Bêta-amyloïde
Les inhibiteurs de bêta-amyloïde sont des composés qui ciblent spécifiquement et inhibent la formation ou l'agrégation des peptides bêta-amyloïdes, impliqués de manière critique dans la pathogenèse de la maladie d'Alzheimer. L'accumulation de plaques bêta-amyloïdes dans le cerveau est l'un des principaux signes pathologiques de la maladie d'Alzheimer, contribuant à la dysfonction neuronale, à la perte synaptique et au déclin cognitif. En empêchant l'agrégation des bêta-amyloïdes, ces inhibiteurs font l'objet de recherches intensives comme agents thérapeutiques potentiels visant à ralentir ou même arrêter la progression de la maladie d'Alzheimer. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de bêta-amyloïde de haute qualité pour soutenir vos recherches sur les troubles neurodégénératifs, l'agrégation des protéines et le développement de thérapies pour la maladie d'Alzheimer.
205 produits trouvés pour "Bêta-amyloïde"
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Eprodisate disodium
CAS :<p>Eprodisate disodium (NC-503) is a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis.</p>Formule :C3H6Na2O6S2Degré de pureté :99.88%Couleur et forme :White Coarse PowderMasse moléculaire :248.19Donanemab
CAS :<p>Donanemab (LY3002813), a humanized IgG1 antibody, targets N-terminal Aβ for potential early Alzheimer's research.</p>Degré de pureté :95%Couleur et forme :LiquidLY 2389575 hydrochloride
CAS :<p>LY2389575 hydrochloride is a selective mGlu3 NAM with 190 nM IC50, increases Mrc1, and aids Alzheimer's research.</p>Formule :C15H16BrCl3N4Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :438.58ALZ-801
CAS :<p>ALZ-801, an oral valine-prodrug of tramiprosate, enhances treatment of Alzheimer's by inhibiting β-amyloid aggregation with better PK and tolerance.</p>Formule :C8H18N2O4SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :238.3Gantenerumab
CAS :<p>Gantenerumab (R-1450) is a humanized antibody targeting amyloid-β (Aβ), used in studies of Alzheimer's disease.</p>Degré de pureté :>95%Couleur et forme :LiquidGlimepiride
CAS :<p>Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.</p>Formule :C24H34N4O5SDegré de pureté :97.84% - 98.87%Couleur et forme :White Cyrstalline SolidMasse moléculaire :490.62Chlorzoxazone
CAS :<p>Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.</p>Formule :C7H4ClNO2Degré de pureté :99.49% - 99.6%Couleur et forme :SolidMasse moléculaire :169.57Birtamimab
CAS :<p>Birtamimab (NEOD001) is a monoclonal antibody selectively targeting and depleting amyloid protein, used in research on light chain amyloidosis.</p>Degré de pureté :>95%Couleur et forme :LiquidLecanemab
CAS :<p>Lecanemab (BAN-2401) is an IgG1 monoclonal antibody targeting soluble aggregated beta amyloid (Abeta) for the study of cognitive disorders.</p>Degré de pureté :95% - 97.3% (SEC-HPLC)Couleur et forme :LiquidCromolyn sodium
CAS :<p>Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.</p>Formule :C23H14Na2O11Degré de pureté :99.4% - 99.95%Couleur et forme :Colorless Crystals From Ethanol + Ether White Crystalline PowderMasse moléculaire :512.33Trontinemab
CAS :<p>Trontinemab, a bispecific humanized IgG1-κ antibody, targets the amyloid beta A4 precursor protein (APP) and transferrin receptor p90, CD71 (TFRC).</p>Degré de pureté :96.77% - 99%Couleur et forme :LiquidAducanumab
CAS :<p>Aducanumab (BIIB037) is an IgG1 antibody targeting amyloid beta to treat Alzheimer's; it's brain-permeable.</p>Degré de pureté :95% - 97.10%Couleur et forme :LiquidMasse moléculaire :145.93 kDaβ-Amyloid (33-40)
CAS :<p>β-Amyloid (33-40) is a peptide comprising amino acids 33 to 40 of the beta-amyloid protein.</p>Formule :C32H58N8O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :730.92GSK-3β inhibitor 27
<p>GSK-3β inhibitor27 (Compound 1c) is a reversible, competitive inhibitor of GSK-3β with an IC50 value of 2.2 μM. It inhibits tau hyperphosphorylation and reduces Aβ protein aggregation, demonstrating metal chelation and neuroprotective potential. GSK-3β inhibitor27 is promising for research into neurodegenerative diseases, such as Alzheimer's disease.</p>Formule :C16H17ClN4O2Couleur et forme :SolidMasse moléculaire :332.79Methoxy-X04
CAS :<p>Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).</p>Formule :C23H20O3Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :344.4β-Amyloid (10-20)
CAS :<p>Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-</p>Formule :C71H99N17O16Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :1446.65β-Amyloid (10-35), amide
CAS :<p>β-Amyloid (10-35), amide, is a chemical compound consisting of 26 amino acids, specifically residues 10-35 of the Aβ peptide.</p>Formule :C133H205N35O36SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2902.33δ-secretase inhibitor 11
CAS :<p>δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.</p>Formule :C10H12N4O2Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :220.23LPYFD-NH2
