BACE
Les inhibiteurs de BACE sont des composés qui ciblent l'enzyme Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), essentielle à la production de bêta-amyloïde, une protéine associée à la formation de plaques amyloïdes dans la maladie d'Alzheimer. En inhibant BACE, ces composés visent à réduire la production de bêta-amyloïde et son accumulation dans le cerveau, ralentissant potentiellement la progression de la maladie d'Alzheimer. Les inhibiteurs de BACE sont un axe majeur dans le développement de stratégies thérapeutiques pour les maladies neurodégénératives. Chez CymitQuimica, nous proposons des inhibiteurs de BACE pour soutenir vos recherches sur la maladie d'Alzheimer, la biologie amyloïde et la neurodégénérescence.
37 produits trouvés pour "BACE"
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Elenbecestat
CAS :Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.Formule :C19H18F3N5O2SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :437.44Ref: TM-T11175
1mg66,00€5mg144,00€10mg236,00€25mg492,00€50mg710,00€100mg973,00€1mL*10mM (DMSO)158,00€BACE1 Protein, Human, Recombinant (hFc)
BACE1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :75.2 kDa (predicted, pro-form); 72.6 kDa (predicted, mature-form); 85-100 kDa (reducing condition, due to glycosylation)Ref: TM-TMPY-00651
1mg4.440,00€5µg80,00€10µg115,00€20µg184,00€50µg370,00€100µg705,00€200µg1.074,00€500µg2.186,00€Anti-BACE1 Antibody-FITC (8D358)
Anti-BACE1 Antibody-FITC (8D358) is a FITC-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-FITC (8D358) can be used in FCM.Couleur et forme :Odour LiquidAnti-BACE1 Antibody-PE (8D358)
Anti-BACE1 Antibody-PE (8D358) is a PE-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-PE (8D358) can be used in FCM.Couleur et forme :Odour LiquidAnti-BACE1 Antibody (2Z488)
Anti-BACE1 Antibody (2Z488) is a Mouse antibody targeting BACE1. Anti-BACE1 Antibody (2Z488) can be used in ELISA.Couleur et forme :Odour LiquidAnti-BACE1 Antibody (2J206)
Anti-BACE1 Antibody (2J206) is an antibody targeting BACE1. Anti-BACE1 Antibody (2J206) can be used in ELISA, WB.Couleur et forme :Odour LiquidAnti-BACE1 Antibody (8A762)
Anti-BACE1 Antibody (8A762) is a Rabbit antibody targeting BACE1. Anti-BACE1 Antibody (8A762) can be used in ELISA.Couleur et forme :Odour LiquidAnti-BACE1 Antibody (3R945)
Anti-BACE1 Antibody (3R945) is a Mouse antibody targeting BACE1. Anti-BACE1 Antibody (3R945) can be used in ELISA.Couleur et forme :Odour LiquidAnti-BACE1 Antibody (8D358)
Anti-BACE1 Antibody (8D358) is a Rabbit antibody targeting BACE1. Anti-BACE1 Antibody (8D358) can be used in FCM,ICC/IF.Couleur et forme :Odour LiquidBACE1 Protein, Human, Recombinant
BACE1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 49 kDa and the accession number is A0A024R3D7.Couleur et forme :Lyophilized PowderMasse moléculaire :49 kDa (predicted); 65 kDa (reducing condition, due to glycosylation)BACE1 Protein, Human, Recombinant (His)
BACE1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :49.5 kDa (predicted); 55-70 kDa (reducing condition, due to glycosylation)Ref: TM-TMPY-00752
1mg3.215,00€5µg80,00€10µg116,00€20µg177,00€50µg353,00€100µg690,00€200µg960,00€500µg1.686,00€Sophoflavescenol
CAS :Sophoflavescenol: PDE5 inhibitor (K(i) 0.005 µM), antioxidant, anti-inflammatory, pro-apoptotic, potential antitumor, mild side effects.Formule :C21H20O6Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :368.38Aloeresin D
CAS :Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).
