Récepteur Trk
Les inhibiteurs des récepteurs Trk ciblent les kinases des récepteurs de la tropomyosine (Trk), une famille de récepteurs à activité tyrosine kinase qui jouent un rôle important dans le développement et la fonction du système nerveux. Les récepteurs Trk sont impliqués dans la signalisation des neurotrophines, essentielle à la survie, à la différenciation et à la croissance des neurones. La dérégulation de la signalisation Trk est associée à des troubles neurologiques et à certains cancers. Chez CymitQuimica, nous proposons des inhibiteurs de récepteurs Trk pour soutenir vos recherches en neurobiologie, oncologie et maladies neurodégénératives.
59 produits trouvés pour "Récepteur Trk"
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Amitriptyline hydrochloride
CAS :<p>Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive</p>Formule :C20H24ClNDegré de pureté :97% - 99.94%Couleur et forme :Crystals White To Off-White PowderMasse moléculaire :313.86CE-245677
CAS :<p>CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.</p>Formule :C24H22Cl2N6O3Degré de pureté :98.99% - 99.23%Couleur et forme :SolidMasse moléculaire :513.38N-Acetyl-5-hydroxytryptamine
CAS :<p>N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.</p>Formule :C12H14N2O2Degré de pureté :98.31% - 99.91%Couleur et forme :SolidMasse moléculaire :218.25CRB-0089
<p>CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.</p>Couleur et forme :Odour LiquidAnti-TrkB/NTRK2 Antibody
<p>Anti-TrkB/NTRK2 Antibody is a human-derived antibody produced in CHO cells, targeting TrkB. For the isotype control of Anti-TrkB/NTRK2 Antibody, refer to HumanIgG2kappa, Isotype Control.</p>Couleur et forme :Odour LiquidAdimanebart
CAS :<p>Amdokitug is a human-derived IgG1λ monoclonal antibody that acts as an inhibitor of MUSK.</p>Couleur et forme :LiquidTrkA-IN-6
<p>TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.</p>Formule :C16H13N3O5Masse moléculaire :327.08552GNF-8625 monopyridin-N-piperazine hydrochloride
CAS :<p>GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.</p>Formule :C25H27ClFN7Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :479.98Protein kinase inhibitor 5 sulfate hydrate
<p>Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].</p>Formule :C29H35F2N7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.69PF-06737007
CAS :<p>PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).</p>Formule :C25H28F4N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.49Selitrectinib
CAS :<p>Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.</p>Formule :C20H21FN6ODegré de pureté :99.55% - ≥95%Couleur et forme :SolidMasse moléculaire :380.42ONO-7475
CAS :<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>Formule :C32H26N4O6Degré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :562.57Entrectinib
CAS :<p>Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.</p>Formule :C31H34F2N6O2Degré de pureté :98.03% - 99.61%Couleur et forme :SolidMasse moléculaire :560.64Milciclib
CAS :<p>Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.</p>Formule :C25H32N8ODegré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :460.57LM22A-4
CAS :<p>LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).</p>Formule :C15H21N3O6Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :339.34Altiratinib
CAS :<p>Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,</p>Formule :C26H21F3N4O4Degré de pureté :99.67% - 99.75%Couleur et forme :SolidMasse moléculaire :510.46Ensartinib hydrochloride
CAS :<p>Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known</p>Formule :C26H29Cl4FN6O3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :634.36Belizatinib
CAS :<p>Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.</p>Formule :C33H44FN5O3Degré de pureté :99.33% - 99.44%Couleur et forme :SolidMasse moléculaire :577.73ANA-12
CAS :<p>ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.</p>Formule :C22H21N3O3SDegré de pureté :99.28% - 99.87%Couleur et forme :SolidMasse moléculaire :407.49LOXO-195
CAS :<p>(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.</p>Formule :C20H21FN6ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :380.42GNF-5837
CAS :<p>GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).</p>Formule :C28H21F4N5O2Degré de pureté :97.26% - 98.08%Couleur et forme :SolidMasse moléculaire :535.49DS-1205
CAS :<p>DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.</p>Formule :C41H42FN5O7Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :735.8GW 441756
CAS :<p>GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.</p>Formule :C17H13N3ODegré de pureté :97.73% - 99.8%Couleur et forme :SolidMasse moléculaire :275.3Tyrphostin AG 879
CAS :<p>Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.</p>Formule :C18H24N2OSDegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :316.46Sitravatinib
CAS :<p>Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and</p>Formule :C33H29F2N5O4SDegré de pureté :98.9% - 99.85%Couleur et forme :SolidMasse moléculaire :629.68LM22B-10
CAS :<p>LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.</p>Formule :C27H33ClN2O4Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :485.01Larotrectinib
CAS :<p>Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).</p>Formule :C21H22F2N6O2Degré de pureté :99.15% - >99.99%Couleur et forme :SolidMasse moléculaire :428.44CH7057288
CAS :<p>CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.</p>Formule :C32H31N3O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :569.67Larotrectinib sulfate
CAS :<p>Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).</p>Formule :C21H22F2N6O2·H2O4SDegré de pureté :98.62% - 99.76%Couleur et forme :SolidMasse moléculaire :526.51Repotrectinib
CAS :<p>Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.</p>Formule :C18H18FN5O2Degré de pureté :99.92% - >99.99%Couleur et forme :SolidMasse moléculaire :355.377,8-Dihydroxyflavone
