Bêta-amyloïde
Les inhibiteurs de bêta-amyloïde sont des composés qui ciblent spécifiquement et inhibent la formation ou l'agrégation des peptides bêta-amyloïdes, impliqués de manière critique dans la pathogenèse de la maladie d'Alzheimer. L'accumulation de plaques bêta-amyloïdes dans le cerveau est l'un des principaux signes pathologiques de la maladie d'Alzheimer, contribuant à la dysfonction neuronale, à la perte synaptique et au déclin cognitif. En empêchant l'agrégation des bêta-amyloïdes, ces inhibiteurs font l'objet de recherches intensives comme agents thérapeutiques potentiels visant à ralentir ou même arrêter la progression de la maladie d'Alzheimer. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de bêta-amyloïde de haute qualité pour soutenir vos recherches sur les troubles neurodégénératifs, l'agrégation des protéines et le développement de thérapies pour la maladie d'Alzheimer.
228 produits trouvés pour "Bêta-amyloïde"
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β-Amyloid (1-11)
CAS :Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluidFormule :C56H76N16O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1325.3β-Amyloid (1-16) acetate
β-Amyloid (1-16) acetate, Fragment of β-Amyloid, N-terminal amino group coordinates metal ions (Cu/Zn), used for Alzheimer's disease research.Formule :C84H119N27O28·xC2H4O2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :1955.04 (free base)G923-0271
CAS :G923-0271 is a TDP-43 inhibitor that improves disease phenotypes in TDP-43 nematode models and reduces the overexpression of human TDP-43, ALS FTD.Formule :C28H23FN4OCouleur et forme :SolidMasse moléculaire :450.51Dalidnetug
CAS :Dalidnetug is a humanized monoclonal antibody that targets human β-amyloid precursor protein (APP). By specifically binding to APP, Dalidnetug reduces the production of β-amyloid (Aβ), thereby demonstrating activity in clearing β-amyloid. This compound holds potential for research in Alzheimer's disease.Couleur et forme :LiquidAZD4694
CAS :Flutafuranol (AZD4694/NAV4694) binds beta-amyloid, potential PET tracer for Alzheimer's. Non-F18 version supplied.Formule :C14H11FN2O2Couleur et forme :SolidMasse moléculaire :258.25Cu(II)GTSM
CAS :Cu(II)GTSM is a cell permeable copper complex inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau.Formule :C6H10CuN6S2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :293.86Ref: TM-T40792
1mg37,00€5mg77,00€1mL*10mM (DMSO)82,00€10mg119,00€25mg263,00€50mg447,00€100mg749,00€200mg1.017,00€TH-237A
CAS :TH-237A is a novel neuroprotective agent exhibiting favorable permeation across the blood-brain barrier.Formule :C18H17F2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :333.335(Rac)-Z-Phe-Phe-FMK
CAS :(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) is a cathepsin L inhibitor that inhibits the tendency of β-amyloid to induce apoptotic changes .Formule :C27H27FN2O4Degré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :462.51Begacestat
CAS :Begacestat (GSI-953) is a potent and selective gamma-secretase inhibitor that inhibits Amyloid-beta, inhibits cleavage of APP,,Alzheimer's disease.Formule :C9H8ClF6NO3S2Couleur et forme :SolidMasse moléculaire :391.74Semagacestat
CAS :Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).Formule :C19H27N3O4Degré de pureté :97.1% - 99.9%Couleur et forme :SolidMasse moléculaire :361.44Simufilam hydrochloride
CAS :Simufilam is an oral, low-toxicity FLNA activator for Alzheimer's research, fixing FLNA structure and reducing pathology.Formule :C15H22ClN3OCouleur et forme :SolidMasse moléculaire :295.81Amyloid β-Protein 10-20 acetate
Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) is a fragment of Amyloid-β peptide, maybe used in the research ofFormule :C73H103N17O18Degré de pureté :97.23%Couleur et forme :SolidMasse moléculaire :1506.65TAE-1
CAS :TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
Formule :C39H51I3N6O9Degré de pureté :94.58%Couleur et forme :SolidMasse moléculaire :1128.57JLK6
CAS :JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signallingFormule :C10H8ClNO3Degré de pureté :96.50%Couleur et forme :SolidMasse moléculaire :225.63Ref: TM-T21890
1mg84,00€5mg152,00€1mL*10mM (DMSO)160,00€10mg212,00€25mg354,00€50mg504,00€100mg685,00€200mg888,00€PBD-150
CAS :PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)Formule :C15H20N4O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :320.41PE859
CAS :PE859 is a potent inhibitor of both tau and Aβ aggregation.Formule :C28H24N4O2Degré de pureté :98.8% - 99.09%Couleur et forme :SolidMasse moléculaire :448.52MK-0752
CAS :MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).Formule :C21H21ClF2O4SDegré de pureté :98% - 99.55%Couleur et forme :SolidMasse moléculaire :442.9RO4929097
CAS :RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).Formule :C22H20F5N3O3Degré de pureté :98.5% - 99.51%Couleur et forme :SolidMasse moléculaire :469.4CRANAD 2
CAS :CRANAD-2, a near-infrared probe, detects amyloid-beta in vivo, increasing fluorescence 70x and shifting blue 90 nm upon binding.Formule :C23H25BF2N2O2Degré de pureté :99.44%Couleur et forme :Dark Blue To Black PowderMasse moléculaire :410.27Anle138b
CAS :Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's diseaseFormule :C16H11BrN2O2Degré de pureté :98.88% - 99.82%Couleur et forme :SolidMasse moléculaire :343.171,1'-Methylenedi-2-naphthol
CAS :1,1'-Methylenedi-2-naphthol target CYP2C19 - cytochrome P450 family 2 subfamily C member 19 (human).Formule :C21H16O2Degré de pureté :98.91%Couleur et forme :Light Pink To Light Brown Crystalline PowderMasse moléculaire :300.35Aftin-4
