Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(940 produits)
- ACK(1 produits)
- AChR(574 produits)
- ATP Citrate Lyase(16 produits)
- Récepteur adrénergique(2.939 produits)
- BACE(36 produits)
- Bêta-amyloïde(204 produits)
- CaMK(68 produits)
- COX(562 produits)
- Récepteur de la dopamine(407 produits)
- Récepteur GABA(336 produits)
- Gamma-sécrétase(59 produits)
- GluR(255 produits)
- GlyT(24 produits)
- Récepteur de l'histamine(358 produits)
- LRRK2(33 produits)
- Récepteur de la mélatonine(24 produits)
- NMDAR(28 produits)
- Récepteur OX(40 produits)
- Récepteur opioïde(296 produits)
Affichez 12 plus de sous-catégories
5400 produits trouvés pour "Neuroscience"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
5-HT7R antagonist 3
CAS :<p>Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.</p>Formule :C30H33FN4O3Couleur et forme :SolidMasse moléculaire :516.612,6-Dimethoxybenzylamine hydrochloride
CAS :<p>2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO) and inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC50 values of 120 μM and 190 μM, respectively.</p>Formule :C9H14ClNO2Couleur et forme :SolidMasse moléculaire :203.666FP0429
CAS :<p>FP0429 is an agonist of mGlu4.</p>Formule :C10H12N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :272.21DL-Thyroxine
CAS :<p>DL-Thyroxine is a thyroid hormone that acts as a monoamine oxidase (monoamine oxidase) inhibitor.</p>Formule :C15H11I4NO4Couleur et forme :SolidMasse moléculaire :776.87LRRK2-IN-16
CAS :<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Formule :C18H19N5OSCouleur et forme :SolidMasse moléculaire :353.441Antioxidant agent-8
<p>Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.</p>Formule :C13H12O5Couleur et forme :SolidMasse moléculaire :248.23(+)-Cevimeline hydrochloride hemihydrate
<p>(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.</p>Formule :C10H19ClNO1·5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :244.78BChE-IN-5
<p>BChE-IN-5: potent, selective BChE inhibitor (IC50: 2.8 nM), more effective on hBChE, potential in Alzheimer's research.</p>Formule :C30H42N4OCouleur et forme :SolidMasse moléculaire :474.68PF-06648671
CAS :<p>PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.</p>Formule :C25H23ClF4N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.92AChE/BuChE-IN-3
CAS :<p>AChE/BuChE-IN-3 inhibits AChE (IC50: 0.65 μM), BuChE (IC50: 5.77 μM), crosses BBB, and hinders Aβ1-42 aggregation for Alzheimer's research.</p>Formule :C30H30F3N3O6Couleur et forme :SolidMasse moléculaire :585.57Carlina oxide
CAS :<p>Carlina oxide is both an AChE inhibitor and an antioxidant, effective in eliminating mosquito larvae (LC50=1.39 μg/mL). Furthermore, Carlina oxide exhibits cytotoxicity in vertebrate cells, human dermis, and HCT116 and MDA-MB231 cell lines.</p>Formule :C13H10OCouleur et forme :SolidMasse moléculaire :182.22LRRK2-IN-3
CAS :<p>LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.</p>Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99LRRK2-IN-5
<p>LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.</p>Formule :C24H26F2N4O2SCouleur et forme :SolidMasse moléculaire :472.55MAO-A/SERT-IN-1
CAS :<p>MAO-A/SERT-IN-1 acts as an inhibitor for both MAO-A and the serotonin transporter (SERT). It decreases the SERT-mediated reuptake of 5-HT and demonstrates neuroprotective properties in cellular inhibition models. Additionally, this compound has shown to alleviate depressive behaviors in both zebrafish and mice.</p>Formule :C19H14N2O5Couleur et forme :SolidMasse moléculaire :350.32PXS-5153A monohydrochloride
CAS :<p>PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.</p>Formule :C20H25Cl2FN4O2SDegré de pureté :98%Couleur et forme :Odour SolidMasse moléculaire :475.41Monoamine Oxidase B inhibitor 1
<p>Potent, selective MAO-B inhibitor; reversible; oral; crosses BBB; IC50=0.02 nM; potential for Parkinson's research.</p>Formule :C18H15FO3Couleur et forme :SolidMasse moléculaire :298.31MAO-IN-4
CAS :<p>MAO-IN-4 (Compound 2l), a monoamine oxidase (MAO) inhibitor, demonstrates IC50 values of 0.07 μM for MAO-A and 0.75 μM for MAO-B. This compound is utilized in studying depression and Parkinson's disease (PD) [1].</p>Formule :C18H11Cl2N3OSCouleur et forme :SolidMasse moléculaire :388.27Glutaminyl Cyclase Inhibitor 3
CAS :<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Formule :C24H32N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.61AChE/Aβ-IN-5
CAS :<p>Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].</p>Formule :C25H24N4Couleur et forme :SolidMasse moléculaire :380.48AChE-IN-63
CAS :<p>AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].</p>Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38UB 165
CAS :<p>Subtype-selective nicotinic agonist</p>Formule :C13H15ClN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :234.72BACE1-IN-2
CAS :<p>BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).</p>Formule :C19H15F4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.35γ-Secretase modulator 11 hydrochloride
CAS :<p>γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).</p>Formule :C28H23ClF2N4O2Couleur et forme :SolidMasse moléculaire :520.96eeAChE-IN-1
