Récepteur Trk
Les inhibiteurs des récepteurs Trk ciblent les kinases des récepteurs de la tropomyosine (Trk), une famille de récepteurs à activité tyrosine kinase qui jouent un rôle important dans le développement et la fonction du système nerveux. Les récepteurs Trk sont impliqués dans la signalisation des neurotrophines, essentielle à la survie, à la différenciation et à la croissance des neurones. La dérégulation de la signalisation Trk est associée à des troubles neurologiques et à certains cancers. Chez CymitQuimica, nous proposons des inhibiteurs de récepteurs Trk pour soutenir vos recherches en neurobiologie, oncologie et maladies neurodégénératives.
56 produits trouvés pour "Récepteur Trk"
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CE-245677
CAS :CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.Formule :C24H22Cl2N6O3Degré de pureté :98.99% - 99.23%Couleur et forme :SolidMasse moléculaire :513.38Ref: TM-T14921
1mg58,00€2mg82,00€5mg113,00€10mg177,00€25mg296,00€50mg409,00€100mg605,00€1mL*10mM (DMSO)129,00€Amitriptyline hydrochloride
CAS :Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormule :C20H24ClNDegré de pureté :97% - 99.94%Couleur et forme :Crystals White To Off-White PowderMasse moléculaire :313.86N-Acetyl-5-hydroxytryptamine
CAS :N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.
Formule :C12H14N2O2Degré de pureté :98.31% - 99.91%Couleur et forme :SolidMasse moléculaire :218.25Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Formule :C29H35F2N7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.69GNF-8625 monopyridin-N-piperazine hydrochloride
CAS :GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Formule :C25H27ClFN7Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :479.98Anti-TrkB/NTRK2 Antibody
Anti-TrkB/NTRK2 Antibody is a human-derived antibody produced in CHO cells, targeting TrkB. For the isotype control of Anti-TrkB/NTRK2 Antibody, refer to HumanIgG2kappa, Isotype Control.Couleur et forme :Odour LiquidAdimanebart
CAS :Amdokitug is a human-derived IgG1λ monoclonal antibody that acts as an inhibitor of MUSK.Couleur et forme :LiquidAnti-NGF/bNGF Antibody (AS2886401-00)
Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.Couleur et forme :Odour LiquidTrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Formule :C16H13N3O5Masse moléculaire :327.08552CRB-0089
CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.Couleur et forme :Odour LiquidPF-06737007
CAS :PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Formule :C25H28F4N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.49Entrectinib
CAS :Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formule :C31H34F2N6O2Degré de pureté :98.03% - 99.61%Couleur et forme :SolidMasse moléculaire :560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€Selitrectinib
CAS :Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Formule :C20H21FN6ODegré de pureté :99.55% - ≥95%Couleur et forme :SolidMasse moléculaire :380.42LM22A-4
CAS :LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).
Formule :C15H21N3O6Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :339.34Altiratinib
CAS :Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formule :C26H21F3N4O4Degré de pureté :99.67% - 99.75%Couleur et forme :SolidMasse moléculaire :510.46Larotrectinib
CAS :Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Formule :C21H22F2N6O2Degré de pureté :99.15% - >99.99%Couleur et forme :SolidMasse moléculaire :428.44Ref: TM-T5995
1mg37,00€5mg74,00€10mg90,00€25mg157,00€50mg236,00€100mg356,00€500mg820,00€1mL*10mM (DMSO)81,00€CH7057288
CAS :CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Formule :C32H31N3O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :569.67Belizatinib
CAS :Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Formule :C33H44FN5O3Degré de pureté :99.33% - 99.44%Couleur et forme :SolidMasse moléculaire :577.73Ref: TM-T4257
1mg40,00€2mg54,00€5mg93,00€10mg133,00€25mg259,00€50mg358,00€100mg500,00€1mL*10mM (DMSO)105,00€LOXO-195
CAS :(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.Formule :C20H21FN6ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :380.42GNF-5837
CAS :GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Formule :C28H21F4N5O2Degré de pureté :97.26% - 98.08%Couleur et forme :SolidMasse moléculaire :535.49Ref: TM-T6097
5mg48,00€10mg80,00€25mg117,00€50mg178,00€100mg295,00€200mg384,00€500mg622,00€1mL*10mM (DMSO)52,00€Cyclotraxin B acetate(1203586-72-4 free base)
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM).Formule :C50H77N13O19S3Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :1260.42DS-1205
CAS :DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formule :C41H42FN5O7Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :735.8GW 441756
CAS :GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.Formule :C17H13N3ODegré de pureté :97.73% - 99.8%Couleur et forme :SolidMasse moléculaire :275.3Tyrphostin AG 879
CAS :Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Formule :C18H24N2OSDegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :316.46ONO-7475
CAS :ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinaseFormule :C32H26N4O6Degré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :562.57ANA-12
CAS :ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
Formule :C22H21N3O3SDegré de pureté :99.28% - 99.87%Couleur et forme :SolidMasse moléculaire :407.497,8-Dihydroxyflavone
CAS :7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.Formule :C15H10O4Degré de pureté :98.48% - 99.81%Couleur et forme :SolidMasse moléculaire :254.24Repotrectinib
CAS :Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
Formule :C18H18FN5O2Degré de pureté :99.92% - >99.99%Couleur et forme :SolidMasse moléculaire :355.37Larotrectinib sulfate
