Cellules souches
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les cellules souches et leurs voies de signalisation, affectant leur capacité à s'auto-renouveler et à se différencier. Ces inhibiteurs sont essentiels dans la recherche axée sur le contrôle du comportement des cellules souches, la compréhension des processus de développement et le développement de thérapies pour des maladies comme le cancer, où les cellules souches sont censées jouer un rôle clé. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de cellules souches pour soutenir vos recherches en médecine régénérative, biologie du développement et oncologie.
234 produits trouvés pour "Cellules souches"
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BMP signaling agonist sb4
CAS :BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Formule :C14H10BrNOSDegré de pureté :99.48% - 99.805%Couleur et forme :SolidMasse moléculaire :320.2Ref: TM-T7799
5mg44,00€10mg57,00€25mg94,00€50mg119,00€100mg177,00€200mg268,00€500mg465,00€1mL*10mM (DMSO)48,00€BMS986260
CAS :BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).Formule :C18H12ClFN6ODegré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :382.78ZINC00881524
CAS :ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
Formule :C21H20N2O3SDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :380.46Adavivint
CAS :Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
Formule :C29H24FN7ODegré de pureté :98.27% - 98.6%Couleur et forme :SolidMasse moléculaire :505.55Porcn-IN-1
CAS :Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).Formule :C25H19FN4ODegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :410.44BIO-013077-01
CAS :BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Formule :C17H13N5Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :287.32Ref: TM-T8330
1mg50,00€5mg92,00€10mg140,00€25mg273,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)138,00€IWP-O1
CAS :IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formule :C26H20N6ODegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :432.48Ref: TM-T5342
2mg39,00€5mg64,00€10mg101,00€25mg163,00€50mg226,00€100mg320,00€200mg459,00€1mL*10mM (DMSO)70,00€Tegatrabetan
CAS :Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Formule :C28H36N4O6S2Degré de pureté :98.01% - 99.18%Couleur et forme :SolidMasse moléculaire :588.74Ref: TM-T5642
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg210,00€50mg334,00€100mg565,00€1mL*10mM (DMSO)96,00€SRI-011381 hydrochloride
CAS :SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Formule :C20H32ClN3ODegré de pureté :99.32% - 99.41%Couleur et forme :SolidMasse moléculaire :365.94Ref: TM-T5129
1mg34,00€2mg44,00€5mg66,00€10mg105,00€25mg215,00€50mg334,00€100mg497,00€200mg755,00€1mL*10mM (DMSO)73,00€AZD1080
CAS :AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Formule :C19H18N4O2Degré de pureté :97.72% - 99.75%Couleur et forme :SolidMasse moléculaire :334.37Ref: TM-T1741
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg429,00€1mL*10mM (DMSO)63,00€IQ 1
CAS :IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.
Formule :C21H22N4O2Degré de pureté :98.57% - ≥95%Couleur et forme :SolidMasse moléculaire :362.42ITD-1
CAS :ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Formule :C27H29NO3Degré de pureté :99.89% - >99.99%Couleur et forme :SolidMasse moléculaire :415.52β-catenin-IN-2
CAS :β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.Formule :C15H14FN3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :255.29Ref: TM-T9696
1mg96,00€5mg227,00€10mg359,00€25mg607,00€50mg868,00€100mg1.169,00€500mg2.365,00€1mL*10mM (DMSO)264,00€Afuresertib hydrochloride
CAS :Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
Formule :C18H18Cl3FN4OSDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :463.8Galunisertib
CAS :Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Formule :C22H19N5ODegré de pureté :97.09% - 99.98%Couleur et forme :SolidMasse moléculaire :369.42Ref: TM-T2510
1g657,00€5mg46,00€10mg52,00€25mg84,00€50mg114,00€100mg178,00€200mg269,00€500mg442,00€1mL*10mM (DMSO)52,00€I3MT-3
CAS :I3MT-3 (HMPSNE) is a selective inhibitor of 3MST, targeting active site cysteine residues and permeating cell membranes.Formule :C17H14N2O2SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :310.37exo-IWR-1
CAS :exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin
Formule :C25H19N3O3Degré de pureté :97.41%Couleur et forme :SolidMasse moléculaire :409.44YO-01027
CAS :YO-01027 (DBZ) is a potent γ-secretase inhibitor.