<p>eeAChE-IN-1 is a strong inhibitor of eeAChE (IC50: 23 nM).</p>Formule :C27H30N6O5SCouleur et forme :SolidMasse moléculaire :550.63U92016A hydrochloride
CAS :<p>U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.</p>Formule :C19H26ClN3Couleur et forme :SolidMasse moléculaire :331.89AChE-IN-8
<p>AChE-IN-8 (Compound 19), potent acetylcholinesterase blocker; IC50 = 1.95 μM; potential Alzheimer's treatment.</p>Formule :C20H22N4O2SCouleur et forme :SolidMasse moléculaire :382.48BACE-1 inhibitor 2
CAS :<p>BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].</p>Formule :C21H21F4N5O3Couleur et forme :SolidMasse moléculaire :467.42SB 243213 dihydrochloride
CAS :<p>SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for</p>Formule :C22H21Cl2F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.33THRX-194556
CAS :<p>THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.</p>Formule :C28H41N5O5SCouleur et forme :SolidMasse moléculaire :559.721SEP-363856 mesylate
CAS :<p>SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.</p>Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38PF-06751979
CAS :<p>PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).</p>Formule :C18H19F2N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :455.5CPPG
CAS :<p>CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.</p>Formule :C11H14NO5PCouleur et forme :SolidMasse moléculaire :271.21RTIOXA-43
CAS :<p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>Formule :C37H37N5O5SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :663.79AAZ-A 154 hydrobromide
CAS :<p>AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.</p>Formule :C14H21BrN2OCouleur et forme :SolidMasse moléculaire :313.23AAZ-A 154 benzoate
CAS :<p>AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.</p>Formule :C21H26N2O3Couleur et forme :SolidMasse moléculaire :354.44AAZ-A 154 hydrochloride
CAS :<p>AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.</p>Formule :C14H21ClN2OCouleur et forme :SolidMasse moléculaire :268.78PXS-4787 hydrochloride
CAS :<p>PXS-4787 hydrochloride is a specific and potent pan-lysyl oxidase inhibitor that effectively eliminates the activity of lysyl oxidase. It exhibits varying IC50 values against different forms of the enzyme, including 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). In addition, PXS-4787 hydrochloride reduces the deposition and cross-linking of collagen I secreted by human fibroblasts.</p>Formule :C10H13ClFNO2SCouleur et forme :SolidMasse moléculaire :265.73Nafimidone hydrochloride
CAS :<p>Nafimidone hydrochloride, an antiepileptic agent, inhibits acetylcholinesterase, protects neurons, and ameliorates cognitive decline. It is utilized in epilepsy research.</p>Formule :C15H13ClN2OCouleur et forme :SolidMasse moléculaire :272.73AAZ-A 154 mesylate
CAS :<p>AAZ-A 154 mesylate mesylate is a selective, competitive, and non-hallucinogenic antagonist of 5-HT2AR. It enhances neuronal growth in rodents and produces enduring beneficial behavioral effects.</p>Formule :C15H24N2O4SCouleur et forme :SolidMasse moléculaire :328.43DA-8031
CAS :<p>DA-8031 is a selective and orally active serotonin reuptake inhibitor. It is utilized in research related to premature ejaculation (PE).</p>Formule :C21H24N2O2Couleur et forme :SolidMasse moléculaire :336.43Sulamserod hydrochloride
CAS :<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Formule :C19H29Cl2N3O5SCouleur et forme :SolidMasse moléculaire :482.42Remlifanserin
CAS :<p>Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).</p>Formule :C24H29F2N3O2Couleur et forme :SolidMasse moléculaire :429.50VA012
CAS :<p>VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.</p>Formule :C21H19N3Couleur et forme :SolidMasse moléculaire :313.40Pomaglumetad methionil
CAS :<p>Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.</p>Formule :C12H20N2O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :384.43(RS)-AMPA hydrochloride
CAS :<p>(RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analog and serves as an efficient selective agonist for the excitatory neurotransmitter L-glutamic acid (L-glutamic acid). It does not interfere with the binding sites of alginate or NMDA receptors.</p>Formule :C7H11ClN2O4Couleur et forme :SolidMasse moléculaire :222.63AAZ-A 154
CAS :<p>AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.</p>Formule :C14H20N2OCouleur et forme :SolidMasse moléculaire :232.32Rodatristat ethyl
CAS :<p>Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.</p>Formule :C29H31ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.045-HT1A antagonist 1
<p>Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.</p>Formule :C23H29ClN6O2Couleur et forme :SolidMasse moléculaire :456.97(E)-CHBO4
CAS :<p>(E)-CHBO4 is an MAO-B inhibitor with an IC50 value of 0.023 μM, making it a potential candidate for research into Parkinson's disease treatment.</p>Formule :C15H10BrFOCouleur et forme :SolidMasse moléculaire :305.142Lu 26-046
CAS :<p>Lu 26-046 is a muscarinic receptor agonist.</p>Formule :C10H12N2OSCouleur et forme :SolidMasse moléculaire :208.28