CAS :<p>7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.</p>Formule :C15H10O4Degré de pureté :98.48% - 99.81%Couleur et forme :SolidMasse moléculaire :254.24Frunevetmab
CAS :<p>Frunevetmab (NV-02) is a feline-adapted monoclonal antibody targeting NGF (nerve growth factor), with a Kd value of 20 pM. Feline osteoarthritis (OA).</p>Degré de pureté :95% - 95%Couleur et forme :LiquidFasinumab
CAS :<p>Fasinumab (anti-NGF mAb) is in Phase III trials for acute sciatica & knee OA. It significantly improves pain & function vs. placebo.</p>Degré de pureté :95%Couleur et forme :LiquidFulranumab
CAS :<p>Fulranumab (AMG-403) is a humanised monoclonal antibody targeting NGF, analgesic effects, and can be used for the study of chronic pain.</p>Degré de pureté :95%Couleur et forme :LiquidTanezumab
CAS :<p>Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF，pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain.</p>Degré de pureté :95%Couleur et forme :LiquidBMS-754807
CAS :<p>BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.</p>Formule :C23H24FN9ODegré de pureté :99.69% - 99.94%Couleur et forme :SolidMasse moléculaire :461.49Protein kinase inhibitor 5
CAS :<p>Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].</p>Formule :C29H31F2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.6Tavilermide
CAS :<p>Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.</p>Formule :C24H32N6O11Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :580.54TrkA-IN-1
CAS :<p>TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.</p>Formule :C25H20N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.45Paltimatrectinib
CAS :<p>Paltimatrectinib (PBI-200) is a tyrosine kinase inhibitor with anticancer activity, and is used in the study of bladder, breast, and colorectal cancers.</p>Formule :C20H15F5N6Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :434.37CG 428
CAS :<p>CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM.</p>Formule :C43H43FN10O6Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :814.86Type II TRK inhibitor 1
CAS :<p>Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type.</p>Formule :C35H33F3N8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :670.68ENT-C225
CAS :<p>ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.</p>Formule :C26H40N4O5Degré de pureté :99.36% - 99.36%Couleur et forme :SolidMasse moléculaire :488.62PF-06733804
CAS :<p>PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.</p>Formule :C20H19F5N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.38TRK-IN-24
CAS :<p>TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L,</p>Formule :C39H45N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :659.82AZ-23
CAS :<p>AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.</p>Formule :C17H19ClFN7ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :391.83TRK-IN-28
CAS :<p>TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1].</p>Formule :C27H25F2N7Couleur et forme :SolidMasse moléculaire :485.53TRK-IN-26
CAS :<p>TRK-IN-26 (compound 12), a TRK inhibitor, holds potential for use in cancer research [1].</p>Formule :C30H22F2N6O4Couleur et forme :SolidMasse moléculaire :568.53TrkA-IN-7
CAS :<p>TrkA-IN-7 (Compound 4) is an inhibitor of tropomyosin receptor kinase A (TrkA), with a Kd value of 40 μM.</p>Formule :C16H13N3O3Couleur et forme :SolidMasse moléculaire :295.293TrkA-IN-8
CAS :<p>TrkA-IN-8 (Compound 2) is a TrkA inhibitor with a Kd value of 3.3 µM. RTKs-IN-1 demonstrates a concentration-dependent inhibitory effect on the proliferation of lung cancer cell lines and holds potential for research in non-small cell lung cancer.</p>Formule :C20H16N4Couleur et forme :SolidMasse moléculaire :312.368TrkA-IN-9
CAS :<p>TrkA-IN-9 (VMD-928) is an orally active and selective inhibitor of tropomyosin receptor kinase A (TrkA). It disrupts downstream signaling pathways activated by nerve growth factor (NGF) binding to TrkA, thereby inhibiting cell proliferation and invasion, and promoting cancer cell death. TrkA-IN-9 shows potential for research in various cancers, including prostate cancer, thymic carcinoma, mesothelioma, head and neck squamous cell carcinoma, lung cancer, ovarian cancer, and hepatocellular carcinoma.</p>Formule :C31H32N4O4Couleur et forme :SolidMasse moléculaire :524.61PF-06273340
CAS :<p>PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。</p>Formule :C23H22ClN7O3Degré de pureté :98% - 98.00%Couleur et forme :SolidMasse moléculaire :479.92NMS-P626
CAS :<p>NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.</p>Formule :C28H35F2N7O4SCouleur et forme :SolidMasse moléculaire :603.68BNN-20
CAS :<p>BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.</p>Formule :C20H30O2Couleur et forme :SolidMasse moléculaire :302.45TrkC-IN-1
CAS :<p>TrkC-IN-1 (Compound 6c) is an inhibitor of TrkC, with IC50 values of 3.3-7.1 and 7.3-10.2 μΜ for EBC-1 and HT-29 cells, respectively. This compound shows potential for research in the field of cancer therapeutics.</p>Formule :C28H20BrN5O2Couleur et forme :SolidMasse moléculaire :538.395ONO-7579
CAS :<p>ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.</p>Formule :C24H18ClF3N6O4SCouleur et forme :SolidMasse moléculaire :578.95HS-345
CAS :<p>HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis). Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.</p>Formule :C19H18N6O2SCouleur et forme :SolidMasse moléculaire :394.45Trk-IN-4
CAS :<p>Trk-IN-4 (PF-6683324) is a potent pan-Trk inhibitor and antinociceptive. It is also a selective type II PTK6 inhibitor antitumor.</p>Formule :C24H23F4N5O4Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :521.46TrkB-IN-1
CAS :<p>TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties.</p>Formule :C19H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :368.34
