Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1494 produits trouvés pour "Autophagie"
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DCAP
CAS :DCAP, a broad-spectrum antibiotic, disrupts the membranes of both Gram-positive and Gram-negative bacteria. Additionally, it inhibits late-stage autophagy by blocking autophagolysosome maturation and interrupting autophagic flux [1].Formule :C19H22Cl2N2O4Couleur et forme :SolidMasse moléculaire :413.3USP30 inhibitor 18
CAS :USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formule :C26H28FN3O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :497.58Ref: TM-T36682
1mg137,00€5mg281,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€500mg2.673,00€1mL*10mM (DMSO)309,00€BPO-27 racemate
CAS :BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.Formule :C26H18BrN3O6Degré de pureté :97.67% - 98.86%Couleur et forme :SolidMasse moléculaire :548.34Ref: TM-T10591
1mg47,00€5mg117,00€10mg170,00€25mg280,00€50mg409,00€100mg565,00€200mg758,00€1mL*10mM (DMSO)135,00€4E2RCat
CAS :4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expressionFormule :C22H14ClNO4S2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :455.93EACC
CAS :EACC inhibits Stx17, blocking autophagosome-lysosome fusion, and is a reversible autophagy inhibitor.
Formule :C13H11N3O6S2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :369.37CXCR2 antagonist 2
CAS :CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.Formule :C17H17FN2O4SCouleur et forme :SolidMasse moléculaire :364.39RK-682
CAS :RK-682 is a natural selective inhibitor of protein tyrosine phosphatases (PTPases).Formule :C21H36O5Couleur et forme :SolidMasse moléculaire :368.51Gly-β-MCA
CAS :Gly-β-MCA is an orally bioactive, entero inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.Formule :C26H43NO6Degré de pureté :≥98.0%Couleur et forme :SolidMasse moléculaire :465.62LY2955303
CAS :LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).Formule :C36H42N4O3Degré de pureté :98.56% - 99.85%Couleur et forme :SolidMasse moléculaire :578.74Di-N-desethyl amiodarone hydrochloride
CAS :Di-N-desethyl Amiodarone hydrochloride, a metabolite of Amiodarone, functions as a potent inhibitor of the respiratory chain [1].Formule :C21H22ClI2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.67Acitretin sodium
CAS :Acitretin sodium is a second-generation, systemic retinoid. It is also has been used in the treatment of psoriasis.Formule :C21H26NaO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.42Beclin1-ATG14L interaction inhibitor 1
CAS :Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L.Formule :C23H24N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.53p38-α MAPK-IN-1
CAS :p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.Formule :C27H35N5O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :477.6Ref: TM-T12347
1mg84,00€5mg170,00€10mg266,00€25mg492,00€50mg737,00€100mg1.108,00€200mg1.485,00€1mL*10mM (DMSO)178,00€ATG12-ATG3 inhibitor 1
CAS :ATG12-ATG3 Inhibitor 1 (compound 189) serves as a potent inhibitor of autophagy [1].Formule :C18H17NO3SCouleur et forme :SolidMasse moléculaire :327.4E6130
CAS :E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Formule :C28H37ClF3N3O3Couleur et forme :SolidMasse moléculaire :556.06CXCR4 antagonist 7
CAS :Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.Formule :C15H17N5O3Couleur et forme :SolidMasse moléculaire :315.33p38 MAPK-IN-1
CAS :p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.Formule :C21H14F2N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.35CXCR2-IN-1
CAS :CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Formule :C19H20Cl2FN3O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :476.35AZ PFKFB3 26
CAS :AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.
Formule :C24H26N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :402.49PHY34
CAS :PHY34 inhibits autophagy at nanomolar potency, with anti-tumor effects on HGSOC in vivo.Formule :C30H30O12Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :582.55Ref: TM-T37376
1mg164,00€2mg235,00€5mg369,00€10mg548,00€25mg879,00€50mg1.198,00€100mg1.596,00€500mg3.212,00€GDC-0349
CAS :GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.Formule :C24H32N6O3Degré de pureté :96.00% - 98.49%Couleur et forme :SolidMasse moléculaire :452.55CXCR2 antagonist 5
CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).