CAS :Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).Formule :C21H22F2N6O2·H2O4SDegré de pureté :98.62% - 99.76%Couleur et forme :SolidMasse moléculaire :526.51Ref: TM-T6880
2mg37,00€5mg54,00€10mg88,00€25mg124,00€50mg155,00€100mg259,00€500mg623,00€1mL*10mM (DMSO)63,00€LM22B-10
CAS :LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Formule :C27H33ClN2O4Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :485.01Sitravatinib
CAS :Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, andFormule :C33H29F2N5O4SDegré de pureté :98.9% - 99.85%Couleur et forme :SolidMasse moléculaire :629.68Ref: TM-T4349
5mg49,00€10mg74,00€25mg130,00€50mg200,00€100mg319,00€200mg507,00€500mg800,00€1mL*10mM (DMSO)69,00€Frunevetmab
CAS :Frunevetmab (NV-02) is a feline-adapted monoclonal antibody targeting NGF (nerve growth factor), with a Kd value of 20 pM. Feline osteoarthritis (OA).Degré de pureté :95% - 95.3% (SDS-PAGE); 98.7% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :147.99 kDaTanezumab
CAS :Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF，pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :145.43 kDaFulranumab
CAS :Fulranumab (AMG-403) is a humanised monoclonal antibody targeting NGF, analgesic effects, and can be used for the study of chronic pain.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :145.37 kDaFasinumab
CAS :Fasinumab (anti-NGF mAb) is in Phase III trials for acute sciatica & knee OA. It significantly improves pain & function vs. placebo.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :144.89 kDaTrkA-IN-1
CAS :TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.Formule :C25H20N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.45Protein kinase inhibitor 5
CAS :Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].Formule :C29H31F2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.6Tavilermide
CAS :Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.Formule :C24H32N6O11Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :580.54ENT-C225
CAS :ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.Formule :C26H40N4O5Degré de pureté :99.36% - 99.36%Couleur et forme :SolidMasse moléculaire :488.62PF-06733804
CAS :PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.Formule :C20H19F5N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.38Paltimatrectinib
CAS :Paltimatrectinib (PBI-200) is a tyrosine kinase inhibitor with anticancer activity, and is used in the study of bladder, breast, and colorectal cancers.Formule :C20H15F5N6Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :434.37TRK-IN-24
CAS :TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L,Formule :C39H45N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :659.82Type II TRK inhibitor 1
CAS :Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type.Formule :C35H33F3N8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :670.68AZ-23
CAS :AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.Formule :C17H19ClFN7ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :391.83TrkA-IN-9
CAS :TrkA-IN-9 (VMD-928) is an orally active and selective inhibitor of tropomyosin receptor kinase A (TrkA). It disrupts downstream signaling pathways activated by nerve growth factor (NGF) binding to TrkA, thereby inhibiting cell proliferation and invasion, and promoting cancer cell death. TrkA-IN-9 shows potential for research in various cancers, including prostate cancer, thymic carcinoma, mesothelioma, head and neck squamous cell carcinoma, lung cancer, ovarian cancer, and hepatocellular carcinoma.Formule :C31H32N4O4Couleur et forme :SolidMasse moléculaire :524.61TrkC-IN-1
CAS :TrkC-IN-1 (Compound 6c) is an inhibitor of TrkC, with IC50 values of 3.3-7.1 and 7.3-10.2 μΜ for EBC-1 and HT-29 cells, respectively. This compound shows potential for research in the field of cancer therapeutics.Formule :C28H20BrN5O2Couleur et forme :SolidMasse moléculaire :538.395BNN-20
CAS :BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.Formule :C20H30O2Couleur et forme :SolidMasse moléculaire :302.45TRK-IN-28
CAS :TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1].Formule :C27H25F2N7Couleur et forme :SolidMasse moléculaire :485.53TRK-IN-26
CAS :TRK-IN-26 (compound 12), a TRK inhibitor, holds potential for use in cancer research [1].Formule :C30H22F2N6O4Couleur et forme :SolidMasse moléculaire :568.53TrkA-IN-7
CAS :TrkA-IN-7 (Compound 4) is an inhibitor of tropomyosin receptor kinase A (TrkA), with a Kd value of 40 μM.Formule :C16H13N3O3Couleur et forme :SolidMasse moléculaire :295.293PF-06273340
CAS :PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。Formule :C23H22ClN7O3Degré de pureté :98% - 98.00%Couleur et forme :SolidMasse moléculaire :479.92TrkA-IN-8
CAS :TrkA-IN-8 (Compound 2) is a TrkA inhibitor with a Kd value of 3.3 µM. RTKs-IN-1 demonstrates a concentration-dependent inhibitory effect on the proliferation of lung cancer cell lines and holds potential for research in non-small cell lung cancer.Formule :C20H16N4Couleur et forme :SolidMasse moléculaire :312.368NMS-P626
CAS :NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.Formule :C28H35F2N7O4SCouleur et forme :SolidMasse moléculaire :603.68ONO-7579
CAS :ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.Formule :C24H18ClF3N6O4SCouleur et forme :SolidMasse moléculaire :578.95Trk-IN-4
CAS :Trk-IN-4 (PF-6683324) is a potent pan-Trk inhibitor and antinociceptive. It is also a selective type II PTK6 inhibitor antitumor.Formule :C24H23F4N5O4Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :521.46TrkB-IN-1
CAS :TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties.
Formule :C19H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :368.34
