COX
Les inhibiteurs de la cyclooxygénase (COX) sont des composés qui bloquent l'activité des enzymes COX, impliquées dans la production de prostaglandines, des médiateurs clés de l'inflammation et de la douleur. En neurosciences, les inhibiteurs de la COX sont étudiés pour leur potentiel à réduire la neuroinflammation, qui est impliquée dans diverses maladies neurodégénératives telles que la maladie d'Alzheimer, la maladie de Parkinson et la sclérose en plaques. En inhibant la COX, ces composés peuvent aider à atténuer les processus inflammatoires dans le cerveau et à protéger contre les lésions neuronales. Chez CymitQuimica, nous fournissons une gamme d'inhibiteurs de la COX pour soutenir vos recherches sur la neuroinflammation, la gestion de la douleur et les maladies neurodégénératives.
562 produits trouvés pour "COX"
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(-)-Epicatechin
CAS :<p>(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization</p>Formule :C15H14O6Degré de pureté :98.55% - 98.80%Couleur et forme :SolidMasse moléculaire :290.27Licofelone
CAS :<p>Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.</p>Formule :C23H22ClNO2Degré de pureté :99.25%Couleur et forme :Yellowish SolidMasse moléculaire :379.88SC-236
CAS :<p>SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).</p>Formule :C16H11ClF3N3O2SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :401.79Chebulagic acid
CAS :<p>Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.</p>Formule :C41H30O27Degré de pureté :97.82% - 99.8%Couleur et forme :SolidMasse moléculaire :954.66(-)-Epicatechin gallate
CAS :<p>(-)-Epicatechin gallate, a catechin isomer and strong antioxidant, affects membrane proteins and alters gA channel function in bilayers.</p>Formule :C22H18O10Degré de pureté :99.16% - 99.93%Couleur et forme :SolidMasse moléculaire :442.37Flurbiprofen Axetil
CAS :<p>Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.</p>Formule :C19H19FO4Degré de pureté :97.58% - 98%Couleur et forme :SolidMasse moléculaire :330.35Phenidone
CAS :<p>Phenidone inhibits COX/LOX, reducing rat autoimmune paralysis and lowering blood pressure in hypertensive rats.</p>Formule :C9H10N2ODegré de pureté :97.24%Couleur et forme :White Solid Solid CrystallineMasse moléculaire :162.19Ataquimas
CAS :<p>Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells.</p>Formule :C11H13N3ODegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :203.24Neochlorogenic acid
CAS :<p>Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.</p>Formule :C16H18O9Degré de pureté :99.12% - 99.54%Couleur et forme :White PowderMasse moléculaire :354.31Ibuprofen Lysine
CAS :<p>Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.</p>Formule :C19H32N2O4Degré de pureté :99.26%Couleur et forme :CoaMasse moléculaire :352.473-TERT-BUTYL-4-HYDROXYANISOLE
CAS :<p>3-tert-Butyl-p-hydroxyanisole is an antioxidant which is produced via water chlorination.</p>Formule :C11H16O2Degré de pureté :99.65%Couleur et forme :White Solid WaxyMasse moléculaire :180.24Diclofenac Epolamine
CAS :<p>Diclofenac Epolamine (DHEP) is a non-steroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic actions.</p>Formule :C20H24Cl2N2O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :411.32SC-560
CAS :<p>SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.</p>Formule :C17H12ClF3N2ODegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :352.74Prim-O-glucosylcimifugin
CAS :<p>Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC stimulated by TNF-alpha, increase the proportion of G0/G1 phase.</p>Formule :C22H28O11Degré de pureté :98.57% - 99.92%Couleur et forme :SolidMasse moléculaire :468.45RHC 80267
CAS :<p>RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)</p>Formule :C20H34N4O4Degré de pureté :99.54%Couleur et forme :White SolidMasse moléculaire :394.51ETHYL CAFFEATE
CAS :<p>Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.</p>Formule :C11H12O4Degré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :208.21Ufenamate
CAS :<p>Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for skin diseases</p>Formule :C18H18F3NO2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :337.34Veratric acid
