Cystéine protéase
Les inhibiteurs de protéases à cystéine sont des composés qui ciblent et inhibent les protéases à cystéine, une classe d'enzymes qui décomposent les protéines en clivant les liaisons peptidiques dans lesquelles un résidu de cystéine agit comme nucléophile. Ces enzymes sont impliquées dans divers processus physiologiques, tels que l'apoptose, la réponse immunitaire et le renouvellement des protéines. Les inhibiteurs de protéases à cystéine sont essentiels pour l'étude de maladies telles que le cancer, les troubles neurodégénératifs et les infections parasitaires. Chez CymitQuimica, nous fournissons des inhibiteurs de protéases à cystéine pour soutenir vos recherches en protéolyse, régulation cellulaire et découverte de médicaments.
117 produits trouvés pour "Cystéine protéase".
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PMSF
CAS :PMSF (Phenylmethylsulfonyl fluoride) is an irreversible inhibitor of serine/cysteine protease , preparation of cell lysates. High-Quality, Low-Cost!Formule :C7H7FO2SDegré de pureté :97.75% - 99.88%Couleur et forme :White SolidMasse moléculaire :174.19Acetyl-Calpastatin (184-210)(human) acetate
Acetyl-Calpastatin acetate inhibits µ-calpain (Ki=0.2nM) and cathepsin L (Ki=6μM) selectively and reversibly.Formule :C144H234N36O46SDegré de pureté :97.84% - 98.16%Couleur et forme :SolidMasse moléculaire :3237.68Z-Leu-Tyr-Chloromethylketone
CAS :Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].Formule :C24H29ClN2O5Couleur et forme :SolidMasse moléculaire :460.95N-CBZ-Phe-Arg-AMC
CAS :Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Formule :C33H36N6O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :612.68Dazcapistat
CAS :Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formule :C21H18FN3O4Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :395.38Ref: TM-T9710
1mg92,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg289,00€25mg522,00€50mg732,00€100mg1.018,00€Leupeptin
CAS :Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.Formule :C20H38N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.562Z-FG-NHO-Bz
CAS :Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].Formule :C26H25N3O6Couleur et forme :SolidMasse moléculaire :475.49Mpro/Cathepsin L-IN-1
Mpro/Cathepsin L-IN-1 (Compound 4d) is an inhibitor of SARS-CoV-2 Mpro and hCatL, with Ki values of 5.54 μM and 0.701 μM, respectively.Formule :C24H32FN3O4Couleur et forme :SolidMasse moléculaire :445.23768FGA139
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.Formule :C48H58BF2N7O5Couleur et forme :SolidMasse moléculaire :861.45605Tacalcitol monohydrate
CAS :Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.Formule :C27H46O4Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :434.65SmCB1-IN-1
SmCB1-IN-1 (Compound 2h) is an inhibitor of the Schistosoma mansoni cathepsin B1 (SmCB1) with a Ki of 0.05 μM. It demonstrates selectivity towards non-target human proteases, showing inhibition rates of 29% for CatB and 37% for CatL at 20 μM. At 1 μM, SmCB1-IN-1 inhibits 68% of Schistosoma mansoni.Formule :C26H25NO6SCouleur et forme :SolidMasse moléculaire :479.14026Cathepsin L-IN-5
CathepsinL-IN-5 (D6-3) is a potent inhibitor of Cathepsin L (CatL) with an IC50 value of 0.27 nM. It effectively blocks the function of CatL and significantly impedes the entry of SARS-CoV-2 pseudovirus into cells by inhibiting the cleavage of the spike protein. CathepsinL-IN-5 is applicable for research on infections.Couleur et forme :Odour SolidPD150606
CAS :PD150606 is a calpain inhibitor with neuroprotective activity that inhibits μ-calpains and interferes with excitotoxicity-dependent motor neuron death.Formule :C9H7IO2SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :306.12Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Couleur et forme :Odour SolidProtease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Couleur et forme :Odour SolidRef: TM-L1100
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderCathepsin D and E FRET Substrate acetate
Fluorogenic substrate for cathepsins D & E, not B/H/L; useful in their mechanistic studies.Formule :C86H124N22O21Degré de pureté :96.47%Couleur et forme :Yellow SolidMasse moléculaire :1802.04Cathepsin L-IN-3
CAS :Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.Formule :C41H49N7O4SCouleur et forme :SolidMasse moléculaire :735.94Cathepsin Inhibitor 4
Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S, with a Ki value of 0.04 nM.
