Récepteur du facteur de croissance des fibroblastes (FGFR)
Les inhibiteurs des récepteurs du facteur de croissance des fibroblastes (FGFR) sont des thérapies ciblées qui bloquent l'activité des FGFR, impliqués dans la prolifération cellulaire, la différenciation et l'angiogenèse. La signalisation FGFR contribue à la formation de nouveaux vaisseaux sanguins dans les tumeurs, favorisant leur croissance et leur survie. Inhiber les FGFR peut donc réduire l'angiogenèse et la progression tumorale. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de FGFR de haute qualité pour soutenir vos recherches en cancérologie, biologie du développement et angiogenèse.
170 produits trouvés pour "Récepteur du facteur de croissance des fibroblastes (FGFR)"
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FGFR1 inhibitor-2
CAS :<p>FGFR1 inhibitor-2, potent at 4.55 μM IC50 in MDA-MB-231, targets triple-negative breast cancer.</p>Formule :C25H22F5N3O3Couleur et forme :SolidMasse moléculaire :507.461Fazpilodemab
CAS :<p>Fazpilodemab (BFKB8488A) is a humanized bispecific antibody that targets and activates the Klotho β and fibroblast growth factor receptor 1c receptor complex.</p>Couleur et forme :LiquidFGFR1 inhibitor 7
<p>FGFR1 Inhibitor 7 (compound 5), a potent FGFR1 tyrosine kinase inhibitor, exhibits an IC50 of 0.33 nM against its target and demonstrates broad-spectrum</p>Formule :C25H16ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.85PKCε (85-92)
CAS :<p>PKCε (85-92) (ψεRACK) is a peptide and selective PKCε activator, induces a pro-angiogenic response, promotes FGF-2 cytosolization, regulates VEGF activity.</p>Formule :C39H54N10O14Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :886.91IMC-D11
<p>IMC-D11 (LY-3076226 antibody) is an IgG1 monoclonal antibody targeting FGFR3. It serves as the antibody component of LY3076226. For its isotype control, refer to Human IgG1 kappa, Isotype Control.</p>Couleur et forme :Odour LiquidEfimosfermin alfa
<p>Efimosfermin alfa is a humanized antibody targeting FGFR1.</p>Couleur et forme :Odour LiquidVofatamab
CAS :<p>Vofatamab (B-701) is a fully human monoclonal antibody targeting FGFR3, often used in combination with other compounds to treat cancer.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :150 kDaRecifercept
CAS :<p>Recifercept (TA-46) is a recombinant human soluble fibroblast growth factor receptor 3, a decoy protein that competes for ligands of mutant FGFR3.</p>Degré de pureté :98.8% (SDS-PAGE); 98.4% (SEC-HPLC) - 98.8% (SDS-PAGE); 98.4% (SEC-HPLC)Couleur et forme :LiquidLC-MB12
CAS :<p>LC-MB12 is a PROTAC FGFR2 compound that degrades FGFR2 and can be used to study gastric cancer.</p>Formule :C43H44Cl2N10O8Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :899.78Gunagratinib
CAS :<p>Gunagratinib (ICP-192) is a pan-FGFR inhibitor, useful in research on FGFR-related diseases.</p>Formule :C22H25N5O4Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :423.47E7090
CAS :<p>E-7090 is a fibroblast growth factor receptor inhibitor. E-7090 is a selective inhibitor of the tyrosine kinase activities of FGFR1, -2, and -3.</p>Formule :C32H37N5O6Couleur et forme :SolidMasse moléculaire :587.67FGFR4-IN-14
<p>FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, showing potent inhibition of cell proliferation in the V550L and N535K mutant</p>Formule :C27H25Cl2N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :522.43BW710
<p>BW710 is an orally active inhibitor specifically targeting fibroblast growth factor receptor 2 (FGFR2). It effectively inhibits the proliferation of BaF3-FGFR2 cells with an IC50 value of 2.8 nM. BW710 completely suppresses FGFR2 enzymatic activity and demonstrates selectivity among 75 tyrosine kinases, including FGFR1, FGFR3, and FGFR4, at a 1 μM concentration. Additionally, BW710 impedes FGFR2 signaling and selectively inhibits the proliferation of cancer cells driven by FGFR2. It exhibits promising pharmacokinetic properties, with an oral bioavailability of 29% in mice.</p>Formule :C28H29FN6O2SCouleur et forme :SolidMasse moléculaire :532.63FGFR-IN-19
<p>Arg-IN-1 is a selective covalent inhibitor targeting Arginine (Arg), with IC50 values of 9.7 nM and 30.4 nM for FGFR2 and FGFR3, respectively. This compound is designed to potentially avoid the off-target toxicity of FGFR1/4 and overcome acquired resistance, offering potential in cancer therapies targeting FGFR.</p>Formule :C36H42N12O6Couleur et forme :SolidMasse moléculaire :738.33503FGFR1 inhibitor-8
<p>FGFR1 inhibitor-8 (Compound 9), an FGFR1 inhibitor with an IC50 of 0.5 nM, binds to the ATP-binding pocket of FGFR1 and exhibits anticancer activity [1].</p>Formule :C26H18ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.88FGFR1/VEGFR2-IN-1
<p>FGFR1/VEGFR2-IN-1 (compound 2b) is an inhibitor of both FGFR1 and VEGFR2, applicable in cancer research [1].</p>Formule :C26H27N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :522.49FGFR2 degrader 1
<p>FGFR2 degrader1 (compound 28E) is a selective PROTACS degrader of FGFR2, with a DC50 of 0.645 nM. FGFR2 plays a significant role in cancer research.</p>Formule :C40H39Cl2N9O6Masse moléculaire :811.24004PROTAC FGFR1 degrader-1
<p>PROTAC FGFR1 degrader-1 (compound S2H) is a targeted degrader of FGFR1, demonstrating an IC50 of 26.81 nM and a DC50 of 39.78 nM in KG1a cells. This compound is composed of a CRBN-type E3 ligase ligand (blue part) Pomalidomide, a target protein ligand (red part) FGFR1ligand-1, and a PROTAC linker (black part) 9-Bromononanoic acid, together forming the conjugate E3LigaseLigand-linker Conjugate 164.</p>Formule :C46H54N8O8Couleur et forme :SolidMasse moléculaire :846.97Nintedanib
CAS :Formule :C31H33N5O4Degré de pureté :>95.0%(T)(HPLC)Couleur et forme :White to Yellow to Yellow green powder to crystalMasse moléculaire :539.64NSC 12
CAS :<p>NSC 12 is an orally active pan-FGF trap that binds FGF2 and interferes with its interaction with FGFR1 with potential FGF-dependent antitumor activity.</p>Formule :C24H34F6O3Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :484.52
