Récepteur TAM
Les inhibiteurs des récepteurs TAM ciblent la famille de récepteurs tyrosine kinases TAM, qui comprend Tyro3, Axl et Mer. Ces récepteurs sont impliqués dans la régulation des réponses immunitaires, la survie cellulaire et l'élimination des cellules apoptotiques. La dérégulation des récepteurs TAM est impliquée dans le cancer, les maladies auto-immunes et l'inflammation chronique. Chez CymitQuimica, nous proposons des inhibiteurs des récepteurs TAM pour soutenir vos recherches en immunologie, oncologie et inflammation.
32 produits trouvés pour "Récepteur TAM"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
TAM-IN-2
CAS :<p>TAM-IN-2 is an inhibitor of TAM.</p>Formule :C31H27F2N7O3Degré de pureté :98.09% - 99.74%Couleur et forme :SolidMasse moléculaire :583.59Tilvestamab
CAS :<p>Tilvestamab (BGB149) is a humanized monoclonal antibody targeting AXL with anti-tumor and anti-fibrotic activities, inhibiting Gas6-induced AXL activation.</p>Degré de pureté :>95%Couleur et forme :LiquidEnapotamab vedotin
CAS :<p>Enapotamab vedotin (anti-AXL ADC) targets AXL with MMAE payload, showing potential against AXL-expressing, EGFR-resistant NSCLC.</p>Degré de pureté :95%Couleur et forme :LiquidMecbotamab vedotin
CAS :<p>Mecbotamab vedotin (BA301) is an inhibitory IgG1 antibody that targets human tyrosine kinase receptor AXL and the humanized murine monoclonal BA301 γ1 chain. It can be utilized in the preparation of immunoconjugates for research into cancers expressing the Axl type.</p>Couleur et forme :LiquidUNC 569 hydrochloride
<p>UNC 569 hydrochloride: reversible ATP-competitive Mer inhibitor, IC50 2.9 nM, Ki 4.3 nM, also inhibits Axl/Tyro3; used in leukemia, teratoid tumor studies.</p>Formule :C22H30ClFN6Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :432.96UNC2541
CAS :<p>UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.</p>Formule :C24H34FN7O2Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :471.572-D08
CAS :<p>2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.</p>Formule :C15H10O5Degré de pureté :98.58% - 98.95%Couleur et forme :SolidMasse moléculaire :270.24Bemcentinib
CAS :<p>Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.</p>Formule :C30H34N8Degré de pureté :97% - 99.8%Couleur et forme :SolidMasse moléculaire :506.64RU-301
CAS :<p>RU-301 is a novel pan-tam inhibitor</p>Formule :C21H19F3N4O4SDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :480.46UNC569
CAS :<p>UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.</p>Formule :C22H29FN6Degré de pureté :98.91% - 99.67%Couleur et forme :SolidMasse moléculaire :396.5BMS 777607
CAS :<p>BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3. BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.</p>Formule :C25H19ClF2N4O4Degré de pureté :98.30% - >99.99%Couleur et forme :SolidMasse moléculaire :512.89CEP-40783
CAS :<p>CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).</p>Formule :C31H26F2N4O6Degré de pureté :99.76% - 99.84%Couleur et forme :SolidMasse moléculaire :588.56Ningetinib Tosylate
CAS :<p>Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.</p>Formule :C38H37FN4O8SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :728.79NPS-1034
CAS :<p>NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.</p>Formule :C31H23F2N5O3Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :551.54Gilteritinib
CAS :<p>Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM,</p>Formule :C29H44N8O3Degré de pureté :97.75% - 99.90%Couleur et forme :SolidMasse moléculaire :552.71UNC2881
CAS :<p>UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.</p>Formule :C25H33N7O2Degré de pureté :98.97% - 99.85%Couleur et forme :SolidMasse moléculaire :463.58SGI-7079
CAS :<p>SGI-7079: selective Axl inhibitor; hinders tumor growth dose-dependently; may target EGFR inhibitor resistance.</p>Formule :C26H26FN7Degré de pureté :95.51% - 99.26%Couleur et forme :SolidMasse moléculaire :455.53LDC1267
CAS :<p>LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).</p>Formule :C30H26F2N4O5Degré de pureté :99.38% - 99.88%Couleur et forme :SolidMasse moléculaire :560.55Ningetinib
CAS :<p>Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.</p>Formule :C31H29FN4O5Degré de pureté :99.95% - 99.98%Couleur et forme :SolidMasse moléculaire :556.58ONO-7475
CAS :<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>Formule :C32H26N4O6Degré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :562.57XL092
CAS :<p>XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.</p>Formule :C29H25FN4O5Degré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :528.53Cabozantinib
CAS :<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Formule :C28H24FN3O5Degré de pureté :99.68% - 99.88%Couleur et forme :SolidMasse moléculaire :501.51Cabozantinib hydrochloride
CAS :<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Formule :C28H25ClFN3O5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :537.96UNC2250
CAS :<p>UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).</p>Formule :C24H36N6O2Degré de pureté :98.57% - 99.87%Couleur et forme :SolidMasse moléculaire :440.58DS-1205
CAS :<p>DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.</p>Formule :C41H42FN5O7Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :735.8Dubermatinib
CAS :<p>Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.</p>Formule :C24H30ClN7O2SDegré de pureté :98.65% - 99.58%Couleur et forme :SolidMasse moléculaire :516.06RU-302
CAS :<p>RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.</p>Formule :C24H24F3N3O2SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :475.53R916562
CAS :<p>R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.</p>Formule :C26H30ClN9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :536.09AXL-IN-14
CAS :<p>AXL-IN-14: orally active, potent AXL inhibitor (IC50=0.8 nM); hinders Gas6/AXL migration, invasion; lowers p-AXL, p-AKT; anti-tumor.</p>Formule :C32H24F2N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.55AXL-IN-15
CAS :<p>AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1</p>Formule :C26H32F3N9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :575.59MerTK-IN-1
CAS :<p>MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.</p>Formule :C23H26N8O4Couleur et forme :SolidMasse moléculaire :478.50MerTK/Axl-IN-1
CAS :<p>MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.</p>Formule :C40H47FN6O4Couleur et forme :SolidMasse moléculaire :694.84