Formule :C15H14F2N4O2SCouleur et forme :SolidMasse moléculaire :352.36CXCR2/CCR7 antagonist-1
CAS :CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.Formule :C23H27N3O5Couleur et forme :SolidMasse moléculaire :425.48DC-LC3in-D5
CAS :DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B.Formule :C19H22Cl2N2O3Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :397.3Ref: TM-T61871
1mg94,00€5mg222,00€10mg356,00€25mg713,00€50mg1.108,00€100mg1.738,00€200mg2.332,00€1mL*10mM (DMSO)245,00€Autophagy activator-1
CAS :Autophagyactivator-1 (Compound B2) is an autophagy activator that induces autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.
Formule :C25H32O8Couleur et forme :SolidMasse moléculaire :460.517LRRK2-IN-16
CAS :LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.Formule :C18H19N5OSCouleur et forme :SolidMasse moléculaire :353.441CXCR2 antagonist 7
CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.Formule :C14H14F2N6OSCouleur et forme :SolidMasse moléculaire :352.36SCH-900875
CAS :SCH-900875 is an orally active, brain-penetrant, and selective inhibitor of the CXCR3 receptor, demonstrating significant selectivity towards CXCR1 and CXCR2 receptors as well. By binding to CXCR3, SCH-900875 blocks the ligands CXCL9, CXCL10, and CXCL11, thereby inhibiting downstream G protein and β-arrestin signaling pathways and reducing inflammation cell migration. This compound holds potential for research into autoimmune diseases (such as rheumatoid arthritis and multiple sclerosis) and inflammatory conditions (such as psoriasis and inflammatory bowel disease).Formule :C28H37ClN8O2Couleur et forme :SolidMasse moléculaire :553.10Z-FY-CHO
CAS :Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.Formule :C26H26N2O5Degré de pureté :95.88%Couleur et forme :SolidMasse moléculaire :446.5Autophagy-lysosome activator-1
Autophagy-lysosome Activator-1 (Compound F1) is an autophagy-lysosome stimulator that effectively induces the degradation of PD-L1 or VISTA in tumor cells.Formule :C17H18N4O2Couleur et forme :SolidMasse moléculaire :310.35LRRK2-IN-12
CAS :LRRK2-IN-12 (compound 1) is a potent inhibitor of LRRK2 (G20195) with an IC 50 of 0.45 nM, LRRK2 WT with an IC 50 of 1.1 nM, and LRRK2 WT ADP-Glo with an IC 50 of 0.46 nM. This compound is utilized in research related to Alzheimer's Disease [1].Formule :C18H17ClN8O2Couleur et forme :SolidMasse moléculaire :412.83LRRK2-IN-19
CAS :LRRK2-IN-19 is a PROTAC-targeted protein ligand utilized in the synthesis of PROTAC JH-XII-03-02. JH-XII-03-02 acts as an effective and selective LRRK2 PROTAC degrader, which is applicable for research in Parkinson's disease.Formule :C19H22N6OCouleur et forme :SolidMasse moléculaire :350.42YOK-1304
CAS :YOK-1304, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62.Formule :C28H35NO4Couleur et forme :SolidMasse moléculaire :449.58EMU-116
CAS :EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.Formule :C25H35N5Couleur et forme :SolidMasse moléculaire :405.58(R,R)-LRRK2-IN-7
CAS :(R,R)-LRRK2-IN-7 is an isomer of LRRK2-IN-7, a potent and selective LRRK2 kinase inhibitor with CNS penetrance. It exhibits an IC50 of 0.9 nM and demonstrates over 1000-fold selectivity compared to other kinases, ion channels, and CYP enzymes.Formule :C24H26N6OMasse moléculaire :414.50BRD5631
CAS :BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway.Formule :C30H35N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.62LRRK2-IN-13
CAS :LRRK2-IN-13 (Compound 13), with an IC50 value of 0.57 nM, serves as an inhibitor of LRRK2 and exhibits properties that allow it to penetrate the brain [1].Formule :C19H19ClN8O2Couleur et forme :SolidMasse moléculaire :426.86LRRK2-IN-20
