degré de pureté :98.57%
Couleur et forme :Solid
Masse moléculaire :326.39
Ref: TM-TQ0026
+ Info
BMS-986176
CAS :
- 1815613-42-3
AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).
Formule :C₁₉H₂₃F₄N₃O
Degré de pureté :98.58% - 98.7%
Couleur et forme :Solid
Masse moléculaire :385.4
Ref: TM-T35856
+ Info
PXS-5153A
CAS :
- 2125956-82-1
PXS-5153A rapidly inhibits lysyl oxidase 2/3 enzymes, blocks activity in 15 mins, and reduces fibrosis.
Formule :C₂₀H₂₅Cl₂FN₄O₂S
Degré de pureté :99.58%
Couleur et forme :Solid
Masse moléculaire :475.41
Ref: TM-T12585
+ Info
LRRK2-IN-6
LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).
Formule :C₂₃H₂₄F₂N₄O₂S
Couleur et forme :Solid
Masse moléculaire :458.52
Ref: TM-T62871
+ Info
AChE-IN-8
AChE-IN-8 (Compound 19), potent acetylcholinesterase blocker; IC50 = 1.95 μM; potential Alzheimer's treatment.
Formule :C₂₀H₂₂N₄O₂S
Couleur et forme :Solid
Masse moléculaire :382.48
Ref: TM-T61648
+ Info
R-137696
CAS :
- 695185-73-0
R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.
Formule :C₁₇H₂₃N₃O₂
Couleur et forme :Solid
Masse moléculaire :301.38
Ref: TM-T201501
+ Info
Antioxidant agent-8
Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.
Formule :C₁₃H₁₂O₅
Couleur et forme :Solid
Masse moléculaire :248.23
Ref: TM-T72506
+ Info
Flucopride
CAS :
- 1639925-34-0
Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.
Formule :C₂₂H₃₃FN₂O₂
Couleur et forme :Solid
Masse moléculaire :376.51
Ref: TM-T201815
+ Info
AChE-IN-25
AChE-IN-25: selective, potent AChE inhibitor, non-competitive, IC50 = 2.95 μM, for Alzheimer's research.
Formule :C₂₀H₁₅ClN₄O₄S
Couleur et forme :Solid
Masse moléculaire :442.88
Ref: TM-T62590
+ Info
Rodatristat ethyl
CAS :
- 1673571-51-1
Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.
Formule :C₂₉H₃₁ClF₃N₅O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :590.04
Ref: TM-T16779
+ Info
Tuclazepam
CAS :
- 51037-88-8
Tuclazepam (KC 1956) is a derivative of the benzodiazepine class of drugs, exhibiting anti-anxiety and sedative properties.
Formule :C₁₇H₁₆Cl₂N₂O
Couleur et forme :Solid
Masse moléculaire :335.23
Ref: TM-T201570
+ Info
BRD0418
CAS :
- 1565827-99-7
BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.
Formule :C₂₉H₃₂N₂O₅
Degré de pureté :99.57%
Couleur et forme :Solid
Masse moléculaire :488.57
Ref: TM-T30577
+ Info
RO-1-5237
CAS :
- 31034-86-3
RO-1-5237, a cholinergic compound and a metabolic product of Pyridostigmine Bromide, is utilized in research for myasthenia gravis.
Formule :C₆H₈BrNO
Couleur et forme :Solid
Masse moléculaire :190.04
Ref: TM-T200816
+ Info
Nedemelteon
CAS :
- 1000334-38-2
Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).
Formule :C₁₅H₁₈N₂O₂
Couleur et forme :Solid
Masse moléculaire :258.32
Ref: TM-T201036
+ Info
BGT1-IN-1
CAS :
- 406947-32-8
BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.
Formule :C₆H₉NO₂
Couleur et forme :Solid
Masse moléculaire :127.14
Ref: TM-T200935
+ Info
Desmethylflunitrazepam
CAS :
- 2558-30-7
Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.
Formule :C₁₅H₁₀FN₃O₃
Couleur et forme :Solid
Masse moléculaire :299.26
Ref: TM-T201723
+ Info
Neral
CAS :
- 106-26-3
Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.
