Ubiquitination
Les inhibiteurs de l'ubiquitination sont des composés qui interfèrent avec le processus d'ubiquitination, par lequel les protéines sont marquées avec des molécules d'ubiquitine pour être dégradées par le protéasome. Ces inhibiteurs sont essentiels pour étudier le renouvellement des protéines, la transduction des signaux et la régulation de divers processus cellulaires. L'ubiquitination joue un rôle clé dans de nombreuses maladies, y compris le cancer, les troubles neurodégénératifs et les dysfonctionnements du système immunitaire. En modulant l'ubiquitination, ces inhibiteurs peuvent fournir des informations sur les mécanismes des maladies et ouvrir de nouvelles voies pour l'intervention thérapeutique. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de l'ubiquitination de haute qualité pour soutenir vos recherches en biologie cellulaire, protéomique et découverte de médicaments.
Sous-catégories appartenant à la catégorie "Ubiquitination"
71 produits trouvés pour "Ubiquitination"
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TAS4464 hydrochloride
CAS :TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).Formule :C21H24ClFN6O6SDegré de pureté :98.61% - 98.96%Couleur et forme :SolidMasse moléculaire :542.97Ref: TM-T13090
1mg66,00€5mg144,00€10mg227,00€25mg455,00€50mg753,00€100mg1.301,00€1mL*10mM (DMSO)167,00€WS-383
CAS :WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Formule :C18H21Cl2N9S2Degré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :498.46Ref: TM-T13349
1mg46,00€2mg58,00€5mg87,00€10mg144,00€25mg283,00€50mg558,00€100mg797,00€500mg1.634,00€1mL*10mM (DMSO)97,00€ML-792
CAS :ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Formule :C21H23BrN6O5SDegré de pureté :99.32% - 99.82%Couleur et forme :SolidMasse moléculaire :551.41Ref: TM-T16102
1mg87,00€2mg113,00€5mg177,00€10mg260,00€25mg409,00€50mg560,00€100mg800,00€1mL*10mM (DMSO)225,00€MF-094
CAS :MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formule :C30H37N3O4SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€200mg934,00€1mL*10mM (DMSO)104,00€NSC232003
CAS :NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Formule :C6H7N3O3Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :169.14UP163
CAS :UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Formule :C20H15ClN2O5SCouleur et forme :SolidMasse moléculaire :430.86dCeMM3
CAS :dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.
Formule :C14H11ClN4OSDegré de pureté :98.48% - 99.41%Couleur et forme :SolidMasse moléculaire :318.78Cbl-b-IN-18
Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ubiquitin ligase Cbl-b, effectively blocking Cbl-b phosphorylation with an IC50 of less than 100 nM.Formule :C33H31F4N7OMasse moléculaire :617.25262UP158
CAS :UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formule :C17H17ClN4O2Couleur et forme :SolidMasse moléculaire :344.8Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Couleur et forme :Odour SolidRef: TM-L8600
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderUSP8-IN-2
CAS :USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.
Formule :C19H20ClF3N4OSDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :444.9UP12
CAS :UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formule :C23H16ClN3O3SCouleur et forme :SolidMasse moléculaire :449.91RNF5 agonist 1
CAS :RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.Formule :C22H18N4SCouleur et forme :SolidMasse moléculaire :370.47SAE-IN-2
SAE-IN-2 (compound 6) is a potent inhibitor of sumoylation-activating enzyme (SAE) with an IC50 value of 27.8 nM.Formule :C27H30ClN5O5S2Masse moléculaire :603.13769Skp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Couleur et forme :Odour SolidCbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ubiquitin ligase Cbl, demonstrating an IC50 of 15 nM. Cbl-b refers to Casitas B-lineage Lymphoma proto-oncogene-b, which can inhibit the activation of T cells, natural killer (NK) cells, and B cells. Cbl-b-IN-15 can activate T cell function with an EC50 of 0.41 μM.Formule :C27H27N5O3Masse moléculaire :469.21139Rugonersen sodium
CAS :Rugonersen sodium is a locked nucleic acid (LNA)-modified antisense oligonucleotide (ASO) designed to reduce the silencing of ubiquitin protein ligase E3A (UBE3A). Angelman syndrome (AS) refers to a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, and Rugonersen has been studied for its potential use in the treatment of AS.Formule :C204H235N63Na19O109P19S19Masse moléculaire :6948.00Post-Translational Modification Compound Library
Contains xnum active small molecules for research related to post-translational modifications (PTMs);
Couleur et forme :Odour SolidRef: TM-L1620
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderMSC1094308
CAS :MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Formule :C29H29F3N2Couleur et forme :SolidMasse moléculaire :462.55COH000
CAS :COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).Formule :C25H25NO5Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :419.47Ref: TM-T5199
1mg170,00€5mg371,00€10mg537,00€25mg964,00€50mg1.333,00€100mg1.882,00€1mL*10mM (DMSO)409,00€ML241
CAS :ML241 is a potent and selective inhibitors of p97 ATPase.Formule :C23H24N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.46IU1-248
CAS :IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Formule :C20H23N3O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :337.42Ref: TM-T9375
1mg50,00€5mg97,00€10mg160,00€25mg319,00€50mg449,00€100mg640,00€200mg893,00€1mL*10mM (DMSO)107,00€CYM5442
