Cystéine protéase
Les inhibiteurs de protéases à cystéine sont des composés qui ciblent et inhibent les protéases à cystéine, une classe d'enzymes qui décomposent les protéines en clivant les liaisons peptidiques dans lesquelles un résidu de cystéine agit comme nucléophile. Ces enzymes sont impliquées dans divers processus physiologiques, tels que l'apoptose, la réponse immunitaire et le renouvellement des protéines. Les inhibiteurs de protéases à cystéine sont essentiels pour l'étude de maladies telles que le cancer, les troubles neurodégénératifs et les infections parasitaires. Chez CymitQuimica, nous fournissons des inhibiteurs de protéases à cystéine pour soutenir vos recherches en protéolyse, régulation cellulaire et découverte de médicaments.
96 produits trouvés pour "Cystéine protéase"
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Cathepsin Inhibitor 4
<p>Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S, with a Ki value of 0.04 nM.</p>Formule :C24H35N3O5Masse moléculaire :445.25767Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Couleur et forme :Odour SolidCathepsin C-IN-6
<p>Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastase</p>Formule :C24H35N5O4·xC2HF3O2Couleur et forme :SolidLeupeptin
CAS :<p>Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.</p>Formule :C20H38N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.562PD150606
CAS :<p>PD150606 is a calpain inhibitor with neuroprotective activity that inhibits μ-calpains and interferes with excitotoxicity-dependent motor neuron death.</p>Formule :C9H7IO2SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :306.12Z-FG-NHO-Bz
CAS :<p>Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].</p>Formule :C26H25N3O6Couleur et forme :SolidMasse moléculaire :475.49VK13
<p>VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.</p>Formule :C24H28N4O5Couleur et forme :SolidMasse moléculaire :452.503Cathepsin D and E FRET Substrate
CAS :Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Formule :C85H122N22O19Couleur et forme :SolidMasse moléculaire :1756.046Tacalcitol monohydrate
CAS :<p>Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.</p>Formule :C27H46O4Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :434.65Z-Phe-Tyr(tBu)-diazomethylketone
CAS :<p>Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.</p>Formule :C31H34N4O5Couleur et forme :SolidMasse moléculaire :542.636Z-L(D-Val)G-CHN2
<p>Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.</p>Formule :C22H31N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.51Relacatib
CAS :<p>Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.</p>Formule :C27H32N4O6SCouleur et forme :SolidMasse moléculaire :540.64Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Couleur et forme :Odour SolidN-CBZ-Phe-Arg-AMC TFA
<p>N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.</p>Formule :C35H37F3N6O8Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :726.7Dazcapistat
CAS :<p>Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.</p>Formule :C21H18FN3O4Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :395.38Ac-PLVE-FMK
CAS :<p>Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl fluoromethylketone (FMKs), serves as a cathepsin inhibitor. It is utilized in cancer research [1].</p>Formule :C25H41FN4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.61FGA139
<p>FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.</p>Formule :C48H58BF2N7O5Couleur et forme :SolidMasse moléculaire :861.45605Mpro/Cathepsin L-IN-1
<p>Mpro/Cathepsin L-IN-1 (Compound 4d) is an inhibitor of SARS-CoV-2 Mpro and hCatL, with Ki values of 5.54 μM and 0.701 μM, respectively.</p>Formule :C24H32FN3O4Masse moléculaire :445.237686,6′-Dihydroxythiobinupharidine
CAS :<p>6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold</p>Formule :C30H42N2O4SCouleur et forme :SolidMasse moléculaire :526.73Cathepsin L-IN-3
CAS :<p>Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.</p>Formule :C41H49N7O4SCouleur et forme :SolidMasse moléculaire :735.94Z-Leu-Tyr-Chloromethylketone
CAS :<p>Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].</p>Formule :C24H29ClN2O5Couleur et forme :SolidMasse moléculaire :460.95N-CBZ-Phe-Arg-AMC
CAS :<p>Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.</p>Formule :C33H36N6O6Degré de pureté :98%Couleur et forme :White To Off-White PowderMasse moléculaire :612.68Gallinamide A TFA
CAS :<p>Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].</p>Formule :C33H53F3N4O9Couleur et forme :SolidMasse moléculaire :706.79Z-Arg-Arg-βNA acetate
CAS :<p>Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.</p>Formule :C32H43N9O6Couleur et forme :SolidMasse moléculaire :649.74Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
