Ubiquitination
Les inhibiteurs de l'ubiquitination sont des composés qui interfèrent avec le processus d'ubiquitination, par lequel les protéines sont marquées avec des molécules d'ubiquitine pour être dégradées par le protéasome. Ces inhibiteurs sont essentiels pour étudier le renouvellement des protéines, la transduction des signaux et la régulation de divers processus cellulaires. L'ubiquitination joue un rôle clé dans de nombreuses maladies, y compris le cancer, les troubles neurodégénératifs et les dysfonctionnements du système immunitaire. En modulant l'ubiquitination, ces inhibiteurs peuvent fournir des informations sur les mécanismes des maladies et ouvrir de nouvelles voies pour l'intervention thérapeutique. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de l'ubiquitination de haute qualité pour soutenir vos recherches en biologie cellulaire, protéomique et découverte de médicaments.
Sous-catégories appartenant à la catégorie "Ubiquitination"
107 produits trouvés pour "Ubiquitination"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
C527
CAS :<p>C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).</p>Formule :C17H8FNO3Degré de pureté :97.22%Couleur et forme :SolidMasse moléculaire :293.25ML-792
CAS :<p>ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.</p>Formule :C21H23BrN6O5SDegré de pureté :99.32% - 99.82%Couleur et forme :SolidMasse moléculaire :551.41IU1-47
CAS :<p>IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。</p>Formule :C19H23ClN2ODegré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :330.85NSC232003
CAS :<p>NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.</p>Formule :C6H7N3O3Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :169.14WS-383
CAS :<p>WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).</p>Formule :C18H21Cl2N9S2Degré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :498.46MF-094
CAS :<p>MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.</p>Formule :C30H37N3O4SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :535.7TAS4464 hydrochloride
CAS :<p>TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).</p>Formule :C21H24ClFN6O6SDegré de pureté :98.61% - 98.96%Couleur et forme :SolidMasse moléculaire :542.97HBX 19818
CAS :<p>HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).</p>Formule :C25H28ClN3ODegré de pureté :97.71%Couleur et forme :SolidMasse moléculaire :421.96USP8-IN-2
CAS :<p>USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.</p>Formule :C19H20ClF3N4OSDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :444.9USP8-IN-3
CAS :<p>USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.</p>Formule :C18H18F3N5O2SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :425.43UP158
CAS :<p>UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.</p>Formule :C17H17ClN4O2Couleur et forme :SolidMasse moléculaire :344.8OTUB2-IN-1
<p>OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).</p>Formule :C19H18N2O6S2Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :434.49E3 ligase Ligand 36
CAS :<p>E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.</p>Formule :C25H30N4O5SCouleur et forme :SolidMasse moléculaire :498.6NSC819701
<p>NSC819701 is a triazole-based inhibitor of p97ATPase. It inhibits the activity of p97ATPase by binding to specific sites on p97.</p>Formule :C30H32F2N8O3SCouleur et forme :SolidMasse moléculaire :622.69OTUB1/USP8-IN-1 HCl
<p>OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemia</p>Formule :C22H17Cl2FN2O4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :463.29Post-Translational Modification Compound Library
<p>Contains xnum active small molecules for research related to post-translational modifications (PTMs);</p>Couleur et forme :Odour SolidE3 ligase Ligand 41
CAS :<p>E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.</p>Formule :C13H12ClF3N2O4Couleur et forme :SolidMasse moléculaire :352.69Skp2 inhibitor 3
<p>Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.</p>Couleur et forme :Odour SolidUP12
CAS :<p>UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.</p>Formule :C23H16ClN3O3SCouleur et forme :SolidMasse moléculaire :449.91dCeMM3
CAS :<p>dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.</p>Formule :C14H11ClN4OSDegré de pureté :98.48% - 99.41%Couleur et forme :SolidMasse moléculaire :318.78BIO-2007817
<p>BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. This compound enhances the activity of wild-type Parkin, stimulates Parkin's autoubiquitination, and induces the appearance of mono-ubiquitinated forms of Miro1 (a Parkin substrate) with an EC50 of 0.17 μM.</p>Formule :C32H36N6O3Couleur et forme :SolidMasse moléculaire :552.67RNF5 agonist 1
