Ubiquitination
Les inhibiteurs de l'ubiquitination sont des composés qui interfèrent avec le processus d'ubiquitination, par lequel les protéines sont marquées avec des molécules d'ubiquitine pour être dégradées par le protéasome. Ces inhibiteurs sont essentiels pour étudier le renouvellement des protéines, la transduction des signaux et la régulation de divers processus cellulaires. L'ubiquitination joue un rôle clé dans de nombreuses maladies, y compris le cancer, les troubles neurodégénératifs et les dysfonctionnements du système immunitaire. En modulant l'ubiquitination, ces inhibiteurs peuvent fournir des informations sur les mécanismes des maladies et ouvrir de nouvelles voies pour l'intervention thérapeutique. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de l'ubiquitination de haute qualité pour soutenir vos recherches en biologie cellulaire, protéomique et découverte de médicaments.
Sous-catégories appartenant à la catégorie "Ubiquitination"
74 produits trouvés pour "Ubiquitination"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Cbl-b-IN-7
CAS :Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50sFormule :C29H31F4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.58CC0651
CAS :CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).Formule :C20H21Cl2NO6Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :442.29Cbl-b-IN-10
CAS :Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (Formule :C31H37F3N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.66Ubiquitination-IN-1
CAS :Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).Formule :C21H14F3N3O2SDegré de pureté :98.396% - 99.88%Couleur et forme :SolidMasse moléculaire :429.42Ref: TM-T13244
5mg66,00€10mg90,00€25mg165,00€50mg264,00€100mg395,00€500mg888,00€1mL*10mM (DMSO)73,00€Cbl-b-IN-12
CAS :Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100Formule :C28H29F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.56PYZD-4409
CAS :PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.
Formule :C14H7ClFN3O5Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :351.67Skp2 inhibitor 2
CAS :Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.Formule :C27H32N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.57UPCDC30766
CAS :UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Formule :C30H32F2N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :594.68LDN-91946
CAS :LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formule :C15H10N2O4SDegré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :314.32Cbl-b-IN-9
CAS :Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFormule :C30H33F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.62Cbl-b-IN-8
CAS :Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5Formule :C35H44F3N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.76Cbl-b-IN-11
CAS :Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) ofFormule :C31H35F5N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.64Cbl-b-IN-6
CAS :Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (Formule :C30H32F5N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.6Cbl-b-IN-13
CAS :Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].Formule :C29H30F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.58UC-764864
CAS :UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFormule :C19H18N2OSDegré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :322.42BC-1293
CAS :BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.Formule :C26H28N4O4SDegré de pureté :98.40%Couleur et forme :SolidMasse moléculaire :492.59DCN1-UBC12-IN-4
CAS :DCN1-UBC12-IN-4 (compound 5p) is an inhibitor of DCN1-UBC12 (IC₅₀ > 10 μM), applicable for investigating cancer cell migration and invasion.Formule :C8H6ClN3SDegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :211.67p97-IN-1
CAS :p97-IN-1 is an orally active inhibitor of p97 with an IC50 of 26 nM. It significantly impedes the proliferation of tumor cells and is applicable for research in acute myeloid leukemia (AML).Formule :C25H26N6O2Couleur et forme :SolidMasse moléculaire :442.51VCP/p97 IN-2
CAS :VCP/p97 IN-2 (Compound V13) is a VCP/p97 inhibitor with an IC50 of 32 nM for p97. It exhibits excellent antitumor activity, significantly suppressing tumor growth in a Molm-13 xenograft mouse model. VCP/p97 IN-2 is applicable for research in acute myeloid leukemia (AML).Formule :C24H23N5O2Couleur et forme :SolidMasse moléculaire :413.47PRC1-IN-1
CAS :PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.Formule :C24H19ClFN3O2Couleur et forme :SolidMasse moléculaire :435.878Cbl-b-IN-26
CAS :Cbl-b-IN-26 (Example A1) is an inhibitor of Cbl-b with a dissociation constant (Kd) of 34.6 nM. It is used in the research of chronic viral infections and cancer.Formule :C21H19F3N6Couleur et forme :SolidMasse moléculaire :412.41SPOP-IN-2
CAS :SPOP-IN-2 (Compound E1) is a potent inhibitor of speckle-type POZ protein (SPOP), with an IC50 of 0.58 μM. It disrupts the interaction between SPOP and substrates and selectively inhibits the proliferation of clear cell renal cell carcinoma (ccRCC).Formule :C15H13ClN2O5SMasse moléculaire :368.79USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.
Formule :C19H20ClN3O5SDegré de pureté :99.76%Couleur et forme :SoildMasse moléculaire :437.9Cbl-b-IN-3
CAS :Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).Cost-effective and quality-assured.Formule :C30H34F3N5ODegré de pureté :97.63%Couleur et forme :SolidMasse moléculaire :537.62Ref: TM-T63790
1mg66,00€5mg145,00€10mg192,00€25mg364,00€50mg558,00€100mg893,00€1mL*10mM (DMSO)172,00€
