Récepteur Trk
Les inhibiteurs des récepteurs Trk ciblent les kinases des récepteurs de la tropomyosine (Trk), une famille de récepteurs à activité tyrosine kinase qui jouent un rôle important dans le développement et la fonction du système nerveux. Les récepteurs Trk sont impliqués dans la signalisation des neurotrophines, essentielle à la survie, à la différenciation et à la croissance des neurones. La dérégulation de la signalisation Trk est associée à des troubles neurologiques et à certains cancers. Chez CymitQuimica, nous proposons des inhibiteurs de récepteurs Trk pour soutenir vos recherches en neurobiologie, oncologie et maladies neurodégénératives.
70 produits trouvés pour "Récepteur Trk".
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N-Acetyl-5-hydroxytryptamine
CAS :N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.Formule :C12H14N2O2Degré de pureté :98.31% - 99.91%Couleur et forme :Yellow SolidMasse moléculaire :218.2518CE-245677
CAS :CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.Formule :C24H22Cl2N6O3Degré de pureté :98.99% - 99.23%Couleur et forme :SolidMasse moléculaire :513.376Amitriptyline hydrochloride
CAS :Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormule :C20H24ClNDegré de pureté :99.39% - 99.94%Couleur et forme :SolidMasse moléculaire :313.864TrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Formule :C16H13N3O5Couleur et forme :SolidMasse moléculaire :327.08552Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Formule :C29H35F2N7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.69Luvagrobart
CAS :Luvagrobart is a human monoclonal antibody targeting NGF that inhibits NGF binding to its receptor and is used in pain therapy research.Degré de pureté :95%Masse moléculaire :~150 kDaGNF-8625 monopyridin-N-piperazine hydrochloride
CAS :GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Formule :C25H27ClFN7Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :479.98TRK-IN-31 hydrochloride
TRK-IN-31 hydrochloride is an orally active TRK inhibitor with an IC50 of 1.8 nM. It demonstrates excellent antiproliferative activity in Ba/F3-MPRIP-TRKAG667C cells and selectively inhibits TRK kinase activity. Additionally, TRK-IN-31 hydrochloride significantly suppresses tumor growth in a Ba/F3-MPRIP-TRKAG667C subcutaneous mouse model.Anti-Human NGF Antibody (5D767)
Anti-NGF Antibody (5D767) is a Rabbit IgG monoclonal antibody targeting Human NGF.Couleur et forme :Odour LiquidAnti-Human NGF Antibody (8W871)
Anti-NGF Antibody (8W871) is a Rabbit IgG monoclonal antibody targeting Human NGF.PF-06737007
CAS :PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Formule :C25H28F4N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.49Anti-Human NGF/bNGF Antibody
Anti-NGF/bNGF Antibody is a neutralizing mAb targeting β-NGF used to study chronic pain and inflammatory mechanisms by blocking NGF signaling.GBR-900
GBR-900 is an anti-TrkA mAb that inhibits pain signaling by blocking NGF binding, used for chronic pain with a better safety profile than anti-NGF antibodies.Degré de pureté :95%Masse moléculaire :145.90 kDa (Predicted)Anti-Human TrkB/NTRK2 Antibody
Anti-TrkB/NTRK2 Antibody is a potent monoclonal antibody targeting the TrkB/NTRK2 receptor. Anti-TrkB/NTRK2 Antibody demonstrates significant receptor engagement activity in vitro and facilitates the measurable protection of neuronal integrity while improving cognitive performance in various preclinical models of neurodegeneration.Couleur et forme :Odour LiquidAnti-Human MUSK Antibody
Anti-MUSK Antibody serves as a functional therapeutic tool specifically designed to enable the precise detection and neutralization of the muscle-specific kinase which plays a pivotal role in the maintenance of the neuromuscular junction structural integrity during strictly monitored laboratory observation periods and molecular investigations to evaluate the pathological consequences of receptor tyrosine kinase inhibition in advanced neuroscience and immunology research models to facilitate the study of neuromuscular disorders.Degré de pureté :95%Masse moléculaire :143.84 kDa (Predicted)CH7057288
CAS :CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Formule :C32H31N3O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :569.671Entrectinib
CAS :Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formule :C31H34F2N6O2Degré de pureté :98.03% - 99.67%Couleur et forme :SolidMasse moléculaire :560.64LOXO-195
CAS :(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.Formule :C20H21FN6ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :380.4187Cyclotraxin B acetate
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM).Formule :C50H77N13O19S3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :1260.42Altiratinib
CAS :Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formule :C26H21F3N4O4Degré de pureté :99.67% - 99.75%Couleur et forme :SolidMasse moléculaire :510.4645
