ALK
Les inhibiteurs d'ALK sont des composés qui ciblent spécifiquement et inhibent la kinase du lymphome anaplasique (ALK), une tyrosine kinase réceptrice impliquée dans le développement et la progression de certains cancers, notamment le cancer du poumon non à petites cellules et le neuroblastome. En inhibant ALK, ces composés bloquent les voies de signalisation qui favorisent la croissance et la survie des cellules tumorales. Chez CymitQuimica, nous proposons des inhibiteurs d'ALK pour soutenir vos recherches en oncologie, thérapies ciblées contre le cancer et transduction du signal.
112 produits trouvés pour "ALK"
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CJ-2360
CAS :<p>CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.</p>Formule :C27H30FN5O2Couleur et forme :SolidMasse moléculaire :475.56ALK-IN-22
CAS :<p>ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.</p>Formule :C24H24ClN7O2Couleur et forme :SolidMasse moléculaire :477.95RIPK2-IN-1
CAS :<p>RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).</p>Formule :C23H27N5O3SCouleur et forme :SolidMasse moléculaire :453.56ALK-IN-21
CAS :<p>ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.</p>Formule :C35H45ClN6O6S4Couleur et forme :SolidMasse moléculaire :809.48Con B-1
CAS :<p>ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .</p>Formule :C38H52ClN7O6SCouleur et forme :SolidMasse moléculaire :770.38SMU-B
CAS :<p>SMU-B is a well-tolerated c-Met/ALK dual inhibitor.</p>Formule :C26H25Cl2FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.41Ficonalkib
CAS :<p>Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.</p>Formule :C29H39N7O3SCouleur et forme :SolidMasse moléculaire :565.73ALK5-IN-30
CAS :<p>ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).</p>Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51XST-14
CAS :<p>XST-14 is a ULK1 inhibitor.XST-14 induces apoptosis and inhibits the growth of HCC cells.</p>Formule :C16H21NO4Degré de pureté :99.84% - 99.84%Couleur et forme :SolidMasse moléculaire :291.34TRK/ALK-IN-1
<p>TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.</p>Formule :C31H35ClF2N8O2SCouleur et forme :SolidMasse moléculaire :657.18ALK5-IN-29
CAS :<p>ALK5-IN-29: selective ALK inhibitor, IC50 ≤ 10 nM, curbs tumor growth, aids in cancer research.</p>Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51TP0427736 hydrochloride
CAS :<p>TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.</p>Formule :C14H11ClN4S2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :334.85UNC5293
CAS :<p>UNC5293: potent oral MERTK inhibitor, Ki=190 pM, IC50=0.9 nM; selective vs Axl/Tyro3/Flt3; good mouse PK; used in leukemia research.</p>Formule :C30H42N6O2Couleur et forme :SolidMasse moléculaire :518.69ALK-IN-6
CAS :<p>ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).</p>Formule :C26H29ClD3N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :533.1ALK/EGFR-IN-3
CAS :<p>ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-</p>Formule :C27H34ClN7O3SCouleur et forme :SolidMasse moléculaire :572.12ALK/ROS1-IN-1
CAS :<p>ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).</p>Formule :C30H35F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.63ALK/EGFR-IN-1
CAS :<p>ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.</p>Formule :C27H34ClN7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.12ALK/EGFR-IN-2
CAS :<p>ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.</p>Formule :C27H34ClN7O3SCouleur et forme :SolidMasse moléculaire :572.12ALK-IN-27
CAS :<p>Neladalkib (NVL-655) is an ALK inhibitor with antitumor activity for the study of non-small cell cancers.</p>Formule :C23H22ClFN6ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :452.91KER047
CAS :<p>ALK2-IN-4, a highly effective ALK2 inhibitor.</p>Formule :C26H30FN7ODegré de pureté :98.49% - >99.99%Couleur et forme :SolidMasse moléculaire :475.56