CAS :<p>Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-</p>Formule :C9H10O4Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :182.17Indomethacin farnesil
CAS :<p>Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.</p>Formule :C34H40ClNO4Degré de pureté :97.29%Couleur et forme :SolidMasse moléculaire :562.14N-trans-Feruloyltyramine
CAS :<p>NTF is hepatoprotective, antioxidant, inhibits COX, prevents platelet aggregation, and reduces melanin by downregulating tyrosinase.</p>Formule :C18H19NO4Degré de pureté :99.56% - >99.99%Couleur et forme :SolidMasse moléculaire :313.35Phenethyl ferulate
CAS :<p>Phenethyl ferulate is a chemopreventive against colon cancer, enhancing apoptosis in tumors and inhibiting COX/5-LOX (IC50: 4.35/5.75 μM).</p>Formule :C18H18O4Degré de pureté :99.88% - 99.91%Couleur et forme :SolidMasse moléculaire :298.33(S)-Flurbiprofen
CAS :<p>Esflurbiprofen is an inhibitor of COX-1 and COX-2.</p>Formule :C15H13FO2Degré de pureté :99.99%Couleur et forme :White To Yellowish Crystalline PowderMasse moléculaire :244.26Dehydrodiisoeugenol
CAS :<p>Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.</p>Formule :C20H22O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :326.39Ketorolac
CAS :<p>Ketorolac (Acuvail) is an NSAID that blocks prostaglandin synthesis, related to heterocyclic acetic acids.</p>Formule :C15H13NO3Degré de pureté :99.68%Couleur et forme :White Crystalline Or White PowderMasse moléculaire :255.27Xanthohumol
CAS :<p>Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-</p>Formule :C21H22O5Degré de pureté :98.19% - 99.67%Couleur et forme :Orange PowderMasse moléculaire :354.4Loxoprofen sodium (dihydrate)
CAS :<p>Loxoprofen sodium dihydrate: Non-steroidal anti-inflammatory with analgesic, antipyretic, antitumor effects; COX-1/COX-2 inhibitor. IC50: 6.5/13.5 μM.</p>Formule :C15H21NaO5Couleur et forme :SolidMasse moléculaire :304.318Tenidap
CAS :<p>Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.</p>Formule :C14H9ClN2O3SDegré de pureté :98.56% - 99.42%Couleur et forme :SolidMasse moléculaire :320.75NF-κB/MAPK-IN-1
CAS :<p>NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).</p>Formule :C27H27NO7Degré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :477.51Bromfenac sodium hydrate
CAS :<p>Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a NSAID with analgesic and anti-inflammatory effects.</p>Formule :C15H12BrNO3H2O·NaDegré de pureté :91.85% - 99.65%Couleur et forme :SolidMasse moléculaire :383.17Oxyphenbutazone
CAS :<p>Oxyphenbutazone: Non-selective COX inhibitor, anti-inflammatory, kills dormant Mycobacterium tuberculosis.</p>Formule :C19H20N2O3Degré de pureté :99.41% - 99.88%Couleur et forme :White To Yellowish White Crystalline Powder SolidMasse moléculaire :324.37Meloxicam
CAS :<p>Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug.</p>Formule :C14H13N3O4S2Degré de pureté :97.09% - 99.60%Couleur et forme :Light Yellow SolidMasse moléculaire :351.40Fenoprofen
CAS :<p>Fenoprofen (LILLY-5385) is a non-steroidal anti-inflammatory compound and a modifier enhancer of the melanocortin receptor, increasing ERK1/2 activation.</p>Formule :C15H14O3Degré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :242.27(S)-(+)-Ibuprofen
CAS :<p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>Formule :C13H18O2Degré de pureté :99.51% - 99.86%Couleur et forme :Colourless Crystalline SolidMasse moléculaire :206.28Paradol
CAS :<p>Paradol, a spicy compound in ginger, offers anti-cancer, anti-inflammatory, antioxidant, and neuroprotective benefits.</p>Formule :C17H26O3Degré de pureté :98.4% - 98.98%Couleur et forme :SolidMasse moléculaire :278.39Fontolizumab
CAS :<p>Fontolizumab (HuZAF) is a humanised IgG1 monoclonal anti-IFN-gamma (IFN-γ) antibody for the study of Crohn's disease.</p>Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :150 (kDa)Aspirin DL-lysine
CAS :<p>Aspirin DL-lysine: a water-soluble, injectable NSAID that may also hinder cancer growth.</p>Formule :C15H22N2O6Couleur et forme :Crystalline SolidMasse moléculaire :326.35Cadonilimab
CAS :<p>Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidImidazole Salicylate
