IGF-1R
Les inhibiteurs d'IGF-1R sont des composés qui ciblent spécifiquement le récepteur du facteur de croissance analogue à l'insuline 1 (IGF-1R), une tyrosine kinase réceptrice impliquée dans la croissance, le développement et la survie cellulaires. La signalisation IGF-1R joue un rôle important dans la progression du cancer, ce qui rend ces inhibiteurs précieux pour la recherche en oncologie. Chez CymitQuimica, nous proposons des inhibiteurs d'IGF-1R pour soutenir vos recherches en biologie du cancer, endocrinologie et développement de thérapies ciblées.
87 produits trouvés pour "IGF-1R"
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NVP-TAE 226
CAS :<p>NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.</p>Formule :C23H25ClN6O3Degré de pureté :98.07% - 98.78%Couleur et forme :SolidMasse moléculaire :468.94MAZ51
CAS :<p>MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.</p>Formule :C21H18N2ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :314.38XL228
CAS :<p>XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).</p>Formule :C22H31N9ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :437.54Ceritinib dihydrochloride
CAS :<p>Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.</p>Formule :C28H38Cl3N5O3SDegré de pureté :99.85% - 99.99%Couleur et forme :SolidMasse moléculaire :631.06NT157
CAS :<p>NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.</p>Formule :C16H14BrNO5SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :412.26Ginsenoside Rg5
CAS :<p>Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.</p>Formule :C42H70O12Degré de pureté :98% - 99.65%Couleur et forme :SolidMasse moléculaire :767Insulin(cattle)
CAS :<p>Insulin(cattle) is a peptide hormone that promotes glycogen synthesis. Insulin) has hypoglycemic activity. Cost-effective and quality-assured.</p>Formule :C254H377N65O75S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5733.49GSK1838705A
CAS :<p>GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.</p>Formule :C27H29FN8O3Degré de pureté :98.89% - >99.99%Couleur et forme :SolidMasse moléculaire :532.57AZ7550
CAS :<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formule :C27H31N7O2Degré de pureté :97.07% - 99.75%Couleur et forme :SolidMasse moléculaire :485.58NVP-ADW742
CAS :<p>NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl</p>Formule :C28H31N5ODegré de pureté :96.14% - 98.70%Couleur et forme :SolidMasse moléculaire :453.58NBI-31772 hydrate
<p>NBI-31772 hydrate blocks IGF and IGFBPs binding, freeing IGF-I with Ki 1-24 nM; it has anxiolytic and antidepressant effects.</p>Formule :C17H13NO8Couleur et forme :SolidMasse moléculaire :372.82Linsitinib
CAS :<p>OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.</p>Formule :C26H23N5ODegré de pureté :99.71% - ≥95%Couleur et forme :SolidMasse moléculaire :421.49AZD-3463
CAS :<p>AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.</p>Formule :C24H25ClN6ODegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :448.95BRD7552
CAS :<p>BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.</p>Formule :C33H33N3O15Degré de pureté :>99.99% - ≥98%Couleur et forme :SolidMasse moléculaire :711.63Sari 59-801
CAS :Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release.Formule :C18H23N3O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :313.39PQ401 hydrochloride (196868-63-0(free base))
<p>PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.</p>Formule :C18H17Cl2N3O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :378.25AG1024
CAS :<p>AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).</p>Formule :C14H13BrN2ODegré de pureté :98% - 99.37%Couleur et forme :SolidMasse moléculaire :305.17Indirubin Derivative E804
CAS :<p>Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.</p>Formule :C20H19N3O4Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :365.38GSK1904529A
CAS :<p>GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .</p>Formule :C44H47F2N9O5SDegré de pureté :98.2% - 99.38%Couleur et forme :SolidMasse moléculaire :851.96Anti-IGFBP2 Antibody (M14)
<p>Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody inhibitor that binds with high affinity to IGFBP2 and prevents its interaction with IGF1. Additionally, Anti-IGFBP2 Antibody (M14) can inhibit the recruitment of human endothelial cells, thereby obstructing tumor progression in human metastatic cancers.</p>Couleur et forme :Odour LiquidFigitumumab
CAS :<p>Figitumumab is a potent anti-IGF1R mAb (IC50=1.8 nM) showing promise in advanced lung squamous cell carcinoma.</p>Degré de pureté :95%Couleur et forme :LiquidDusigitumab
CAS :<p>Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidVeligrotug
CAS :<p>Veligrotug is an IV anti-IGF-1R antibody for thyroid eye disease, reducing diplopia and orbital inflammation, supporting autoimmune ophthalmopathy research.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidS961
CAS :<p>S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.</p>Formule :C211H297N55O71S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4804.13BMS-754807
CAS :<p>BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.</p>Formule :C23H24FN9ODegré de pureté :99.69% - 99.94%Couleur et forme :SolidMasse moléculaire :461.49AZ12253801
CAS :<p>AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.</p>Formule :C21H22N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.45BM-131246
CAS :<p>BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.</p>Formule :C22H20N2O4SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :408.47D-(+)-Sorbose
CAS :<p>D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.</p>Formule :C6H12O6Couleur et forme :SolidMasse moléculaire :180.16KU14R
CAS :<p>KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.</p>Formule :C13H14N2ODegré de pureté :98%Couleur et forme :White SolidMasse moléculaire :214.26NT219
CAS :<p>NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.</p>Formule :C16H14BrNO5SDegré de pureté :98.06% - 99.72%Couleur et forme :SolidMasse moléculaire :412.26I-OMe-Tyrphostin AG 538
CAS :<p>I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.</p>Formule :C17H12INO5Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :437.19Protonstatin-1
CAS :<p>Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.</p>Formule :C8H5NO2S2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :211.26BMS-695735
CAS :<p>BMS-695735: benzimidazole, inhibits IGF-1 receptor, broad antitumor effects, affects CYP3A4, low solubility, binds plasma proteins.</p>Formule :C26H31ClFN7OCouleur et forme :SolidMasse moléculaire :512.02Tyrphostin AG 538
CAS :<p>Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.</p>Formule :C16H11NO5Degré de pureté :98.75%Couleur et forme :SoildMasse moléculaire :297.26IGF-1R inhibitor-4
CAS :<p>IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.</p>Formule :C13H15ClN4OCouleur et forme :SolidMasse moléculaire :278.737CL-A3-7
CAS :<p>CL-A3-7 is a viral-cell fusion inhibitor targeting the RSVF protein. It functions by blocking the interaction between the virus and the host's IGF1R, effectively inhibiting the infection of both wild-type and K394R mutant strains of RSV. This compound is suitable for use in antiviral drug development and resistance studies related to RSV.</p>Formule :C24H22Br2F2N2O3Couleur et forme :SolidMasse moléculaire :584.25AGL-2263
CAS :<p>AGL-2263 is a blocker of insulin receptor (IR)</p>Formule :C17H10N2O5Couleur et forme :SolidMasse moléculaire :322.27