CAS :CYM5442 is an S1P agonist, targeting to Sphingosine.Formule :C23H27N3O4Degré de pureté :98.02% - 99.48%Couleur et forme :SolidMasse moléculaire :409.48CB-5083
CAS :CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Formule :C24H23N5O2Degré de pureté :95.95% - 99.92%Couleur et forme :SolidMasse moléculaire :413.47Ref: TM-T6796
1mg43,00€2mg56,00€5mg93,00€10mg130,00€25mg281,00€50mg444,00€100mg650,00€500mg1.369,00€1mL*10mM (DMSO)92,00€NMS-873
CAS :NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Formule :C27H28N4O3S2Degré de pureté :99.05% - 99.85%Couleur et forme :SolidMasse moléculaire :520.67ML240
CAS :ML240 is a selective, ATP-competitive p97 inhibitor.Formule :C23H20N6ODegré de pureté :99.73% - >99.99%Couleur et forme :SolidMasse moléculaire :396.44Ref: TM-T3535
1mg35,00€2mg50,00€5mg77,00€10mg105,00€25mg178,00€50mg295,00€100mg477,00€200mg677,00€1mL*10mM (DMSO)84,00€ML241 hydrochloride
CAS :ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Formule :C23H25ClN4ODegré de pureté :99.91% - 99.96%Couleur et forme :SolidMasse moléculaire :408.92MID-1
CAS :MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formule :C12H11N3O4SDegré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :293.3Ref: TM-T8773
1mg52,00€5mg92,00€10mg138,00€25mg245,00€50mg363,00€100mg515,00€200mg700,00€1mL*10mM (DMSO)103,00€WSB1 Degrader 1
CAS :WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.Formule :C21H22N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :334.41VLX1570
CAS :VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formule :C23H17F2N3O6Degré de pureté :98.53% - 99.91%Couleur et forme :SolidMasse moléculaire :469.39Ref: TM-T4067
1mg96,00€2mg155,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€1mL*10mM (DMSO)265,00€ML-323
CAS :ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Formule :C23H24N6Degré de pureté :99.87% - 99.96%Couleur et forme :SolidMasse moléculaire :384.48PR-619
CAS :PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.Formule :C7H5N5S2Degré de pureté :97.25% - >99.99%Couleur et forme :SolidMasse moléculaire :223.28TCID
CAS :TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formule :C9H2Cl4O2Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :283.92DKM 2-93
CAS :DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).Formule :C11H14ClNO3Degré de pureté :98.37% - 99.39%Couleur et forme :SolidMasse moléculaire :243.69Skp2 Inhibitor C1
CAS :Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.Formule :C18H13BrN2O4S2Degré de pureté :97.36%Couleur et forme :SolidMasse moléculaire :465.34Ref: TM-T4253
2mg34,00€5mg52,00€10mg85,00€25mg164,00€50mg264,00€100mg386,00€200mg537,00€1mL*10mM (DMSO)54,00€Subasumstat
CAS :Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.Formule :C25H28ClN5O5S2Degré de pureté :97.02% - 98.22%Couleur et forme :SolidMasse moléculaire :578.1BC-1382
CAS :BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).Formule :C23H29N3O5SDegré de pureté :99.15% - 99.94%Couleur et forme :SolidMasse moléculaire :459.56Ref: TM-T8564
1mg81,00€5mg170,00€10mg250,00€25mg505,00€50mg730,00€100mg1.018,00€200mg1.369,00€1mL*10mM (DMSO)240,00€GS143
CAS :GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Formule :C28H19FN2O4Degré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :466.46Ref: TM-T25465
2mg35,00€5mg55,00€10mg87,00€25mg161,00€50mg245,00€100mg358,00€200mg520,00€1mL*10mM (DMSO)57,00€LANOSTEROL
CAS :Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.Formule :C30H50ODegré de pureté :97.99% - 99.67%Couleur et forme :SolidMasse moléculaire :426.72ICCB-19 hydrochloride
CAS :ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Formule :C12H22ClN3OSDegré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :291.84Ref: TM-T8931L
5mg34,00€10mg50,00€25mg90,00€50mg138,00€100mg198,00€200mg296,00€500mg469,00€1mL*10mM (DMSO)34,00€BI8626
CAS :BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cellsFormule :C25H28N8Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :440.54Ref: TM-T14569
1mg87,00€5mg178,00€10mg260,00€25mg462,00€50mg655,00€100mg887,00€200mg1.198,00€1mL*10mM (DMSO)203,00€FX12
CAS :FX12 acts as a selective inhibitor and degrader of the RNF5 E3 ubiquitin ligase. It directly binds to RNF5, inhibiting its E3 activity in vitro and facilitates the proteasomal degradation of RNF5 in cells through ERAD.Formule :C10H8O4SMasse moléculaire :224.23Smurf1-IN-1
CAS :Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFormule :C24H29ClN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.98DT204
CAS :DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Formule :C19H13BrClNO5SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :482.73USP22-IN-1
CAS :USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formule :C22H18N4Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :338.41P22074
CAS :P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formule :C12H9NO3S2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :279.33Ref: TM-T28284
1mg144,00€5mg330,00€10mg452,00€25mg633,00€50mg842,00€100mg1.159,00€200mg1.549,00€1mL*10mM (DMSO)251,00€CB-5339
CAS :p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].
Formule :C24H24N6ODegré de pureté :97.66%Couleur et forme :SoildMasse moléculaire :412.49Cbl-b-IN-11
CAS :Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) ofFormule :C31H35F5N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.64LDN-91946
CAS :LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formule :C15H10N2O4SDegré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :314.32PYZD-4409
CAS :PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.
Formule :C14H7ClFN3O5Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :351.67