CAS :LRRK2-IN-20 (EX. 4.64) is a selective inhibitor of LRRK2 with a potency of pIC50 at 0.7921 nM. This compound is applicable in research studies focused on Parkinson's Disease (PD).Formule :C24H32ClN7OCouleur et forme :SolidMasse moléculaire :470.01TMU 35435
CAS :TMU 35435 is an inhibitor of histone deacetylases (HDAC). It enhances radiosensitivity by inducing the accumulation of misfolded proteins and autophagy (autophagy) in TNBC, and inhibits the NHEJ pathway through ubiquitination of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).Formule :C22H25N3O3Couleur et forme :SolidMasse moléculaire :379.45SLW131
CAS :SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Formule :C21H27N5O5SCouleur et forme :SolidMasse moléculaire :461.535Autophagy-IN-7
CAS :Autophagy-IN-7 is an autophagy inhibitor for use in studying solid tumours.
Formule :C15H11N7Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :289.29LRRK2-IN-14
CAS :LRRK2-IN-14 (Compound 8), an orally active inhibitor of LRRK2, exhibits an IC 50 of 6.3 nM against LRRK2(G2019S) cell activity and demonstrates inhibitory effects on hERG with an IC 50 of 22 μM. Additionally, LRRK2-IN-14 is permeable to the blood-brain barrier [1].Formule :C17H18F3N5O2Couleur et forme :SolidMasse moléculaire :381.35CXCR7 modulator 2
CAS :CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.Formule :C29H42N6O3Couleur et forme :SolidMasse moléculaire :522.68CXCR2 antagonist 6
CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).Formule :C17H16F2N4OSCouleur et forme :SolidMasse moléculaire :362.4LRRK2-IN-6
LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).Formule :C23H24F2N4O2SCouleur et forme :SolidMasse moléculaire :458.52SYUIQ-5
CAS :SYUIQ-5 is a ligand for G-quadruplex structures. It plays a role in stabilizing G-quadruplexes and inducing senescence. Additionally, SYUIQ-5 inhibits the activity of the c-myc gene promoter. By displacing TRF2 from telomeres, SYUIQ-5 induces telomeric damage, which triggers autophagy (autophagy) in cancer cells.Formule :C20H22N4Couleur et forme :SolidMasse moléculaire :318.415YW3-56 (hydrochloride) (technical grade)
CAS :YW3-56: PAD2 & PAD4 inhibitor (IC50 = 0.5-5 μM), halts U2OS cell growth (IC50 ~2.5 μM), reduces S-180 & MDA-MB-231 tumor growth in mice.Formule :C27H33Cl2N5O2Couleur et forme :SolidMasse moléculaire :530.49HDAC1-IN-8
CAS :HDAC1-IN-8 (compound 5c) is a potent and selective HDAC1 inhibitor, with IC50 values of 11.94 µM for HDAC1, 22.95 µM for HDAC6, and greater than 500 µM for HDAC8. It exhibits antiproliferative activity, induces cell cycle arrest in G1 and G2/M phases, and triggers autophagy (autophagy). Additionally, HDAC1-IN-8 demonstrates anticancer properties and holds potential for lung cancer research.Formule :C22H24N2O4Couleur et forme :SolidMasse moléculaire :380.437HMG499
CAS :HMG499 inhibits HMG-CoA reductase (IC50: 0.41μM), reduces statin-induced HMGCR, lowers cholesterol, and lessens atherosclerosis.Formule :C33H54O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.78Acetylpepstatin
CAS :Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease.Formule :C33H61N5O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :703.875SHS206
SHS206 (compound 6n) is an orally active mitochondrial uncoupler that decreases triglyceride levels in the liver. Demonstrating in vivo efficacy in a GAN mouse model, SHS206 also exhibits inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH).Formule :C14H7F6N3OCouleur et forme :SolidMasse moléculaire :347.22SH498
CAS :SH498 is a novel Bmi-1-mediated anti-tumor agent with significant anti-proliferative effects.
