Ubiquitination
Les inhibiteurs de l'ubiquitination sont des composés qui interfèrent avec le processus d'ubiquitination, par lequel les protéines sont marquées avec des molécules d'ubiquitine pour être dégradées par le protéasome. Ces inhibiteurs sont essentiels pour étudier le renouvellement des protéines, la transduction des signaux et la régulation de divers processus cellulaires. L'ubiquitination joue un rôle clé dans de nombreuses maladies, y compris le cancer, les troubles neurodégénératifs et les dysfonctionnements du système immunitaire. En modulant l'ubiquitination, ces inhibiteurs peuvent fournir des informations sur les mécanismes des maladies et ouvrir de nouvelles voies pour l'intervention thérapeutique. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de l'ubiquitination de haute qualité pour soutenir vos recherches en biologie cellulaire, protéomique et découverte de médicaments.
Sous-catégories appartenant à la catégorie "Ubiquitination"
70 produits trouvés pour "Ubiquitination".
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WS-383
CAS :WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Formule :C18H21Cl2N9S2Degré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :498.46Ref: TM-T13349
1mg43,00€2mg55,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg137,00€25mg268,00€50mg530,00€100mg755,00€500mg1.549,00€ML-792
CAS :ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Formule :C21H23BrN6O5SDegré de pureté :99.32% - 99.82%Couleur et forme :SolidMasse moléculaire :551.41Ref: TM-T16102
1mg87,00€2mg113,00€5mg177,00€1mL*10mM (DMSO)225,00€10mg260,00€25mg409,00€50mg560,00€100mg800,00€NSC232003
CAS :NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Formule :C6H7N3O3Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :169.14Antitumor agent-153
Antitumor agent-153 (compound 11b) is an inhibitor of H2A histone ubiquitination, optimized from PRT4165. It can reduce the viability of human osteosarcoma U2OS cells and decrease monoubiquitination of histone H2A, demonstrating anticancer activity.Formule :C16H8N2O6Couleur et forme :SolidMasse moléculaire :324.03824Post-Translational Modification Compound Library
Contains xnum active small molecules for research related to post-translational modifications (PTMs);
Couleur et forme :Odour SolidRef: TM-L1620
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderCbl-b-IN-19
Cbl-b-IN-19 (Compound 49) is an inhibitor of the E3 ligase Cbl-b, effectively suppressing its phosphorylation with an IC50 of less than 100 nM.Formule :C34H31F3N8OCouleur et forme :SolidMasse moléculaire :624.25729Cbl-b-IN-18
Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ubiquitin ligase Cbl-b, effectively blocking Cbl-b phosphorylation with an IC50 of less than 100 nM.Formule :C33H31F4N7OCouleur et forme :SolidMasse moléculaire :617.25262Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Couleur et forme :Odour SolidRef: TM-L8600
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderObudanersen
CAS :Obudanersen is an antisense oligonucleotide designed to target and inhibit the expression of the UBE3A antisense transcript (UBE3A-AS) and is used in the study of Angelman syndrome.MRC37
MRC37 is a potent and selective small molecule ligand for TRIM21, binding to the PRYSPRY domain of TRIM21. It inhibits the innate antiviral function of TRIM21 by preventing antibody neutralization of adenovirus 5 (Adv5). Additionally, MRC37 can inhibit the Trim-Away technique, a targeted protein degradation method that recruits TRIM21 to specific proteins via electroporated antibodies.dCeMM3
CAS :dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.Formule :C14H11ClN4OSDegré de pureté :98.48% - 99.49%Couleur et forme :SolidMasse moléculaire :318.78Skp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Couleur et forme :Odour SolidCbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ubiquitin ligase Cbl, demonstrating an IC50 of 15 nM. Cbl-b refers to Casitas B-lineage Lymphoma proto-oncogene-b, which can inhibit the activation of T cells, natural killer (NK) cells, and B cells. Cbl-b-IN-15 can activate T cell function with an EC50 of 0.41 μM.Formule :C27H27N5O3Couleur et forme :SolidMasse moléculaire :469.21139SAE-IN-2
SAE-IN-2 (compound 6) is a potent inhibitor of sumoylation-activating enzyme (SAE) with an IC50 value of 27.8 nM.Formule :C27H30ClN5O5S2Couleur et forme :SolidMasse moléculaire :603.13769Apazunersen
CAS :Apazunersen is an antisense oligonucleotide designed to target and inhibit the expression of UBE3A antisense transcript (UBE3A-AS). This inhibition prevents the silencing of paternal alleles of the UBE3A gene, thereby reactivating the expression of the defective protein. It is utilized in the research of Angelman syndrome.BRD5529
CAS :BRD5529 selective CARD9–TRIM62 interaction inhibitor for ubiquitination pathway regulation, innate immunity, inflammatory signaling and CARD9 immune response research.Formule :C25H31N5O4Couleur et forme :SolidMasse moléculaire :465.55MSC1094308
CAS :MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Formule :C29H29F3N2Couleur et forme :SolidMasse moléculaire :462.55LS-102
CAS :LS-102: E3 ligase inhibitor, IC50 35 μM, potential RA therapy.Formule :C24H36N8ODegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :452.6Ref: TM-T11879
1mg47,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg145,00€25mg256,00€50mg409,00€100mg590,00€200mg827,00€ML240
CAS :ML240 is a selective, ATP-competitive p97 inhibitor.Formule :C23H20N6ODegré de pureté :99.73% - >99.99%Couleur et forme :White SolidMasse moléculaire :396.44Ref: TM-T3535
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg105,00€25mg178,00€50mg295,00€100mg477,00€200mg677,00€CYM5442
CAS :CYM5442 is an S1P agonist, targeting to Sphingosine.Formule :C23H27N3O4Degré de pureté :98.02% - 99.48%Couleur et forme :White SolidMasse moléculaire :409.48