Formule :C26H23F2N3O3Degré de pureté :97.21% - 99.58%Couleur et forme :SolidMasse moléculaire :463.48Belumosudil
CAS :Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Formule :C26H24N6O2Degré de pureté :97.64% - 98.59%Couleur et forme :SolidMasse moléculaire :452.51Ref: TM-T6867
2mg48,00€5mg73,00€10mg90,00€25mg166,00€50mg250,00€100mg376,00€500mg895,00€1mL*10mM (DMSO)79,00€GSK269962A
CAS :GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.Formule :C29H30N8O5Degré de pureté :99.14% - 99.71%Couleur et forme :SolidMasse moléculaire :570.6IHR-1
CAS :IHR-1, a Smo inhibitor (IC50 7.6 nM), blocks Hedgehog pathway, not Wnt/Notch, and prevents Smo in primary cilium.Formule :C20H12Cl4N2O2Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :454.13Ref: TM-T24159
2mg33,00€5mg50,00€10mg80,00€25mg131,00€50mg193,00€100mg290,00€200mg416,00€1mL*10mM (DMSO)55,00€MRT-14
CAS :MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.Formule :C24H24N4O5Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :448.47Lats-IN-1
CAS :Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.Formule :C18H14N4OSDegré de pureté :97.54% - 99.79%Couleur et forme :SolidMasse moléculaire :334.39Ref: TM-T9053
1mg52,00€2mg73,00€5mg105,00€10mg167,00€25mg309,00€50mg416,00€100mg592,00€200mg842,00€1mL*10mM (DMSO)118,00€LY3200882
CAS :LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Formule :C24H29N5O3Degré de pureté :99.46% - 99.63%Couleur et forme :SolidMasse moléculaire :435.52XMU-MP-1
CAS :XMU-MP-1 is a reversible and selective MST1/2 kinase inhibitor, IC50 values for MST1 and MST2 are 71.1 nM and 38.1 nM, respectively. High-Quality, Low-Cost!Formule :C17H16N6O3S2Degré de pureté :99.68% - 99.86%Couleur et forme :SolidMasse moléculaire :416.48Ref: TM-T4212
1mg52,00€2mg79,00€5mg97,00€10mg153,00€25mg305,00€50mg512,00€100mg663,00€1mL*10mM (DMSO)95,00€Fosciclopirox
CAS :Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entireFormule :C13H20NO6PDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :317.27Ref: TM-T9422
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€AR-A014418
CAS :AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.Formule :C12H12N4O4SDegré de pureté :>99.99% - ≥95%Couleur et forme :SolidMasse moléculaire :308.31SRI-011381
CAS :SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Formule :C20H31N3ODegré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :329.48SB 216763
CAS :SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Formule :C19H12Cl2N2O2Degré de pureté :98.9% - 99.13%Couleur et forme :SolidMasse moléculaire :371.22Ref: TM-T3077
2mg39,00€5mg52,00€10mg79,00€25mg131,00€50mg197,00€100mg334,00€500mg803,00€1mL*10mM (DMSO)52,00€PF-5274857
CAS :PF-5274857: selective hedgehog pathway inhibitor (IC50: 5.8 nM, Ki: 4.6 nM), treats brain tumors, crosses blood-brain barrier, orally stable.Formule :C20H25ClN4O3SDegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :436.96MYF-01-37
CAS :MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.Formule :C15H17F3N2ODegré de pureté :99.46% - 99.5%Couleur et forme :SolidMasse moléculaire :298.3Ref: TM-T22372
2mg38,00€5mg57,00€10mg90,00€25mg166,00€50mg281,00€100mg421,00€500mg888,00€1mL*10mM (DMSO)63,00€SD-208
CAS :SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.Formule :C17H10ClFN6Degré de pureté :98.72% - 99.65%Couleur et forme :SolidMasse moléculaire :352.75VP3.15 dihydrobromide
CAS :VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Formule :C20H24Br2N4OSDegré de pureté :99.67% - ≥95%Couleur et forme :SolidMasse moléculaire :528.3LGK974
CAS :LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Formule :C23H20N6ODegré de pureté :98.8% - >99.99%Couleur et forme :SolidMasse moléculaire :396.44Ref: TM-T2618
1mg46,00€2mg62,00€5mg90,00€10mg156,00€25mg288,00€50mg515,00€100mg737,00€1mL*10mM (DMSO)90,00€SJ000291942
CAS :SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Formule :C16H15FN2O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :318.3Ref: TM-T4662
1mg34,00€2mg44,00€5mg63,00€10mg100,00€25mg205,00€50mg349,00€100mg557,00€200mg790,00€1mL*10mM (DMSO)71,00€Indirubin-3′-oxime
CAS :Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
Formule :C16H11N3O2Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :277.28RKI1313