CAS :<p>neuroprotective peptide that binds to amyloid beta (Aβ)</p>Formule :C33H44N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :652.74BSB
CAS :<p>BSB is a Congo red-derived fluorescent probe, an amyloid protein imaging agent, interacting with amyloid fibrils formed by Aβ (1-40) peptides in rodents.</p>Formule :C24H17BrO6Degré de pureté :95.53%Couleur et forme :SolidMasse moléculaire :481.29β-Amyloid (22-35)
CAS :<p>β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells.</p>Formule :C59H102N16O21SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1403.62β-Amyloid (22-40)
CAS :<p>This synthetic peptide consists of amino acids 22 to 40 of beta amyloid protein.</p>Formule :C78H135N21O26SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1815.1β-Amyloid (13-27)
CAS :<p>β-Amyloid (13-27) is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein.</p>Formule :C84H126N24O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1856.05β-Amyloid (1-16)
CAS :<p>β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid.</p>Formule :C84H119N27O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1955.04Amyloid β Peptide (42-1)(human) acetate
<p>Amyloid β Peptide (42-1)(human) acetate is the inactive form of Amyloid β Peptide (1-42).</p>Degré de pureté :95.20%Couleur et forme :SoildPep63
CAS :Pep63, a neuroprotective peptide (VFQVRARTVA), enhances synaptic plasticity and memory. It competitively binds with Aβ1-42 oligomers, thereby inhibiting the formation of Aβ fibrils. Pep63 is employed in research focused on Alzheimer's disease (AD).Formule :C51H87N17O13Masse moléculaire :1146.34Chemerin-9 (149-157) TFA
<p>Chemerin-9 (149-157) TFA is a peptide located at positions 149-157 of chemerin-9, acting as a ChemR23/CMKLR1 agonist.</p>Formule :C56H67F3N10O15Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :1177.18β-Amyloid Protein Precursor 770 (135-155)
CAS :<p>Beta-Amyloid Protein Precursor 770 (135-155)Aβ Protein Precursor 770 (135-155)</p>Formule :C116H172N35O31S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2617.96Crenezumab
CAS :<p>Crenezumab (MABT 5102A) is a fully humanized anti-amyloid-beta antibody that binds to multiple forms of amyloid-beta (Aβ) for the study of Alzheimer's disease.</p>Degré de pureté :97.5% (SDS-PAGE); 95.3% (SEC-HPLC) - 97.5% (SDS-PAGE); 95.3% (SEC-HPLC)Couleur et forme :Liquidβ-Amyloid (4-10)
CAS :<p>Antibodies corresponding to beta-amyloid (4-10) are effective in vivo inhibitors of cytotoxicity, amyloid plaque formation and special memory disturbances in</p>Formule :C39H52N12O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :880.9p-HTAA
CAS :<p>Pentamer Hydrogen Thiophene Acetic Acid (p-HTAA) is a compound that specifically targets and labels amyloid-beta (Aβ) deposits in the brains of living mice [1].</p>Formule :C24H16O4S5Couleur et forme :SolidMasse moléculaire :528.71β-Amyloid (12-28)
CAS :<p>Amyloid β-peptide fragment; minimum section required to bind to brain proteins.</p>Formule :C89H135N25O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1955.18RAGE antagonist peptide
CAS :<p>RAGE antagonist blocks S100P/A4, HMGB-1; hinders glioma growth, metastasis; reduces PDAC cell growth, NF-κB activity; counters TDI effects in mice.</p>Formule :C57H101N13O17SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1272.56Biotinoyl tripeptide-1
CAS :<p>Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging.</p>Formule :C24H38N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.67β-Amyloid (1-28)
CAS :<p>β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding.</p>Formule :C145H209N41O46Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3262.51β-Amyloid (1-40)
CAS :<p>Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases.</p>Formule :C194H295N53O58SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4329.82γ-Secretase Modulators
CAS :<p>gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β.</p>Formule :C26H24F3N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.48Glycerophosphorylethanolamine (sodium salt)
CAS :<p>Glycerophosphorylethanolamine, a phosphatidylethanolamine metabolite, elevates in Alzheimer's and promotes Aβ40 aggregation.</p>Formule :C5H13NNaO6PCouleur et forme :SolidMasse moléculaire :237.12Aβ-IN-6
<p>Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's</p>Formule :C28H31N3O4Couleur et forme :SolidMasse moléculaire :473.56JNK3 inhibitor-9
<p>JNK3inhibitor-9 (Compound 24a) is a potent, selective JNK3 inhibitor capable of crossing the blood-brain barrier (BBB), demonstrating an IC50 value of 12 nM. It effectively inhibits GSK3α/β, which is involved in Tau phosphorylation, with IC50 values of 14 nM and 35 nM, respectively. JNK3inhibitor-9 also reduces the phosphorylation of c-Jun and APP and protects neurons from Aβ1-42 toxicity.</p>Formule :C25H27N7O2Couleur et forme :SolidMasse moléculaire :457.528Biphenyl-3′,3,4,4′-tetrol
CAS :<p>Biphenyl-3′,3,4,4′-tetrol (BPT) is a potent inhibitor of Aβ40 aggregation and can be utilized in research related to neurodegenerative diseases such as Alzheimer's.</p>Formule :C12H10O4Couleur et forme :SolidMasse moléculaire :218.21β-Amyloid (1-20)
