ALK
Les inhibiteurs d'ALK sont des composés qui ciblent spécifiquement et inhibent la kinase du lymphome anaplasique (ALK), une tyrosine kinase réceptrice impliquée dans le développement et la progression de certains cancers, notamment le cancer du poumon non à petites cellules et le neuroblastome. En inhibant ALK, ces composés bloquent les voies de signalisation qui favorisent la croissance et la survie des cellules tumorales. Chez CymitQuimica, nous proposons des inhibiteurs d'ALK pour soutenir vos recherches en oncologie, thérapies ciblées contre le cancer et transduction du signal.
144 produits trouvés pour "ALK".
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ALK/ROS1-IN-3
ALK/ROS1-IN-3 (compound C01) is a dual inhibitor targeting ROS1 and ALK, with IC50 values of 42.3 nM for ROS1G2032R and 49.1 nM for ALKG1202R.Formule :C32H32N4O2Couleur et forme :SolidMasse moléculaire :504.25253ALK5 Inhibitor II (hydrochloride)
CAS :ALK5 Inhibitor II has IC50s: 4 nM (auto), 18 nM (TGF-β assay), 23 nM (binding, HepG2).Formule :C17H13N5·HClDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.8ALKBH5-IN-5
CAS :ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Formule :C13H13NO3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :231.25Ref: TM-T203011
5mg34,00€10mg46,00€1mL*10mM (DMSO)49,00€25mg84,00€50mg120,00€100mg178,00€200mg268,00€ALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.Formule :C32H28F2N4O3Couleur et forme :SolidMasse moléculaire :554.586Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Degré de pureté :98%Couleur et forme :Odour SolidPROTAC ALK degrader-3
PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.Formule :C50H60ClN9O7SCouleur et forme :SolidMasse moléculaire :966.59dALK-3
dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.Formule :C39H45ClN7O5PCouleur et forme :SolidMasse moléculaire :758.245ALK degrader 2
ALK degrader 2 is an orally active ALK degrader that reduces EML4-ALK protein levels (DC50= 8 nM) and nucleophosmin (NPM)-ALK protein levels (DC50= 102 nM). It facilitates ALK degradation through the Hsp70 chaperone system and the ubiquitin-proteasome pathway. In H3122 cells, ALK degrader 2 causes significant cell cycle arrest at the S phase and induces apoptosis. Additionally, it demonstrates antitumor activity in mice with H3122 xenograft tumors. ALK degrader 2 is a useful compound in researching non-small cell lung cancer (NSCLC).Couleur et forme :Odour Solid2-Keto Crizotinib
CAS :2-Keto Crizotinib is an active lactam metabolite of crizotinib.Formule :C21H20Cl2FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.32TL13-12
CAS :TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).Formule :C45H53ClN10O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :961.49TL13-110
CAS :Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).Formule :C49H62ClN9O9SCouleur et forme :SolidMasse moléculaire :988.59TL13-112
CAS :TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Formule :C49H60ClN9O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1002.57ALK-IN-9
CAS :ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.Formule :C20H21FN6O3Couleur et forme :SolidMasse moléculaire :412.425LAE-102
LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.Couleur et forme :Odour LiquidALK2-IN-6
CAS :ALK2-IN-6 is a potent and selective ALK2 inhibitor with an IC50 of 9 nM. ALK2-IN-6 exhibits excellent brain permeability and effectively suppresses bone morphogenetic protein signaling across various preclinical cancer models for the treatment of diffuse intrinsic pontine glioma.Formule :C26H31N3O3Degré de pureté :99.97%Couleur et forme :Gray SolidMasse moléculaire :433.54ALK-IN-12
CAS :ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.Formule :C24H30ClN6O2PCouleur et forme :SolidMasse moléculaire :500.97LDN 193688
CAS :LDN 193688 is a BMP kinase inhibitor preferential for the ALK2 site, acting by binding to the ALK site,progressive osseous fibrodysplasia.Formule :C22H16N4ODegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :352.39CPD-1224
CAS :CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Formule :C43H47ClN8O7SCouleur et forme :SolidMasse moléculaire :855.4FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Couleur et forme :LiquidRef: TM-L1610
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderEW-7195
CAS :EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.Formule :C23H18N8Degré de pureté :99.98%Couleur et forme :White SolidMasse moléculaire :406.44Ref: TM-T38752
1mg124,00€2mg177,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg507,00€25mg1.009,00€50mg1.648,00€100mg2.602,00€