Formule :C27H25F3N2O4Couleur et forme :SolidMasse moléculaire :498.49SORT1-IN-2
CAS :SORT1-IN-2 (compound 6) is an inhibitor of SORT1.Formule :C21H29N3O4Couleur et forme :SolidMasse moléculaire :387.47QW24
CAS :QW24 down-regulates BMI-1, exhibits potent antitumour effects and is used as an effective therapeutic agent in the treatment of clinical colorectal cancer.Formule :C27H28N2O4Couleur et forme :SolidMasse moléculaire :444.52ATG12-IN-1
CAS :ATG12-IN-1 (compound 4) acts as an autophagy inhibitor targeting the ATG12-ATG3 protein-protein interaction (IC50= 9 μM), suitable for research in cancer studies.Formule :C23H15ClN4O2Couleur et forme :SolidMasse moléculaire :414.84SW063058
CAS :SW063058 is an autophagy inducer that specifically disrupts the interaction between Beclin 1 and Bcl-2 without affecting the interactions of Bcl-2 with pro-apoptotic members (such as Bax and BIM). By inhibiting the negative regulation of Beclin 1 (key to autophagy initiation) by Bcl-2, SW063058 enhances autophagic activity without inducing cytotoxicity, apoptosis, or other forms of cell death in vitro.Formule :C22H15BrFIN2O2Couleur et forme :SolidMasse moléculaire :565.17HDAC10-IN-2
HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39CXCR4 antagonist 3
CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.Formule :C22H31N5Couleur et forme :SolidMasse moléculaire :365.52Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12LRRK2-IN-4
CAS :LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99DQ661
CAS :DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.Formule :C41H47Cl2N5O2Couleur et forme :SolidMasse moléculaire :712.75Rosiglitazone sodium
CAS :Rosiglitazone sodium is an effective and selective PPARγ activator, with EC50 values of 30 nM for PPARγ1, 100 nM for PPARγ2, and 60 nM for PPARγ. It also has an approximate Kd of 40 nM for PPARγ. Additionally, Rosiglitazone sodium acts as a regulator of TRP channels, inhibiting the activities of TRPM2 and TRPM3, while activating TRPC5.Formule :C18H18N3NaO3SCouleur et forme :SolidMasse moléculaire :379.41ST-539
CAS :ST-539 is an inhibitor of the deubiquitinating enzyme USP30, with an IC50 of 0.37 μM. It enhances the ubiquitination of mitochondrial proteins and induces mitophagy (autophagy), thereby regulating mitochondrial homeostasis. ST-539 is applicable for research in neurodegenerative diseases.Formule :C30H31N3O4SCouleur et forme :SolidMasse moléculaire :529.65LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.Formule :C24H26F2N4O2SCouleur et forme :SolidMasse moléculaire :472.55SRI-31255
CAS :SRI-31255 is an orally active LRRK2 inhibitor, with IC50 values of 520 nM for human wild-type (WT) and 427 nM for the G2019S mutant. It inhibits kinase activity by binding to the ATP-binding pocket of LRRK2, providing neuroprotective effects. SRI-31255 serves as a lead compound for developing LRRK2-targeted therapies for Parkinson’s disease research.Formule :C15H14N4Couleur et forme :SolidMasse moléculaire :250.30CCX662
CAS :CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Formule :C28H37N5O4SCouleur et forme :SolidMasse moléculaire :539.69Anle138b-F105
CAS :Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) with a DC50 value of 3 nM. It targets tauP301L for lysosomal degradation.Formule :C36H37FN4O5Couleur et forme :SolidMasse moléculaire :624.7LC3B recruiter 1
CAS :LC3B recruiter 1 (compound 33R) is an LC3B recruiting fragment. It directly interacts with LC3B, exhibiting a Kd value of 2.87 µM.Formule :C14H10ClN3O2Couleur et forme :SolidMasse moléculaire :287.701ACT-672125
CAS :ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.Formule :C25H25F3N10O2SCouleur et forme :SolidMasse moléculaire :586.59PARL-IN-1
PARL-IN-1: Strong PARL blocker, IC50 28 nM, boosts PINK1/Parkin mitophagy.Formule :C40H58N6O7Couleur et forme :SolidMasse moléculaire :734.92ACT-777991
