Récepteur du facteur de croissance des fibroblastes (FGFR)
Les inhibiteurs des récepteurs du facteur de croissance des fibroblastes (FGFR) sont des thérapies ciblées qui bloquent l'activité des FGFR, impliqués dans la prolifération cellulaire, la différenciation et l'angiogenèse. La signalisation FGFR contribue à la formation de nouveaux vaisseaux sanguins dans les tumeurs, favorisant leur croissance et leur survie. Inhiber les FGFR peut donc réduire l'angiogenèse et la progression tumorale. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de FGFR de haute qualité pour soutenir vos recherches en cancérologie, biologie du développement et angiogenèse.
177 produits trouvés pour "Récepteur du facteur de croissance des fibroblastes (FGFR)"
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FGFR1 inhibitor-9
FGFR1 inhibitor-9 (Compound 7) is an FGFR1 inhibitor with potent binding affinity, exhibiting an IC50 of 0.85 nM.Formule :C27H20ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.9FGFR-IN-14
FGFR-IN-14 (compound 10h) is a pan-FGFR inhibitor. It effectively inhibits FGFR1, FGFR2, FGFR3, and the FGFR2V564F gatekeeper mutant, with IC50 values of 46, 41, 99, and 62 nM, respectively. Additionally, FGFR-IN-14 demonstrates strong antiproliferative effects on NCI-H520 lung cancer cells and SNU-16 and KATO III gastric cancer cells, with IC50 values of 19, 59, and 73 nM, respectively.Formule :C24H19F2N7O2Masse moléculaire :475.15683ODM-203 sodium
ODM-203 sodium is an orally bioavailable selective and efficient FGFR and VEGFR inhibitor with antitumor activity, used in solid tumor research.Formule :C26H20F2N5NaO2SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :527.52Vosoritide
CAS :Vosoritide (BMN 111), a CNP analogue, targets NPR-B, inhibits FGFR3, aiding achondroplasia, dwarfism study.Formule :C176H290N56O51S3Couleur et forme :SolidMasse moléculaire :4102.73FGFR4-IN-19
FGFR4-IN-19 (compound 8B) is a potent covalent inhibitor of fibroblast growth factor receptor 4 (FGFR4) with an IC50 value of 1.2 nM. It achieves high efficiency and selectivity by covalently targeting the rare cysteine (C552) in the FGFR4 kinase domain. FGFR4-IN-19 is applicable for hepatocellular carcinoma (HCC) research.Formule :C21H14Cl3N5O4Masse moléculaire :505.01114FGFR1 inhibitor-2
CAS :FGFR1 inhibitor-2, potent at 4.55 μM IC50 in MDA-MB-231, targets triple-negative breast cancer.Formule :C25H22F5N3O3Couleur et forme :SolidMasse moléculaire :507.461Bemarituzumab
CAS :Bemarituzumab: humanized IgG1 antibody inhibits FGFR2b, may be used in cancer research.Degré de pureté :SDS-PAGE:95% SEC-HPLC:99.99%Couleur et forme :LiquidMasse moléculaire :144 kDaPNU-145156E (FCE26644)
CAS :PNU-145156E, an angiogenesis blocker with anti-tumor effects in mice, inhibits growth factors in animal studies.Formule :C45H36N10Na4O17S4Degré de pureté :96.15%Couleur et forme :SolidMasse moléculaire :1209.04FGFR4-IN-20
FGFR4-IN-20 (comp 11) is an orally active and selective FGFR4 inhibitor, demonstrating IC50 values of 19 nM against Huh7 cells and 36 nM for FGFR4 kinase. It is utilized in hepatocellular carcinoma research.Formule :C26H22Cl2N4O3Masse moléculaire :508.1069PKCε (85-92)
CAS :PKCε (85-92) (ψεRACK) is a peptide and selective PKCε activator, induces a pro-angiogenic response, promotes FGF-2 cytosolization, regulates VEGF activity.Formule :C39H54N10O14Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :886.91IMC-D11
IMC-D11 (LY-3076226 antibody) is an IgG1 monoclonal antibody targeting FGFR3. It serves as the antibody component of LY3076226. For its isotype control, refer to Human IgG1 kappa, Isotype Control.Couleur et forme :Odour LiquidBR-cpd7
BR-cpd7 is a PROTAC degrader of fibroblast growth factor receptors (FGFR1/2) with a DC50 of 10 nM. It is capable of arresting the cell cycle and inhibiting the proliferation of tumor cells with aberrant activation of FGFR1/2.Formule :C44H47Cl2N11O8Masse moléculaire :927.29861FGFR-IN-19
Arg-IN-1 is a selective covalent inhibitor targeting Arginine (Arg), with IC50 values of 9.7 nM and 30.4 nM for FGFR2 and FGFR3, respectively. This compound is designed to potentially avoid the off-target toxicity of FGFR1/4 and overcome acquired resistance, offering potential in cancer therapies targeting FGFR.Formule :C36H42N12O6Couleur et forme :SolidMasse moléculaire :738.33503BW710
BW710 is an orally active inhibitor specifically targeting fibroblast growth factor receptor 2 (FGFR2). It effectively inhibits the proliferation of BaF3-FGFR2 cells with an IC50 value of 2.8 nM. BW710 completely suppresses FGFR2 enzymatic activity and demonstrates selectivity among 75 tyrosine kinases, including FGFR1, FGFR3, and FGFR4, at a 1 μM concentration. Additionally, BW710 impedes FGFR2 signaling and selectively inhibits the proliferation of cancer cells driven by FGFR2. It exhibits promising pharmacokinetic properties, with an oral bioavailability of 29% in mice.
Formule :C28H29FN6O2SCouleur et forme :SolidMasse moléculaire :532.63Vofatamab
CAS :Vofatamab (B-701) is a fully human monoclonal antibody targeting FGFR3, often used in combination with other compounds to treat cancer.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :150 kDaFGFR1/VEGFR2-IN-1
FGFR1/VEGFR2-IN-1 (compound 2b) is an inhibitor of both FGFR1 and VEGFR2, applicable in cancer research [1].
Formule :C26H27N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :522.49FGFR2 degrader 1
FGFR2 degrader1 (compound 28E) is a selective PROTACS degrader of FGFR2, with a DC50 of 0.645 nM. FGFR2 plays a significant role in cancer research.Formule :C40H39Cl2N9O6Masse moléculaire :811.24004PROTAC FGFR1 degrader-1
PROTAC FGFR1 degrader-1 (compound S2H) is a targeted degrader of FGFR1, demonstrating an IC50 of 26.81 nM and a DC50 of 39.78 nM in KG1a cells. This compound is composed of a CRBN-type E3 ligase ligand (blue part) Pomalidomide, a target protein ligand (red part) FGFR1ligand-1, and a PROTAC linker (black part) 9-Bromononanoic acid, together forming the conjugate E3LigaseLigand-linker Conjugate 164.Formule :C46H54N8O8Couleur et forme :SolidMasse moléculaire :846.97Recifercept
CAS :Recifercept (TA-46) is a recombinant human soluble fibroblast growth factor receptor 3, a decoy protein that competes for ligands of mutant FGFR3.Degré de pureté :98.8% (SDS-PAGE); 98.4% (SEC-HPLC) - 98.8% (SDS-PAGE); 98.4% (SEC-HPLC)Couleur et forme :LiquidE7090
CAS :E-7090 is a fibroblast growth factor receptor inhibitor. E-7090 is a selective inhibitor of the tyrosine kinase activities of FGFR1, -2, and -3.Formule :C32H37N5O6Couleur et forme :SolidMasse moléculaire :587.67