CAS :<p>This synthetic peptide consists of amino acids 1 to 20 of beta amyloid protein.</p>Formule :C113H157N31O32Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2461.7β-Amyloid (35-42)
CAS :<p>β-Amyloid (35-42) is a peptide derived from the beta-amyloid protein, encompassing amino acids 35 through 42.</p>Formule :C33H60N8O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :744.94AZD4694 Precursor
CAS :<p>AZD4694 Precursor used for synthesizing [18F]AZD4694, a high-affinity amyloid-β imaging agent.</p>Formule :C22H25N3O7Couleur et forme :SolidMasse moléculaire :443.45DDC 2′,3′-O-disulfate
<p>DDC 2′,3′-O-disulfate (compound 4) inhibits the fibrillization and oligomerization of Aβ42, showing promise for Alzheimer's disease (AD) research [1].</p>Formule :C17H16O11S2Couleur et forme :SolidMasse moléculaire :460.43Aβ-IN-8
<p>Aβ-IN-8, also known as compound 7e, is a potent inhibitor of Aβ aggregation [1].</p>Formule :C22H16F3N3O3SCouleur et forme :SolidMasse moléculaire :459.44β-Amyloid (1-9)
CAS :<p>This is an N-terminal fragment of beta amyloid.</p>Formule :C42H60N14O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1033.01Aβ-IN-7
<p>Aβ-IN-7 (compound 5a) acts as a potent inhibitor of Aβ aggregation, stabilizing Aβ monomers at 50 μM concentration to prevent them from forming larger oligomers</p>Formule :C14H10N2SCouleur et forme :SolidMasse moléculaire :238.31AC 253
CAS :<p>Amylin (AMY3) receptor antagonist; blocks cAMP, Ca2+, PKA, MAPK, Akt, and cFOS activity; prevents Aβ-induced neuronal death. Cyclic AC 253 variant exists.</p>Formule :C122H196N40O39Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2847.11β-Amyloid (1-11)
CAS :<p>Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid</p>Formule :C56H76N16O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1325.3β-Amyloid (18-28)
CAS :<p>Intracerebroventricular administration of synthetic peptides Beta-amyloid (12-20), (12-28), and (18-28) causes amnesia in mice.</p>Formule :C55H81N13O18Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1212.31BIBD-124
CAS :<p>BIBD-124, with an IC50 value of 9.51 nM, effectively binds to amyloid beta (Aβ) plaques.</p>Formule :C19H24FN3O3Couleur et forme :SolidMasse moléculaire :361.41(Gln22)-Amyloid β-Protein (1-42)
CAS :<p>(Gln22)-Amyloid β-Protein (1-42), a Dutch mutation (E22Q) variant of β-Amyloid (1-42), demonstrates increased fibrillogenic and pathogenic characteristics [1].</p>Formule :C203H312N56O59SCouleur et forme :SolidMasse moléculaire :4513.05β-Amyloid (1-34)
CAS :<p>This is a fragment of beta-amyloid peptide. It has amino acids 1 through 34.</p>Formule :C170H253N47O52Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3787.21H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]-2-methyl-1-(4-methylphenyl)-, ethyl ester
CAS :<p>Compound 5936-0108对β-淀粉样蛋白可能具有调节作用。</p>Formule :C26H34N2O7Degré de pureté :99.44%Couleur et forme :SoildMasse moléculaire :486.56Anti-Amyloid β Antibody (scFv59)
<p>Anti-Amyloid Beta Antibody (scFv59) is a human-derived antibody produced in CHO cells that targets Amyloid-β. For isotype control, please refer to Human IgG1 kappa, Isotype Control.</p>Couleur et forme :Odour Liquidβ-Amyloid (12-20)
CAS :<p>β-Amyloid (12-20) is a peptide fragment of β-Amyloid.Thsis peptide contain the amino acid residues VFF at position (18-20), suggesting that this triad has</p>Formule :C57H83N15O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1154.36β-Amyloid (29-40)
CAS :<p>β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties</p>Formule :C49H88N12O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1085.362002-H20
CAS :<p>2002-H20 is an Aβ42-induced cytotoxicity inhibitor. It acts by binding the Alzheimer's Aβ peptide and reducing its cytotoxicity.</p>Formule :C20H15N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.358BSBM6
CAS :<p>BSBM6 is an inhibitor of Aβ aggregation and neuronal toxicity that acts by reversing the aggregation and toxicity of amyloid-β peptides.</p>Formule :C23H29N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.49C18 L-erythro Ceramide (d18:1/18:0)
CAS :<p>C18 L-erythro Ceramide, a natural stereoisomer, inhibits rat brain mt-CDase with IC50 of 8.8 μM.</p>Formule :C36H71NO3Couleur et forme :SolidMasse moléculaire :565.95FITC-β-Ala-Amyloid β-Protein (1-42)
CAS :<p>FITC-β-Ala-Amyloid β-Protein (1-42) is a polypeptide identified through peptide screening. This screening method predominantly utilizes immunoassays to gather active polypeptides and is used in studying protein interactions, conducting functional analyses, and screening antigen epitopes, with particular application in the research and development of active molecules.</p>Formule :C227H327N57O66S2Masse moléculaire :4971.34251β-Amyloid (35-25)
CAS :<p>β-Amyloid (35-25) is the reverse sequence of β-Amyloid (25-35).</p>Formule :C45H81N13O14SMasse moléculaire :1060.27Amyloid β-Protein (1-24)
