Récepteur Trk
Les inhibiteurs des récepteurs Trk ciblent les kinases des récepteurs de la tropomyosine (Trk), une famille de récepteurs à activité tyrosine kinase qui jouent un rôle important dans le développement et la fonction du système nerveux. Les récepteurs Trk sont impliqués dans la signalisation des neurotrophines, essentielle à la survie, à la différenciation et à la croissance des neurones. La dérégulation de la signalisation Trk est associée à des troubles neurologiques et à certains cancers. Chez CymitQuimica, nous proposons des inhibiteurs de récepteurs Trk pour soutenir vos recherches en neurobiologie, oncologie et maladies neurodégénératives.
57 produits trouvés pour "Récepteur Trk".
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CE-245677
CAS :CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.Formule :C24H22Cl2N6O3Degré de pureté :98.99% - 99.23%Couleur et forme :SolidMasse moléculaire :513.38Ref: TM-T14921
1mg58,00€2mg82,00€5mg113,00€1mL*10mM (DMSO)129,00€10mg177,00€25mg296,00€50mg409,00€100mg605,00€Amitriptyline hydrochloride
CAS :Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormule :C20H24ClNDegré de pureté :99.39% - 99.94%Couleur et forme :SolidMasse moléculaire :313.86N-Acetyl-5-hydroxytryptamine
CAS :N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.Formule :C12H14N2O2Degré de pureté :98.31% - 99.91%Couleur et forme :Yellow SolidMasse moléculaire :218.25CRB-0089
CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.Couleur et forme :Odour LiquidGNF-8625 monopyridin-N-piperazine hydrochloride
CAS :GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Formule :C25H27ClFN7Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :479.98Anti-NGF/bNGF Antibody (AS2886401-00)
Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.Couleur et forme :Odour LiquidProtein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Formule :C29H35F2N7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.69TRK-IN-31 hydrochloride
TRK-IN-31 hydrochloride is an orally active TRK inhibitor with an IC50 of 1.8 nM. It demonstrates excellent antiproliferative activity in Ba/F3-MPRIP-TRKAG667C cells and selectively inhibits TRK kinase activity. Additionally, TRK-IN-31 hydrochloride significantly suppresses tumor growth in a Ba/F3-MPRIP-TRKAG667C subcutaneous mouse model.Anti-TrkB/NTRK2 Antibody
Anti-TrkB/NTRK2 Antibody is a potent monoclonal antibody targeting the TrkB/NTRK2 receptor. Anti-TrkB/NTRK2 Antibody demonstrates significant receptor engagement activity in vitro and facilitates the measurable protection of neuronal integrity while improving cognitive performance in various preclinical models of neurodegeneration.Couleur et forme :Odour LiquidTrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Formule :C16H13N3O5Couleur et forme :SolidMasse moléculaire :327.08552Anti-NGF Antibody (5D767)
Anti-NGF Antibody (5D767) is a Rabbit IgG monoclonal antibody targeting Human NGF.Couleur et forme :Odour LiquidPF-06737007
CAS :PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Formule :C25H28F4N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.49Altiratinib
CAS :Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formule :C26H21F3N4O4Degré de pureté :99.67% - 99.75%Couleur et forme :SolidMasse moléculaire :510.46Selitrectinib
CAS :Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Formule :C20H21FN6ODegré de pureté :99.57% - ≥95%Couleur et forme :SolidMasse moléculaire :380.42DS-1205
CAS :DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formule :C41H42FN5O7Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :735.8LM22A-4
CAS :LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).Formule :C15H21N3O6Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :339.34CH7057288
CAS :CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Formule :C32H31N3O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :569.67Larotrectinib
CAS :Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Formule :C21H22F2N6O2Degré de pureté :99.15% - >99.99%Couleur et forme :SolidMasse moléculaire :428.44Ref: TM-T5995
1mg37,00€5mg74,00€1mL*10mM (DMSO)81,00€10mg90,00€25mg157,00€50mg236,00€100mg356,00€500mg820,00€Entrectinib
CAS :Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formule :C31H34F2N6O2Degré de pureté :98.03% - 99.61%Couleur et forme :SolidMasse moléculaire :560.64Ref: TM-T3678
2mg39,00€5mg56,00€1mL*10mM (DMSO)65,00€10mg84,00€25mg105,00€50mg159,00€100mg268,00€500mg655,00€Belizatinib
CAS :Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Formule :C33H44FN5O3Degré de pureté :99.33% - 99.44%Couleur et forme :SolidMasse moléculaire :577.73Ref: TM-T4257
1mg40,00€2mg54,00€5mg93,00€1mL*10mM (DMSO)105,00€10mg133,00€25mg259,00€50mg358,00€100mg500,00€
