Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1489 produits trouvés pour "Autophagie"
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BRD5631
CAS :BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway.Formule :C30H35N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.62LRRK2-IN-19
CAS :LRRK2-IN-19 is a PROTAC-targeted protein ligand utilized in the synthesis of PROTAC JH-XII-03-02. JH-XII-03-02 acts as an effective and selective LRRK2 PROTAC degrader, which is applicable for research in Parkinson's disease.Formule :C19H22N6OCouleur et forme :SolidMasse moléculaire :350.42LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.Formule :C24H26F2N4O2SCouleur et forme :SolidMasse moléculaire :472.55LRRK2-IN-20
CAS :LRRK2-IN-20 (EX. 4.64) is a selective inhibitor of LRRK2 with a potency of pIC50 at 0.7921 nM. This compound is applicable in research studies focused on Parkinson's Disease (PD).Formule :C24H32ClN7OCouleur et forme :SolidMasse moléculaire :470.01CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formule :C15H14F2N4O2SCouleur et forme :SolidMasse moléculaire :352.36DC-LC3in-D5
CAS :DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B.Formule :C19H22Cl2N2O3Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :397.3Ref: TM-T61871
1mg99,00€5mg235,00€10mg376,00€25mg753,00€50mg1.169,00€100mg1.833,00€200mg2.460,00€1mL*10mM (DMSO)259,00€Rosiglitazone sodium
CAS :Rosiglitazone sodium is an effective and selective PPARγ activator, with EC50 values of 30 nM for PPARγ1, 100 nM for PPARγ2, and 60 nM for PPARγ. It also has an approximate Kd of 40 nM for PPARγ. Additionally, Rosiglitazone sodium acts as a regulator of TRP channels, inhibiting the activities of TRPM2 and TRPM3, while activating TRPC5.Formule :C18H18N3NaO3SCouleur et forme :SolidMasse moléculaire :379.41HDAC1-IN-8
CAS :HDAC1-IN-8 (compound 5c) is a potent and selective HDAC1 inhibitor, with IC50 values of 11.94 µM for HDAC1, 22.95 µM for HDAC6, and greater than 500 µM for HDAC8. It exhibits antiproliferative activity, induces cell cycle arrest in G1 and G2/M phases, and triggers autophagy (autophagy). Additionally, HDAC1-IN-8 demonstrates anticancer properties and holds potential for lung cancer research.Formule :C22H24N2O4Couleur et forme :SolidMasse moléculaire :380.437BRD1991
CAS :BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.Formule :C33H35Cl2N3O4Couleur et forme :SolidMasse moléculaire :608.55Acetylpepstatin
CAS :Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease.Formule :C33H61N5O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :703.875Stauprimide
CAS :Stauprimide inhibits MYC by blocking NME2, reducing MYC transcription in ESCs.Formule :C35H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.62HDAC10-IN-2
HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39CXCR2 antagonist 6
CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).Formule :C17H16F2N4OSCouleur et forme :SolidMasse moléculaire :362.4CXCR4 modulator-1
CAS :CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.Formule :C23H27N5O2Couleur et forme :SolidMasse moléculaire :405.49SW063058
CAS :SW063058 is an autophagy inducer that specifically disrupts the interaction between Beclin 1 and Bcl-2 without affecting the interactions of Bcl-2 with pro-apoptotic members (such as Bax and BIM). By inhibiting the negative regulation of Beclin 1 (key to autophagy initiation) by Bcl-2, SW063058 enhances autophagic activity without inducing cytotoxicity, apoptosis, or other forms of cell death in vitro.Formule :C22H15BrFIN2O2Couleur et forme :SolidMasse moléculaire :565.17CXCR7 modulator 2
CAS :CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.Formule :C29H42N6O3Couleur et forme :SolidMasse moléculaire :522.68Z-FY-CHO
CAS :Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.Formule :C26H26N2O5Degré de pureté :95.88%Couleur et forme :SolidMasse moléculaire :446.5SCH 563705
CAS :SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formule :C23H27N3O5Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :425.48DCC-3116
CAS :DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.Formule :C26H36F3N7O2Degré de pureté :98.55%Couleur et forme :SoildMasse moléculaire :535.61Gepotidacin mesylate dihydrate
CAS :Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.Formule :C25H36N6O8SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :580.65