CAS :<p>Amyloid β-Protein (1-24) is a peptide identified through peptide screening. This tool predominantly employs immunoassays to gather and analyze active peptides. Peptide screening is utilized in studies involving protein interactions, functional analysis, and epitope screening, particularly relevant in the research and development of active molecules.</p>Formule :C130H183N35O40Masse moléculaire :2876.05β-Amyloid (11-22)
CAS :<p>β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s</p>Formule :C70H102N18O18Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1483.677-Deoxy-trans-dihydronarciclasine
CAS :<p>7-Deoxy-trans-dihydronarciclasine is an alkaloid that functions as a tobacco mosaic virus (TMV) inhibitor with an IC50 of 1.80 μM and also serves as an anti-</p>Formule :C14H15NO6Couleur et forme :SolidMasse moléculaire :293.27Aβ1-14-εK-KKK-MvF5 Th
<p>Aβ1-14-εK-KKK-MvF5 Th (UB311 immunogen I) is a biologically active peptide and one of the Aβ1–14 targeting peptides (B-cell epitope) used in UB-311.</p>Formule :C199H318N56O55Masse moléculaire :4372.38081Dalidnetug
CAS :<p>Dalidnetug is a humanized monoclonal antibody that targets human β-amyloid precursor protein (APP). By specifically binding to APP, Dalidnetug reduces the production of β-amyloid (Aβ), thereby demonstrating activity in clearing β-amyloid. This compound holds potential for research in Alzheimer's disease.</p>Couleur et forme :LiquidAmyloid-Forming peptide GNNQQNY
CAS :<p>Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental in</p>Formule :C33H48N12O14Couleur et forme :SolidMasse moléculaire :836.81G923-0271
CAS :<p>G923-0271 is a TDP-43 inhibitor that improves disease phenotypes in TDP-43 nematode models and reduces the overexpression of human TDP-43, ALS FTD.</p>Formule :C28H23FN4OCouleur et forme :SolidMasse moléculaire :450.51(Glu20)-Amyloid β-Protein (1-42)
CAS :<p>(Glu20)-Amyloid β-Protein (1-42) represents a variant of amyloid β-protein (Aβ) that fibrillizes more slowly.</p>Formule :C199H309N55O62SCouleur et forme :SolidMasse moléculaire :4495.98(D-Asp1)-Amyloid β-Protein (1-42)
CAS :<p>(D-Asp1)-Amyloid β-Protein (1-42), a peptide fragment of amyloid β-protein (Aβ), serves as the primary constituent of vascular and parenchymal amyloid deposits</p>Formule :C203H311N55O60SCouleur et forme :SolidMasse moléculaire :4514.04Acetyl-Tau Peptide (273-284) amide
CAS :<p>Acetyl-Tau Peptide (273-284) amide inhibits Ac-Aβ(25–35)-NH2 aggregation and models Aβ/Tau interaction.</p>Formule :C64H116N18O17Couleur et forme :SolidMasse moléculaire :1409.72CHF-5022
CAS :<p>CHF-5022 is a nonsteroidal anti-inflammatory drug that selectively inhibits the production of beta-amyloid protein (1-42) (ABETA42).</p>Formule :C17H12F4O2Couleur et forme :SolidMasse moléculaire :324.27FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
<p>FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium) is a FITC-labeled amyloid beta monomer, Alzheimer’s research, drug screening, and biomolecular studies.</p>Formule :C227H330N58O66S2Couleur et forme :SolidMasse moléculaire :4991.532,3-Dehydrosilybin A
CAS :<p>2,3-Dehydrosilybin A is a useful organic compound for research related to life sciences and the catalog number is T125202.</p>Formule :C25H20O10Couleur et forme :SolidMasse moléculaire :480.425β-Amyloid (1-38), mouse, rat
CAS :<p>β-Amyloid (1-38), derived from mice and rats, is a chemical compound comprising 38 amino acids, specifically residues 1-38 of the Aβ peptide.</p>Couleur et forme :Solidβ-Amyloid (1-43)(human) TFA
<p>β-Amyloid (1-43)(human) TFA exhibits greater aggregation tendencies and heightened toxicity compared to its well-established counterpart, Aβ1-42.</p>Formule :C209H319F3N56O64SCouleur et forme :SolidMasse moléculaire :4729.215-FAM-β-Amyloid (1-28)
<p>5-FAM-β-Amyloid (1-28) is a fluorescently-labeled peptide corresponding to the first 28 amino acids of the β-Amyloid protein.</p>Formule :C166H219N41O52Couleur et forme :SolidMasse moléculaire :3620.76β-Amyloid (1-17)
CAS :<p>This synthetic peptide consists of amino acids 1 to 17 of beta amyloid protein. This peptide can be employed in beta amyloid solubility studies.</p>Formule :C90H130N28O29Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2068.2AChE/Aβ-IN-6
<p>BACE1-IN-15 (compound 4j) serves as an effective inhibitor of BACE1 (β-secretase), efficiently mitigating the copper-induced toxicity of Aβ, with an EC50 value of 0.68 μM.</p>Couleur et forme :Odour SolidBiotin-β-Amyloid (1-42), human TFA
<p>Biotin-β-Amyloid (1-42), human TFA, also known as Biotin-Amyloid β-Peptide (1-42) (human) TFA, is a biotin-labeled 42-amino acid peptide implicated in the</p>Formule :C215H326F3N57O64S2Couleur et forme :SolidMasse moléculaire :4854.36mcK6A1
<p>mcK6A1 serves as an inhibitor of amyloid-β (Aβ) aggregation, selectively binding to the 16KLVFFA21 fragment of Aβ42, leading to the formation of an extended β-sheet structure and preventing the formation of Aβ42 oligomers. This compound is valuable for research into Alzheimer's disease and other amyloid-related disorders.</p>Formule :C71H99N17O16Couleur et forme :SolidMasse moléculaire :1446.65(Met(O)35)-Amyloid β-Protein (1-42)
