Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1428 produits trouvés pour "Autophagie"
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Fe-TMPyP
CAS :<p>Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.</p>Formule :C44H36Cl5FeN8Couleur et forme :SolidMasse moléculaire :909.92PHTPP-1304
CAS :<p>PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.</p>Formule :C51H50F6N4O7Couleur et forme :SolidMasse moléculaire :944.96Schisandrin A
CAS :<p>Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM</p>Formule :C24H32O6Degré de pureté :99.21% - 99.901%Couleur et forme :SolidMasse moléculaire :416.51TC14012 TFA
<p>TC14012 TFA is a peptide-mimetic CXCR4 antagonist and CXCR7 agonist that promotes the recruitment of β-arrestin by CXCR7 .</p>Formule :C92H141F3N34O21S2Degré de pureté :96.31%Couleur et forme :SolidMasse moléculaire :2180.44Nictide
CAS :<p>Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.</p>Formule :C123H193N45O28Couleur et forme :SolidMasse moléculaire :2750.13Clionamine B
CAS :<p>Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.</p>Formule :C27H45NO3Couleur et forme :SolidMasse moléculaire :431.65Acridine homodimer
CAS :<p>Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.</p>Formule :C38H42Cl2N6O2Couleur et forme :SolidMasse moléculaire :685.69CXM102
<p>CXM102 is an activator of autophagy. This compound induces autophagy in aged BMSCs, rejuvenating them and promoting their preferential differentiation into osteoblasts. CXM102 enhances the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. In middle-aged male mice, it stimulates bone anabolic metabolism, reduces marrow adipocytes, delays bone loss, lowers serum inflammation levels, reduces organ fibrosis, and extends lifespan.</p>Formule :C28H27NO3Couleur et forme :SolidMasse moléculaire :425.52NAMPT degrader-1
<p>Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.</p>Formule :C56H68ClN9O5S2Couleur et forme :SolidMasse moléculaire :1046.78Sulfadiazine
CAS :<p>Sulfadiazine, a short-acting sulfonamide, blocks bacterial folic acid synthesis; used with pyrimethamine to treat toxoplasmosis in AIDS, newborns.</p>Formule :C10H10N4O2SDegré de pureté :99.32%Couleur et forme :White To Slightly Yellow Crystalline PowderMasse moléculaire :250.28Desethylamiodarone hydrochloride
CAS :<p>Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.</p>Formule :C23H26ClI2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :653.72G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Formule :C27H31IN2O3Couleur et forme :SolidMasse moléculaire :558.45MRT 67307 dihydrochloride
CAS :<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Formule :C26H38Cl2N6O2Degré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :537.53RK-682 (calcium salt)
CAS :<p>RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.</p>Formule :C42H74CaO10Couleur et forme :SolidMasse moléculaire :779.122AZD4721
CAS :<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Formule :C19H25FN4O5S2Couleur et forme :SolidMasse moléculaire :472.55Cyanine 5 Tyramide methyl indole
<p>Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.</p>Formule :C40H47N3O8S2Couleur et forme :SolidMasse moléculaire :761.95TSPO Ligand-Linker Conjugates 1
<p>TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.</p>Formule :C32H55N3O10SCouleur et forme :SolidMasse moléculaire :673.86Tigecycline mesylate
CAS :<p>Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Formule :C30H43N5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :681.75Cy3-dCTP
<p>Cy3-dCTP, a fluorescent cyanine-dye-labeled nucleotide triphosphate, serves as a DNA imaging probe.</p>Formule :C43H51Li4N6O20P3S2Couleur et forme :SolidMasse moléculaire :1156.71Tetramethylrhodamine-dUTP
<p>Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .</p>Formule :C43H52N6O19P3Couleur et forme :SolidMasse moléculaire :1049.82
