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DUB

DUB

Les inhibiteurs de déubiquitinases (DUB) ciblent les enzymes qui retirent les molécules d'ubiquitine des protéines, régulant ainsi la stabilité, la localisation et l'activité des protéines dans la cellule. Les déubiquitinases jouent un rôle essentiel dans divers processus cellulaires, notamment la régulation du cycle cellulaire, la réparation de l'ADN et les réponses immunitaires. La dérégulation de l'activité des DUB est liée au cancer, aux troubles neurodégénératifs et aux infections virales. Les inhibiteurs de DUB peuvent moduler ces processus, offrant des approches thérapeutiques potentielles pour ces conditions. Chez CymitQuimica, nous proposons des inhibiteurs de DUB pour soutenir vos recherches en homéostasie des protéines, en oncologie et en neurobiologie.

93 produits trouvés pour "DUB".

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  • MF-094

    CAS :
    MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.
    Formule :C30H37N3O4S
    Degré de pureté :99.93%
    Couleur et forme :Solid
    Masse moléculaire :535.7

    Ref: TM-T12024

    1mg
    40,00€
    5mg
    93,00€
    1mL*10mM (DMSO)
    99,00€
    10mg
    137,00€
    25mg
    268,00€
    50mg
    430,00€
    100mg
    620,00€
    200mg
    884,00€
  • GRL0617

    CAS :
    GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).
    Formule :C20H20N2O
    Degré de pureté :99.31%
    Couleur et forme :Solid
    Masse moléculaire :304.39

    Ref: TM-T11464

    1mg
    34,00€
    5mg
    74,00€
    1mL*10mM (DMSO)
    82,00€
    10mg
    105,00€
    25mg
    178,00€
    50mg
    313,00€
    100mg
    500,00€
    500mg
    1.063,00€
  • IU1-47

    CAS :
    IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。
    Formule :C19H23ClN2O
    Degré de pureté :98.94%
    Couleur et forme :Solid
    Masse moléculaire :330.85

    Ref: TM-T15604

    1mg
    34,00€
    5mg
    64,00€
    1mL*10mM (DMSO)
    70,00€
    10mg
    109,00€
    25mg
    222,00€
    50mg
    358,00€
    100mg
    593,00€
    200mg
    830,00€
  • C527

    CAS :
    C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
    Formule :C17H8FNO3
    Degré de pureté :97.22%
    Couleur et forme :Solid
    Masse moléculaire :293.25

    Ref: TM-T14852

    5mg
    33,00€
    10mg
    50,00€
    25mg
    92,00€
    50mg
    132,00€
    100mg
    205,00€
    200mg
    299,00€
  • HBX 19818

    CAS :
    HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
    Formule :C25H28ClN3O
    Degré de pureté :97.71%
    Couleur et forme :Solid
    Masse moléculaire :421.96

    Ref: TM-T15464

    1mg
    35,00€
    5mg
    80,00€
    1mL*10mM (DMSO)
    89,00€
    10mg
    111,00€
    25mg
    177,00€
    50mg
    253,00€
    100mg
    353,00€
    200mg
    502,00€
  • USP7-IN-15


    USP7-IN-15 (compound J21) is an inhibitor of USP7, exhibiting an IC50 value of 41.35 ± 2.16 nM.
    Couleur et forme :Odour Solid

    Ref: TM-T200570

    10mg
    À demander
    50mg
    À demander
  • Ubiquitination Compound Library


    A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening;
    Couleur et forme :Odour Solid

    Ref: TM-L8600

    1mg
    À demander
    30μL*10mM (DMSO)
    À demander
    50μL*10mM (DMSO)
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    100μL*10mM (DMSO)
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    250μL*10mM (DMSO)
    À demander
  • BAY-728


    BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].
    Formule :C24H28F3N5O2S
    Couleur et forme :Solid
    Masse moléculaire :507.57

    Ref: TM-T75101

    2mg
    127,00€
  • MS7131


    MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.
    Couleur et forme :Odour Solid

