Ubiquitination
Les inhibiteurs de l'ubiquitination sont des composés qui interfèrent avec le processus d'ubiquitination, par lequel les protéines sont marquées avec des molécules d'ubiquitine pour être dégradées par le protéasome. Ces inhibiteurs sont essentiels pour étudier le renouvellement des protéines, la transduction des signaux et la régulation de divers processus cellulaires. L'ubiquitination joue un rôle clé dans de nombreuses maladies, y compris le cancer, les troubles neurodégénératifs et les dysfonctionnements du système immunitaire. En modulant l'ubiquitination, ces inhibiteurs peuvent fournir des informations sur les mécanismes des maladies et ouvrir de nouvelles voies pour l'intervention thérapeutique. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de l'ubiquitination de haute qualité pour soutenir vos recherches en biologie cellulaire, protéomique et découverte de médicaments.
Sous-catégories appartenant à la catégorie "Ubiquitination"
107 produits trouvés pour "Ubiquitination"
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CB-5083
CAS :<p>CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).</p>Formule :C24H23N5O2Degré de pureté :95.95% - 99.92%Couleur et forme :SolidMasse moléculaire :413.47Skp2 Inhibitor C1
CAS :<p>Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.</p>Formule :C18H13BrN2O4S2Degré de pureté :97.36%Couleur et forme :SolidMasse moléculaire :465.34ML364
CAS :<p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>Formule :C24H18F3N3O3S2Degré de pureté :99.35% - >99.99%Couleur et forme :SolidMasse moléculaire :517.54BC-1382
CAS :<p>BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).</p>Formule :C23H29N3O5SDegré de pureté :99.15% - 99.94%Couleur et forme :SolidMasse moléculaire :459.56NSC632839
CAS :<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Formule :C21H22ClNODegré de pureté :99.74% - 99.88%Couleur et forme :SolidMasse moléculaire :339.86SJB2-043
CAS :<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Formule :C17H9NO3Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :275.26DUB-IN-2
CAS :<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Formule :C15H9N5ODegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :275.26GNE-6640
CAS :<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Formule :C20H18N4ODegré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :330.38USP7-IN-8
CAS :<p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>Formule :C21H21N3O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :347.41Subasumstat
CAS :<p>Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.</p>Formule :C25H28ClN5O5S2Degré de pureté :97.02% - 98.22%Couleur et forme :SolidMasse moléculaire :578.1CYM5442
CAS :<p>CYM5442 is an S1P agonist, targeting to Sphingosine.</p>Formule :C23H27N3O4Degré de pureté :98.02% - 99.48%Couleur et forme :SolidMasse moléculaire :409.48IU1-248
CAS :<p>IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].</p>Formule :C20H23N3O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :337.42LANOSTEROL
CAS :<p>Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.</p>Formule :C30H50ODegré de pureté :97.99% - 99.67%Couleur et forme :SolidMasse moléculaire :426.72USP1-IN-2
CAS :<p>USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.</p>Formule :C26H22F4N6ODegré de pureté :99.69% - 99.88%Couleur et forme :SolidMasse moléculaire :510.486BI8626
CAS :<p>BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cells</p>Formule :C25H28N8Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :440.54USP28-IN-4
CAS :<p>USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Formule :C22H18Cl2N2O3SDegré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :461.36FT827
CAS :<p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>Formule :C27H28N6O5SDegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :548.61DT204
CAS :<p>DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.</p>Formule :C19H13BrClNO5SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :482.73USP28-IN-3
CAS :<p>USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Formule :C23H20Cl2N2O3SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :475.39I-138
CAS :<p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>Formule :C26H23F3N6ODegré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :492.5Smurf1-IN-1
CAS :<p>Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy</p>Formule :C24H29ClN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.98OTUB1/USP8-IN-1
CAS :<p>OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.</p>Formule :C22H16ClFN2O4Degré de pureté :98.59%Couleur et forme :SoildMasse moléculaire :426.83CB-5339
CAS :<p>p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].</p>Formule :C24H24N6ODegré de pureté :97.66%Couleur et forme :SoildMasse moléculaire :412.49GSK2643943A
CAS :<p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>Formule :C17H12FN3Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :277.3SJB3-019A
CAS :<p>SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times</p>Formule :C16H8N2O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :276.25NAcM-OPT
CAS :<p>NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).</p>Formule :C23H29Cl2N3ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :434.4USP30 inhibitor 11
CAS :<p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>Formule :C17H16N6O2SDegré de pureté :98.84% - 99.59%Couleur et forme :SolidMasse moléculaire :368.41P22074
CAS :<p>P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.</p>Formule :C12H9NO3S2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :279.33USP22-IN-1
CAS :<p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>Formule :C22H18N4Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :338.41Ubiquitination-IN-1
CAS :<p>Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).</p>Formule :C21H14F3N3O2SDegré de pureté :98.396% - 99.88%Couleur et forme :SolidMasse moléculaire :429.42USP30 inhibitor 18
CAS :<p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>Formule :C26H28FN3O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :497.58Cbl-b-IN-13
CAS :<p>Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].</p>Formule :C29H30F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.58Cbl-b-IN-6
CAS :<p>Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (</p>Formule :C30H32F5N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.6Cbl-b-IN-10
CAS :<p>Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (</p>Formule :C31H37F3N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.66Cbl-b-IN-9
CAS :<p>Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximal</p>Formule :C30H33F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.62Cbl-b-IN-12
CAS :<p>Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100</p>Formule :C28H29F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.56Cbl-b-IN-7
CAS :<p>Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50s</p>Formule :C29H31F4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.58Skp2 inhibitor 2
CAS :<p>Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.</p>Formule :C27H32N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.57Cbl-b-IN-8
CAS :<p>Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5</p>Formule :C35H44F3N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.76Cbl-b-IN-11
CAS :<p>Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) of</p>Formule :C31H35F5N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.64USP7-IN-1
CAS :<p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>Formule :C23H24ClN3O3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :425.91LDN-91946
CAS :<p>LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).</p>Formule :C15H10N2O4SDegré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :314.32UPCDC30766
CAS :<p>UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].</p>Formule :C30H32F2N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :594.68FT671
CAS :<p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>Formule :C24H23F4N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :533.48PYZD-4409
CAS :<p>PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.</p>Formule :C14H7ClFN3O5Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :351.67CC0651
CAS :<p>CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).</p>Formule :C20H21Cl2NO6Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :442.29UC-764864
CAS :<p>UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling in</p>Formule :C19H18N2OSDegré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :322.42IMP-1710
CAS :<p>IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.</p>Formule :C23H19N5ODegré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :381.43BC-1293
CAS :<p>BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.</p>Formule :C26H28N4O4SDegré de pureté :98.40%Couleur et forme :SolidMasse moléculaire :492.59PRC1-IN-1
CAS :<p>PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.</p>Formule :C24H19ClFN3O2Couleur et forme :SolidMasse moléculaire :435.878