Formule :C24H35N3O5Masse moléculaire :445.257676,6′-Dihydroxythiobinupharidine
CAS :6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFormule :C30H42N2O4SCouleur et forme :SolidMasse moléculaire :526.73Hepcidin-1 (mouse)
CAS :Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.Formule :C111H169N31O35S8Couleur et forme :SolidMasse moléculaire :2754.24Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFormule :C24H35N5O4·xC2HF3O2Couleur et forme :SolidMpro/Cathepsin L-IN-2
Mpro/Cathepsin L-IN-2 (Compound 1) is an irreversible dual inhibitor targeting the main protease of SARS-CoV-2 (Mpro, pIC50=8.61) and human cathepsin L (hCTSL, pIC50=7.64). Mpro/Cathepsin L-IN-2 shows potential for use in research related to COVID-19 and other coronavirus infections.Couleur et forme :Odour SolidZ-Arg-Arg-βNA acetate
CAS :Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.Formule :C32H43N9O6Couleur et forme :SolidMasse moléculaire :649.74Cathepsin D and E FRET Substrate
CAS :Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Formule :C85H122N22O19Couleur et forme :SolidMasse moléculaire :1756.046Cathepsin D/E Substrate, Fluorogenic
CathepsinD/E Substrate, Fluorogenic, is an 11-amino acid peptide specifically designed as a substrate for cathepsins D and E, demonstrating selectivity by not acting as a substrate for cathepsins B, H, or L.Formule :C83H119N21O18Couleur et forme :SolidMasse moléculaire :1697.9042VK13
VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.Formule :C24H28N4O5Couleur et forme :SolidMasse moléculaire :452.503CTSL/CAPN1-IN-1
CTSL/CAPN1-IN-1 (compound 14a) is an orally active inhibitor targeting CTSL and CAPN1, with IC50 values of 3.34 nM and 375.1 nM, respectively. It exhibits both anti-coronavirus and anti-inflammatory activities.Formule :C34H33FN4O6Couleur et forme :SolidMasse moléculaire :612.23841Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.Couleur et forme :Odour SolidZ-Phe-Tyr(tBu)-diazomethylketone
CAS :Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.Formule :C31H34N4O5Couleur et forme :SolidMasse moléculaire :542.636Z-L(D-Val)G-CHN2
Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.Formule :C22H31N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.51Relacatib
CAS :Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.Formule :C27H32N4O6SCouleur et forme :SolidMasse moléculaire :540.64N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Formule :C35H37F3N6O8Degré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :726.7Gallinamide A TFA
CAS :Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].Formule :C33H53F3N4O9Couleur et forme :SolidMasse moléculaire :706.79Ac-PLVE-FMK
CAS :Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl fluoromethylketone (FMKs), serves as a cathepsin inhibitor. It is utilized in cancer research [1].Formule :C25H41FN4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.61LN5P45
LN5P45, an OTUB2 inhibitor (IC50: 2.3 μM), promotes monoubiquitination of OTUB2 at lysine 31 and is utilized in the study of tumor progression and metastasis [1Formule :C13H15ClN2O2Couleur et forme :SolidMasse moléculaire :266.72Odanacatib
CAS :Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.Formule :C25H27F4N3O3SDegré de pureté :98.53% - 99.53%Couleur et forme :SolidMasse moléculaire :525.56JTE-607
CAS :JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.Formule :C25H33Cl4N3O5Degré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :597.36Ref: TM-T27695
1mg42,00€5mg93,00€1mL*10mM (DMSO)109,00€10mg150,00€25mg310,00€50mg492,00€100mg707,00€200mg973,00€Aloxistatin
CAS :Aloxistatin (E64d) inhibits cysteine proteases, blocks calpain in platelets, and prevents blood clotting.Formule :C17H30N2O5Degré de pureté :99.46% - 99.69%Couleur et forme :SolidMasse moléculaire :342.43Balicatib
CAS :Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.Formule :C23H33N5O2Degré de pureté :97.78% - 98.17%Couleur et forme :SolidMasse moléculaire :411.54E 64c
CAS :E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.Formule :C15H26N2O5Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :314.382-Cyanopyrimidine
CAS :2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)Formule :C5H3N3Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :105.1CA-074 methyl ester
CAS :CA-074 methyl ester (Cathepsin B Inhibitor IV) is a selective inhibitor of Cathepsin B (IC50=36.3 nM). neuroprotective effect. High-Quality, Low-Cost!Formule :C19H31N3O6Degré de pureté :97.26% - 99.58%Couleur et forme :SolidMasse moléculaire :397.47KGP94
CAS :KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.Formule :C14H12BrN3OSDegré de pureté :99.6%Couleur et forme :White SolidMasse moléculaire :350.23Ref: TM-T27730
1mg65,00€5mg138,00€1mL*10mM (DMSO)152,00€10mg215,00€25mg359,00€50mg510,00€100mg692,00€200mg928,00€LY 3000328
CAS :LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S.Cost-effective and quality-assured.Formule :C25H29FN4O5Degré de pureté :97.83% - 99.54%Couleur et forme :White SolidMasse moléculaire :484.52Ref: TM-TQ0116
1mg90,00€2mg130,00€5mg198,00€1mL*10mM (DMSO)207,00€10mg263,00€25mg462,00€50mg672,00€100mg945,00€L-006235
CAS :L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.Formule :C24H30N6O2SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :466.6Ref: TM-T21616
2mg39,00€5mg60,00€1mL*10mM (DMSO)62,00€10mg92,00€25mg177,00€50mg299,00€100mg432,00€200mg602,00€MDL-28170
CAS :MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Formule :C22H26N2O4Degré de pureté :95.06%Couleur et forme :SolidMasse moléculaire :382.45Ref: TM-T2470
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)75,00€10mg90,00€25mg128,00€50mg167,00€100mg284,00€(1S,2R)-Alicapistat
CAS :(1S,2R)-Alicapistat inhibits calpains 1 and 2, shows promise for Alzheimer's, and has an IC50 of 395 nM.Formule :C25H27N3O4Degré de pureté :99.60%Couleur et forme :White SolidMasse moléculaire :433.5Ref: TM-T60150
1mg64,00€5mg142,00€1mL*10mM (DMSO)167,00€10mg197,00€25mg299,00€50mg400,00€100mg537,00€ALLM
CAS :ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Formule :C19H35N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.56S 2160
CAS :S 2160 is a synthetic chromogenic substrate for thrombin.Formule :C33H40N8O6Couleur et forme :SolidMasse moléculaire :644.72Cathepsin Inhibitor 1
CAS :Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.Formule :C20H24ClN5O2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :401.89Ref: TM-T6015
1mg46,00€5mg90,00€1mL*10mM (DMSO)100,00€10mg144,00€25mg236,00€50mg371,00€100mg522,00€200mg743,00€
