Cellules souche et Dérivés
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les voies de signalisation et les protéines impliquées dans le maintien, la différenciation et la prolifération des cellules souches. Ces inhibiteurs sont cruciaux pour comprendre la biologie des cellules souches et pour développer des stratégies visant à manipuler les cellules souches à des fins thérapeutiques, telles que la médecine régénérative et le traitement du cancer. En contrôlant le destin des cellules souches, ces inhibiteurs peuvent aider à orienter la différenciation des cellules souches en types cellulaires spécifiques ou à prévenir une croissance cellulaire indésirable. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de cellules souches de haute qualité pour soutenir vos recherches en biologie des cellules souches, biologie du développement et médecine régénérative.
Sous-catégories appartenant à la catégorie "Cellules souche et Dérivés"
- Gamma-sécrétase(61 produits)
- Hérisson/Smoothened(49 produits)
- Voie de signalisation Hippo(7 produits)
- JAK(243 produits)
- Porc-épic(9 produits)
- ROCK(62 produits)
- STAT(98 produits)
- Cellules souches(211 produits)
- TGF-beta/Smad(59 produits)
- Wnt/beta-caténine(60 produits)
Affichez 2 plus de sous-catégories
493 produits trouvés pour "Cellules souche et Dérivés"
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Momelotinib HCl
CAS :Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.Formule :C23H24Cl2N6O2Couleur et forme :SolidMasse moléculaire :487.38exo-IWR-1
CAS :exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin
Formule :C25H19N3O3Degré de pureté :97.41%Couleur et forme :SolidMasse moléculaire :409.44Cerdulatinib
CAS :Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Formule :C20H27N7O3SDegré de pureté :98.74% - 99.49%Couleur et forme :SolidMasse moléculaire :445.54Ref: TM-T2487
1mg42,00€2mg52,00€5mg74,00€10mg101,00€25mg175,00€50mg268,00€100mg409,00€200mg573,00€500mg888,00€1mL*10mM (DMSO)81,00€Upadacitinib
CAS :Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.Formule :C17H19F3N6ODegré de pureté :98.96% - 99.94%Couleur et forme :SolidMasse moléculaire :380.37Ref: TM-T7503
2mg55,00€5mg89,00€10mg116,00€25mg198,00€50mg276,00€100mg389,00€200mg595,00€1mL*10mM (DMSO)44,00€Pyridone 6
CAS :Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).Formule :C18H16FN3ODegré de pureté :97.1% - 98.74%Couleur et forme :SolidMasse moléculaire :309.34Ref: TM-T3080
1mg50,00€2mg71,00€5mg105,00€10mg173,00€25mg358,00€50mg587,00€100mg888,00€200mg1.198,00€1mL*10mM (DMSO)110,00€WHI-P97
CAS :WHI-P97 is a rationally designed potent inhibitor of JAK-3.Formule :C16H13Br2N3O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :455.1Belumosudil
CAS :Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Formule :C26H24N6O2Degré de pureté :97.64% - 98.59%Couleur et forme :SolidMasse moléculaire :452.51Ref: TM-T6867
2mg48,00€5mg73,00€10mg90,00€25mg166,00€50mg250,00€100mg376,00€500mg895,00€1mL*10mM (DMSO)79,00€BD750
CAS :BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormule :C14H13N3OSDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :271.34Pacritinib hydrochloride
CAS :Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.Formule :C28H32N4O3·xClHCouleur et forme :Solid2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS :2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.Formule :C16H13Cl2N3O2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :350.2IHR-1
CAS :IHR-1, a Smo inhibitor (IC50 7.6 nM), blocks Hedgehog pathway, not Wnt/Notch, and prevents Smo in primary cilium.Formule :C20H12Cl4N2O2Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :454.13Ref: TM-T24159
2mg33,00€5mg50,00€10mg80,00€25mg131,00€50mg193,00€100mg290,00€200mg416,00€1mL*10mM (DMSO)55,00€MRT-14
CAS :MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.Formule :C24H24N4O5Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :448.47SAR-20347
CAS :SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).Formule :C21H18ClFN4O4Degré de pureté :98.99% - 99.77%Couleur et forme :SolidMasse moléculaire :444.84Ref: TM-T4210