Formule :C₁₀H₁₆O
Couleur et forme :Solid
Masse moléculaire :152.23
Ref: TM-T201808
+ Info
YNT-3708
CAS :
- 2923137-99-7
YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.
Formule :C₃₅H₃₆N₄O₆S
Couleur et forme :Solid
Masse moléculaire :640.749
Ref: TM-T206764
+ Info
Terguride
CAS :
- 37686-84-3
Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.
Formule :C₂₀H₂₈N₄O
Couleur et forme :Solid
Masse moléculaire :340.46
Ref: TM-T71847
+ Info
AAK1-IN-2 TFA
AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.
Formule :C₂₄H₂₂F₆N₄O₄
Couleur et forme :Solid
Masse moléculaire :544.45
Ref: TM-T63833
+ Info
BChE-IN-2
BChE-IN-2, a pyrimidine/pyridine derivative, potently inhibits BChE (Ki 0.099 μM) and shows promise in AD research.
Formule :C₂₂H₃₁N₅
Couleur et forme :Solid
Masse moléculaire :365.52
Ref: TM-T61408
+ Info
AChE-IN-63
CAS :
- 876685-78-8
AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].
Formule :C₁₈H₁₉N₅O
Couleur et forme :Solid
Masse moléculaire :321.38
Ref: TM-T85555
+ Info
Glutaminyl Cyclase Inhibitor 3
CAS :
- 2092921-50-9
Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.
Formule :C₂₄H₃₂N₆O₂S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :468.61
Ref: TM-T11422
+ Info
MAO-A inhibitor 1
CAS :
- 119229-96-8
MAO-A Inhibitor 1 (compound VIII) acts as a MAO-A inhibitor and exhibits an IC50 value of 100 μM [1].
Formule :C₁₄H₁₂O₄
Couleur et forme :Solid
Masse moléculaire :244.24
Ref: TM-T86857
+ Info
Amyloid-β-IN-2
CAS :
- 1603833-55-1
Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.
Formule :C₂₂H₂₁F₂N₃O₂
Couleur et forme :Solid
Masse moléculaire :397.42
Ref: TM-T207418
+ Info
ROS151
ROS151 is an AChE inhibitor with IC50 values of 14 nM (hAChE), 1.68 μM (eqBChE), and 8.17 μM (hFAAH). Additionally, it acts as a chelating agent for Fe3+ and Cu2+. ROS151 is utilized in research related to Alzheimer's disease.
Formule :C₁₈H₁₈FN₃O₆
Couleur et forme :Solid
Masse moléculaire :391.35
Ref: TM-T201447
+ Info
AChE/Aβ-IN-5
CAS :
- 181114-32-9
Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].
Formule :C₂₅H₂₄N₄
Couleur et forme :Solid
Masse moléculaire :380.48
Ref: TM-T85551
+ Info
5-HT7R antagonist 3
CAS :
- 1887043-58-4
Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.
Formule :C₃₀H₃₃FN₄O₃
Couleur et forme :Solid
Masse moléculaire :516.61
Ref: TM-T201849
+ Info
AGH-107
CAS :
- 2172907-10-5
AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.
Formule :C₁₃H₁₂IN₃
Couleur et forme :Solid
Masse moléculaire :337.16
Ref: TM-T201735
+ Info
SZ1676
CAS :
- 159325-23-2
SZ1676 is a derivative of SZ1677, which is an agent of neuromuscular blocking.
Formule :C₃₇H₅₉BrN₂O₆
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :707.78
Ref: TM-T13908
+ Info
AAK1-IN-3 TFA
AAK1-IN-3 TFA, an AAK1 inhibitor with IC50 of 11 nM, crosses the blood-brain barrier, is a quinoline analogue, and may aid neuropathic pain research.
Formule :C₂₄H₂₂F₆N₄O₄
Couleur et forme :Solid
Masse moléculaire :544.45
Ref: TM-T63834
+ Info
Tipindole
CAS :
- 7489-66-9
Tipindole is a serotonin antagonist utilized in research related to depression.
Formule :C₁₆H₂₀N₂O₂S
Couleur et forme :Solid
Masse moléculaire :304.41
Ref: TM-T201819
+ Info
PF470
CAS :
- 1539296-45-1
PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.