CAS :<p>RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.</p>Formule :C22H18N4SCouleur et forme :SolidMasse moléculaire :370.47UP163
CAS :<p>UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.</p>Formule :C20H15ClN2O5SCouleur et forme :SolidMasse moléculaire :430.86Ubiquitination Compound Library
<p>A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；</p>Couleur et forme :Odour SolidUSP8-IN-1
CAS :<p>USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].</p>Formule :C18H21N5O3SDegré de pureté :99.07%Couleur et forme :SoildMasse moléculaire :387.46STD1T
CAS :<p>STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.</p>Formule :C19H19N3O4S2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :417.5MSC1094308
CAS :<p>MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.</p>Formule :C29H29F3N2Couleur et forme :SolidMasse moléculaire :462.55USP25/28 inhibitor AZ1
CAS :<p>USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.</p>Formule :C17H16BrF4NO2Degré de pureté :99.79% - 99.79%Couleur et forme :SolidMasse moléculaire :422.21IU1-248
CAS :<p>IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].</p>Formule :C20H23N3O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :337.42XL177A
CAS :<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Formule :C48H57ClN8O5Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :861.47DUB-IN-3
CAS :<p>DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.</p>Formule :C16H9N5ODegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :287.28NSC632839
CAS :<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Formule :C21H22ClNODegré de pureté :99.74% - 99.88%Couleur et forme :SolidMasse moléculaire :339.86ML241
CAS :<p>ML241 is a potent and selective inhibitors of p97 ATPase.</p>Formule :C23H24N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.46ML240
CAS :<p>ML240 is a selective, ATP-competitive p97 inhibitor.</p>Formule :C23H20N6ODegré de pureté :99.73% - >99.99%Couleur et forme :SolidMasse moléculaire :396.44BC-1382
CAS :<p>BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).</p>Formule :C23H29N3O5SDegré de pureté :99.15% - 99.94%Couleur et forme :SolidMasse moléculaire :459.56USP7/USP47 inhibitor
CAS :<p>USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,</p>Formule :C18H11Cl2N3O3S3Degré de pureté :98.5% - 98.71%Couleur et forme :SolidMasse moléculaire :484.4GNE-6640
CAS :<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Formule :C20H18N4ODegré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :330.38Skp2 Inhibitor C1
CAS :<p>Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.</p>Formule :C18H13BrN2O4S2Degré de pureté :97.36%Couleur et forme :SolidMasse moléculaire :465.34SJB2-043
CAS :<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Formule :C17H9NO3Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :275.26PR-619
CAS :<p>PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.</p>Formule :C7H5N5S2Degré de pureté :97.25% - >99.99%Couleur et forme :SolidMasse moléculaire :223.28NMS-873
CAS :<p>NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.</p>Formule :C27H28N4O3S2Degré de pureté :99.05% - 99.85%Couleur et forme :SolidMasse moléculaire :520.67USP7-IN-8
CAS :<p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>Formule :C21H21N3O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :347.41ML-323
CAS :<p>ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.</p>Formule :C23H24N6Degré de pureté :99.87% - 99.96%Couleur et forme :SolidMasse moléculaire :384.48DUB-IN-2
CAS :<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Formule :C15H9N5ODegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :275.26ML364
CAS :<p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>Formule :C24H18F3N3O3S2Degré de pureté :99.35% - >99.99%Couleur et forme :SolidMasse moléculaire :517.54GNE-6776
CAS :<p>GNE-6776 is a selective USP7 inhibitor.</p>Formule :C20H20N4O2Degré de pureté :96.59% - 98.2%Couleur et forme :SolidMasse moléculaire :348.4VLX1570
CAS :<p>VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.</p>Formule :C23H17F2N3O6Degré de pureté :98.53% - 99.91%Couleur et forme :SolidMasse moléculaire :469.39P005091
CAS :<p>P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.</p>Formule :C12H7Cl2NO3S2Degré de pureté :99.53% - 99.87%Couleur et forme :SolidMasse moléculaire :348.22WSB1 Degrader 1
CAS :<p>WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.</p>Formule :C21H22N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :334.412-D08
CAS :<p>2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.</p>Formule :C15H10O5Degré de pureté :98.58% - 98.95%Couleur et forme :SolidMasse moléculaire :270.24