CAS :RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFormule :C17H16N4O2SDegré de pureté :99.53% - ≥95%Couleur et forme :SolidMasse moléculaire :340.4Ref: TM-T2011
1mg70,00€5mg142,00€10mg207,00€25mg369,00€50mg540,00€100mg772,00€500µg49,00€1mL*10mM (DMSO)160,00€LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Formule :C25H44F6N6O9Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :686.64Ref: TM-T7676
2mg42,00€5mg54,00€10mg84,00€25mg138,00€50mg207,00€100mg316,00€200mg442,00€1mL*10mM (DMSO)93,00€Kartogenin
CAS :Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Formule :C20H15NO3Degré de pureté :96.25% - 97.79%Couleur et forme :SolidMasse moléculaire :317.34TBB
CAS :TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
Formule :C6HBr4N3Degré de pureté :98.51% - 99.45%Couleur et forme :Off-White SolidMasse moléculaire :434.71BML-284
CAS :BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.Formule :C19H18N4O3Degré de pureté :99.91% - 99.921%Couleur et forme :SolidMasse moléculaire :350.37Ref: TM-T3144
5mg60,00€10mg88,00€25mg140,00€50mg253,00€100mg427,00€200mg615,00€500mg938,00€1mL*10mM (DMSO)66,00€IWP L6
CAS :IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
Formule :C25H20N4O2S2Degré de pureté :99.51% - >99.99%Couleur et forme :SolidMasse moléculaire :472.58PF-4800567
CAS :PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.Formule :C17H18ClN5O2Degré de pureté :99.74% - 99.76%Couleur et forme :SolidMasse moléculaire :359.81PRI-724
CAS :PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.
Formule :C33H35N6O7PDegré de pureté :98.25% - 99.11%Couleur et forme :SoildMasse moléculaire :658.64EasyStep Human Cys-C(CystatinC) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Cys-C, and the Human Cys-C standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human Cys-C. After TMB substrate solution is added, only those wells that contain Human Cys-C and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human Cys-C in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidVT107
CAS :VT107 is a potent pan-TEAD autopalmitoylation inhibitor. VT-107 can be used in cancer therapy research.Cost-effective and quality-assured.Formule :C25H20F3N3ODegré de pureté :99.72% - 99.92%Couleur et forme :SolidMasse moléculaire :435.44Ref: TM-T35545
1mg130,00€5mg314,00€10mg477,00€25mg768,00€50mg1.045,00€100mg1.406,00€200mg1.882,00€1mL*10mM (DMSO)343,00€RO7185876
CAS :RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Formule :C25H28F3N7Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :483.532CHIR 98024
CAS :CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Formule :C20H17Cl2N9O2Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :486.31Ref: TM-T3074
1mg44,00€2mg55,00€5mg96,00€10mg153,00€25mg298,00€50mg487,00€100mg705,00€1mL*10mM (DMSO)97,00€YAP/TAZ inhibitor-2
CAS :Potent oral TEAD-YAP/TAZ inhibitor-2 with 3 nM EC50; exhibits anti-proliferative and antitumor effects.Formule :C19H14F4N4ODegré de pureté :98.65%Couleur et forme :SoildMasse moléculaire :390.33Ref: TM-T60218
1mg87,00€2mg113,00€5mg177,00€10mg281,00€25mg475,00€50mg687,00€100mg964,00€500mg1.918,00€1mL*10mM (DMSO)197,00€Ginisortamab
CAS :Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, IC50=8.2 nM and 9 nM against human and mouse Gremlin-1, respectively.Degré de pureté :95% - 96.0% (SDS-PAGE); 97.0% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :147.55 kDaTrevogrumab
CAS :Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).Degré de pureté :95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.02 kDaTEAD-IN-6
CAS :TEAD-IN-6 (Example 11-1) is a TEAD modulator that inhibits the YAP1/TAZ-TEAD interaction, and has applications in cancer research [1].Formule :C19H17F3N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.42VT103
CAS :VT103, an oral TEAD1 palmitoylation inhibitor, shows promise against various cancers by disrupting YAP/TAZ-TEAD interactions.Formule :C18H17F3N4O2SDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :410.41Ref: TM-T62077
1mg112,00€5mg268,00€10mg424,00€25mg735,00€50mg1.071,00€100mg1.549,00€200mg2.097,00€1mL*10mM (DMSO)295,00€JAK3/BTK-IN-2
CAS :JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.