Formule :C₁₈H₁₆N₆O
Couleur et forme :Solid
Masse moléculaire :332.36
Ref: TM-T200534
+ Info
TP003
CAS :
- 628690-75-5
TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.
Formule :C₂₃H₁₆F₃N₃O
Degré de pureté :99.17%
Couleur et forme :Solid
Masse moléculaire :407.39
Ref: TM-T23466
+ Info
AChE-IN-47
CAS :
- 3033056-55-9
AChE-IN-47 (compound g17) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 0.24 μM. It prevents the self-aggregation of β-amyloid peptides and exhibits neuroprotective properties by effectively reducing the accumulation of intracellular reactive oxygen species (ROS).
Formule :C₂₀H₁₇F₃N₄O₄S
Masse moléculaire :466.43
Ref: TM-T208738
+ Info
CaMKK2-IN-1
CAS :
- 3032691-65-6
CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.
Formule :C₂₂H₂₂N₂O₃
Masse moléculaire :362.42
Ref: TM-T208827
+ Info
(S)-Norfluoxetine
CAS :
- 126924-38-7
(S)-Norfluoxetine, the S enantiomer of Norfluoxetine, functions as a selective serotonin reuptake inhibitor. It enhances allopregnanolone levels and reduces aggression in socially isolated mice.
Formule :C₁₆H₁₆F₃NO
Couleur et forme :Solid
Masse moléculaire :295.3
Ref: TM-T201552
+ Info
PXS-4787 hydrochloride
CAS :
- 2409964-40-3
PXS-4787 hydrochloride is a specific and potent pan-lysyl oxidase inhibitor that effectively eliminates the activity of lysyl oxidase. It exhibits varying IC50 values against different forms of the enzyme, including 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). In addition, PXS-4787 hydrochloride reduces the deposition and cross-linking of collagen I secreted by human fibroblasts.
Formule :C₁₀H₁₃ClFNO₂S
Couleur et forme :Solid
Masse moléculaire :265.73
Ref: TM-T201314
+ Info
(S)-YNT-3708
CAS :
- 2923138-00-3
(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.
Formule :C₃₅H₃₆N₄O₆S
Couleur et forme :Solid
Masse moléculaire :640.749
Ref: TM-T206866
+ Info
SB 243213 dihydrochloride
CAS :
- 1780372-25-9
SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for
Formule :C₂₂H₂₁Cl₂F₃N₄O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :501.33
Ref: TM-T12859L
+ Info
VU6005806
CAS :
- 2180914-37-6
VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.
Formule :C₁₇H₁₆F₃N₇O₂S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :439.41
Ref: TM-T13322
+ Info
Relicpixant
CAS :
- 2445366-94-7
Relicpixant is a potent purine receptor (P2X) antagonist.
Formule :C₂₀H₁₉ClF₂N₄O₅S
Couleur et forme :Solid
Masse moléculaire :500.9
Ref: TM-T200883
+ Info
γ-secretase modulator 6
CAS :
- 1255700-88-9
Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.
Formule :C₂₅H₂₆N₆O₂
Couleur et forme :Solid
Masse moléculaire :442.513
Ref: TM-T206107
+ Info
Amyloid-β-IN-3
CAS :
- 1603833-56-2
Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.
Formule :C₂₂H₂₁F₂N₃O₂
Couleur et forme :Solid
Masse moléculaire :397.42
Ref: TM-T207233
+ Info
MAO-B-IN-42
CAS :
- 2568016-10-2
MAO-B-IN-42 (Compound 4f) is a selective and reversible monoamine oxidase-B (MAO-B) inhibitor, with an IC50 value of 0.184 μM. By blocking the oxidative deamination of monoamines catalyzed by MAO-B, it helps maintain neurotransmitter levels. MAO-B-IN-42 shows potential for research into Parkinson's disease.
Formule :C₁₉H₁₂FNO₂
Couleur et forme :Solid
Masse moléculaire :305.302
Ref: TM-T206712
+ Info
Monoamine Oxidase B inhibitor 2
MAO-B inhibitor 2: potent, reversible, oral, selective (IC50=1.33 nM), BBB-penetrant, with anti-oxidant and anti-inflammatory effects for Parkinson's study.