<p>Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.</p>Couleur et forme :Odour SolidHepcidin-1 (mouse)
CAS :<p>Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.</p>Formule :C111H169N31O35S8Couleur et forme :SolidMasse moléculaire :2754.24LN5P45
<p>LN5P45, an OTUB2 inhibitor (IC50: 2.3 μM), promotes monoubiquitination of OTUB2 at lysine 31 and is utilized in the study of tumor progression and metastasis [1</p>Formule :C13H15ClN2O2Couleur et forme :SolidMasse moléculaire :266.72L-006235
CAS :L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.Formule :C24H30N6O2SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :466.6CA-074 methyl ester
CAS :<p>CA-074 methyl ester (Cathepsin B Inhibitor IV) is a selective inhibitor of Cathepsin B (IC50=36.3 nM). neuroprotective effect. High-Quality, Low-Cost!</p>Formule :C19H31N3O6Degré de pureté :97.26% - 99.58%Couleur et forme :SolidMasse moléculaire :397.47Odanacatib
CAS :<p>Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.</p>Formule :C25H27F4N3O3SDegré de pureté :98.53% - 99.53%Couleur et forme :SolidMasse moléculaire :525.56LY 3000328
CAS :<p>LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S.Cost-effective and quality-assured.</p>Formule :C25H29FN4O5Degré de pureté :97.83% - 99.54%Couleur et forme :SolidMasse moléculaire :484.52E-64
CAS :<p>E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.</p>Formule :C15H27N5O5Degré de pureté :98% - 99.95%Couleur et forme :White SolidMasse moléculaire :357.41MDL-28170
CAS :<p>MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.</p>Formule :C22H26N2O4Degré de pureté :95.06%Couleur et forme :SolidMasse moléculaire :382.45JTE-607
CAS :<p>JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.</p>Formule :C25H33Cl4N3O5Degré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :597.36KGP94
CAS :<p>KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.</p>Formule :C14H12BrN3OSDegré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :350.23Balicatib
CAS :<p>Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.</p>Formule :C23H33N5O2Degré de pureté :97.78% - 98.17%Couleur et forme :White To Off-White Solid PowderMasse moléculaire :411.542-Cyanopyrimidine
CAS :<p>2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)</p>Formule :C5H3N3Degré de pureté :99.27%Couleur et forme :Crystalline SolidMasse moléculaire :105.1(1S,2R)-Alicapistat
CAS :<p>(1S,2R)-Alicapistat inhibits calpains 1 and 2, shows promise for Alzheimer's, and has an IC50 of 395 nM.</p>Formule :C25H27N3O4Degré de pureté :99.60%Couleur et forme :SoildMasse moléculaire :433.5Cathepsin Inhibitor 1
CAS :<p>Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.</p>Formule :C20H24ClN5O2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :401.89Calpain Inhibitor XII
CAS :<p>Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a calpain I inhibitor that inhibits calpain II and cathepsin B.</p>Formule :C26H34N4O5Couleur et forme :SolidMasse moléculaire :482.57LmCPB-IN-1
CAS :<p>LmCPB-IN-1, compound 35, is a reversible inhibitor of LmCPB with strong binding (pKi 9.7).</p>Formule :C18H30N6O2Couleur et forme :SolidMasse moléculaire :362.47DTS
CAS :<p>DTS is a selective and isoform-specific RSK1 kinase inhibitor. It also has broad cancer therapeutic potential.</p>Formule :C14H14S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :278.46Cathepsin L/S-IN-1
<p>Cathepsin L/S-IN-1 inhibits Cathepsin L & S (IC50: 4.10 & 1.79 μM) and reduces metastasis in pancreatic cancer cells.</p>Formule :C29H33BrN4O4SCouleur et forme :SolidMasse moléculaire :613.57JPM-OEt
CAS :<p>JPM-OEt: broad-spectrum, covalent cysteine cathepsin inhibitor with antitumor effects.</p>Formule :C20H28N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.45GSK-2793660
CAS :<p>GSK-2793660, an oral, irreversible CTSC inhibitor, aids bronchiectasis research.</p>Formule :C20H27N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.45Gü1303
CAS :<p>Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK).</p>Formule :C20H22N4O3Couleur et forme :SolidMasse moléculaire :366.41Cysteine Protease inhibitor
CAS :<p>Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine Protease</p>Formule :C18H14N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.33GSK2793660 HCl
CAS :<p>GSK2793660 is a irreversible covalent α,β-unsaturated amide based DPP1 inhibitor.</p>Formule :C22H32ClN3O3Couleur et forme :SolidMasse moléculaire :421.96JNJ-10329670
CAS :<p>JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.</p>Formule :C30H34ClF3N6O3SCouleur et forme :SolidMasse moléculaire :651.14Gü2602
CAS :<p>Gü2602 inhibits the cathepsin K zymogen autocatalytic activation that is a potent, reversible inhibitor of cathepsin K (CatK) with a Ki of 0.013 nM for mature</p>Formule :C16H22N4O3Couleur et forme :SolidMasse moléculaire :318.37