1mg34,00€5mg75,00€10mg110,00€25mg215,00€50mg334,00€100mg557,00€200mg775,00€1mL*10mM (DMSO)84,00€LY3200882
CAS :LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Formule :C24H29N5O3Degré de pureté :99.46% - 99.63%Couleur et forme :SolidMasse moléculaire :435.52RKI1313
CAS :RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFormule :C17H16N4O2SDegré de pureté :99.53% - ≥95%Couleur et forme :SolidMasse moléculaire :340.4Ref: TM-T2011
1mg70,00€5mg142,00€10mg207,00€25mg369,00€50mg540,00€100mg772,00€500µg49,00€1mL*10mM (DMSO)160,00€Fosciclopirox
CAS :Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entireFormule :C13H20NO6PDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :317.27Ref: TM-T9422
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€Atractylenolide I
CAS :Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formule :C15H18O2Degré de pureté :97.55% - 99.92%Couleur et forme :SolidMasse moléculaire :230.30AR-A014418
CAS :AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.Formule :C12H12N4O4SDegré de pureté :>99.99% - ≥95%Couleur et forme :SolidMasse moléculaire :308.31GLPG0634 analog
CAS :GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.Formule :C23H18N6O2Degré de pureté :99.52% - >99.99%Couleur et forme :SolidMasse moléculaire :410.43Ref: TM-T3076
1mg38,00€2mg50,00€5mg84,00€10mg137,00€25mg250,00€50mg442,00€100mg623,00€500mg1.305,00€1mL*10mM (DMSO)93,00€Lats-IN-1
CAS :Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.Formule :C18H14N4OSDegré de pureté :97.54% - 99.79%Couleur et forme :SolidMasse moléculaire :334.39Ref: TM-T9053
1mg52,00€2mg73,00€5mg105,00€10mg167,00€25mg309,00€50mg416,00€100mg592,00€200mg842,00€1mL*10mM (DMSO)118,00€IMR-1
CAS :IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formule :C15H15NO5S2Degré de pureté :97.96% - 98.38%Couleur et forme :SolidMasse moléculaire :353.41XL019
CAS :XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.Formule :C25H28N6O2Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :444.53Ref: TM-T3072
2mg43,00€5mg63,00€10mg92,00€25mg150,00€50mg215,00€100mg321,00€200mg477,00€1mL*10mM (DMSO)78,00€MK-0752 Sodium
CAS :Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.Formule :C21H21ClF2NaO4SCouleur et forme :SolidMasse moléculaire :465.89ZM39923 hydrochloride
CAS :ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91SB 216763
CAS :SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Formule :C19H12Cl2N2O2Degré de pureté :98.9% - 99.13%Couleur et forme :SolidMasse moléculaire :371.22Ref: TM-T3077
2mg39,00€5mg52,00€10mg79,00€25mg131,00€50mg197,00€100mg334,00€500mg803,00€1mL*10mM (DMSO)52,00€JANEX-1
CAS :JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.Formule :C16H15N3O3Degré de pureté :98% - 99.81%Couleur et forme :SolidMasse moléculaire :297.31Peficitinib
CAS :Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formule :C18H22N4O2Degré de pureté :98.67% - 99.4%Couleur et forme :SolidMasse moléculaire :326.39Ref: TM-T6933
2mg38,00€5mg63,00€10mg99,00€25mg172,00€50mg268,00€100mg416,00€200mg610,00€1mL*10mM (DMSO)70,00€LY900009
CAS :LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Formule :C23H27N3O4Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :409.48Ref: TM-T9015
1mg35,00€5mg80,00€10mg112,00€25mg197,00€50mg290,00€100mg420,00€200mg590,00€1mL*10mM (DMSO)87,00€Protosappanin A
CAS :Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Formule :C15H12O5Degré de pureté :99.42% - 99.82%Couleur et forme :SolidMasse moléculaire :272.25Ref: TM-TJS1779
1mg88,00€5mg195,00€10mg318,00€25mg523,00€50mg743,00€100mg999,00€1mL*10mM (DMSO)178,00€Delgocitinib EtOH
CAS :Delgocitinib (LEO-124249/JTE052) is a selective JAK inhibitor used for reducing skin inflammation and treating chronic dermatitis.Formule :C18H24N6O2Couleur et forme :SolidMasse moléculaire :356.43Deucravacitinib
CAS :Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Formule :C20H19D3N8O3Degré de pureté :98.52% - >99.99%Couleur et forme :SolidMasse moléculaire :425.46Ref: TM-T14687
