IGF-1R
Les inhibiteurs d'IGF-1R sont des composés qui ciblent spécifiquement le récepteur du facteur de croissance analogue à l'insuline 1 (IGF-1R), une tyrosine kinase réceptrice impliquée dans la croissance, le développement et la survie cellulaires. La signalisation IGF-1R joue un rôle important dans la progression du cancer, ce qui rend ces inhibiteurs précieux pour la recherche en oncologie. Chez CymitQuimica, nous proposons des inhibiteurs d'IGF-1R pour soutenir vos recherches en biologie du cancer, endocrinologie et développement de thérapies ciblées.
118 produits trouvés pour "IGF-1R".
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VRDN-002
VRDN-002 is a humanized monoclonal antibody (mAb) targeting IGF1R/CD221. It is designed to reduce inflammation and exophthalmos associated with thyroid eye disease (TED). Additionally, VPI-2690B is utilized in research related to Graves' ophthalmopathy.IRAB-B
IRAB-B is a human monoclonal antibody that targets INSR. As an insulin receptor (IR) antagonist, it is useful for research on insulin resistance and diabetes.Anti-Human IGF1R/CD221 Antibody
Anti-IGF1R/CD221 Antibody is a mAb targeting CD221 that inhibits tumor cell growth by blocking IGF-1 mediated signaling pathways.Anti-Human CD220/Insulin Receptor Antibody (IR 83-22)
Anti-CD220/Insulin Receptor Antibody (IR 83-22) is a mouse IgG1 chimeric antibody designed to target the human CD220/Insulin Receptor. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control.XOMA 129
XOMA 129 is a human monoclonal antibody that targets the insulin receptor (INSR). This compound acts as an antagonist to the insulin receptor (IR), effectively inhibiting the decrease of blood glucose levels. XOMA 129 is applicable in the research of hypoglycemia.BIIB022
BIIB022 is a human IgG4 monoclonal antibody (mAb) targeting IGF1R/CD221. It inhibits the phosphorylation of IGF-1 and IGF-2-induced IGF-1R and its downstream substrates. BIIB022 is applicable for research in lung cancer, pancreatic cancer, and colon cancer. The recommended isotype control is Human IgG4 kappa, Isotype Control.BM-131246
CAS :BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.Formule :C22H20N2O4SDegré de pureté :>99.99%Couleur et forme :White SolidMasse moléculaire :408.47IMP2-IN-2
CAS :IMP2-IN-2: potent, selective IMP2 inhibitor; IC50s: 120.9 μM (RNA_A), 236.7 μM (RNA_B); used in cancer research.Formule :C22H19F3N2O3SCouleur et forme :SolidMasse moléculaire :448.46D-(+)-Sorbose
CAS :D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.Formule :C6H12O6Couleur et forme :SolidMasse moléculaire :180.16I-OMe-Tyrphostin AG 538
CAS :I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.Formule :C17H12INO5Degré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :437.1854NT219
CAS :NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formule :C16H14BrNO5SDegré de pureté :98.06% - 99.72%Couleur et forme :SolidMasse moléculaire :412.255Protonstatin-1
CAS :Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.Formule :C8H5NO2S2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :211.261BMS-695735
CAS :BMS-695735: benzimidazole, inhibits IGF-1 receptor, broad antitumor effects, affects CYP3A4, low solubility, binds plasma proteins.Formule :C26H31ClFN7OCouleur et forme :SolidMasse moléculaire :512.02NBI-6024
CAS :NBI-6024, an altered peptide ligand (APL), serves as an epitope for interferon-gamma-producing T helper lymphocytes associated with inflammation in patientsFormule :C66H112N20O21Couleur et forme :SolidMasse moléculaire :1521.72Tyrphostin AG 538
CAS :Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.Formule :C16H11NO5Degré de pureté :98.75%Couleur et forme :SoildMasse moléculaire :297.2622IGF-1R inhibitor-4
CAS :IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.Formule :C13H15ClN4OCouleur et forme :SolidMasse moléculaire :278.737ZIGIR
ZIGIR enables insulin-based sorting of pure alpha and beta cells, revealing zinc(II) in human delta cell granules.Formule :C39H40N6O3Degré de pureté :98.34% - 99.32%Couleur et forme :Pink SolidMasse moléculaire :640.77BMS-577098
CAS :BMS-577098 is an orally active ATP-competitive inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) with an IC50 value of 0.016 μM, exhibiting antitumor properties.Formule :C28H33ClN6O3Masse moléculaire :537.06