    Ref: TM-T206796

    10mg
    À demander
    50mg
    À demander
  • JAMM protein inhibitor 2 

    CAS :
    JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.
    Formule :C21H26N2O2
    Degré de pureté :98.57%
    Couleur et forme :Solid
    Masse moléculaire :338.44

    Ref: TM-T9892

    1mL*10mM (DMSO)
    44,00€
    1mg
    49,00€
    5mg
    101,00€
    10mg
    164,00€
    25mg
    334,00€
    50mg
    494,00€
    100mg
    702,00€
  • USP7-IN-10 hydrochloride


    USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39
    Formule :C26H30Cl2N4O3S
    Couleur et forme :Solid
    Masse moléculaire :549.51

    Ref: TM-T78150

    5mg
    À demander
    50mg
    À demander
  • GK16S


    GK16S, a UCHL1 chemogenomic probe, serves as a complementary tool to GK13S for the investigation of UCHL1 function in cellular studies [1].
    Formule :C11H15N3O
    Couleur et forme :Soild
    Masse moléculaire :205.12151

    Ref: TM-T78425

    5mg
    À demander
    50mg
    À demander
  • GK13S


    G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.
    Formule :C21H22N6O2
    Couleur et forme :Solid
    Masse moléculaire :390.44

    Ref: TM-T75182

    5mg
    À demander
    50mg
    À demander
  • USP7-IN-16

    CAS :
    USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.
    Formule :C43H45N7O6S
    Couleur et forme :Solid
    Masse moléculaire :787.93

    Ref: TM-T203646

    10mg
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    50mg
    À demander
  • Q14


    Q14 is a polypeptide derived from the transmembrane (TM) domain of USP30 (ubiquitin specific peptidase30) and is capable of inhibiting the deubiquitination activity of USP30 (IC50=57.2 nM). By hindering the interaction between USP30’s transmembrane and catalytic domains, it lowers USP30 activity. The Q14 polypeptide contains an LC3 interaction region (LIR) motif, enabling it to bind with LC3, thereby accelerating autophagosome formation and promoting mitophagy. Q14 is applicable in the study of neurodegenerative diseases, mitochondrial quality control, and cellular metabolism.
    Formule :C101H168N32O23
    Couleur et forme :Solid
    Masse moléculaire :2197.29601

    Ref: TM-TP3624

    10mg
    À demander
    50mg
    À demander
  • UBD1031


    UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.
    Couleur et forme :Odour Solid

    Ref: TM-T206459

    10mg
    À demander
    50mg
    À demander
  • (R)-CMPD-39


    (R)-CMPD-39 is the R-enantiomer of CMPD-39. CMPD-39 acts as a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 with an IC50 of approximately 20 nM and demonstrates high selectivity for other DUB family members at concentrations ranging from 1-100 μM. By inhibiting USP30's deubiquitination activity, CMPD-39 enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP and promotes the accumulation of phosphorylated ubiquitin. This process accelerates both mitophagy and pexophagy. Additionally, CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson’s disease patients.

    Ref: TM-TYD-02872

    10mg
    À demander
    50mg
    À demander
  • Subquinocin


    Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.
    Formule :C20H27N3O4S
    Couleur et forme :Solid
    Masse moléculaire :405.17223

    Ref: TM-T207399

    10mg
    À demander
    50mg
    À demander
  • Ga-CY03


    Ga-CY03 (compound) is a FAP-tracing molecule designed based on the FAP inhibitor QI-18 and labeled with [Ga].
    Formule :C53H63F2GaN13O15
    Couleur et forme :Solid
    Masse moléculaire :1229.87

    Ref: TM-T201823

    10mg
    À demander
    50mg
    À demander
  • USP7 Ligand-Linker Conjugates 1


    USP7Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate comprising a USP7 ligand and a PROTAC linker, capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACUSP7 Degrader-1.
    Couleur et forme :Odour Solid

    Ref: TM-T211917

    10mg
    À demander
    50mg
    À demander