Bêta-amyloïde
Les inhibiteurs de bêta-amyloïde sont des composés qui ciblent spécifiquement et inhibent la formation ou l'agrégation des peptides bêta-amyloïdes, impliqués de manière critique dans la pathogenèse de la maladie d'Alzheimer. L'accumulation de plaques bêta-amyloïdes dans le cerveau est l'un des principaux signes pathologiques de la maladie d'Alzheimer, contribuant à la dysfonction neuronale, à la perte synaptique et au déclin cognitif. En empêchant l'agrégation des bêta-amyloïdes, ces inhibiteurs font l'objet de recherches intensives comme agents thérapeutiques potentiels visant à ralentir ou même arrêter la progression de la maladie d'Alzheimer. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de bêta-amyloïde de haute qualité pour soutenir vos recherches sur les troubles neurodégénératifs, l'agrégation des protéines et le développement de thérapies pour la maladie d'Alzheimer.
205 produits trouvés pour "Bêta-amyloïde"
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JLK6
CAS :<p>JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling</p>Formule :C10H8ClNO3Degré de pureté :96.50%Couleur et forme :SolidMasse moléculaire :225.63PBD-150
CAS :<p>PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)</p>Formule :C15H20N4O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :320.41CRANAD 2
CAS :<p>CRANAD-2, a near-infrared probe, detects amyloid-beta in vivo, increasing fluorescence 70x and shifting blue 90 nm upon binding.</p>Formule :C23H25BF2N2O2Degré de pureté :99.44%Couleur et forme :Dark Blue To Black PowderMasse moléculaire :410.271,1'-Methylenedi-2-naphthol
CAS :<p>1,1'-Methylenedi-2-naphthol target CYP2C19 - cytochrome P450 family 2 subfamily C member 19 (human).</p>Formule :C21H16O2Degré de pureté :98.91%Couleur et forme :Light Pink To Light Brown Crystalline PowderMasse moléculaire :300.35Azeliragon HCl
CAS :<p>Azeliragon: potent oral RAGE inhibitor, blocks Alzheimer's-linked amyloid brain entry.</p>Formule :C32H40Cl3N3O2Couleur et forme :SolidMasse moléculaire :605.04Semagacestat
CAS :<p>Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).</p>Formule :C19H27N3O4Degré de pureté :97.1% - 99.9%Couleur et forme :SolidMasse moléculaire :361.44FPS-ZM1
CAS :<p>FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.</p>Formule :C20H22ClNODegré de pureté :99.32% - 99.52%Couleur et forme :SolidMasse moléculaire :327.85Dihydroergocristine mesylate
CAS :<p>DHEC mesylate is a vasodilator and α-adrenergic antagonist used for vascular dementia and as a geroprotector.</p>Formule :C36H45N5O8SDegré de pureté :98.9% - 99.65%Couleur et forme :SolidMasse moléculaire :707.84Miridesap
CAS :<p>Miridesap (GSK2315698) rapidly depletes SAP in blood, cerebrospinal fluid, and amyloid deposits via liver clearance.</p>Formule :C16H24N2O6Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :340.37Pyridoxal 5'-phosphate hydrate
CAS :<p>Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,</p>Formule :C8H10NO6PDegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :247.14PiB
CAS :<p>PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</p>Formule :C14H12N2OSDegré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :256.32Cromoglicic acid
CAS :<p>Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.</p>Formule :C23H16O11Degré de pureté :99.55% - >99.99%Couleur et forme :Colorless Crystals From Ethanol + Ether Physical Description Solid (Ntp 1992)Masse moléculaire :468.37Benzenesulfonamide
CAS :<p>Benzenesulfonamide (Benzosulfonamide) ia an inhibitor of carbonic anhydrases.</p>Formule :C6H7NO2SDegré de pureté :99.42% - 99.99%Couleur et forme :White Crystalline PowderMasse moléculaire :157.19Semax acetate(80714-61-0 free base)
CAS :<p>Semax acetate is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.</p>Formule :C39H55N9O12SDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :873.98Azeliragon
CAS :<p>Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-</p>Formule :C32H38ClN3O2Degré de pureté :96.7% - 98.33%Couleur et forme :SolidMasse moléculaire :532.12ARN2966
CAS :<p>ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.</p>Formule :C12H12N2ODegré de pureté :99.52% - 99.86%Couleur et forme :SolidMasse moléculaire :200.24Edonerpic maleate
CAS :<p>Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).</p>Formule :C20H25NO6SDegré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :407.48LX2343