Formule :C₁₉H₁₉FO₃
Couleur et forme :Solid
Masse moléculaire :314.35
Ref: TM-T60806
+ Info
Beloxepin
CAS :
- 135928-30-2
Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.
Formule :C₁₉H₂₁NO₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :295.38
Ref: TM-T26765
+ Info
Poskine
CAS :
- 585-14-8
Poskine is an anticholinergic and central nervous system depressant. It is utilized in research related to Parkinson's disease and motion sickness.
Formule :C₂₀H₂₅NO₅
Couleur et forme :Solid
Masse moléculaire :359.42
Ref: TM-T201100
+ Info
Fletazepam
CAS :
- 34482-99-0
Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.
Formule :C₁₇H₁₃ClF₄N₂
Couleur et forme :Solid
Masse moléculaire :356.74
Ref: TM-T201147
+ Info
ZK 93426 hydrochloride
CAS :
- 1216792-30-1
benzodiazepine receptor antagonist,competitive
Formule :C₁₈H₂₁ClN₂O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :348.82
Ref: TM-T23562
+ Info
F 14679
CAS :
- 208109-38-0
F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
Formule :C₂₁H₂₅ClF₂N₄O
Degré de pureté :99.09%
Couleur et forme :Solid
Masse moléculaire :422.9
Ref: TM-T62269
+ Info
Rodatristat
CAS :
- 1673568-73-4
Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).
Formule :C₂₇H₂₇ClF₃N₅O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :561.98
Ref: TM-T16780
+ Info
BACE1-IN-8
BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).
Formule :C₂₉H₄₅N₅O₇
Couleur et forme :Solid
Masse moléculaire :575.7
Ref: TM-T64074
+ Info
γ-Secretase modulator 11 hydrochloride
CAS :
- 2434630-30-3
γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).
Formule :C₂₈H₂₃ClF₂N₄O₂
Couleur et forme :Solid
Masse moléculaire :520.96
Ref: TM-T63638
+ Info
Tebideutorexant
CAS :
- 1637681-55-0
Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.
Formule :C₂₃H₁₆D₂F₄N₄O₂
Degré de pureté :98.89%
Couleur et forme :Solid
Masse moléculaire :460.42
Ref: TM-T70332
+ Info
BMS-901715
CAS :
- 1699861-37-4
BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).
Formule :C₂₂H₂₈N₁₀O
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :448.52
Ref: TM-T10571
+ Info
(E)-CHBO4
CAS :
- 126473-61-8
(E)-CHBO4 is an MAO-B inhibitor with an IC50 value of 0.023 μM, making it a potential candidate for research into Parkinson's disease treatment.
Formule :C₁₅H₁₀BrFO
Couleur et forme :Solid
Masse moléculaire :305.142
Ref: TM-T204977
+ Info
YM-31636 free base
CAS :
- 159081-22-8
YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.
Formule :C₁₄H₁₁N₃S
Couleur et forme :Solid
Masse moléculaire :253.32
Ref: TM-T201587
+ Info
DL-Thyroxine
CAS :
- 300-30-1
DL-Thyroxine is a thyroid hormone that acts as a monoamine oxidase (monoamine oxidase) inhibitor.
Formule :C₁₅H₁₁I₄NO₄
Couleur et forme :Solid
Masse moléculaire :776.87
Ref: TM-T204436
+ Info
(+)-Sparteine sulfate pentahydrate
(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.
Formule :C₁₅H₃₈N₂O₉S
Couleur et forme :Solid
Masse moléculaire :422.54
Ref: TM-T62265
+ Info
ChE/Aβ1-42-IN-1
ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability.
Formule :C₁₉H₂₄N₂O₃
Couleur et forme :Solid
Masse moléculaire :328.41
Ref: TM-T60940
+ Info
GABAA receptor agonist 2
Compound 4c, a potent GABAA agonist with anti-depressive effects in mouse FST/TST, shows promise in depression research.
Formule :C₂₂H₃₆O₅
Couleur et forme :Solid
Masse moléculaire :380.52
Ref: TM-T61625
+ Info
AChE/BACE1/GSK3β-IN-1
AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β.
Formule :C₂₆H₂₇FN₂O₄
Couleur et forme :Solid
Masse moléculaire :450.5
Ref: TM-T62719
+ Info
(9R)-RO7185876
CAS :
- 2226077-86-5
(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.