CAS :<p>Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.</p>Formule :C10H10N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :206.2Indometacin Farnesil
CAS :Formule :C34H40ClNO4Degré de pureté :>98.0%(HPLC)Couleur et forme :Light yellow to Yellow to Orange clear liquidMasse moléculaire :562.15Ketorolac-d5
CAS :<p>Ketorolac-d5 is a deuterated compound of ketorolac for isotope tracing. Ketorolac is a non-steroidal anti-inflammatory agent and inhibitor of COX-1 and COX-2.</p>Formule :C15H8D5NO3Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :260.3Nepafenac-d5
CAS :<p>Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 .</p>Formule :C15H14N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :259.31AHR-10037
CAS :<p>AHR-10037, a NSAID, offers pain relief, fever reduction, safety, and low stomach risk, acting as a prodrug for COX inhibitors.</p>Formule :C15H13ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :288.73Amfenac
CAS :<p>Amfenac promotes apoptosis in ARPE-19 cell culture.</p>Formule :C15H13NO3Couleur et forme :SolidMasse moléculaire :255.27Pelubiprofen
CAS :<p>Pelubiprofen is a non-steroidal anti-inflammatory agent and a COX-2 inhibitor, which effectively reduces PGE(2) production by inhibiting COX activity.</p>Formule :C16H18O3Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :258.31COX-2-IN-2
CAS :<p>COX-2-IN-2 selectively inhibits COX2 (IC50: 0.24 μM); COX-2-IN-1 offers anti-inflammatory and pain relief.</p>Formule :C17H12FN3O2SDegré de pureté :97.62%Couleur et forme :SolidMasse moléculaire :341.36COX-2-IN-26
CAS :<p>COX-2-IN-26: Oral, selective COX-2 inhibitor, low IC50s; anti-inflammatory with GI safety.</p>Formule :C23H21N7OS3Couleur et forme :SolidMasse moléculaire :507.65Loxoprofenol-SRS tromethamine
CAS :<p>Loxoprofenol-SRS tromethamine (HR1405-01), a metabolite of Loxoprofen, is a safe IV NSAID with strong anti-inflammatory and pain relief properties.</p>Formule :C19H31NO6Couleur et forme :SolidMasse moléculaire :369.45COX-2-IN-24
CAS :<p>COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects.</p>Formule :C24H24BrN5O3S2Couleur et forme :SolidMasse moléculaire :574.51COX-2-IN-18
CAS :<p>COX-2-IN-18 is a potent COX-2 inhibitor similar to Celecoxib, showing promise in cancer research. IC50=0.775μM.</p>Formule :C18H19N3O3S2Couleur et forme :SolidMasse moléculaire :389.49COX-2-IN-14
CAS :<p>COX-2-IN-14 (2a) is a potent, selective COX-2 inhibitor with high affinity and notable anti-inflammatory effects in mice.</p>Formule :C18H18N4O6Couleur et forme :SolidMasse moléculaire :386.364SC57666
CAS :<p>SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.</p>Formule :C18H17FO2SDegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :316.39FR-188582
CAS :<p>FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).</p>Formule :C16H13ClN2O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.8Anti-inflammatory agent 56
CAS :<p>Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties by</p>Formule :C21H15F3N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.43COX/5-LO-IN-1
CAS :<p>COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.</p>Formule :C16H15FN2O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :318.37MK-0703
CAS :<p>MK-0703 is a selective cyclooxygenase-2 inhibitor.</p>Formule :C17H22O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.42COX-2/15-LOX-IN-1
CAS :<p>COX-2/15-LOX-IN-1 is a dual inhibitor for COX-2/15-LOX with anti-inflammatory properties (IC50: COX-1 10.65μM, COX-2 0.075μM, 15-LOX 2.98μM).</p>Formule :C21H21N7S3Couleur et forme :SolidMasse moléculaire :467.63COX-2-IN-17
CAS :<p>COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.</p>Formule :C20H23ClN6O2Couleur et forme :SolidMasse moléculaire :414.89COX-2-IN-23
CAS :<p>COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.</p>Formule :C24H25N5O3S2Couleur et forme :SolidMasse moléculaire :495.62COX-1/2-IN-3
CAS :<p>COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].</p>Formule :C14H8N2O8Couleur et forme :SolidMasse moléculaire :332.22COX-1/2-IN-1
CAS :<p>"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."</p>Formule :C15H10BrClN2OCouleur et forme :SolidMasse moléculaire :349.61K-80001