Formule :C25H32N8O2Degré de pureté :99.64% - 99.87%Couleur et forme :SolidMasse moléculaire :476.57Aβ42-IN-2
CAS :Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Formule :C24H26N6O2Degré de pureté :98.09% - 99.87%Couleur et forme :SolidMasse moléculaire :430.5Ref: TM-T9641
1mg42,00€5mg94,00€10mg134,00€25mg215,00€50mg304,00€100mg420,00€200mg582,00€1mL*10mM (DMSO)93,00€TEAD-IN-2
CAS :TEAD-IN-2 is a potent and bifunctional TEAD inhibitor to induce TEAD protein degradation via the ubiquitination pathway, with anticancer potential.Formule :C16H18BrF3N2OCouleur et forme :SolidMasse moléculaire :391.23CJJ300
CAS :CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Formule :C30H33N3Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :435.6Ref: TM-T62483
2mg35,00€5mg51,00€10mg90,00€25mg164,00€50mg259,00€100mg393,00€200mg552,00€1mL*10mM (DMSO)57,00€CAY10746
CAS :CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Formule :C26H23N3O5Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :457.48Ref: TM-T36196
2mg35,00€5mg57,00€10mg90,00€25mg182,00€50mg274,00€100mg434,00€200mg582,00€1mL*10mM (DMSO)57,00€BRD0209
CAS :BRD0209 is a highly selective and potent GSK3 inhibitor.
Formule :C22H25N3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :347.45AF-2112
AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.
Formule :C21H18FNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.37Chromenone 1
CAS :Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).Formule :C18H10F3N3O2Degré de pureté :99.83% - 99.93%Couleur et forme :SolidMasse moléculaire :357.29Ref: TM-T61301
1mg52,00€5mg111,00€10mg162,00€25mg235,00€50mg330,00€100mg452,00€200mg607,00€1mL*10mM (DMSO)113,00€JA310
CAS :JA310 is a highly selective inhibitor of the MST3 kinase, demonstrating significant cellular potency with an EC50 value of 106 nM [1].Formule :C17H19N7OCouleur et forme :SolidMasse moléculaire :337.38(Rac)-SIS3 free base
CAS :SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Formule :C28H27N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.53TGFβRI-IN-1
CAS :TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,Formule :C20H14D3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.4Wnt pathway activator 2
CAS :Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.Formule :C17H15NO4Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :297.31Ref: TM-T13345
1mg52,00€5mg100,00€10mg160,00€25mg329,00€50mg533,00€100mg770,00€200mg1.035,00€1mL*10mM (DMSO)111,00€GSK-3β inhibitor 12
CAS :GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFormule :C14H13N3OSDegré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :271.34MSC-4106
CAS :MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.
Formule :C18H12F3N3O2Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :359.3XL413 xHCl
CAS :BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215
Formule :C14H12ClN3O2·xHClDegré de pureté :99.37% - 99.67%Couleur et forme :SolidMasse moléculaire :326.18IHMT-MST1-58
CAS :IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.
Formule :C21H22N6O3SDegré de pureté :98.31% - 99.92%Couleur et forme :SolidMasse moléculaire :438.5BIP-135
CAS :BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.
Formule :C21H13BrN2O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :421.24GSK-3β inhibitor 2
CAS :GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50
Formule :C14H14N4O3SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :318.35ABC1183
CAS :ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.
Formule :C18H14N4OSDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :334.39LEQ506
CAS :LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.Formule :C25H32N6ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :432.56Ref: TM-T11838
1mg64,00€5mg145,00€10mg210,00€25mg338,00€50mg455,00€100mg610,00€200mg823,00€1mL*10mM (DMSO)160,00€CID-5056270
CAS :CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma
Formule :C17H13N3O3SDegré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :339.37GSK-3 Inhibitor XIII
CAS :GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.Formule :C18H15N5Degré de pureté :99.85% - 99.86%Couleur et forme :SolidMasse moléculaire :301.35Ref: TM-T78578
1mg106,00€5mg243,00€10mg437,00€25mg934,00€50mg1.283,00€100mg1.730,00€200mg2.337,00€1mL*10mM (DMSO)251,00€GSK-3β inhibitor 11
CAS :GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.