Formule :C29H32O11Degré de pureté :98.11% - 99.57%Couleur et forme :SolidMasse moléculaire :556.56Eslicarbazepine Acetate
CAS :Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.Formule :C17H16N2O3Degré de pureté :99.58% - >99.99%Couleur et forme :White To Off-White SolidMasse moléculaire :296.32Ref: TM-T3285
5mg38,00€10mg50,00€25mg92,00€50mg124,00€100mg170,00€200mg268,00€500mg393,00€1mL*10mM (DMSO)55,00€LX2343
CAS :LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.Formule :C22H19ClN2O6SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :474.91Ref: TM-T4398
2mg37,00€5mg52,00€10mg84,00€25mg137,00€50mg229,00€100mg340,00€200mg472,00€1mL*10mM (DMSO)58,00€Scoulerine
CAS :Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1).Formule :C19H21NO4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :327.37Aloenin
CAS :1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
Formule :C19H22O10Degré de pureté :99.42% - 99.69%Couleur et forme :SolidMasse moléculaire :410.37Umibecestat HCl
CAS :Umibecestat HCl (CNP520 HCl) is an efficient β-secretase (BACE1/BACE2) inhibitor that reduces Aβ levels in mice and rats.Formule :C19H16Cl2F7N5O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :550.26Tenuifolin
CAS :Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.Formule :C36H56O12Degré de pureté :97.37% - 99.54%Couleur et forme :SolidMasse moléculaire :680.82LY2886721
CAS :LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
Formule :C18H16F2N4O2SDegré de pureté :99% - 99.75%Couleur et forme :SolidMasse moléculaire :390.41Epiberberine
CAS :1.Formule :C20H18NO4Degré de pureté :98.52% - 99.59%Couleur et forme :SolidMasse moléculaire :336.36LY2811376
CAS :LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).Formule :C15H14F2N4SDegré de pureté :99% - 99.01%Couleur et forme :SolidMasse moléculaire :320.36Ref: TM-T2639
1mg52,00€2mg73,00€5mg123,00€10mg205,00€25mg374,00€50mg560,00€100mg800,00€1mL*10mM (DMSO)123,00€AZD3839 free base
CAS :AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.Formule :C24H16F3N5Degré de pureté :99.93% - 99.96%Couleur et forme :SolidMasse moléculaire :431.41BACE-IN-1 acetate
BACE-IN-1 acetate (350228-37-4), a BACE1 inhibitor with three disulfide bonds and N-linked glycosylation, is used in assays.Formule :C75H122N16O29Degré de pureté :96.98%Couleur et forme :SolidMasse moléculaire :1711.86Verubecestat
CAS :Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.Formule :C17H17F2N5O3SDegré de pureté :94.64% - 99.55%Couleur et forme :SolidMasse moléculaire :409.41Ref: TM-T7011
2mg40,00€5mg60,00€10mg88,00€25mg153,00€50mg216,00€100mg354,00€500mg825,00€1mL*10mM (DMSO)66,00€Epiberberine chloride
CAS :Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.Formule :C20H18ClNO4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :371.81DSS30
CAS :DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.Formule :C16H14ClNO3S2Degré de pureté :99.19% - 99.4%Couleur et forme :SolidMasse moléculaire :367.87Lanabecestat
CAS :Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.Formule :C26H28N4ODegré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :412.53BACE1-IN-1
CAS :BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).Formule :C18H14F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.33Atabecestat
CAS :Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.Formule :C18H14FN5OSDegré de pureté :99.21% - 99.77%Couleur et forme :SolidMasse moléculaire :367.4Ref: TM-T14338
1mg123,00€5mg295,00€10mg477,00€25mg954,00€50mg1.279,00€100mg1.728,00€1mL*10mM (DMSO)326,00€BACE1-IN-2
CAS :BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).Formule :C19H15F4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.35BACE1-IN-5
CAS :BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.Formule :C18H16F5N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.41PF-06751979
CAS :PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).Formule :C18H19F2N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :455.5AM-6494
CAS :AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Formule :C22H21F2N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.5BACE1-IN-4
CAS :BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.Formule :C21H23F2N5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.57Umibecestat
CAS :Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM & 10 nM), potentially for Alzheimer's research.Formule :C19H15ClF7N5O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :513.8Ref: TM-T13253
1mg172,00€5mg354,00€10mg512,00€25mg852,00€50mg1.159,00€100mg1.568,00€1mL*10mM (DMSO)398,00€NB-360
CAS :NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.Formule :C21H19F4N5O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :449.4Ref: TM-T12188
1mg104,00€5mg215,00€10mg318,00€25mg510,00€50mg692,00€100mg888,00€500mg1.783,00€1mL*10mM (DMSO)235,00€
