Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1427 produits trouvés pour "Autophagie"
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Ezetimibe-d4
CAS :<p>Ezetimibe D4, a deuterium-labeled variant of Ezetimibe, functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activation</p>Formule :C24H21F2NO3Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :413.45Ponatinib-d8
CAS :<p>Ponatinib D8 is a deuterium-enriched, oral multi-kinase inhibitor (Abl, PDGFRα, VEGFR2, FGFR1, Src; IC50s: 0.37-5.4 nM).</p>Formule :C29H27F3N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.61Anti-LRRK2 Antibody (1C773)
<p>Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.</p>Couleur et forme :Odour LiquidTetrahydrocurcumin D6
CAS :<p>Tetrahydrocurcumin D6 is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin displays inhibitory activity for CYP2C9 and CYP3A4.</p>Formule :C21H24O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.45Manzamine A
CAS :<p>Manzamine A, from marine sponges, blocks GSK-3, halts cancer growth, prevents bacterial infections, and reduces tau phosphorylation.</p>Formule :C36H44N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.775PS372424 hydrochloride
CAS :<p>PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.</p>Formule :C33H45ClN6O4Degré de pureté :95.03%Couleur et forme :SolidMasse moléculaire :625.2Idelalisib D5
CAS :<p>Idelalisib D5, a version of Idelalisib marked with deuterium, is an orally bioavailable and highly selective inhibitor of p110δ.</p>Formule :C22H18FN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.45Ladarixin
CAS :<p>Ladarixin (DF 2156A free base) is an orally active, non-competitive CXCR1/CXCR2 allosteric inhibitor that suppresses AKT, NF-κB, and angiogenesis.</p>Formule :C11H12F3NO6S2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :375.34Levomepromazine
CAS :<p>Levomepromazine (Methotrimeprazine) is a Ca2+ release inducer with antiviral, anti-inflammatory, neuroprotective, sedative, and anti-nociceptive activities.</p>Formule :C19H24N2OSDegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :328.47Curcumin-d6
CAS :<p>Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a</p>Formule :C21H20O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.422ACT-1004-1239
CAS :<p>ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.</p>Formule :C27H28F2N6O3Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :522.55Motixafortide
CAS :<p>Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).</p>Formule :C97H144FN33O19S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2159.52CXCR2 antagonist 8
CAS :<p>CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.</p>Formule :C14H13N3O5Couleur et forme :SolidMasse moléculaire :303.27ATI-2341
CAS :<p>ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.</p>Formule :C104H178N26O25S2Couleur et forme :SolidMasse moléculaire :2256.82THZ-P1-2
CAS :<p>THZ-P1-2 is a PI5P4K inhibitor with anti-leukemic activity and can be used in the study of leukemia.</p>Formule :C31H29N7O2Couleur et forme :SolidMasse moléculaire :531.61Rosuvastatin Sodium
CAS :<p>Rosuvastatin Sodium: HMGCR inhibitor, blocks hERG (IC50: 11 nM, 195 nM), reduces hERG expression, hinders Hsp70-hERG interaction.</p>Formule :C22H27FN3NaO6SCouleur et forme :SolidMasse moléculaire :503.52Loperamide-d6 hydrochloride
CAS :<p>Loperamide D6 HCl: Deuterium-enriched opioid for diarrhea.</p>Formule :C29H34Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.54Br-DAPI
CAS :<p>IST5-002 (N6-Benzyladenosine-5'-phosphate) is a Stat5a/b inhibitor with anticancer activity and is used in cancer research.</p>Formule :C16H14BrN5Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :356.22OR-1855
CAS :<p>OR-1855 is an active Levosimendan metabolite, has effect on human myometrial contractility.</p>Formule :C11H13N3ODegré de pureté :98%Couleur et forme :Pale Yellow SolidMasse moléculaire :203.24Aliskiren
CAS :<p>Aliskiren (CGP 60536) is a renin inhibitor (IC50: 1.5 nM) with antihypertensive activity and is used in the treatment of various cardiovascular diseases.</p>Formule :C30H53N3O6Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :551.76Venetoclax-d8
CAS :Venetoclax-d8 (ABT-199-d8) is a deuterated form of Venetoclax, a potent, selective, and orally active Bcl-2 inhibitor that induces autophagy and apoptosis.Formule :C45H42D8ClN7O7SCouleur et forme :SolidMasse moléculaire :876.49Omeprazole-d3
CAS :<p>Omeprazole D3 is deuterium labeled Omeprazole. Omeprazole is a proton pump inhibitor (PPI)</p>Formule :C17H19N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.44IKK 16 hydrochloride
CAS :<p>IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.</p>Formule :C28H30ClN5OSCouleur et forme :SolidMasse moléculaire :520.09Pemetrexed disodium heptahydrate
CAS :<p>Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits TS, DHFR and GARFT, inhibits precursor purine and pyrimidine nucleotides.</p>Formule :C20H33N5Na2O13Degré de pureté :99.783%Couleur et forme :SolidMasse moléculaire :597.49Brivanib
CAS :<p>Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against</p>Formule :C19H19FN4O3Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :370.38Peptide R TFA
<p>Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.</p>Formule :C39H57N13O8S2·xC2HF3O2Couleur et forme :SolidMasse moléculaire :900.08 (free base)Cediranib maleate