Formule :C20H15N3O4SDegré de pureté :97.33%Couleur et forme :SolidMasse moléculaire :393.42SJ000063181
CAS :SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.
Formule :C14H14ClFN2O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :296.72FzM1
CAS :FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Formule :C21H16N2O2SDegré de pureté :99.37% - 99.89%Couleur et forme :SolidMasse moléculaire :360.43Ref: TM-T24076
1mg42,00€5mg64,00€10mg99,00€25mg188,00€50mg328,00€100mg528,00€500mg1.130,00€1mL*10mM (DMSO)62,00€TT-10
CAS :TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.
Formule :C11H10FN3OS2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :283.35JAK1-IN-8
CAS :JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Formule :C22H23FN4O3SDegré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :442.51LM-41
CAS :LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.Formule :C19H14FNO2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :307.32SWTX-143
CAS :SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptionalFormule :C19H18F3N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :361.36ABBV-712
CAS :ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases
Formule :C24H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.5ML115
CAS :ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Formule :C15H15ClN2O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :322.74Ref: TM-T35544
1mg95,00€5mg227,00€10mg359,00€25mg630,00€50mg882,00€100mg1.188,00€200mg1.596,00€500mg2.357,00€1mL*10mM (DMSO)251,00€TGFβ-IN-5
CAS :TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.Formule :C20H16N4Degré de pureté :99.29% - 99.62%Couleur et forme :SolidMasse moléculaire :312.37ROCK2-IN-6 hydrochloride
CAS :ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Formule :C26H22ClF2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.95DT-6
CAS :DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing
Formule :C89H130N20O29S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2008.23TM2 TEAD inhibitor
CAS :TM2 TEAD inhibitor, a robust and reversible inhibitor of the TEA domain transcription factor, presents dual inhibitory concentrations (IC50) of 38 nM for TEAD4Formule :C26H33N3O3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :435.57Stafib-2
CAS :Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,
Formule :C28H26N2O12P2Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :644.463,7-DMF
CAS :3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formule :C17H14O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29BRD5648
CAS :BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.Formule :C20H23N3ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :321.42Myristoyl tetrapeptide-12
CAS :Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].Formule :C32H63N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.89TP0427736
CAS :TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.Formule :C14H10N4S2Degré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :298.39YAP-TEAD-IN-2
CAS :YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)Formule :C25H24ClFN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.92ROCK-IN-1
CAS :ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurologicalFormule :C20H18FN3ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :335.37GNE-7883
CAS :GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.Formule :C28H29FN6O2Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :500.57Ref: TM-T78558
1mg116,00€5mg283,00€10mg455,00€25mg747,00€50mg1.026,00€100mg1.444,00€200mg1.882,00€1mL*10mM (DMSO)310,00€YAP/TAZ inhibitor-3
CAS :YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor applicable for relevant research within the life sciences field.Formule :C21H18F3NO3Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :389.37Ref: TM-T87651
1mg90,00€5mg215,00€10mg344,00€25mg695,00€50mg1.108,00€100mg1.791,00€200mg2.412,00€1mL*10mM (DMSO)236,00€Casein kinase 1δ-IN-13
CAS :Casein kinase1δ-IN-13 (compound 401) is an inhibitor of Casein kinase1δ. It is utilized in the research of neurodegenerative diseases.Formule :C15H13N3O2SCouleur et forme :SolidMasse moléculaire :299.35WZ-2-033
CAS :WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.Formule :C25H18F3N3O4SCouleur et forme :SolidMasse moléculaire :513.49Kartogenin sodium
CAS :Kartogenin (KGN) sodium acts as an inducer of chondrogenic tissue formation (EC 50: 100 nM). It promotes chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and modulating the CBFβ-RUNX1 transcriptional program. Additionally, Kartogenin sodium aids tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. It is extensively utilized in cell-free therapies for cartilage regeneration and protection, tendon-bone healing, wound healing, and limb development. The compound is also vital for cartilage repair, coordinating limb development, and osteoarthritis (OA) research [1] [2] [3] [4].Formule :C20H14NNaO3Couleur et forme :SolidMasse moléculaire :339.32