<p>(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that of</p>Formule :C203H311N55O61SCouleur et forme :SolidMasse moléculaire :4530.04(Met(O2)35)-Amyloid β-Protein (1-42)
<p>(Met(O2)35)-Amyloid β-Protein (1-42) is a peptide [1] .</p>Formule :C203H311N55O62SCouleur et forme :SolidMasse moléculaire :4546.04Amyloid β-Protein (3-42)
CAS :<p>Amyloid β-Protein (3-42), the precursor of Pyr peptide, serves as the foundation of the amyloid template block in Alzheimer's disease when modified to</p>Couleur et forme :SolidSabirnetug
CAS :<p>Sabirnetug is a humanized IgG2κ monoclonal antibody that specifically targets the amyloid-β (A4) precursor protein.</p>Couleur et forme :LiquidSQ-3
<p>SQ-3, a quinoline analogue, prefers α-syn (Ki=39.3nM) to Aβ (Ki=230nM), and [18F]SQ3 is a lead for α-syn probes. [1]</p>Formule :C21H21FN2OCouleur et forme :SolidMasse moléculaire :336.4Davunetide
CAS :<p>Davunetide: neuroprotective 8-amino acid peptide, improves daily function in schizophrenia, boosts memory in mild cognitive impairment.</p>Formule :C36H60N10O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :824.92SEN177
CAS :<p>SEN177 shows the potential in the research of Huntington's disease that is a potent inhibitor of glutaminyl cyclase (QPCT) with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). The Ki value of SEN177 for human glutaminyl cyclase (hQC) is 20 nM. SEN177 significantly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates [1].</p>Formule :C18H19FN6Couleur et forme :SolidMasse moléculaire :338.38TH-237A
CAS :<p>TH-237A is a novel neuroprotective agent exhibiting favorable permeation across the blood-brain barrier.</p>Formule :C18H17F2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :333.335(Rac)-Z-Phe-Phe-FMK
CAS :<p>(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) is a cathepsin L inhibitor that inhibits the tendency of β-amyloid to induce apoptotic changes .</p>Formule :C27H27FN2O4Degré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :462.51Begacestat
CAS :Begacestat (GSI-953) is a potent and selective gamma-secretase inhibitor that inhibits Amyloid-beta, inhibits cleavage of APP,,Alzheimer's disease.Formule :C9H8ClF6NO3S2Couleur et forme :SolidMasse moléculaire :391.74AZD4694
CAS :<p>Flutafuranol (AZD4694/NAV4694) binds beta-amyloid, potential PET tracer for Alzheimer's. Non-F18 version supplied.</p>Formule :C14H11FN2O2Couleur et forme :SolidMasse moléculaire :258.25Cu(II)GTSM
CAS :<p>Cu(II)GTSM is a cell permeable copper complex inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau.</p>Formule :C6H10CuN6S2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :293.86EUK-134
CAS :<p>EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.</p>Formule :C18H18ClMnN2O4Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :416.74LY2811376
CAS :<p>LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).</p>Formule :C15H14F2N4SDegré de pureté :99% - 99.01%Couleur et forme :SolidMasse moléculaire :320.36Anle138b
CAS :<p>Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease</p>Formule :C16H11BrN2O2Degré de pureté :98.88% - 99.82%Couleur et forme :SolidMasse moléculaire :343.17Frentizole
CAS :<p>Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction</p>Formule :C15H13N3O2SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :299.35TAE-1
CAS :<p>TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.</p>Formule :C39H51I3N6O9Degré de pureté :94.58%Couleur et forme :SolidMasse moléculaire :1128.57JLK6
CAS :<p>JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling</p>Formule :C10H8ClNO3Degré de pureté :96.50%Couleur et forme :SolidMasse moléculaire :225.63PBD-150
CAS :<p>PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)</p>Formule :C15H20N4O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :320.41CRANAD 2
CAS :<p>CRANAD-2, a near-infrared probe, detects amyloid-beta in vivo, increasing fluorescence 70x and shifting blue 90 nm upon binding.</p>Formule :C23H25BF2N2O2Degré de pureté :99.44%Couleur et forme :Dark Blue To Black PowderMasse moléculaire :410.271,1'-Methylenedi-2-naphthol
CAS :<p>1,1'-Methylenedi-2-naphthol target CYP2C19 - cytochrome P450 family 2 subfamily C member 19 (human).</p>Formule :C21H16O2Degré de pureté :98.91%Couleur et forme :Light Pink To Light Brown Crystalline PowderMasse moléculaire :300.35Azeliragon HCl
CAS :<p>Azeliragon: potent oral RAGE inhibitor, blocks Alzheimer's-linked amyloid brain entry.</p>Formule :C32H40Cl3N3O2Couleur et forme :SolidMasse moléculaire :605.04Semagacestat
CAS :<p>Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).</p>Formule :C19H27N3O4Degré de pureté :97.1% - 99.9%Couleur et forme :SolidMasse moléculaire :361.44FPS-ZM1
CAS :<p>FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.</p>Formule :C20H22ClNODegré de pureté :99.32% - 99.52%Couleur et forme :SolidMasse moléculaire :327.85Dihydroergocristine mesylate