CAS :<p>LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.</p>Formule :C22H19ClN2O6SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :474.91Aftin-4
CAS :<p>Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.</p>Formule :C20H28N6ODegré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :368.48RO4929097
CAS :<p>RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).</p>Formule :C22H20F5N3O3Degré de pureté :98.5% - 99.51%Couleur et forme :SolidMasse moléculaire :469.4MK-0752
CAS :<p>MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).</p>Formule :C21H21ClF2O4SDegré de pureté :98% - 99.55%Couleur et forme :SolidMasse moléculaire :442.9PE859
CAS :<p>PE859 is a potent inhibitor of both tau and Aβ aggregation.</p>Formule :C28H24N4O2Degré de pureté :98.8% - 99.09%Couleur et forme :SolidMasse moléculaire :448.52Solanezumab
CAS :<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>Degré de pureté :96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.1 (kDa)γ-Secretase modulator 13
CAS :<p>γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.</p>Formule :C22H23FN6SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :422.52Remternetug
CAS :<p>Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidBapineuzumab
CAS :<p>Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).</p>Degré de pureté :95%Couleur et forme :LiquidDezamizumab
CAS :<p>Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidHomotaurine-d6
CAS :<p>Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.</p>Formule :C3D6H3NO3SCouleur et forme :SolidMasse moléculaire :145.214-(6-Bromo-2-benzothiazolyl)benzenamine
CAS :<p>4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.</p>Formule :C13H9BrN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.19Aftin-5
CAS :<p>Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.</p>Formule :C19H26N6OCouleur et forme :SolidMasse moléculaire :354.454-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS :<p>4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).</p>Formule :C14H11BrN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.22Nicardipine pyridine metabolite II
CAS :<p>Nicardipine pyridine metabolite II is a biaoctive chemical.</p>Formule :C26H27N3O6Couleur et forme :SolidMasse moléculaire :477.51SEN-1269
CAS :<p>SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.</p>Formule :C18H18N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :322.36RU-505
CAS :<p>RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.</p>Formule :C28H32FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.58Astrophloxine
CAS :<p>Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and</p>Formule :C27H33IN2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :512.47Aβ Fibrillization modulator 1
CAS :<p>Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.</p>Formule :C17H12N4O3SSeCouleur et forme :SolidMasse moléculaire :431.33Neuroinflammatory-IN-2
CAS :<p>Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.</p>Formule :C25H27FN2O3Couleur et forme :SolidMasse moléculaire :422.49ELND006
CAS :<p>ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.</p>Formule :C20H14F5N3O2SCouleur et forme :SolidMasse moléculaire :455.4THK-523
CAS :<p>THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.</p>Formule :C17H15FN2OCouleur et forme :SolidMasse moléculaire :282.31TC-E 5006
CAS :<p>γ-secretase modulator</p>Formule :C29H29F4NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.54OAB-14
CAS :<p>OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.</p>Formule :C32H46N4O2Couleur et forme :SolidMasse moléculaire :518.73Caprospinol
CAS :<p>Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity.</p>Formule :C33H52O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.76AZ4800
CAS :<p>AZD4800 is a gamma secretase modulators.</p>Formule :C24H29N5O3Couleur et forme :SolidMasse moléculaire :435.52RS-0466
CAS :<p>RS-0466 is an β-amyloid-induced cytotoxicity inhibitor.</p>Formule :C17H17N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.35YIAD-0205
CAS :<p>YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial</p>Formule :C26H16Br2ClN3Couleur et forme :SolidMasse moléculaire :565.69K 01-162
CAS :<p>K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.</p>Formule :C15H14BrNCouleur et forme :SolidMasse moléculaire :288.18KMS88009
