Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1428 produits trouvés pour "Autophagie"
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Corynoxine
CAS :<p>Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.</p>Formule :C22H28N2O4Degré de pureté :96.83% - 99.93%Couleur et forme :SolidMasse moléculaire :384.47STO-609
CAS :<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Formule :C19H10N2O3Degré de pureté :97.14% - 98.8%Couleur et forme :SolidMasse moléculaire :314.29Ataluren
CAS :<p>Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.</p>Formule :C15H9FN2O3Degré de pureté :99.16% - 99.84%Couleur et forme :SolidMasse moléculaire :284.24CHIR-99021
CAS :<p>View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.</p>Formule :C22H18Cl2N8Degré de pureté :97.94% - ≥95%Couleur et forme :SolidMasse moléculaire :465.34Momelotinib
CAS :<p>Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.</p>Formule :C23H22N6O2Degré de pureté :97.47% - 99.56%Couleur et forme :SolidMasse moléculaire :414.46Tanespimycin
CAS :<p>Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!</p>Formule :C31H43N3O8Degré de pureté :99.07% - 99.83%Couleur et forme :Dark Purple SolidMasse moléculaire :585.69Bergapten
CAS :<p>Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.</p>Formule :C12H8O4Degré de pureté :99.48% - ≥95%Couleur et forme :Needles From Alcohol; Soln In Sulfuric Acid Is Yellow-Gold Physical Description Grayish-White Micr°Crystalline Powder Or Yellow Fluffy Solid (Ntp 1992)Masse moléculaire :216.19IOWH-032
CAS :<p>IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.</p>Formule :C22H15Br2N3O4Degré de pureté :98.92% - ≥95%Couleur et forme :SolidMasse moléculaire :545.18Sinomenine
CAS :<p>Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.</p>Formule :C19H23NO4Degré de pureté :99.02% - 99.73%Couleur et forme :White PowderMasse moléculaire :329.39Isorhapontigenin
CAS :<p>Isorhapontigenin: a methoxylated stilbenoid isomer of rhapontigenin, similar to resveratrol, present in Gnetum spp. and Aiphanes aculeata seeds.</p>Formule :C15H14O4Degré de pureté :98.49% - 99.85%Couleur et forme :Off White Crystals PowerMasse moléculaire :258.27Dantrolene
CAS :<p>Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.</p>Formule :C14H10N4O5Degré de pureté :99.97%Couleur et forme :Crystals From Aq DimethylformamideMasse moléculaire :314.25Pinocembrin
CAS :<p>Pinocembrin (5,7-Dihydroxyflavanone) is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.</p>Formule :C15H12O4Degré de pureté :99.61% - >99.99%Couleur et forme :SolidMasse moléculaire :256.25MW-150 dihydrochloride dihydrate
CAS :<p>MW-150: selective CNS-penetrant p38α MAPK inhibitor, orally active, Ki 101 nM, blocks MK2 phosphorylation in glia.</p>Formule :C24H29Cl2N5O2Couleur et forme :SolidMasse moléculaire :490.43Cediranib
CAS :<p>Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.</p>Formule :C25H27FN4O3Degré de pureté :97.21% - 99.94%Couleur et forme :SolidMasse moléculaire :450.51Tubastatin A Hydrochloride
CAS :<p>Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM).</p>Formule :C20H21N3O2·HClDegré de pureté :97.24% - 99.15%Couleur et forme :SolidMasse moléculaire :371.86Quizartinib
CAS :<p>Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.</p>Formule :C29H32N6O4SDegré de pureté :98% - 99.42%Couleur et forme :SolidMasse moléculaire :560.67Apigenin
CAS :<p>Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants.</p>Formule :C15H10O5Degré de pureté :97.64% - 99.66%Couleur et forme :Yellow Needles From Aqueous Pyridine SolidMasse moléculaire :270.24U0126-EtOH
CAS :<p>U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!</p>Formule :C18H16N6S2·C2H6ODegré de pureté :99.72% - 99.88%Couleur et forme :SolidMasse moléculaire :426.6Tenovin-6
CAS :<p>Tenovin-6 is a p53 transcriptional activity agonist.</p>Formule :C25H34N4O2SDegré de pureté :97.71% - >99.99%Couleur et forme :SolidMasse moléculaire :454.63AZD1208
CAS :<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Formule :C21H21N3O2SDegré de pureté :97.24% - 99.83%Couleur et forme :SolidMasse moléculaire :379.48UBCS039
CAS :<p>UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)</p>Formule :C16H13N3Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :247.29Ligustilide
CAS :<p>3-Butylidene-4,5-dihydrophthalide is an effective constituent extracted from Angelica sinensis.</p>Formule :C12H14O2Degré de pureté :96.03% - 98.14%Couleur et forme :Yellow Brown PowderMasse moléculaire :190.24Pinosylvin
CAS :<p>Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.</p>Formule :C14H12O2Degré de pureté :99.89% - 99.91%Couleur et forme :SolidMasse moléculaire :212.24Berbamine dihydrochloride
CAS :<p>Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.</p>Formule :C37H42Cl2N2O6Degré de pureté :95% - 99.99%Couleur et forme :SolidMasse moléculaire :681.65Isosorbide Mononitrate
CAS :<p>Isosorbide Mononitrate (Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.</p>Formule :C6H9NO6Degré de pureté :98.16%Couleur et forme :Isosorbide-5-Mononitrate Is A Crystalline Solid It Is Very Flammable And May Be Toxic By IngestionMasse moléculaire :191.14Entinostat
