c-Kit
Les inhibiteurs de c-Kit sont des composés qui bloquent l'activité du Récepteur du Facteur de Cellules Souches (c-Kit), une tyrosine kinase jouant un rôle crucial dans la survie, la prolifération et la différenciation cellulaires, en particulier dans les cellules hématopoïétiques. Les mutations de c-Kit sont liées à divers cancers, notamment les tumeurs stromales gastro-intestinales (GIST) et la leucémie. Chez CymitQuimica, nous proposons des inhibiteurs de c-Kit pour soutenir vos recherches en oncologie, hématologie et biologie des cellules souches.
101 produits trouvés pour "c-Kit"
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Ki20227
CAS :<p>Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM).</p>Formule :C24H24N4O5SDegré de pureté :98.97% - 99.88%Couleur et forme :SolidMasse moléculaire :480.54Flumatinib
CAS :<p>Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.</p>Formule :C29H29F3N8ODegré de pureté :99.39% - 99.95%Couleur et forme :SolidMasse moléculaire :562.59AZD2932
CAS :<p>AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.</p>Formule :C24H25N5O4Degré de pureté :97.71% - 98.37%Couleur et forme :SolidMasse moléculaire :447.49AZD3229 Tosylate
CAS :<p>AZD3229 Tosylate is a highly potent inhibitor targeting mutant forms of the pan-KIT enzyme, with a primary application in the treatment of gastrointestinal</p>Formule :C31H34FN7O6SCouleur et forme :SolidMasse moléculaire :651.71Midostaurin
CAS :<p>PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.</p>Formule :C35H30N4O4Degré de pureté :97.61% - >99.99%Couleur et forme :SolidMasse moléculaire :570.64Dovitinib lactate
CAS :<p>Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).</p>Formule :C24H27FN6O4Degré de pureté :99.54% - 99.77%Couleur et forme :SolidMasse moléculaire :482.51Tandutinib
CAS :<p>Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3</p>Formule :C31H42N6O4Degré de pureté :99.45% - ≥98%Couleur et forme :White SolidMasse moléculaire :562.7Vimseltinib
CAS :<p>Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).</p>Formule :C23H25N7O2Degré de pureté :99.05% - 99.57%Couleur et forme :SolidMasse moléculaire :431.49SKLB4771
CAS :<p>SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.</p>Formule :C25H27N7O3S2Degré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :537.66AZD3229
CAS :<p>AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.</p>Formule :C24H26FN7O3Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :479.51c-Kit-IN-1
CAS :<p>c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).</p>Formule :C26H21F2N5O3Degré de pureté :98.72% - 98.73%Couleur et forme :SolidMasse moléculaire :489.47Imatinib
CAS :<p>Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit</p>Formule :C29H31N7ODegré de pureté :99.42% - 99.94%Couleur et forme :Off White PowderMasse moléculaire :493.6Telatinib
CAS :<p>Telatinib (Bay 57-9352) inhibits VEGFR2/3, c-Kit, PDGFRα with IC50s: 6 nM, 4 nM, 1 nM, 15 nM.</p>Formule :C20H16ClN5O3Degré de pureté :97.61% - 99.81%Couleur et forme :SolidMasse moléculaire :409.83Linifanib
CAS :<p>Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and</p>Formule :C21H18FN5ODegré de pureté :98% - 98.24%Couleur et forme :SolidMasse moléculaire :375.4GW786034B
CAS :<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Formule :C21H23N7O2S·HClDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :473.98N-Desethylsunitinib hydrochloride
CAS :<p>N-Desethylsunitinib HCl, active sunitinib metabolite, inhibits VEGFR, PDGFRβ, KIT.</p>Formule :C20H24ClFN4O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :406.88Motesanib
CAS :<p>Motesanib (AMG 706) orally blocks VEGFR, PDGFR, Kit, Ret; curbing angiogenesis and cancer cell growth.</p>Formule :C22H23N5ODegré de pureté :98% - 99.09%Couleur et forme :SolidMasse moléculaire :373.45Regorafenib
CAS :<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Formule :C21H15ClF4N4O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :482.82Lenvatinib mesylate
CAS :<p>Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.</p>Formule :C22H23ClN4O7SDegré de pureté :99.03% - 99.79%Couleur et forme :SolidMasse moléculaire :522.96Tyrphostin AG1296
CAS :<p>Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.</p>Formule :C16H14N2O2Degré de pureté :99.94% - >99.99%Couleur et forme :SolidMasse moléculaire :266.29Dovitinib lactate hydrate
CAS :<p>Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).</p>Formule :C24H27FN6O4Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :482.51Amuvatinib
CAS :<p>Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.</p>Formule :C23H21N5O3SDegré de pureté :99.38% - >99.99%Couleur et forme :SolidMasse moléculaire :447.51Pexidartinib
CAS :<p>Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential</p>Formule :C20H15ClF3N5Degré de pureté :98.34% - 99.45%Couleur et forme :SolidMasse moléculaire :417.81Cabozantinib