CAS :<p>DHEC mesylate is a vasodilator and α-adrenergic antagonist used for vascular dementia and as a geroprotector.</p>Formule :C36H45N5O8SDegré de pureté :98.9% - 99.65%Couleur et forme :SolidMasse moléculaire :707.84Miridesap
CAS :<p>Miridesap (GSK2315698) rapidly depletes SAP in blood, cerebrospinal fluid, and amyloid deposits via liver clearance.</p>Formule :C16H24N2O6Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :340.37Pyridoxal 5'-phosphate hydrate
CAS :<p>Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,</p>Formule :C8H10NO6PDegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :247.14PiB
CAS :<p>PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</p>Formule :C14H12N2OSDegré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :256.32Cromoglicic acid
CAS :<p>Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.</p>Formule :C23H16O11Degré de pureté :99.55% - >99.99%Couleur et forme :Colorless Crystals From Ethanol + Ether Physical Description Solid (Ntp 1992)Masse moléculaire :468.37Benzenesulfonamide
CAS :<p>Benzenesulfonamide (Benzosulfonamide) ia an inhibitor of carbonic anhydrases.</p>Formule :C6H7NO2SDegré de pureté :99.42% - 99.99%Couleur et forme :White Crystalline PowderMasse moléculaire :157.19Semax acetate(80714-61-0 free base)
CAS :<p>Semax acetate is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.</p>Formule :C39H55N9O12SDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :873.98Azeliragon
CAS :<p>Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-</p>Formule :C32H38ClN3O2Degré de pureté :96.7% - 98.33%Couleur et forme :SolidMasse moléculaire :532.12ARN2966
CAS :<p>ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.</p>Formule :C12H12N2ODegré de pureté :99.52% - 99.86%Couleur et forme :SolidMasse moléculaire :200.24Edonerpic maleate
CAS :<p>Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).</p>Formule :C20H25NO6SDegré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :407.48LX2343
CAS :<p>LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.</p>Formule :C22H19ClN2O6SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :474.91Aftin-4
CAS :<p>Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.</p>Formule :C20H28N6ODegré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :368.48RO4929097
CAS :<p>RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).</p>Formule :C22H20F5N3O3Degré de pureté :98.5% - 99.51%Couleur et forme :SolidMasse moléculaire :469.4MK-0752
CAS :<p>MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).</p>Formule :C21H21ClF2O4SDegré de pureté :98% - 99.55%Couleur et forme :SolidMasse moléculaire :442.9PE859
CAS :<p>PE859 is a potent inhibitor of both tau and Aβ aggregation.</p>Formule :C28H24N4O2Degré de pureté :98.8% - 99.09%Couleur et forme :SolidMasse moléculaire :448.52Solanezumab
CAS :<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>Degré de pureté :96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.1 (kDa)γ-Secretase modulator 13
CAS :<p>γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.</p>Formule :C22H23FN6SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :422.52Remternetug
CAS :<p>Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidBapineuzumab
CAS :<p>Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).</p>Degré de pureté :95%Couleur et forme :LiquidDezamizumab
CAS :<p>Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidHomotaurine-d6
CAS :<p>Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.</p>Formule :C3D6H3NO3SCouleur et forme :SolidMasse moléculaire :145.214-(6-Bromo-2-benzothiazolyl)benzenamine
CAS :<p>4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.</p>Formule :C13H9BrN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.19Aftin-5
CAS :<p>Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.</p>Formule :C19H26N6OCouleur et forme :SolidMasse moléculaire :354.454-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS :<p>4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).</p>Formule :C14H11BrN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.22Nicardipine pyridine metabolite II
CAS :<p>Nicardipine pyridine metabolite II is a biaoctive chemical.</p>Formule :C26H27N3O6Couleur et forme :SolidMasse moléculaire :477.51SEN-1269
CAS :<p>SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.</p>Formule :C18H18N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :322.36RU-505
CAS :<p>RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.</p>Formule :C28H32FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.58Astrophloxine
CAS :<p>Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and</p>Formule :C27H33IN2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :512.47Aβ Fibrillization modulator 1
CAS :<p>Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.</p>Formule :C17H12N4O3SSeCouleur et forme :SolidMasse moléculaire :431.33Neuroinflammatory-IN-2
CAS :<p>Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.</p>Formule :C25H27FN2O3Couleur et forme :SolidMasse moléculaire :422.49ELND006
