FLT
Les inhibiteurs de la tyrosine kinase FLT (Fms-like) sont des composés qui ciblent les récepteurs FLT, impliqués dans la régulation de l'angiogenèse via la voie du VEGF (facteur de croissance endothélial vasculaire). Les récepteurs FLT jouent un rôle crucial dans le développement de nouveaux vaisseaux sanguins dans les tumeurs. L'inhibition des récepteurs FLT peut réduire efficacement l'angiogenèse et la croissance tumorale, ce qui rend ces inhibiteurs importants en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de FLT de haute qualité pour soutenir vos recherches en oncologie, biologie vasculaire et angiogenèse.
86 produits trouvés pour "FLT".
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
PDGFRα/FLT3-ITD-IN-1
CAS :PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively.Formule :C27H39N9OCouleur et forme :SolidMasse moléculaire :505.66BSc5371
CAS :BSc5371: Irreversible FLT3 inhibitor; Kds 0.83-5.8 nM for various FLT3 mutants including wild type.Formule :C24H31N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.6PDGFRα/FLT3-ITD-IN-3
CAS :PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to beFormule :C26H39N9Couleur et forme :SolidMasse moléculaire :477.65FLT3-IN-11
CAS :FLT3-IN-11, an oral FLT3 kinase inhibitor: potent, selective, IC50 - wild-type 7.22 nM, FLT3-D835Y 4.95 nM, anti-AML IC50 3.2 nM for MV4-11.Formule :C20H25F3N6OCouleur et forme :SolidMasse moléculaire :422.45HP1328
CAS :HP1328: potent FLT3/ITD inhibitor, reduces leukemia, extends survival in mice, belongs to benzoimidazole family.Formule :C23H23N3O3Couleur et forme :SolidMasse moléculaire :389.45TG-46
CAS :TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.Formule :C26H34N6O3SDegré de pureté :98.82% - 99.86%Couleur et forme :SolidMasse moléculaire :510.65FLT3-IN-4
CAS :FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenousFormule :C23H25N7O2Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :431.49GTP-14564
CAS :GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3.Formule :C15H10N2ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :234.2527UNC4203
CAS :UNC4203 inhibits MERTK (1.2 nM), AXL (140 nM), TYRO3 (42 nM), FLT3 (90 nM); potent, selective, oral.Formule :C30H44N6OCouleur et forme :SolidMasse moléculaire :504.71HPK1-IN-2 dihydrochloride
CAS :HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].Formule :C19H22Cl2N6OSCouleur et forme :SolidMasse moléculaire :453.39OTS447
CAS :OTS447 is a potent FLT3 inhibitor (IC50: 21 nM) with potential anticancer activity for cancer research .Formule :C27H32ClN3O2Degré de pureté :98.25%Couleur et forme :Green SolidMasse moléculaire :466.02SG3-179
CAS :SG3-179 is a BET inhibitor.Formule :C28H35ClFN7O3SCouleur et forme :SolidMasse moléculaire :604.14TAK-659
CAS :TAK-659 is a spleen tyrosine kinase (SYK) inhibitor.Formule :C17H21FN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.39FLT3/ITD-IN-5
CAS :FLT3/ITD-IN-5 (Example 6) is an orally active inhibitor of both FLT3 and FLT3-ITD, exhibiting IC50 values of 0.088 nM and 0.348 nM, respectively. This compound is utilized in cancer research.Formule :C23H25N7O2Couleur et forme :SolidMasse moléculaire :431.49FLT3/ITD-IN-1
FLT3/ITD-IN-1 inhibits FLT3-ITD with IC50s: 38.2 nM (FLT3) and 144.1 nM (ITD), and fights acute myeloid leukemia.Formule :C19H22N6O2Couleur et forme :SolidMasse moléculaire :366.42D-65476
CAS :D-65476 is a type III receptor tyrosine kinase (Flt3) inhibitor. It inhibits the proliferation of TEL-Flt3 transfected BA/F3 cells in the absence of IL-3, with an IC50 of 0.2 μM, and is useful for researching Flt3-driven leukemia.Formule :C21H18N2O3Couleur et forme :SolidMasse moléculaire :346.38FLT3-IN-38
CAS :FLT3-IN-38 (Flt-3 Inhibitor II) is a compound that acts as an FLT3 inhibitor. It also exhibits off-target effects by inhibiting the serine/threonine kinase haspin, a mitotic signaling coordinator. FLT3-IN-38 has potential applications in cancer research.Formule :C17H12N2O3Masse moléculaire :292.29BDT001
CAS :BDT001 (Example 1) is a selective antagonist of the FLT3 receptor, which can be utilized in research related to painful conditions, cancer, and autoimmune diseases.Formule :C18H19ClN2O4SMasse moléculaire :394.87Lomonitinib
CAS :Lomonitinib is a potent and selective pan-FLT3/IRAK4 inhibitor with antitumor properties. It shows promise for research in myeloid leukemia.Formule :C27H24N4O2Couleur et forme :SolidMasse moléculaire :436.505Multi-kinase inhibitor 4
CAS :Multi-kinase inhibitor 4 (compound 14) serves as an orally effective inhibitor targeting FLT1, KDR, FLT3, FLT4, PDGFRα, and PDGFRβ, exhibiting IC50 values of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, and 0.89 nM respectively. This compound plays a crucial role in cancer research.Formule :C25H24N6O2Couleur et forme :SolidMasse moléculaire :440.50