Formule :C₂₅H₂₈F₃N₇
Couleur et forme :Solid
Masse moléculaire :483.532
Ref: TM-T204358
+ Info
(R)-Norfluoxetine
CAS :
- 130194-43-3
(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine. It functions as a potent serotonin reuptake inhibitor, with a Ki value of 13 nM. This compound is utilized in the research of depression.
Formule :C₁₆H₁₆F₃NO
Couleur et forme :Solid
Masse moléculaire :295.299
Ref: TM-T204202
+ Info
FCOB02
CAS :
- 3064236-41-2
FCOB02 is a monoamine oxidase B (MAO-B) ligand. It can be labeled as [18F]FCOB02, serving as a 4-methylcoumarin-like targeting probe. [18F]FCOB02 demonstrates high affinity for MAO-B, with an IC50 of 10.68 nM. It is utilized for specific imaging and quantitative analysis of MAO-B in vivo.
Formule :C₁₆H₁₂FNO₃
Couleur et forme :Solid
Masse moléculaire :285.27
Ref: TM-T206703
+ Info
LB-102
CAS :
- 2227154-23-4
LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.
Formule :C₁₈H₂₉N₃O₄S
Couleur et forme :Solid
Masse moléculaire :383.51
Ref: TM-T200914
+ Info
Aβ-IN-2
Aβ-IN-2 is a peptide inhibitor of Aβ1-42.
Formule :C₃₇H₅₁NO
Couleur et forme :Solid
Masse moléculaire :525.81
Ref: TM-T63689
+ Info
LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.
Formule :C₃₂H₃₉N₃O·HCl·xH₂O
Couleur et forme :Solid
Ref: TM-T64269
+ Info
P2X7 receptor antagonist-5
CAS :
- 3046388-16-0
P2X7 receptor antagonist-5 (compound 13a) is a potent, orally active, and long-lasting antagonist of the P2X7 receptor.
Formule :C₂₁H₁₇F₃N₆O₃S₂
Couleur et forme :Solid
Masse moléculaire :522.52
Ref: TM-T201089
+ Info
Cyproflanilide
CAS :
- 2375110-88-4
Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.
Formule :C₂₈H₁₇BrF₁₂N₂O₂
Couleur et forme :Solid
Masse moléculaire :721.33
Ref: TM-T201028
+ Info
Remlifanserin
CAS :
- 2289704-13-6
Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).
Formule :C₂₄H₂₉F₂N₃O₂
Couleur et forme :Solid
Masse moléculaire :429.50
Ref: TM-T201055
+ Info
(S)-Praziquantel
CAS :
- 57452-97-8
(S)-Praziquantel is the inactive isomer of R-praziquantel.
Formule :C₁₉H₂₄N₂O₂
Couleur et forme :Solid
Masse moléculaire :312.406
Ref: TM-T206068
+ Info
Dihydro-β-erythroidine hydrobromide
CAS :
- 29734-68-7
Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).
Formule :C₁₆H₂₂BrNO₃
Degré de pureté :98%
Couleur et forme :White Solid
Masse moléculaire :356.26
Ref: TM-T11041
+ Info
BChE-IN-5
BChE-IN-5: potent, selective BChE inhibitor (IC50: 2.8 nM), more effective on hBChE, potential in Alzheimer's research.
Formule :C₃₀H₄₂N₄O
Couleur et forme :Solid
Masse moléculaire :474.68
Ref: TM-T63091
+ Info
MAO-B-IN-5
CAS :
- 849909-77-9
MAO-B-IN-5: potent, selective oral MAO-B inhibitor, IC50=0.204μM, potential for Parkinson's research.
Formule :C₁₉H₂₁FN₂O₂
Degré de pureté :97.68%
Couleur et forme :Solid
Masse moléculaire :328.38
Ref: TM-T9759
+ Info
MAO-B-IN-10
MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.
Formule :C₂₃H₂₆N₂O₄
Couleur et forme :Solid
Masse moléculaire :394.46
Ref: TM-T61830
+ Info
AM9405
AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.
Formule :C₂₄H₃₃BrN₂O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :461.44
Ref: TM-T10294
+ Info
LRRK2-IN-16
CAS :
- 852375-30-5
LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.