CAS :<p>ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.</p>Formule :C20H14F5N3O2SCouleur et forme :SolidMasse moléculaire :455.4THK-523
CAS :<p>THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.</p>Formule :C17H15FN2OCouleur et forme :SolidMasse moléculaire :282.31TC-E 5006
CAS :<p>γ-secretase modulator</p>Formule :C29H29F4NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.54OAB-14
CAS :<p>OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.</p>Formule :C32H46N4O2Couleur et forme :SolidMasse moléculaire :518.73Caprospinol
CAS :<p>Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity.</p>Formule :C33H52O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.76AZ4800
CAS :<p>AZD4800 is a gamma secretase modulators.</p>Formule :C24H29N5O3Couleur et forme :SolidMasse moléculaire :435.52RS-0466
CAS :<p>RS-0466 is an β-amyloid-induced cytotoxicity inhibitor.</p>Formule :C17H17N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.35YIAD-0205
CAS :<p>YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial</p>Formule :C26H16Br2ClN3Couleur et forme :SolidMasse moléculaire :565.69K 01-162
CAS :<p>K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.</p>Formule :C15H14BrNCouleur et forme :SolidMasse moléculaire :288.18KMS88009
CAS :<p>KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.</p>Formule :C19H19NO2Couleur et forme :SolidMasse moléculaire :293.36Chrysamine G
CAS :<p>Chrysamine G, Congo red analog, blocks Aβ toxicity, probes Alzheimer's amyloid.</p>Formule :C26H16N4Na2O6Couleur et forme :SolidMasse moléculaire :526.416Glutaminyl Cyclase Inhibitor 2
CAS :<p>Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).</p>Formule :C19H20FN3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :309.38JNJ-40418677
CAS :<p>JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.</p>Formule :C26H22F6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.44BChE-IN-8
CAS :<p>BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.</p>Formule :C18H12BrN7O2Couleur et forme :SolidMasse moléculaire :438.24BACE1/2-IN-1
CAS :<p>BACE1/2-IN-1 inhibits BACE1/2 with IC50s of 0.01μM/0.0053μM, has better permeability and lower Pgp efflux but reduced metabolic stability.</p>Formule :C21H31N5OSCouleur et forme :SolidMasse moléculaire :401.57Antioxidant agent-2
CAS :<p>Antioxidant agent-2 (3c), BBB-permeable, selectively chelates metals; shows neuroprotection, fights liver damage in Alzheimer's research.</p>Formule :C23H26N2O7Couleur et forme :SolidMasse moléculaire :442.46SV5
CAS :<p>SV5: potent anti-Alzheimer's, protects SHSY-5Y from Aβ1-42 death, stable with optimal pharmacology in plasma, antioxidant, neuroprotective.</p>Formule :C21H30N2O4S2Couleur et forme :SolidMasse moléculaire :438.6γ-Secretase modulator 12
CAS :<p>γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM.</p>Formule :C25H23N3O2Couleur et forme :SolidMasse moléculaire :397.47AY1511
CAS :<p>AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].</p>Formule :C17H14O6Couleur et forme :SolidMasse moléculaire :314.29TML-6
CAS :<p>TML-6, an oral derivative of curcumin, may help in Alzheimer's research by targeting amyloid production and various molecular pathways.</p>Formule :C30H37NO7Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :523.62BuChE-IN-2
CAS :<p>BuChE-IN-2 inhibits BuChE (IC50: 1.28 μM), NO (0.67 μM), Aβ, ROS, chelates Cu2+, penetrates BBB, used in Alzheimer's research.</p>Formule :C28H20F4N6O3Couleur et forme :SolidMasse moléculaire :564.49Glutaminyl Cyclase Inhibitor 5
<p>Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of</p>Formule :C22H30N6OCouleur et forme :SolidMasse moléculaire :394.51Aleplasinin
CAS :<p>Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic</p>Formule :C28H27NO3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :425.52Buntanetap
CAS :<p>Buntanetap ((+)-Phenserine) is an inhibitor of TINAPs used in the study of neurological disorders, endocrine and metabolic disorders, and cardiovascular disease</p>Formule :C20H23N3O2Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :337.42Glutaminyl Cyclase Inhibitor 1
CAS :<p>Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.</p>Formule :C21H24FN3O2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :369.43Aβ-IN-1
CAS :<p>Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).</p>Formule :C35H49NDegré de pureté :99.1%Couleur et forme :SoildMasse moléculaire :483.77amyloid P-IN-1
CAS :<p>amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and</p>Formule :C30H44N2O14Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :656.68Fenlean
CAS :<p>"Fenlean (FLZ) in phase I trial at Chinese Academy's Institute of Pharmacy for Parkinson's treatment."</p>Formule :C26H27NO6Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :449.5Ezeprogind disulfate
CAS :<p>Ezeprogind disulfate: neurotrophic inducer targeting neurodegeneration causes like Abeta, tau; for neurological disorder research.</p>Formule :C25H48N6O8S2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :624.81DSS30
