ALK
Les inhibiteurs d'ALK sont des composés qui ciblent spécifiquement et inhibent la kinase du lymphome anaplasique (ALK), une tyrosine kinase réceptrice impliquée dans le développement et la progression de certains cancers, notamment le cancer du poumon non à petites cellules et le neuroblastome. En inhibant ALK, ces composés bloquent les voies de signalisation qui favorisent la croissance et la survie des cellules tumorales. Chez CymitQuimica, nous proposons des inhibiteurs d'ALK pour soutenir vos recherches en oncologie, thérapies ciblées contre le cancer et transduction du signal.
157 produits trouvés pour "ALK".
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dALK-3
dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.Formule :C39H45ClN7O5PCouleur et forme :SolidMasse moléculaire :758.245ALK2-IN-2
CAS :ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.Formule :C28H27N5O2SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :497.611ALK2-IN-5
CAS :ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].Formule :C24H32N8O2Couleur et forme :SolidMasse moléculaire :464.56TGFBR1-IN-1
CAS :TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).Formule :C23H17N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.48EML4-ALK kinase inhibitor 1
CAS :Potent oral EML4-ALK inhibitor with a 1 nM IC50.Formule :C31H48N8O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :580.7646ALK5-IN-26
CAS :ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM).Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51OD36
CAS :OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.Formule :C16H15ClN4O2Degré de pureté :99.45%Couleur et forme :White SolidMasse moléculaire :330.769ALK-IN-5
CAS :ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).Formule :C24H25FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.49OD36 hydrochloride
CAS :OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficientlyFormule :C16H16Cl2N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :367.23J-1048
CAS :J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/Formule :C23H17FN6S2Couleur et forme :SolidMasse moléculaire :460.55ALK-IN-22
CAS :ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.Formule :C24H24ClN7O2Couleur et forme :SolidMasse moléculaire :477.95RIPK2-IN-1
CAS :RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).Formule :C23H27N5O3SCouleur et forme :SolidMasse moléculaire :453.56ALK-IN-21
CAS :ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.Formule :C35H45ClN6O6S4Couleur et forme :SolidMasse moléculaire :809.48Con B-1
CAS :ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .Formule :C38H52ClN7O6SCouleur et forme :SolidMasse moléculaire :770.38SMU-B
CAS :SMU-B is a well-tolerated c-Met/ALK dual inhibitor.Formule :C26H25Cl2FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.41Ficonalkib
CAS :Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.Formule :C29H39N7O3SCouleur et forme :SolidMasse moléculaire :565.73LAE-102
LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.Couleur et forme :Odour LiquidCJ-2360
CAS :CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.Formule :C27H30FN5O2Couleur et forme :SolidMasse moléculaire :475.56TRK/ALK-IN-1
TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.Formule :C31H35ClF2N8O2SCouleur et forme :SolidMasse moléculaire :657.18DLX-521
DLX-521 is an antibody that inhibits ALK. It is applicable in the diagnosis and research of lung cancer.