CAS :<p>K-80001 is a selective RXRα ligand and a COX-1/2 inhibitor, exhibiting IC50 values of 82.9μM for RXRα, 3.4μM for COX-1, and 1.2μM for COX-2, respectively [1].</p>Formule :C20H17FO2Couleur et forme :SolidMasse moléculaire :308.35Anti-inflammatory agent 8
CAS :<p>Anti-inflammatory agent 8 targets COX-2 over COX-1, IC50 of 0.09 nM, orally bioavailable.</p>Formule :C18H15N5OS2Couleur et forme :SolidMasse moléculaire :381.47Apricoxib
CAS :<p>Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.</p>Formule :C19H20N2O3SCouleur et forme :SolidMasse moléculaire :356.44COX-2/sEH-IN-1
CAS :<p>COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.</p>Formule :C23H18F3N5O3SCouleur et forme :SolidMasse moléculaire :501.48Naproxen glucuronide
CAS :<p>Naproxen glucuronide: NSAID, propionic class, eases pain, fever, inflammation. Nonselective COX blocker.</p>Formule :C20H22O9Couleur et forme :SolidMasse moléculaire :406.38AL-8417
CAS :<p>AL-8417 is an enzyme inhibitor with antioxidant, anti-inflammatory, and cytostatic properties; prevents vitrectomy-induced lens alterations.</p>Formule :C29H34O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.58PD 127443
CAS :<p>PD 127443 is a Leukotriene B4 antagonist, it is also a dual inhibitor of cyclooxygenase and 5-lipoxygenase.</p>Formule :C20H28N2OCouleur et forme :SolidMasse moléculaire :312.45COX-2-IN-32
CAS :<p>COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.</p>Formule :C25H24O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.45Thiazolinobutazone
CAS :<p>Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.</p>Formule :C22H26N4O2SCouleur et forme :SolidMasse moléculaire :410.53ASP-6537
CAS :<p>ASP-6537 is a selective and reversible inhibitor of cyclooxygenase-1.</p>Formule :C17H17N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.34COX/5-LOX-IN-1
CAS :<p>Compound 6b is a potent dual inhibitor of COX/5-LOX with IC50s: 1.07μM (COX-1), 0.55μM (COX-2), 0.28μM (5-LOX) for inflammation research.</p>Formule :C18H30O3Couleur et forme :SolidMasse moléculaire :294.43Pifoxime
CAS :<p>Pifoxime: a NSAID with COX-1/2 inhibition, used in anti-inflammatory treatment and neuropsychiatric studies.</p>Formule :C15H20N2O3Couleur et forme :SolidMasse moléculaire :276.33COX-2-IN-16
CAS :<p>COX-2-IN-16: potent, selective oral COX-2 blocker, IC50=102 μM, reduces NO, anti-inflammatory.</p>Formule :C19H12BrN3O2Couleur et forme :SolidMasse moléculaire :394.22COX-2/5-LOX-IN-3
CAS :<p>COX-2/5-LOX-IN-3 inhibits COX-2/5-LOX with IC50s: COX-1 45.73μM, COX-2 5.45μM, 5-LOX 4.33μM; promising for inflammation research.</p>Formule :C17H16ClN3O2SCouleur et forme :SolidMasse moléculaire :361.85ATB-337
CAS :<p>S-Diclofenac, an NSAID with H2S-releasing moiety, protects gastric mucosa while inhibiting prostaglandins.</p>Formule :C23H15Cl2NO2S3Couleur et forme :SolidMasse moléculaire :504.47Flosulide
CAS :<p>Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.</p>Formule :C16H13F2NO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :353.34AHR-6293
CAS :<p>AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties.</p>Formule :C15H12ClNO3Couleur et forme :SolidMasse moléculaire :289.71NCX 466
CAS :<p>cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor</p>Formule :C20H24N2O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.41Etoricoxib HCl
CAS :<p>Etoricoxib HCl is a synthetic NSAID that inhibits COX-2, blocking prostaglandin production.</p>Formule :C18H16Cl2N2O2SCouleur et forme :SolidMasse moléculaire :395.30Lobeglitazone Sulfate
CAS :<p>Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.</p>Formule :C24H26N4O9S2Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :578.61LY 25648
CAS :<p>LY 25648 is an antagonist of leukotriene B4.</p>Formule :C19H27NO2SCouleur et forme :SolidMasse moléculaire :333.49ZXX2-77
CAS :<p>ZXX2-77 is a cyclooxygenase-1 inhibitor.</p>Formule :C13H13ClN2O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.77LY 150310
CAS :<p>LY 150310, a histamine H1-receptor antagonist, can alter prostanoid concentrations in vitro and in vivo.</p>Formule :C13H14N2Couleur et forme :SolidMasse moléculaire :198.26PC407-ws
CAS :<p>PC407-ws is a water-soluble novel COX-2 inhibitor.</p>Formule :C24H18F3N3Na2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :563.46Isonixin