Formule :C₁₈H₁₉N₅OS
Couleur et forme :Solid
Masse moléculaire :353.441
Ref: TM-T204380
+ Info
Serotonin maleate
CAS :
- 18525-25-2
Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.
Formule :C₁₄H₁₆N₂O₅
Couleur et forme :Solid
Masse moléculaire :292.287
Ref: TM-T204388
+ Info
Moxetomidate
CAS :
- 1567838-90-7
Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.
Formule :C₁₅H₁₈N₂O₃
Couleur et forme :Solid
Masse moléculaire :274.315
Ref: TM-T205308
+ Info
AChE-IN-84
CAS :
- 3779-42-8
AChE-IN-84 (compound 21) is an inhibitor of AChE.
Formule :C₆H₁₅Br₂N
Couleur et forme :Solid
Masse moléculaire :260.998
Ref: TM-T205413
+ Info
25B-NBOH hydrochloride
CAS :
- 1539266-16-4
25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.
Formule :C₁₇H₂₁BrClNO₃
Couleur et forme :Solid
Masse moléculaire :402.711
Ref: TM-T204858
+ Info
D3/5-HT receptor modulator-1
CAS :
- 898532-85-9
D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.
Formule :C₂₄H₂₉N₃O₂
Couleur et forme :Solid
Masse moléculaire :391.506
Ref: TM-T205297
+ Info
SB 243213 hydrochloride
CAS :
- 200940-23-4
SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It
Formule :C₂₂H₂₀ClF₃N₄O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :464.87
Ref: TM-T12859
+ Info
Anti-Aβ agent 1A
Anti-Aβ agent 1A is a potent anti-amyloid-β agent.
Formule :C₃₅H₄₉NO₄
Couleur et forme :Solid
Masse moléculaire :547.77
Ref: TM-T63873
+ Info
UB 165
CAS :
- 200432-86-6
Subtype-selective nicotinic agonist
Formule :C₁₃H₁₅ClN₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :234.72
Ref: TM-T23485
+ Info
Aβ42-IN-1
CAS :
- 2582757-69-3
Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).
Formule :C₂₉H₂₇ClN₄O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :499
Ref: TM-T10211
+ Info
5-IAI hydrochloride
CAS :
- 1782044-60-3
5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.
Formule :C₉H₁₁ClIN
Couleur et forme :Solid
Masse moléculaire :295.548
Ref: TM-T204949
+ Info
BF-168
CAS :
- 634911-47-0
BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).
Formule :C₁₈H₁₇FN₂O₂
Couleur et forme :Solid
Masse moléculaire :312.34
Ref: TM-T10529
+ Info
P2X4 antagonist-1
CAS :
- 2055601-42-6
P2X4 antagonist-1 is a potent P2X4 receptor antagonist used in the study of neurological, cardiovascular, and immune system diseases.
Formule :C₂₀H₁₅Cl₃N₂O₄S
Degré de pureté :99.9%
Couleur et forme :Solid
Masse moléculaire :485.77
Ref: TM-T87086
+ Info
GABA-IN-4
CAS :
- 61-38-1
GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.
Formule :C₁₇H₁₃ClN₂O₂
Couleur et forme :Solid
Masse moléculaire :312.75
Ref: TM-T205501
+ Info
Ro4368554
CAS :
- 478082-99-4
Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.
Formule :C₁₉H₂₁N₃O₂S
Couleur et forme :Solid
Masse moléculaire :355.454
Ref: TM-T204915
+ Info
hAChE-IN-10
CAS :
- 3058182-98-9
hAChE-IN-10 (Compound ET11) is an inhibitor of human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. This compound is capable of scavenging free radicals and exhibits antioxidant activity. Additionally, hAChE-IN-10 demonstrates metal-chelating properties, inhibiting Cu2+-induced Aβ1-42 aggregation, reducing amyloid plaque formation, and offering neuroprotective effects. It also ameliorates cognitive impairment in mice induced by Scopolamine.
Formule :C₂₅H₂₄ClFN₆O₂
Couleur et forme :Solid
Masse moléculaire :494.948
Ref: TM-T204876
+ Info
MAO-A inhibitor 3
CAS :
- 35924-44-8
MAO-A inhibitor3 (Compound 360) is an MAO-A inhibitor with an IC50 greater than 100 μM. It is utilized in the investigation of neurological disorders.