CAS :<p>DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.</p>Formule :C16H14ClNO3S2Degré de pureté :99.19% - 99.4%Couleur et forme :SolidMasse moléculaire :367.87MAO-B-IN-9
CAS :<p>MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence.</p>Formule :C18H24N2O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :300.4BI-1408
CAS :<p>BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).</p>Formule :C22H23FN6Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :390.46MK-3328
CAS :<p>MK-3328, a potential Alzheimer's drug, binds β-Amyloid with strong affinity (IC50:10.5 nM) and may serve as a PET ligand to gauge plaque load.</p>Formule :C14H9FN4ODegré de pureté :99.70% - >99.99%Couleur et forme :SolidMasse moléculaire :268.25PPI-1019
CAS :<p>PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).</p>Formule :C36H54N6O5Degré de pureté :95.16% - 98.16%Couleur et forme :SolidMasse moléculaire :650.85QM-FN-SO3
CAS :<p>QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].</p>Formule :C29H25N4NaO3S2Couleur et forme :SolidMasse moléculaire :564.65Anti-amyloid agent-1
CAS :<p>Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].</p>Formule :C21H17F3N2O3Couleur et forme :SolidMasse moléculaire :402.37PQM130
CAS :<p>PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.</p>Formule :C23H27NO4Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :381.46ELND007
CAS :<p>ELND007 is a Gamma secretase inhibitor.</p>Formule :C19H14F4N4O2SCouleur et forme :SolidMasse moléculaire :438.4Aβ/tau aggregation-IN-3
CAS :<p>Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functional</p>Formule :C23H22N4O3Couleur et forme :SolidMasse moléculaire :402.45TRV-1387
CAS :<p>TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].</p>Formule :C23H25F3N4O2Couleur et forme :SolidMasse moléculaire :446.47BMS 433796
CAS :<p>BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.</p>Formule :C21H20F2N4O4Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :430.4RAGE/SERT-IN-1
CAS :<p>RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and</p>Formule :C38H41ClN4OSCouleur et forme :SolidMasse moléculaire :637.28QR-0217
CAS :<p>QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.</p>Formule :C19H13NO3Couleur et forme :SolidMasse moléculaire :303.31NNC 26-9100
CAS :<p>Somatostatin sst4 receptor agonist</p>Formule :C22H25BrCl2N6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.35γ-Secretase-IN-1
CAS :<p>γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.</p>Formule :C27H24F2N4O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :490.5MDR-1339
CAS :<p>MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.</p>Formule :C20H22O4Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :326.39Glutaminyl Cyclase Inhibitor 3
CAS :<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Formule :C24H32N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.61Antioxidant agent-8
<p>Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.</p>Formule :C13H12O5Couleur et forme :SolidMasse moléculaire :248.23Amilo-5MER
CAS :<p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>Formule :C23H40N6O9SCouleur et forme :SolidMasse moléculaire :576.664Amyloid-β-IN-2
CAS :<p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42Anti-Aβ agent 1A
<p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>Formule :C35H49NO4Couleur et forme :SolidMasse moléculaire :547.77MAO-B-IN-10
<p>MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.</p>Formule :C23H26N2O4Couleur et forme :SolidMasse moléculaire :394.46Aβ42 agonist-1
CAS :<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Formule :C15H11NO2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :237.25Aβ aggregation-IN-1
CAS :<p>Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.</p>Formule :C9H8BF3O2Couleur et forme :SolidMasse moléculaire :215.965Buntanetap L-Tartrate
CAS :<p>Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].</p>Formule :C24H29N3O8Couleur et forme :SolidMasse moléculaire :487.50cSPM
<p>cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.</p>Formule :C27H57N7Couleur et forme :SolidMasse moléculaire :479.79QP5020
CAS :<p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>Formule :C20H19FN6Masse moléculaire :362.40BF-168
CAS :<p>BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).</p>Formule :C18H17FN2O2Couleur et forme :SolidMasse moléculaire :312.342002-G12
CAS :<p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>Formule :C20H16N6Couleur et forme :SolidMasse moléculaire :340.381(9R)-RO7185876
CAS :<p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>Formule :C25H28F3N7Couleur et forme :SolidMasse moléculaire :483.532IXA62
CAS :<p>IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.</p>Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.458Amyloid-β-IN-3
CAS :<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42γ-secretase modulator 6
CAS :<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Formule :C25H26N6O2Couleur et forme :SolidMasse moléculaire :442.513
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