CAS :<p>Isonixin is used for the treatment of inflammation and pain associated with musculoskeletal and joint disorders.</p>Formule :C14H14N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :242.27Prostaglandin G/H synthase 1 inhibitor
CAS :<p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>Formule :C13H11ClN2ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :246.69Tenosal
CAS :<p>Tenosal obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid, and with analgesic and antipyretic properties, anti-inflammatory.</p>Formule :C12H8O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.25LY 178002
CAS :<p>LY 178002 inhibits 5-LPO (IC50: 0.6 μM), PLA2, and LTB4 production; weak on cyclooxygenase.</p>Formule :C18H25NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.46L 748780
CAS :<p>L 748780 is a selective inducible COX-2 inhibitor.</p>Formule :C19H14Cl3NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.68Eicosatetraynoic acid
CAS :<p>ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).</p>Formule :C20H24O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.4COX-2-IN-20
CAS :<p>COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].</p>Formule :C11H9ClFN3O2Couleur et forme :SolidMasse moléculaire :269.66Feprazone
CAS :<p>Feprazone (DA-2370) possesses anti-inflammatory and antiadipogenic properties. Feprazone can be used in studies about the treatment of joint and muscular pain.</p>Formule :C20H20N2O2Degré de pureté :99.6% - 99.89%Couleur et forme :SolidMasse moléculaire :320.39Tilmacoxib
CAS :<p>Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).</p>Formule :C16H19FN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.4COX-2-IN-1
CAS :<p>COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).</p>Formule :C18H14ClF3N4O2SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :442.84Carpro-AM1
CAS :<p>Carpro-AM1, dual FAAH/COX inhibitor, IC50: 94 nM.</p>Formule :C21H18ClN3OCouleur et forme :SolidMasse moléculaire :363.84Enflicoxib
CAS :<p>Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.</p>Formule :C16H12F5N3O2SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :405.34Insulin levels modulator
CAS :<p>Insulin level regulators can be used to treat diabetes.</p>Formule :C21H23N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.52SC58451
CAS :<p>SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.</p>Formule :C20H19FO2SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :342.43COX-2-IN-21
CAS :<p>COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.</p>Formule :C21H22N6O4Couleur et forme :SolidMasse moléculaire :422.44APHS
CAS :<p>APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.</p>Formule :C15H18O2SCouleur et forme :SolidMasse moléculaire :262.37Safrole oxide
CAS :<p>Safrole oxide inhibits neuronal growth, induces apoptosis, elevates COX-2, IL-8, ROS, promoting endothelial-to-neuron-like cell transdifferentiation.</p>Formule :C10H10O3Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :178.18(-)-Ibuprofenamide
CAS :<p>(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.</p>Formule :C13H19NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :205.3Piroxicam cinnamate
CAS :<p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>Formule :C24H19N3O5SCouleur et forme :SolidMasse moléculaire :461.49GW-406381
CAS :<p>GW-406381 is a highly selective COX-2 inhibitor peripherally and centrally, reducing spontaneous ectopic discharges following chronic compressive injury.</p>Formule :C21H19N3O3SDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :393.46COX-2/5-LOX-IN-2
CAS :<p>COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.</p>Formule :C18H13N3O4S2Couleur et forme :SolidMasse moléculaire :399.44COX-2-IN-19
CAS :<p>COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.</p>Formule :C18H18N4O2SCouleur et forme :SolidMasse moléculaire :354.43Timegadine
CAS :<p>Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM</p>Formule :C20H23N5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.5ADU-S100
CAS :<p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>Formule :C20H24N10O10P2S2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :690.54COX-2/5-LOX-IN-1