Formule :C₁₁H₈O₅
Couleur et forme :Solid
Masse moléculaire :220.178
Ref: TM-T205117
+ Info
LOXL2-IN-1 tosylate
LOX-IN-5 tosylate (compound 22) is a selective oral inhibitor of lysyl oxidase-like 2 (LOXL2) with an IC50 of less than 300 nM, and it exhibits anti-fibrotic properties.
Formule :C₂₈H₃₃FN₄O₅S₂
Couleur et forme :Solid
Masse moléculaire :588.714
Ref: TM-T205044
+ Info
VU6016235
CAS :
- 2344787-70-6
VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.
Formule :C₂₁H₂₂N₄OS
Couleur et forme :Solid
Masse moléculaire :378.49
Ref: TM-T201326
+ Info
8 Hydroxy PIPAT oxalate
CAS :
- 1451210-48-2
8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.
Formule :C₁₈H₂₄INO₅
Couleur et forme :Solid
Masse moléculaire :461.29
Ref: TM-T201052
+ Info
MAO-B-IN-34
CAS :
- 86710-21-6
MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase B.
Formule :C₁₅H₉Cl₂NO₃
Couleur et forme :Solid
Masse moléculaire :322.14
Ref: TM-T200499
+ Info
Aβ aggregation-IN-1
CAS :
- 352525-91-8
Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.
Formule :C₉H₈BF₃O₂
Couleur et forme :Solid
Masse moléculaire :215.965
Ref: TM-T204182
+ Info
BChE-IN-3
BChE-IN-3: Selective, pseudo-irreversible BChE inhibitor (IC50: 56.9 nM); borderline reversible AChE inhibitor.
Formule :C₂₆H₄₁N₃O₂
Couleur et forme :Solid
Masse moléculaire :427.62
Ref: TM-T62336
+ Info
Zanapezil fumarate
CAS :
- 263248-42-6
Zanapezil is an acetylcholinesterase (AChE) inhibitor. Zanapezil increases choline acetyltransferase activity in cultured rat septal cholinergic neurons.
Formule :C₂₉H₃₆N₂O₅
Couleur et forme :Solid
Masse moléculaire :492.61
Ref: TM-T29203
+ Info
Azotomycin
CAS :
- 7644-67-9
Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.
Formule :C₁₇H₂₃N₇O₈
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :453.41
Ref: TM-T26729
+ Info
VU6007496
CAS :
- 2127101-85-1
VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).
Formule :C₂₅H₂₇N₅O₂
Couleur et forme :Solid
Masse moléculaire :429.51
Ref: TM-T200762
+ Info
BACE1-IN-2
CAS :
- 1352416-78-4
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
Formule :C₁₉H₁₅F₄N₅O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :421.35
Ref: TM-T10451
+ Info
LY593093
CAS :
- 1108748-12-4
LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.
Formule :C₃₂H₃₀FN₃O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :507.6
Ref: TM-T27961
+ Info
1,9-Dideoxyforskolin
CAS :
- 64657-18-7
The compound is an inactive analog of forskolin(an adenylyl cyclase activator).
Formule :C₂₂H₃₄O₅
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :378.5
Ref: TM-T22467
+ Info
EF1502 free base
CAS :
- 684645-54-3
EF1502 is a potent and selective GABA transporter inhibitor.
Formule :C₂₂H₂₆N₂O₂S₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :414.58
Ref: TM-T27241
+ Info
Metoquizine
CAS :
- 7125-67-9
Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.
Formule :C₂₂H₂₇N₅O
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :377.48
Ref: TM-T25805
+ Info
Pareptide monohydrochloride
CAS :
- 63236-23-7
Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).
Formule :C₁₄H₂₇ClN₄O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :334.84
Ref: TM-T13707
+ Info
SB 258741 hydrochloride
SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].
Formule :C₁₉H₃₁ClN₂O₂S
Couleur et forme :Solid
Masse moléculaire :386.98
Ref: TM-T61724
+ Info
YM 202074
CAS :
- 299900-84-8
metabotropic glutamate receptor type 1 (mGlu1) antagonist
Formule :C₅₆H₇₂N₈O₁₆S₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :1177.34
Ref: TM-T23544
+ Info
PXS-5153A monohydrochloride
CAS :
- 2125956-82-1
PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.