CAS :<p>KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.</p>Formule :C19H19NO2Couleur et forme :SolidMasse moléculaire :293.36Chrysamine G
CAS :<p>Chrysamine G, Congo red analog, blocks Aβ toxicity, probes Alzheimer's amyloid.</p>Formule :C26H16N4Na2O6Couleur et forme :SolidMasse moléculaire :526.416Glutaminyl Cyclase Inhibitor 2
CAS :<p>Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).</p>Formule :C19H20FN3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :309.38JNJ-40418677
CAS :<p>JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.</p>Formule :C26H22F6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.44BChE-IN-8
CAS :<p>BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.</p>Formule :C18H12BrN7O2Couleur et forme :SolidMasse moléculaire :438.24BACE1/2-IN-1
CAS :<p>BACE1/2-IN-1 inhibits BACE1/2 with IC50s of 0.01μM/0.0053μM, has better permeability and lower Pgp efflux but reduced metabolic stability.</p>Formule :C21H31N5OSCouleur et forme :SolidMasse moléculaire :401.57Antioxidant agent-2
CAS :<p>Antioxidant agent-2 (3c), BBB-permeable, selectively chelates metals; shows neuroprotection, fights liver damage in Alzheimer's research.</p>Formule :C23H26N2O7Couleur et forme :SolidMasse moléculaire :442.46SV5
CAS :<p>SV5: potent anti-Alzheimer's, protects SHSY-5Y from Aβ1-42 death, stable with optimal pharmacology in plasma, antioxidant, neuroprotective.</p>Formule :C21H30N2O4S2Couleur et forme :SolidMasse moléculaire :438.6γ-Secretase modulator 12
CAS :<p>γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM.</p>Formule :C25H23N3O2Couleur et forme :SolidMasse moléculaire :397.47AY1511
CAS :<p>AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].</p>Formule :C17H14O6Couleur et forme :SolidMasse moléculaire :314.29TML-6
CAS :<p>TML-6, an oral derivative of curcumin, may help in Alzheimer's research by targeting amyloid production and various molecular pathways.</p>Formule :C30H37NO7Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :523.62BuChE-IN-2
CAS :<p>BuChE-IN-2 inhibits BuChE (IC50: 1.28 μM), NO (0.67 μM), Aβ, ROS, chelates Cu2+, penetrates BBB, used in Alzheimer's research.</p>Formule :C28H20F4N6O3Couleur et forme :SolidMasse moléculaire :564.49Glutaminyl Cyclase Inhibitor 5
<p>Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of</p>Formule :C22H30N6OCouleur et forme :SolidMasse moléculaire :394.51Aleplasinin
CAS :<p>Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic</p>Formule :C28H27NO3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :425.52Buntanetap
CAS :<p>Buntanetap ((+)-Phenserine) is an inhibitor of TINAPs used in the study of neurological disorders, endocrine and metabolic disorders, and cardiovascular disease</p>Formule :C20H23N3O2Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :337.42Glutaminyl Cyclase Inhibitor 1
CAS :<p>Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.</p>Formule :C21H24FN3O2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :369.43Aβ-IN-1
CAS :<p>Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).</p>Formule :C35H49NDegré de pureté :99.1%Couleur et forme :SoildMasse moléculaire :483.77amyloid P-IN-1
CAS :<p>amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and</p>Formule :C30H44N2O14Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :656.68Fenlean
CAS :<p>"Fenlean (FLZ) in phase I trial at Chinese Academy's Institute of Pharmacy for Parkinson's treatment."</p>Formule :C26H27NO6Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :449.5Ezeprogind disulfate
CAS :<p>Ezeprogind disulfate: neurotrophic inducer targeting neurodegeneration causes like Abeta, tau; for neurological disorder research.</p>Formule :C25H48N6O8S2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :624.81DSS30
CAS :<p>DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.</p>Formule :C16H14ClNO3S2Degré de pureté :99.19% - 99.4%Couleur et forme :SolidMasse moléculaire :367.87MAO-B-IN-9
CAS :<p>MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence.</p>Formule :C18H24N2O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :300.4BI-1408
CAS :<p>BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).</p>Formule :C22H23FN6Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :390.46MK-3328
CAS :<p>MK-3328, a potential Alzheimer's drug, binds β-Amyloid with strong affinity (IC50:10.5 nM) and may serve as a PET ligand to gauge plaque load.</p>Formule :C14H9FN4ODegré de pureté :99.70% - >99.99%Couleur et forme :SolidMasse moléculaire :268.25PPI-1019
