Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1428 produits trouvés pour "Autophagie"
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CXCR2 antagonist 7
<p>CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.</p>Formule :C14H14F2N6OSCouleur et forme :SolidMasse moléculaire :352.36CCX662
CAS :<p>CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.</p>Formule :C28H37N5O4SCouleur et forme :SolidMasse moléculaire :539.69Autophagy-IN-7
CAS :<p>Autophagy-IN-7 is an autophagy inhibitor for use in studying solid tumours.</p>Formule :C15H11N7Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :289.29SYUIQ-5
CAS :<p>SYUIQ-5 is a ligand for G-quadruplex structures. It plays a role in stabilizing G-quadruplexes and inducing senescence. Additionally, SYUIQ-5 inhibits the activity of the c-myc gene promoter. By displacing TRF2 from telomeres, SYUIQ-5 induces telomeric damage, which triggers autophagy (autophagy) in cancer cells.</p>Formule :C20H22N4Couleur et forme :SolidMasse moléculaire :318.415HMG499
CAS :<p>HMG499 inhibits HMG-CoA reductase (IC50: 0.41μM), reduces statin-induced HMGCR, lowers cholesterol, and lessens atherosclerosis.</p>Formule :C33H54O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.78YOK-1304
CAS :<p>YOK-1304, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62.</p>Formule :C28H35NO4Couleur et forme :SolidMasse moléculaire :449.58Anle138b-F105
CAS :<p>Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) with a DC50 value of 3 nM. It targets tauP301L for lysosomal degradation.</p>Formule :C36H37FN4O5Couleur et forme :SolidMasse moléculaire :624.7SLW131
CAS :<p>SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.</p>Formule :C21H27N5O5SCouleur et forme :SolidMasse moléculaire :461.535Autophagy-lysosome activator-1
<p>Autophagy-lysosome Activator-1 (Compound F1) is an autophagy-lysosome stimulator that effectively induces the degradation of PD-L1 or VISTA in tumor cells.</p>Formule :C17H18N4O2Couleur et forme :SolidMasse moléculaire :310.35CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formule :C15H14F2N4O2SCouleur et forme :SolidMasse moléculaire :352.36SHS206
<p>SHS206 (compound 6n) is an orally active mitochondrial uncoupler that decreases triglyceride levels in the liver. Demonstrating in vivo efficacy in a GAN mouse model, SHS206 also exhibits inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH).</p>Formule :C14H7F6N3OCouleur et forme :SolidMasse moléculaire :347.22CXCR4 modulator-1
CAS :<p>CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.</p>Formule :C23H27N5O2Couleur et forme :SolidMasse moléculaire :405.49BRD1991
CAS :<p>BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.</p>Formule :C33H35Cl2N3O4Couleur et forme :SolidMasse moléculaire :608.55DQ661
CAS :<p>DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.</p>Formule :C41H47Cl2N5O2Couleur et forme :SolidMasse moléculaire :712.75LRRK2-IN-6
<p>LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).</p>Formule :C23H24F2N4O2SCouleur et forme :SolidMasse moléculaire :458.52SCH-900875
CAS :<p>SCH-900875 is an orally active, brain-penetrant, and selective inhibitor of the CXCR3 receptor, demonstrating significant selectivity towards CXCR1 and CXCR2 receptors as well. By binding to CXCR3, SCH-900875 blocks the ligands CXCL9, CXCL10, and CXCL11, thereby inhibiting downstream G protein and β-arrestin signaling pathways and reducing inflammation cell migration. This compound holds potential for research into autoimmune diseases (such as rheumatoid arthritis and multiple sclerosis) and inflammatory conditions (such as psoriasis and inflammatory bowel disease).</p>Formule :C28H37ClN8O2Couleur et forme :SolidMasse moléculaire :553.10CXCR4 antagonist 10
CAS :<p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>Formule :C18H18N4O4Couleur et forme :SolidMasse moléculaire :354.36LRRK2-IN-4
CAS :<p>LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.</p>Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99DCC-3116
CAS :<p>DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.</p>Formule :C26H36F3N7O2Degré de pureté :98.55%Couleur et forme :SoildMasse moléculaire :535.61Gepotidacin mesylate dihydrate
CAS :<p>Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.</p>Formule :C25H36N6O8SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :580.65Dusquetide
CAS :<p>Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.</p>Formule :C25H47N9O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.709VUF11207 trifluoroacetate salt
CAS :<p>VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.</p>Formule :C29H36F4N2O6Couleur et forme :SolidMasse moléculaire :584.609Pepstatin Ammonium
<p>Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM</p>Formule :C34H66N6O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :702.92Dihydrocelastrol
CAS :<p>Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE co</p>Formule :C29H40O4Couleur et forme :SolidMasse moléculaire :452.63EIPA hydrochloride
CAS :<p>EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.</p>Formule :C11H19Cl2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.22CXCR4-IN-1
CAS :<p>CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic</p>Formule :C23H32N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.54FR 167653
CAS :<p>FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.</p>Formule :C24H20FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.51VISTA-IN-2
CAS :<p>VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy,</p>Formule :C23H23N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.45
