ALK
Les inhibiteurs d'ALK sont des composés qui ciblent spécifiquement et inhibent la kinase du lymphome anaplasique (ALK), une tyrosine kinase réceptrice impliquée dans le développement et la progression de certains cancers, notamment le cancer du poumon non à petites cellules et le neuroblastome. En inhibant ALK, ces composés bloquent les voies de signalisation qui favorisent la croissance et la survie des cellules tumorales. Chez CymitQuimica, nous proposons des inhibiteurs d'ALK pour soutenir vos recherches en oncologie, thérapies ciblées contre le cancer et transduction du signal.
147 produits trouvés pour "ALK".
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EW-7195
CAS :EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.Formule :C23H18N8Degré de pureté :99.98%Couleur et forme :White SolidMasse moléculaire :406.44Ref: TM-T38752
1mg124,00€2mg177,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg507,00€25mg1.009,00€50mg1.648,00€100mg2.602,00€LDN-193189 Tetrahydrochloride
CAS :LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Formule :C25H26Cl4N6Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :552.33Alectinib
CAS :Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Formule :C30H34N4O2Degré de pureté :98% - 99.94%Couleur et forme :White SolidMasse moléculaire :482.62Ref: TM-T1936
2mg44,00€5mg65,00€1mL*10mM (DMSO)70,00€10mg82,00€50mg100,00€100mg159,00€200mg245,00€500mg414,00€A 77-01
CAS :A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Formule :C18H14N4Degré de pureté :98.82% - ≥95%Couleur et forme :SolidMasse moléculaire :286.33Ref: TM-T2098
1mg40,00€2mg52,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg118,00€25mg200,00€50mg280,00€100mg394,00€200mg580,00€Brigatinib
CAS :Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.Formule :C29H39ClN7O2PDegré de pureté :97.18% - >99.99%Couleur et forme :White SolidMasse moléculaire :584.09Ref: TM-T3621
2mg34,00€5mg48,00€1mL*10mM (DMSO)62,00€10mg63,00€25mg92,00€50mg108,00€100mg158,00€200mg227,00€500mg385,00€Crizotinib hydrochloride
CAS :Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formule :C21H23Cl3FN5ODegré de pureté :98.73% - 98.87%Couleur et forme :SolidMasse moléculaire :486.8Ref: TM-T8399
5mg34,00€1mL*10mM (DMSO)35,00€10mg50,00€25mg78,00€50mg94,00€100mg131,00€200mg162,00€500mg215,00€CEP-37440
CAS :CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Formule :C30H38ClN7O3Degré de pureté :98.86% - 99.98%Couleur et forme :White SolidMasse moléculaire :580.12LDN193189
CAS :LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Formule :C25H22N6Degré de pureté :98% - 99.86%Couleur et forme :SolidMasse moléculaire :406.48CH5424802 analog
CAS :CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Formule :C28H30N4O2Degré de pureté :98.96%Couleur et forme :White SolidMasse moléculaire :454.56Ref: TM-T9224
1mg124,00€5mg271,00€1mL*10mM (DMSO)324,00€10mg408,00€25mg672,00€50mg945,00€100mg1.279,00€RepSox
CAS :RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Formule :C17H13N5Degré de pureté :99.10% - 99.92%Couleur et forme :Gray SolidMasse moléculaire :287.32Ref: TM-T6337
1mg34,00€2mg46,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg80,00€25mg116,00€50mg169,00€100mg241,00€500mg597,00€5-phenylthieno[2,3-d]pyrimidin-4-amine
CAS :5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Formule :C12H9N3SDegré de pureté :97%Couleur et forme :Yellow SolidMasse moléculaire :227.29Ref: TM-T50042
2mg43,00€5mg60,00€1mL*10mM (DMSO)60,00€10mg90,00€25mg138,00€50mg200,00€100mg301,00€200mg432,00€AZD-3463
CAS :AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formule :C24H25ClN6ODegré de pureté :99.13% - 99.97%Couleur et forme :Cyan SolidMasse moléculaire :448.95GSK1838705A
CAS :GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formule :C27H29FN8O3Degré de pureté :98.89% - >99.99%Couleur et forme :Yellow SolidMasse moléculaire :532.57BIBF0775
CAS :BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).Formule :C31H34N4O2Degré de pureté :99.45% - 99.79%Couleur et forme :SolidMasse moléculaire :494.63Ref: TM-T5197
1mg40,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg128,00€25mg205,00€50mg288,00€100mg414,00€200mg578,00€Lorlatinib
CAS :Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogeneFormule :C21H19FN6O2Degré de pureté :99.77% - 99.95%Couleur et forme :SolidMasse moléculaire :406.41Ref: TM-T3061
1mg34,00€2mg42,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg89,00€25mg137,00€50mg212,00€100mg374,00€DMH-1
CAS :DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.Formule :C24H20N4ODegré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :380.44ML347
CAS :ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Formule :C22H16N4ODegré de pureté :99.30% - ≥95%Couleur et forme :SolidMasse moléculaire :352.39Crizotinib acetate
CAS :Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Formule :C23H26Cl2FN5O3Couleur et forme :SolidMasse moléculaire :510.39ALK5-IN-10
CAS :Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Formule :C22H18BrN7Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :460.33Ref: TM-T9837
10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander200mgÀ demander1mg93,00€5mg182,00€1mL*10mM (DMSO)215,00€GW788388
CAS :GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.Formule :C25H23N5O2Degré de pureté :98.03% - 99.58%Couleur et forme :SolidMasse moléculaire :425.48
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