CAS :Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.Formule :C20H28N6ODegré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :368.48Edonerpic maleate
CAS :Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).Formule :C20H25NO6SDegré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :407.48Frentizole
CAS :Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interactionFormule :C15H13N3O2SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :299.35Azeliragon HCl
CAS :Azeliragon: potent oral RAGE inhibitor, blocks Alzheimer's-linked amyloid brain entry.Formule :C32H40Cl3N3O2Couleur et forme :SolidMasse moléculaire :605.04β-amyloid 1-11 acetate(190436-05-6 free base)
β-amyloid 1-11 acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Formule :C58H80N16O24Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :1385.37EUK-134
CAS :EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Formule :C18H18ClMnN2O4Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :416.74β-Amyloid (31-35)
CAS :β-Amyloid (31-35) (β-Amyloid 31-35) is the shortest sequence of native Amyloid-β peptide.Formule :C25H47N5O6SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :545.74ARN2966
CAS :ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.Formule :C12H12N2ODegré de pureté :99.52% - 99.86%Couleur et forme :SolidMasse moléculaire :200.24Ref: TM-T7490
1mg34,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg113,00€25mg222,00€50mg358,00€100mg530,00€500mg1.153,00€β-Amyloid 15-21 acetate
β-Amyloid 15-21 acetate (Beta-Amyloid (15-21) acetate) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Formule :C45H69N9O11Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :912.1Dihydroergocristine mesylate
CAS :DHEC mesylate is a vasodilator and α-adrenergic antagonist used for vascular dementia and as a geroprotector.Formule :C36H45N5O8SDegré de pureté :98.9% - 99.79%Couleur et forme :SolidMasse moléculaire :707.84RAGE antagonist peptide acetate
RAGE antagonist peptide acetate blocks RAGE-ligands like HMGB-1, has anti-tumor, and anti-inflammatory effects.Formule :C59H105N13O19SDegré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :1332.61Miridesap
CAS :Miridesap (GSK2315698) rapidly depletes SAP in blood, cerebrospinal fluid, and amyloid deposits via liver clearance.Formule :C16H24N2O6Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :340.37Pyridoxal 5'-phosphate hydrate
CAS :Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,Formule :C8H10NO6PDegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :247.14PiB
CAS :PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.
Formule :C14H12N2OSDegré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :256.32Cromoglicic acid
CAS :Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.
Formule :C23H16O11Degré de pureté :99.55% - >99.99%Couleur et forme :Colorless Crystals From Ethanol + Ether Physical Description Solid (Ntp 1992)Masse moléculaire :468.37Benzenesulfonamide
CAS :Benzenesulfonamide (Benzosulfonamide) ia an inhibitor of carbonic anhydrases.Formule :C6H7NO2SDegré de pureté :99.42% - 99.99%Couleur et forme :White Crystalline PowderMasse moléculaire :157.19Semax acetate(80714-61-0 free base)
CAS :Semax acetate is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.Formule :C39H55N9O12SDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :873.98LPYFD-NH2 acetate
LPYFD-NH2 acetate shows some inhibitory effect on the aggregation of Abeta(1-42).Formule :C35H48N6O10Degré de pureté :96.51%Couleur et forme :SolidMasse moléculaire :712.79Ref: TM-T22932L
1mg66,00€5mg130,00€10mg187,00€1mL*10mM (DMSO)188,00€25mg309,00€50mg439,00€100mg590,00€200mg793,00€Colivelin
CAS :Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).Formule :C119H206N32O35Degré de pureté :96.56%Couleur et forme :SolidMasse moléculaire :2645.14-Hydroxyindole
CAS :4-Hydroxyindole: aromatic, antioxidant, used in cancer treatment and preventing neurodegenerative diseases.Formule :C8H7NODegré de pureté :97.05% - 98.13%Couleur et forme :Off-White Cyrstalline SolidMasse moléculaire :133.15Solanezumab
CAS :Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.Degré de pureté :96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.07 kDaγ-Secretase modulator 13
CAS :γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.Formule :C22H23FN6SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :422.52Dezamizumab
CAS :Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.Degré de pureté :95% - 98.2% (SDS-PAGE); 98.7% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.82 kDaHomotaurine-d6
CAS :Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.Formule :C3D6H3NO3SCouleur et forme :SolidMasse moléculaire :145.214-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS :4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).Formule :C14H11BrN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.22Nicardipine pyridine metabolite II
CAS :Nicardipine pyridine metabolite II is a biaoctive chemical.Formule :C26H27N3O6Couleur et forme :SolidMasse moléculaire :477.514-(6-Bromo-2-benzothiazolyl)benzenamine
CAS :4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.Formule :C13H9BrN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.19Aftin-5
CAS :Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.Formule :C19H26N6OCouleur et forme :SolidMasse moléculaire :354.45Eprodisate
CAS :Eprodisate disrupts protein-glycosaminoglycan binding, halting amyloid fibril formation, potentially delaying AA amyloidosis progression.Formule :C3H8O6S2Couleur et forme :SolidMasse moléculaire :204.22