CAS :<p>PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).</p>Formule :C36H54N6O5Degré de pureté :95.16% - 98.16%Couleur et forme :SolidMasse moléculaire :650.85QM-FN-SO3
CAS :<p>QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].</p>Formule :C29H25N4NaO3S2Couleur et forme :SolidMasse moléculaire :564.65Anti-amyloid agent-1
CAS :<p>Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].</p>Formule :C21H17F3N2O3Couleur et forme :SolidMasse moléculaire :402.37PQM130
CAS :<p>PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.</p>Formule :C23H27NO4Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :381.46ELND007
CAS :<p>ELND007 is a Gamma secretase inhibitor.</p>Formule :C19H14F4N4O2SCouleur et forme :SolidMasse moléculaire :438.4Aβ/tau aggregation-IN-3
CAS :<p>Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functional</p>Formule :C23H22N4O3Couleur et forme :SolidMasse moléculaire :402.45TRV-1387
CAS :<p>TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].</p>Formule :C23H25F3N4O2Couleur et forme :SolidMasse moléculaire :446.47BMS 433796
CAS :<p>BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.</p>Formule :C21H20F2N4O4Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :430.4RAGE/SERT-IN-1
CAS :<p>RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and</p>Formule :C38H41ClN4OSCouleur et forme :SolidMasse moléculaire :637.28QR-0217
CAS :<p>QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.</p>Formule :C19H13NO3Couleur et forme :SolidMasse moléculaire :303.31NNC 26-9100
CAS :<p>Somatostatin sst4 receptor agonist</p>Formule :C22H25BrCl2N6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.35γ-Secretase-IN-1
CAS :<p>γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.</p>Formule :C27H24F2N4O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :490.5MDR-1339
CAS :<p>MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.</p>Formule :C20H22O4Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :326.39Glutaminyl Cyclase Inhibitor 3
CAS :<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Formule :C24H32N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.61Antioxidant agent-8
<p>Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.</p>Formule :C13H12O5Couleur et forme :SolidMasse moléculaire :248.23Amilo-5MER
CAS :<p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>Formule :C23H40N6O9SCouleur et forme :SolidMasse moléculaire :576.664Amyloid-β-IN-2
CAS :<p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42Anti-Aβ agent 1A
<p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>Formule :C35H49NO4Couleur et forme :SolidMasse moléculaire :547.77MAO-B-IN-10
<p>MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.</p>Formule :C23H26N2O4Couleur et forme :SolidMasse moléculaire :394.46Aβ42 agonist-1
CAS :<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Formule :C15H11NO2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :237.25Aβ aggregation-IN-1
CAS :<p>Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.</p>Formule :C9H8BF3O2Couleur et forme :SolidMasse moléculaire :215.965Buntanetap L-Tartrate
CAS :<p>Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].</p>Formule :C24H29N3O8Couleur et forme :SolidMasse moléculaire :487.50cSPM
<p>cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.</p>Formule :C27H57N7Couleur et forme :SolidMasse moléculaire :479.79QP5020
CAS :<p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>Formule :C20H19FN6Masse moléculaire :362.40BF-168
CAS :<p>BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).</p>Formule :C18H17FN2O2Couleur et forme :SolidMasse moléculaire :312.342002-G12
CAS :<p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>Formule :C20H16N6Couleur et forme :SolidMasse moléculaire :340.381(9R)-RO7185876
CAS :<p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>Formule :C25H28F3N7Couleur et forme :SolidMasse moléculaire :483.532IXA62
CAS :<p>IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.</p>Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.458Amyloid-β-IN-3
CAS :<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42γ-secretase modulator 6
CAS :<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Formule :C25H26N6O2Couleur et forme :SolidMasse moléculaire :442.513