CAS :<p>COX-2/5-LOX-IN-1, a benzothiophen-2-yl pyrazole, inhibits COX-2 & 5-LOX with IC50: COX-1 (12.13μM), COX-2 (0.4μM), 5-LOX (4.96μM). Better than Celecoxib.</p>Formule :C14H10ClN3O4S2Couleur et forme :SolidMasse moléculaire :383.83Heterophdoid A
CAS :<p>Heterophdoid A is an anti-inflammatory agent that inhibits NO production in BV-2 cells (IC50: 5.93 μM).</p>Formule :C26H42O10Couleur et forme :SolidMasse moléculaire :514.61Naproxcinod
CAS :<p>Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.</p>Formule :C18H21NO6Couleur et forme :SolidMasse moléculaire :347.36Nitroflurbiprofen
CAS :<p>Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive</p>Formule :C19H20FNO5Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :361.36COX-2-IN-28
CAS :<p>COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).</p>Formule :C30H27N7S3Couleur et forme :SolidMasse moléculaire :581.78COX-2-IN-11
CAS :<p>COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].</p>Formule :C12H12OS3Couleur et forme :SolidMasse moléculaire :268.42Naproxen etemesil
CAS :<p>Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.</p>Formule :C17H20O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.4Apyramide
CAS :<p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>Formule :C27H23ClN2O5Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :490.93ABT-963
CAS :<p>ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.</p>Formule :C22H22F2N2O5SDegré de pureté :98% - 99.85%Couleur et forme :SolidMasse moléculaire :464.48ER-34122
CAS :<p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>Formule :C27H26ClN3O5Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :507.96Eltenac
CAS :<p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>Formule :C12H9Cl2NO2SDegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :302.18Sudoxicam
CAS :<p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>Formule :C13H11N3O4S2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :337.37LM-1685
CAS :<p>LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。</p>Formule :C18H16ClNO4SDegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :377.84SC-75416
CAS :<p>SC-75416, a cyclooxygenase-2 (COX-2) inhibitor, is used potentially for the treatment of postoperative inflammation.</p>Formule :C15H14ClF3O3Degré de pureté :98.67% - 98.67%Couleur et forme :SolidMasse moléculaire :334.72BN-82451 2HCl
CAS :<p>BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntington’s disease.</p>Formule :C18H28Cl2N2OSDegré de pureté :99.84% - >99.99%Couleur et forme :SolidMasse moléculaire :391.4Indazole-Cl
CAS :<p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>Formule :C13H9ClN2O2Degré de pureté :99.02% - 99.86%Couleur et forme :SolidMasse moléculaire :260.68Biofor 389
CAS :<p>Biofor 389 (BF389) has anti-inflammatory activity and can be used to study arthritis.</p>Formule :C20H29NO3Degré de pureté :98.84% - 99.97%Couleur et forme :SolidMasse moléculaire :331.45L 651896
CAS :<p>L 651896 is an inhibitor of 5-lipoxygenase.</p>Formule :C18H18O3Degré de pureté :96.06% - 99.85%Couleur et forme :SolidMasse moléculaire :282.33Prostaglandin E2 Ethanolamide
CAS :<p>Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].</p>Formule :C22H37NO5Couleur et forme :SolidMasse moléculaire :395.54Benoxaprofen
CAS :<p>Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.</p>Formule :C16H12ClNO3Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :301.72BW 755C
CAS :<p>BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.</p>Formule :C10H10F3N3Degré de pureté :96.52%Couleur et forme :SolidMasse moléculaire :229.2Antioxidant agent-15
CAS :<p>Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.</p>Formule :C19H14O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :274.31Thioflosulide
CAS :<p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>Formule :C16H13F2NO3S2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :369.41Thromboxane B3
CAS :<p>Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.</p>Formule :C20H32O6Couleur et forme :SolidMasse moléculaire :368.5Amtolmetin guacil
CAS :<p>Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性，具有额外的镇痛、解热和胃保护特性。</p>Formule :C24H24N2O5Degré de pureté :99.85%Couleur et forme :White Needle-Shaped CrystalMasse moléculaire :420.46(-)-Bornyl ferulate