CAS :<p>Entinostat (MS-275) is an HDAC class I with oral activity. Entinostat has antitumor activity. Cost-effective and quality-assured.</p>Formule :C21H20N4O3Degré de pureté :98% - 99.74%Couleur et forme :SolidMasse moléculaire :376.41CCT128930 hydrochloride
CAS :<p>CCT128930 hydrochloride: Potent AKT inhibitor (IC50=6 nM), 28x selective over PKA, 20x over p70S6K, induces cell cycle arrest & DNA damage.</p>Formule :C18H21Cl2N5Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :378.3Gartanin
CAS :<p>Gartanin enhances androgen receptor degradation and has neuroprotective effects by boosting HO-1, AMPK, SIRT1, and PGC-1α pathways.</p>Formule :C23H24O6Degré de pureté :99.64% - 99.85%Couleur et forme :SolidMasse moléculaire :396.43PTC-209 hydrobromide
CAS :<p>PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in</p>Formule :C17H13Br2N5OS·HBrDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :576.1Autogramin-1
CAS :<p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>Formule :C23H27N5O5SDegré de pureté :97.69% - 99.25%Couleur et forme :SolidMasse moléculaire :485.56XL388
CAS :<p>XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.</p>Formule :C23H22FN3O4SDegré de pureté :99.39% - 99.53%Couleur et forme :SolidMasse moléculaire :455.5NSC 185058
CAS :<p>NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.</p>Formule :C11H9N3SDegré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :215.27PF-543 hydrochloride
CAS :<p>PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2</p>Formule :C27H32ClNO4SDegré de pureté :98.9% - 99.93%Couleur et forme :SolidMasse moléculaire :502.1URMC-099
CAS :<p>URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.</p>Formule :C27H27N5Degré de pureté :99.32% - 99.98%Couleur et forme :SolidMasse moléculaire :421.54Autocamtide-2-related inhibitory peptide
CAS :<p>Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Formule :C64H116N22O19Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :1497.74PF-06447475
CAS :<p>PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.</p>Formule :C17H15N5ODegré de pureté :98.61% - 99.62%Couleur et forme :SolidMasse moléculaire :305.33Onjisaponin B
CAS :<p>Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-</p>Formule :C75H112O35Degré de pureté :99.20% - 99.972%Couleur et forme :SolidMasse moléculaire :1573.67A-867744
CAS :<p>A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).</p>Formule :C20H19ClN2O3SDegré de pureté :95.66%Couleur et forme :SolidMasse moléculaire :402.89MRT68921
CAS :<p>MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.</p>Formule :C25H34N6ODegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :434.58TA-01
CAS :<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Formule :C20H12F3N3Degré de pureté :99.55% - 99.94%Couleur et forme :SolidMasse moléculaire :351.32PI3Kδ-IN-15
CAS :<p>CAL-101 (Idelalisib) is a selective inhibitor of p110δ; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ.</p>Formule :C21H16FN7ODegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :401.4Lanatoside C
CAS :<p>Lanatoside C, a cardiac glycoside, treats heart failure and arrhythmia; taken orally or IV.</p>Formule :C49H76O20Degré de pureté :98.3% - >99.99%Couleur et forme :SolidMasse moléculaire :985.12Spautin-1
CAS :<p>Spautin-1 is an autophagy inhibitor that can suppress the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Cost-effective and quality-assured.</p>Formule :C15H11F2N3Degré de pureté :97.69% - 98.99%Couleur et forme :SolidMasse moléculaire :271.26Sofalcone
CAS :<p>Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.</p>Formule :C27H30O6Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :450.52Hesperadin
CAS :<p>Hesperadin(IC50=250 nM) effectively inhibits Aurora B.</p>Formule :C29H32N4O3SDegré de pureté :98.04% - 99.44%Couleur et forme :SolidMasse moléculaire :516.65Nitroprusside disodium dihydrate
CAS :<p>Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.</p>Formule :C5H4FeN6Na2O3Degré de pureté :98%Couleur et forme :Bright RedMasse moléculaire :297.95UNC1999
CAS :<p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>Formule :C33H43N7O2Degré de pureté :99.19% - >99.99%Couleur et forme :SolidMasse moléculaire :569.74Paris saponin VII
CAS :<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formule :C51H82O21Degré de pureté :99.51% - 99.63%Couleur et forme :SolidMasse moléculaire :1031.18Ivacaftor
CAS :<p>Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,</p>Formule :C24H28N2O3Degré de pureté :99% - 99.98%Couleur et forme :SolidMasse moléculaire :392.49α-Thujone
CAS :<p>α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.</p>Formule :C10H16ODegré de pureté :97.02% - 98.41%Couleur et forme :Less Or Almost Colorless Liquid With A Menthol- Like Odor (Albert-Puleo 1978; Budavari 1996) Colorless Or Almost Colorless Liquid With A Menthol- Like Odor (Albert-Puleo 1978; Budavari 1996)Masse moléculaire :152.23