Formule :C₂₀H₂₅Cl₂FN₄O₂S
Degré de pureté :98%
Couleur et forme :Odour Solid
Masse moléculaire :475.41
Ref: TM-T12585L
+ Info
HDAC6-IN-9
CAS :
- 2796282-58-9
HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.
Formule :C₁₉H₁₆N₂O₃
Degré de pureté :98.84%
Couleur et forme :Solid
Masse moléculaire :320.34
Ref: TM-T60856
+ Info
LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.
Formule :C₂₄H₂₆F₂N₄O₂S
Couleur et forme :Solid
Masse moléculaire :472.55
Ref: TM-T63057
+ Info
PTCA
CAS :
- 871326-47-5
PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.
Formule :C₁₀H₅Cl₂NO₂S
Couleur et forme :Solid
Masse moléculaire :274.123
Ref: TM-T204835
+ Info
AChE/BChE-IN-19
CAS :
- 3036136-22-5
AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.
Formule :C₂₆H₂₂N₄O₃
Masse moléculaire :438.48
Ref: TM-T209831
+ Info
MAO-B-IN-28
CAS :
- 3028096-72-9
MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 value of 1.9±0.5 nM, potentially serving as a candidate molecule for neurodegenerative disease research.
Formule :C₁₉H₁₀F₃NO₄S
Masse moléculaire :405.35
Ref: TM-T208337
+ Info
AZD 2066 hydrate
AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].
Formule :C₁₉H₁₈ClN₅O₃
Couleur et forme :Solid
Masse moléculaire :386.33
Ref: TM-T61708
+ Info
SB 224289
CAS :
- 180083-23-2
SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.
Formule :C₃₂H₃₂N₄O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :520.62
Ref: TM-T19690
+ Info
COX-2-IN-47
CAS :
- 2043670-02-4
COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.
Formule :C₁₈H₁₈N₂O₄
Couleur et forme :Solid
Masse moléculaire :326.35
Ref: TM-T200034
+ Info
VA012
CAS :
- 885898-58-8
VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.
Formule :C₂₁H₁₉N₃
Couleur et forme :Solid
Masse moléculaire :313.40
Ref: TM-T200241
+ Info
MAO-A/SERT-IN-1
CAS :
- 3001361-38-9
MAO-A/SERT-IN-1 acts as an inhibitor for both MAO-A and the serotonin transporter (SERT). It decreases the SERT-mediated reuptake of 5-HT and demonstrates neuroprotective properties in cellular inhibition models. Additionally, this compound has shown to alleviate depressive behaviors in both zebrafish and mice.
Formule :C₁₉H₁₄N₂O₅
Couleur et forme :Solid
Masse moléculaire :350.32
Ref: TM-T200256
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5-HT2A/5-HT2C inverse agonist 1
CAS :
- 2718990-76-0
5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.
Formule :C₂₄H₃₅N₅O₂
Couleur et forme :Solid
Masse moléculaire :425.57
Ref: TM-T200089
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R-96544 hydrochloride
CAS :
- 167144-79-8
5-HT2 receptor antagonist
Formule :C₂₂H₂₉NO₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :355.47
Ref: TM-T23219
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QP5020
CAS :
- 3027434-06-3
QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.
Formule :C₂₀H₁₉FN₆
Masse moléculaire :362.40
Ref: TM-T208804
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HW161023
CAS :
- 2920698-73-1
HW161023 (compound) is an orally active inhibitor of AP2 associated protein kinase 1 (AAK1), exhibiting IC50 values of 5.4 nM for AAK1 and 11.9 μM for hERG. HW161023 can suppress pain response in a rat model of chronic sciatic nerve compression injury.
Formule :C₂₀H₂₄F₂N₄O
Couleur et forme :Solid
Masse moléculaire :374.428
Ref: TM-T206896
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Pomaglumetad methionil
CAS :
- 956385-05-0
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
Formule :C₁₂H₂₀N₂O₈S₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :384.43
Ref: TM-T12520