CAS :ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.Formule :C20H20F6N8O2SCouleur et forme :SolidMasse moléculaire :550.48CXCR2 antagonist 4
CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.Formule :C15H14F2N4OS2Couleur et forme :SolidMasse moléculaire :368.424-FPBUA
CAS :4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.Formule :C31H23FO7Couleur et forme :SolidMasse moléculaire :526.51LRRK2-IN-2
CAS :LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.Formule :C23H23Cl2F3N6O2Couleur et forme :SolidMasse moléculaire :543.37(R)-SCH 546738
CAS :(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Formule :C23H31Cl2N7OCouleur et forme :SolidMasse moléculaire :492.45CXCR7 antagonist-1 hydrochloride
CAS :CXCR7 antagonist-1 hydrochloride, Inhibits SDF-1 (CXCL12) or I-TAC binding to CXCR7, used for tumor and inflammation research.Formule :C21H20ClFN6ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :426.87HDAC10-IN-1
HDAC10-IN-1 is a potent, selective HDAC10 inhibitor (IC50=58 nM) affecting autophagy in FLT3-ITD+ acute myeloid leukemia cells.Formule :C18H23N3O2Couleur et forme :SolidMasse moléculaire :313.39CXCR4 antagonist 10
CAS :CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Formule :C18H18N4O4Couleur et forme :SolidMasse moléculaire :354.36Stauprimide
CAS :Stauprimide inhibits MYC by blocking NME2, reducing MYC transcription in ESCs.Formule :C35H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.62SCH 563705
CAS :SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formule :C23H27N3O5Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :425.48BRD1991
CAS :BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.Formule :C33H35Cl2N3O4Couleur et forme :SolidMasse moléculaire :608.55CXCR4 modulator-1
CAS :CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.Formule :C23H27N5O2Couleur et forme :SolidMasse moléculaire :405.49LRRK2-IN-3
CAS :LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99Gepotidacin mesylate dihydrate
CAS :Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.Formule :C25H36N6O8SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :580.65DCC-3116
CAS :DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.Formule :C26H36F3N7O2Degré de pureté :98.55%Couleur et forme :SoildMasse moléculaire :535.61VUF11207 trifluoroacetate salt
CAS :VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.Formule :C29H36F4N2O6Couleur et forme :SolidMasse moléculaire :584.609Dusquetide
CAS :Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.Formule :C25H47N9O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.709Pepstatin Ammonium
Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nMFormule :C34H66N6O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :702.92Dihydrocelastrol
CAS :Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE coFormule :C29H40O4Couleur et forme :SolidMasse moléculaire :452.63Salvianolic acid B
CAS :Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia miltiorrhiza extract with antiplatelet aggregation and antithrombotic effects.
Formule :C36H30O16Degré de pureté :99.75% - 99.86%Couleur et forme :Yellow SolidMasse moléculaire :718.61FR 167653
CAS :FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.Formule :C24H20FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.51EIPA hydrochloride
CAS :EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.Formule :C11H19Cl2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.22CXCR4-IN-1
CAS :CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic
Formule :C23H32N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.54VISTA-IN-2
CAS :VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy,
Formule :C23H23N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.45