1mg56,00€5mg137,00€10mg248,00€25mg389,00€50mg575,00€100mg817,00€1mL*10mM (DMSO)149,00€Momelotinib
CAS :Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formule :C23H22N6O2Degré de pureté :97.07% - 99.56%Couleur et forme :SolidMasse moléculaire :414.46Ref: TM-T1849
1mg35,00€2mg50,00€5mg77,00€10mg89,00€25mg158,00€50mg245,00€100mg385,00€200mg592,00€1mL*10mM (DMSO)84,00€(Z)-LFM-A13
CAS :(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.Formule :C11H8Br2N2O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :360VP3.15 dihydrobromide
CAS :VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Formule :C20H24Br2N4OSDegré de pureté :99.67% - ≥95%Couleur et forme :SolidMasse moléculaire :528.3LGK974
CAS :LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Formule :C23H20N6ODegré de pureté :98.8% - >99.99%Couleur et forme :SolidMasse moléculaire :396.44Ref: TM-T2618
1mg46,00€2mg62,00€5mg90,00€10mg156,00€25mg288,00€50mg515,00€100mg737,00€1mL*10mM (DMSO)90,00€PF-670462
CAS :PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.Formule :C19H22Cl2FN5Degré de pureté :99.42% - 99.72%Couleur et forme :SolidMasse moléculaire :410.32MYF-01-37
CAS :MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.Formule :C15H17F3N2ODegré de pureté :99.46% - 99.5%Couleur et forme :SolidMasse moléculaire :298.3Ref: TM-T22372
2mg38,00€5mg57,00€10mg90,00€25mg166,00€50mg281,00€100mg421,00€500mg888,00€1mL*10mM (DMSO)63,00€AT9283
CAS :AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
Formule :C19H23N7O2Degré de pureté :99.83% - 99.98%Couleur et forme :SolidMasse moléculaire :381.43Curculigoside
CAS :1.Formule :C22H26O11Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :466.44CEP-33779
CAS :CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.Formule :C24H26N6O2SDegré de pureté :98.24% - ≥95%Couleur et forme :SolidMasse moléculaire :462.57Ref: TM-T6122
1mg43,00€2mg56,00€5mg93,00€10mg137,00€25mg231,00€50mg356,00€100mg530,00€500mg1.153,00€1mL*10mM (DMSO)92,00€Baricitinib phosphate
CAS :Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.Formule :C16H20N7O6PSDegré de pureté :99.4% - 99.91%Couleur et forme :SolidMasse moléculaire :469.41Ref: TM-T2360
5mg40,00€10mg52,00€25mg73,00€50mg93,00€100mg105,00€200mg157,00€500mg260,00€1mL*10mM (DMSO)46,00€WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.Formule :C16H14Br2ClN3O3Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :491.56Ref: TM-T4657L
2mg34,00€5mg48,00€10mg86,00€25mg138,00€50mg182,00€100mg261,00€200mg371,00€1mL*10mM (DMSO)73,00€SJ000291942
CAS :SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Formule :C16H15FN2O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :318.3Ref: TM-T4662
1mg34,00€2mg44,00€5mg63,00€10mg100,00€25mg205,00€50mg349,00€100mg557,00€200mg790,00€1mL*10mM (DMSO)71,00€ZINC00881524
CAS :ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
Formule :C21H20N2O3SDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :380.46Abrocitinib
CAS :Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formule :C14H21N5O2SDegré de pureté :99.09% - 99.91%Couleur et forme :SolidMasse moléculaire :323.41LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Formule :C25H44F6N6O9Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :686.64Ref: TM-T7676
2mg42,00€5mg54,00€10mg84,00€25mg138,00€50mg207,00€100mg316,00€200mg442,00€1mL*10mM (DMSO)93,00€SC99
CAS :SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :336.15Ref: TM-T8719
1mg43,00€5mg87,00€10mg133,00€25mg227,00€50mg344,00€100mg429,00€200mg597,00€1mL*10mM (DMSO)94,00€Kartogenin
CAS :Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Formule :C20H15NO3Degré de pureté :96.25% - 97.79%Couleur et forme :SolidMasse moléculaire :317.34TBB
CAS :TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
Formule :C6HBr4N3Degré de pureté :98.51% - 99.45%Couleur et forme :Off-White SolidMasse moléculaire :434.71ITD-1
CAS :ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Formule :C27H29NO3Degré de pureté :99.89% - >99.99%Couleur et forme :SolidMasse moléculaire :415.52