CAS :<p>(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-</p>Formule :C20H26O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :330.42Cimicoxib
CAS :<p>Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.</p>Formule :C16H13ClFN3O3SDegré de pureté :98.22%Couleur et forme :SolidMasse moléculaire :381.81COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Formule :C31H32FN5O2SCouleur et forme :SolidMasse moléculaire :557.68COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Formule :C17H19NO3Couleur et forme :SolidMasse moléculaire :285.34COX-2-IN-13
<p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>Formule :C19H18N2O5SCouleur et forme :SolidMasse moléculaire :386.42COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Formule :C19H19N3O4S2Couleur et forme :SolidMasse moléculaire :417.5Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Formule :C18H15N5O2SCouleur et forme :SolidMasse moléculaire :365.41Soquelitinib
CAS :<p>Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.</p>Formule :C25H30N4O4S2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :514.66NLRP3-IN-69
CAS :<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Formule :C25H24O7Couleur et forme :SolidMasse moléculaire :436.454Anti-inflammatory agent 10
<p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>Formule :C17H13BrN4O3S2Couleur et forme :SolidMasse moléculaire :465.34STAT1/3-IN-1
CAS :<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Formule :C28H25ClN6O5Couleur et forme :SolidMasse moléculaire :560.988XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Formule :C24H20N4O2SCouleur et forme :SolidMasse moléculaire :428.51COX-2-IN-6
CAS :<p>COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.</p>Formule :C20H27NO6SDegré de pureté :99.29% - 99.69%Couleur et forme :SoildMasse moléculaire :409.5COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Formule :C15H10ClIN2OCouleur et forme :SolidMasse moléculaire :396.61COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formule :C22H23FN2O6S2Couleur et forme :SolidMasse moléculaire :494.56(R)-Ketoprofen
CAS :<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Formule :C16H14O3Couleur et forme :SolidMasse moléculaire :254.28Ambuic acid
CAS :<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Formule :C19H26O6Couleur et forme :SolidMasse moléculaire :350.41COX-2-IN-7
<p>COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.</p>Formule :C15H13N3O2S2Couleur et forme :SolidMasse moléculaire :331.41Sabialimon P
CAS :<p>Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.</p>Formule :C31H50O4Couleur et forme :SolidMasse moléculaire :486.73Neral
CAS :<p>Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.</p>Formule :C10H16OCouleur et forme :SolidMasse moléculaire :152.23COX-2-IN-51
CAS :<p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>Formule :C23H18F4O3SCouleur et forme :SolidMasse moléculaire :450.446COX-2/15-LOX-IN-5
CAS :<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Formule :C25H21N3O3SCouleur et forme :SolidMasse moléculaire :443.52COX-2/NO-IN-1
<p>COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>Formule :C15H15NO3Couleur et forme :SolidMasse moléculaire :257.28COX-2-IN-47
CAS :<p>COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.</p>Formule :C18H18N2O4Couleur et forme :SolidMasse moléculaire :326.35COX-2/PI3K-IN-2
<p>COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>Formule :C16H17N5O2Couleur et forme :SolidMasse moléculaire :311.34COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Formule :C19H14ClN5S2Couleur et forme :SolidMasse moléculaire :411.93COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Formule :C25H23N5O4S2Couleur et forme :SolidMasse moléculaire :521.61Racemic Naproxen
CAS :<p>Racemic Naproxen is a biochemical substance.</p>Formule :C14H14O3Degré de pureté :98%Couleur et forme :Crystals From Acetone-Hexane White SolidMasse moléculaire :230.26Alminoprofen
CAS :<p>Alminoprofen: NSAID; reduces anaphylactic bronchoconstriction at 30 mg/kg intraduodenally.</p>Formule :C13H17NO2Couleur et forme :SolidMasse moléculaire :219.28