CAS :<p>Cediranib maleate (AZD2171 maleate) is a VEGFR2 inhibitor that inhibits Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit.</p>Formule :C29H31FN4O7Couleur et forme :SolidMasse moléculaire :566.58Resveratrol analog 1
CAS :<p>Resveratrol analog 1 is a natural product analog of resveratrol, which has more significant anti-leukemic activity than resveratrol.</p>Formule :C14H11FO2Degré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :230.23Rupatadine
CAS :<p>Rupatadine (UR-12592, rupatadine) is a potent and orally available dual antagonist of PAF and histamine H1 receptors ,allergic and anti-inflammatory.</p>Formule :C26H26ClN3Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :415.96Metformin-d6 hydrochloride
CAS :<p>Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.</p>Formule :C4H12ClN5Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :171.66Pyrazinamide-d3
CAS :<p>Pyrazinamide-d3 is a deuterated compound of Pyrazinamide. Pyrazinamide has a CAS number of 98-96-4. Pyrazinamide, an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.</p>Formule :C5D3H2N3OCouleur et forme :SolidMasse moléculaire :126.13Dexamethasone-d5
CAS :<p>Dexamethasone-d5 is a deuterated compound of Dexamethasone.</p>Formule :C22H24D5FO5Couleur et forme :SolidMasse moléculaire :397.49Afatinib D6
CAS :<p>Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor.</p>Formule :C24H25ClFN5O3Couleur et forme :SolidMasse moléculaire :491.98V-9302 hydrochloride
CAS :<p>V-9302 hydrochloride is a competitive transmembrane glutamine flux antagonist that selectively targets the amino acid transporter ASCT2/SLC1A5.</p>Formule :C34H39ClN2O4Degré de pureté :97.31%Couleur et forme :SolidMasse moléculaire :575.14Nilotinib-d6
CAS :<p>Nilotinib D6 is a deuterium labeled Nilotinib which is an orally available inhibitor of Bcr-Abl tyrosine kinase ,and with antineoplastic activity.</p>Formule :C28H22F3N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.55Megestrol Acetate-d3
CAS :<p>Megestrol Acetate-d3 is a deuterated compound of Megestrol Acetate. Megestrol Acetate has a CAS number of 595-33-5. Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.</p>Formule :C24H29D3O4Couleur et forme :SolidMasse moléculaire :387.53Silibinin-d3
<p>Silibinin-d3 is the deuterium-labelled compound of silibinin, used for isotope tracing. Silibinin inhibit cancer cell proliferation and migration.</p>Formule :C25H22O10Couleur et forme :SolidMasse moléculaire :485.46Isorhapontigenin
CAS :<p>Isorhapontigenin: a methoxylated stilbenoid isomer of rhapontigenin, similar to resveratrol, present in Gnetum spp. and Aiphanes aculeata seeds.</p>Formule :C15H14O4Degré de pureté :98.49% - 99.85%Couleur et forme :Off White Crystals PowerMasse moléculaire :258.27Valproic Acid
CAS :<p>Valproic Acid (2-Propylpentanoic Acid) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels.</p>Formule :C8H16O2Degré de pureté :97.78% - 99%Couleur et forme :Colourless To Pale Yellow Liquid ViscousMasse moléculaire :144.21Ginkgolide K
CAS :<p>Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.</p>Formule :C20H22O9Degré de pureté :99.44% - 99.72%Couleur et forme :SolidMasse moléculaire :406.38Momelotinib
CAS :<p>Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.</p>Formule :C23H22N6O2Degré de pureté :97.47% - 99.56%Couleur et forme :SolidMasse moléculaire :414.46Clematichinenoside AR
CAS :<p>Clematichinenoside AR is anti-inflammatory, immunosuppressive, and combats arthritis via PI3K/Akt and TNF-α pathways.</p>Formule :C82H134O43Degré de pureté :99.04% - 99.69%Couleur et forme :SolidMasse moléculaire :1807.92Tanespimycin
CAS :<p>Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!</p>Formule :C31H43N3O8Degré de pureté :99.07% - 99.83%Couleur et forme :Dark Purple SolidMasse moléculaire :585.69Selenomethionine
CAS :<p>DL-Selenomethionine (SeMet) is a selenium analog of methionine, substituting sulfur with selenium, and can replace methionine in proteins.</p>Formule :C5H11NO2SeDegré de pureté :98% - 99.95%Couleur et forme :Transparent Hexagonal Sheets Or Plates; Metallic Luster Of Crystals SolidMasse moléculaire :196.11Dimethyl fumarate
CAS :<p>Dimethyl fumarate (DMF) is an orally Nrf2 activator. Dimethyl fumarate has antimicrobial and anti-inflammatory activities. Cost-effective and quality-assured.</p>Formule :C6H8O4Degré de pureté :90.51% - >99.99%Couleur et forme :White To Off-White Powder White Crystalline PowderMasse moléculaire :144.13ABT-751
CAS :<p>ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.</p>Formule :C18H17N3O4SDegré de pureté :98.84% - 99.50%Couleur et forme :SolidMasse moléculaire :371.41GNE0877
CAS :<p>GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).</p>Formule :C14H16F3N7Degré de pureté :98.01% - 99.97%Couleur et forme :SolidMasse moléculaire :339.32Autophinib
CAS :<p>Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and</p>Formule :C14H11ClN6O3Degré de pureté :99.25% - 99.41%Couleur et forme :SolidMasse moléculaire :346.73Corynoxine
CAS :<p>Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.</p>Formule :C22H28N2O4Degré de pureté :96.83% - 99.93%Couleur et forme :SolidMasse moléculaire :384.47STO-609
CAS :<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Formule :C19H10N2O3Degré de pureté :97.14% - 98.8%Couleur et forme :SolidMasse moléculaire :314.29
