c-Kit
Les inhibiteurs de c-Kit sont des composés qui bloquent l'activité du Récepteur du Facteur de Cellules Souches (c-Kit), une tyrosine kinase jouant un rôle crucial dans la survie, la prolifération et la différenciation cellulaires, en particulier dans les cellules hématopoïétiques. Les mutations de c-Kit sont liées à divers cancers, notamment les tumeurs stromales gastro-intestinales (GIST) et la leucémie. Chez CymitQuimica, nous proposons des inhibiteurs de c-Kit pour soutenir vos recherches en oncologie, hématologie et biologie des cellules souches.
118 produits trouvés pour "c-Kit"
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c-Kit-IN-3
CAS :c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).Formule :C26H20ClF3N2O4Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :516.9Ref: TM-T10651
1mg82,00€5mg154,00€10mg240,00€1mL*10mM (DMSO)316,00€25mg396,00€50mg532,00€100mg745,00€500mg1.494,00€KI-328
CAS :KI-328: novel selective KIT kinase inhibitor; blocks Wt/mutant-KIT cell growth; low effect on D816V-KIT.Formule :C25H25N7O3Couleur et forme :SolidMasse moléculaire :471.51APcK110
CAS :"APcK110, a potent novel Kit inhibitor, outperforms imatinib/dasatinib in halting OCI/AML3 and HMC1.2 cell growth, also inhibiting Kit-signaling."Formule :C20H16FN3O2Couleur et forme :SolidMasse moléculaire :349.36KBP-7018
CAS :KBP-7018 is a selective TKI targeting c-KIT, RET, and PDGFR for mechanistic studies of fibrotic signaling and kinase-driven diseases.Formule :C31H30N4O5Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :538.59c-Kit-IN-2
CAS :c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (Formule :C25H29N9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.62Chiauranib
CAS :Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47Ref: TM-T35570
1mg66,00€5mg144,00€1mL*10mM (DMSO)157,00€10mg245,00€25mg492,00€50mg710,00€100mg973,00€Tafetinib
CAS :Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.Formule :C24H29FN4O2Degré de pureté :96.23%Couleur et forme :SolidMasse moléculaire :424.51Agerafenib hydrochloride
CAS :Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).Formule :C24H23ClF3N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.92Labuxtinib
CAS :Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Formule :C20H16FN5O2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :377.37Ref: TM-T79851
1mg132,00€5mg319,00€1mL*10mM (DMSO)354,00€10mg512,00€25mg1.018,00€50mg1.468,00€100mg1.972,00€200mg2.655,00€N-desmethyl Regorafenib N-oxide
CAS :N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.Formule :C20H13ClF4N4O4Couleur et forme :SolidMasse moléculaire :484.79Henatinib
CAS :Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.Formule :C25H29FN4O4Couleur et forme :SolidMasse moléculaire :468.52SIM010603
CAS :SIM010603, an oral RTK inhibitor, targets Kit, VEGFR-2, PDGFR-β, RET, FLT3 (IC50: 5.0-68.1 nmol/l), inhibits cell proliferation and angiogenesis.Formule :C22H25FN4O2Couleur et forme :SolidMasse moléculaire :396.46AMG-25
CAS :AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.Formule :C23H17N5O2Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :395.41c-Kit-IN-8
CAS :C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.Formule :C24H26FN5O4Couleur et forme :SolidMasse moléculaire :467.49Protein kinase inhibitor 10
CAS :Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.Formule :C14H9FN6S2Couleur et forme :SolidMasse moléculaire :344.39c-Kit-IN-7
CAS :c-Kit-IN-7 (compound 104) serves as an effective inhibitor of c-Kit, exhibiting an IC50 of 10 nM or less. It plays a crucial role in cancer research.Formule :C27H32FN7O3Couleur et forme :SolidMasse moléculaire :521.59c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.
Couleur et forme :Lyophilized PowderMasse moléculaire :58.50 kDa (predicted); 87.1 kDa (reducing conditions)VEGFR-IN-1
CAS :VEGFR inhibitorFormule :C19H16ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :337.8