CAS :<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Formule :C28H24FN3O5Degré de pureté :99.68% - 99.88%Couleur et forme :SolidMasse moléculaire :501.51Flumatinib mesylate
CAS :<p>Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.</p>Formule :C30H33F3N8O4SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :658.69Cabozantinib hydrochloride
CAS :<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Formule :C28H25ClFN3O5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :537.96Dovitinib
CAS :<p>Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.</p>Formule :C21H21FN6ODegré de pureté :99.35% - 99.92%Couleur et forme :SolidMasse moléculaire :392.43Sitravatinib
CAS :<p>Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and</p>Formule :C33H29F2N5O4SDegré de pureté :98.9% - 99.85%Couleur et forme :SolidMasse moléculaire :629.68Masitinib mesylate
CAS :<p>Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;</p>Formule :C29H34N6O4S2Degré de pureté :97.67% - 98.44%Couleur et forme :SolidMasse moléculaire :594.75Toceranib
CAS :<p>Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.</p>Formule :C22H25FN4O2Degré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :396.46c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
<p>The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :58.60 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Anti-Mouse CD117 Antibody
<p>Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen.</p>Degré de pureté :98%Couleur et forme :Odour SolidBarzolvolimab
CAS :<p>Barzolvolimab (CDX 0159), a humanized IgG1 monoclonal antibody, blocks KIT activation and treats chronic urticaria.</p>Couleur et forme :LiquidBriquilimab
CAS :<p>Briquilimab is a humanized antibody that inhibits the SCF-KIT interaction, inducing mast cell apoptosis for research into inflammatory diseases.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidGW694590A
CAS :<p>GW694590A (UNC10112731) functions as a MYC protein stabilizer that enhances the levels of endogenous MYC protein. It also acts on receptor tyrosine kinases, inhibiting DDR2, KIT, and PDGFRα by 81%, 68%, and 67% at a concentration of 1 μM, respectively. As a protein kinase inhibitor, GW694590A affects both ATP-dependent and ATP-independent luciferases, potentially influencing the Fluc reporter gene [1].</p>Formule :C22H19N5O4Couleur et forme :SolidMasse moléculaire :417.42APcK110
CAS :<p>"APcK110, a potent novel Kit inhibitor, outperforms imatinib/dasatinib in halting OCI/AML3 and HMC1.2 cell growth, also inhibiting Kit-signaling."</p>Formule :C20H16FN3O2Couleur et forme :SolidMasse moléculaire :349.36Bezuclastinib
CAS :<p>Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.</p>Formule :C19H17N5ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :331.37AC710
CAS :<p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>Formule :C31H42N6O4Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :562.7c-Kit-IN-3
CAS :<p>c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).</p>Formule :C26H20ClF3N2O4Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :516.9c-Kit-IN-2
CAS :<p>c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (</p>Formule :C25H29N9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.62KBP-7018
CAS :<p>KBP-7018: potent tyrosine kinase inhibitor targeting c-KIT, RET, PDGFR with IC50s of 10, 7.6, 25nM.</p>Formule :C31H30N4O5Couleur et forme :SolidMasse moléculaire :538.59Sitravatinib malate
CAS :<p>Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5</p>Formule :C37H35F2N5O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :763.76Chiauranib
CAS :<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47Tafetinib
CAS :<p>Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.</p>Formule :C24H29FN4O2Degré de pureté :96.23%Couleur et forme :SolidMasse moléculaire :424.51Agerafenib hydrochloride
CAS :<p>Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).</p>Formule :C24H23ClF3N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.92Henatinib
CAS :<p>Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.</p>Formule :C25H29FN4O4Couleur et forme :SolidMasse moléculaire :468.52c-Kit-IN-8
CAS :<p>C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.</p>Formule :C24H26FN5O4Couleur et forme :SolidMasse moléculaire :467.49AMG-25
CAS :<p>AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.</p>Formule :C23H17N5O2Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :395.41Protein kinase inhibitor 10
CAS :<p>Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.</p>Formule :C14H9FN6S2Couleur et forme :SolidMasse moléculaire :344.39c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
<p>c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :58.50 kDa (predicted); 87.1 kDa (reducing conditions)
