Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1428 produits trouvés pour "Autophagie"
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AS-605240
CAS :<p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>Formule :C12H7N3O2SDegré de pureté :97% - 99.91%Couleur et forme :SolidMasse moléculaire :257.27Degrasyn
CAS :<p>Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.</p>Formule :C19H18BrN3ODegré de pureté :98.32% - 99.98%Couleur et forme :SolidMasse moléculaire :384.27Nesolicaftor
CAS :<p>Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.</p>Formule :C18H18N4O4Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :354.36Norepinephrine
CAS :<p>Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway.</p>Formule :C8H11NO3Degré de pureté :99.43% - 99.84%Couleur et forme :Colorless Microcrystals SolidMasse moléculaire :169.18Purvalanol A
CAS :<p>Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.</p>Formule :C19H25ClN6ODegré de pureté :98.13% - 99.68%Couleur et forme :PowderMasse moléculaire :388.89Hydroxychloroquine
CAS :<p>HCQ, an anti-malarial, may induce cancer cell death and is being explored for COVID-19.</p>Formule :C18H26ClN3ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :335.87Talarozole
CAS :<p>Talarozole is an oral RAMBA for treating acne and psoriasis, inhibiting CYP26A1/26B1 with IC50s of 5.4/0.46 nM.</p>Formule :C21H23N5SDegré de pureté :97.51%Couleur et forme :SolidMasse moléculaire :377.51PD146176
CAS :<p>PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.</p>Formule :C15H11NSDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :237.32Nordihydroguaiaretic acid
CAS :<p>Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.</p>Formule :C18H22O4Degré de pureté :97.82% - 99.91%Couleur et forme :SolidMasse moléculaire :302.36Torin 2
CAS :<p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>Formule :C24H15F3N4ODegré de pureté :98.31% - 99.32%Couleur et forme :SolidMasse moléculaire :432.4Regorafenib
CAS :<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Formule :C21H15ClF4N4O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :482.82IITZ-01
CAS :<p>IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)</p>Formule :C26H23FN8ODegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :482.51Paeonol
CAS :<p>Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.</p>Formule :C9H10O3Degré de pureté :98.55% - 99.56%Couleur et forme :White To Beige Crystalline PowderMasse moléculaire :166.17PF-3845
CAS :<p>PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.</p>Formule :C24H23F3N4O2Degré de pureté :99.54% - 99.58%Couleur et forme :SolidMasse moléculaire :456.46A-867744
CAS :<p>A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).</p>Formule :C20H19ClN2O3SDegré de pureté :95.66%Couleur et forme :SolidMasse moléculaire :402.89Apigenin
CAS :<p>Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants.</p>Formule :C15H10O5Degré de pureté :97.64% - 99.66%Couleur et forme :Yellow Needles From Aqueous Pyridine SolidMasse moléculaire :270.24ABT-751
CAS :<p>ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.</p>Formule :C18H17N3O4SDegré de pureté :98.84% - 99.50%Couleur et forme :SolidMasse moléculaire :371.41Cordycepin
CAS :<p>Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic</p>Formule :C10H13N5O3Degré de pureté :99.87% - >99.99%Couleur et forme :Crystalline SolidMasse moléculaire :251.24TFEB activator 1
CAS :<p>TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's</p>Formule :C19H18O3Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :294.34Corosolic acid
CAS :<p>Corosolic acid inhibits angiogenesis, suppresses FAK, fights various cancers, induces apoptosis, and degrades β-catenin.</p>Formule :C30H48O4Degré de pureté :99.46% - 99.88%Couleur et forme :Fine-Brown Yellow PowderMasse moléculaire :472.7Eprenetapopt
CAS :<p>Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells.</p>Formule :C10H17NO3Degré de pureté :98.75% - 99.57%Couleur et forme :SolidMasse moléculaire :199.25WYE-354
CAS :<p>WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).</p>Formule :C24H29N7O5Degré de pureté :97.86% - 99.61%Couleur et forme :SolidMasse moléculaire :495.53(-)-Epigallocatechin
CAS :<p>(-)-Epigallocatechin, the predominant flavonoid in green tea, possesses the unique ability to attach to unfolded native polypeptides, thereby inhibiting their</p>Formule :C15H14O7Degré de pureté :98.83% - >99.99%Couleur et forme :White PowderMasse moléculaire :306.27ML-SA1
CAS :<p>ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity.</p>Formule :C22H22N2O3Degré de pureté :99.34% - 99.71%Couleur et forme :SolidMasse moléculaire :362.42Sedanolide
CAS :<p>Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery.</p>Formule :C12H18O2Degré de pureté :≥95% - ≥98%Couleur et forme :SolidMasse moléculaire :194.27Oprozomib
CAS :<p>Oprozomib inhibits 20S proteasome β5/LMP7, is orally available, and may have cancer-fighting properties. IC50: β5 - 36 nM; LMP7 - 82 nM.</p>Formule :C25H32N4O7SDegré de pureté :98% - 99.87%Couleur et forme :SolidMasse moléculaire :532.61Bicyclol
CAS :<p>Bicyclol is an oral anti-hepatitis drug, decreasing ALT/AST levels by 50% and inhibiting HBV/HCV, boosting efficacy with interferon/lamivudine/adefovir.</p>Formule :C19H18O9Degré de pureté :99.64% - 99.85%Couleur et forme :SolidMasse moléculaire :390.34NS1643
CAS :<p>NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.</p>Formule :C15H10F6N2O3Degré de pureté :98.37% - 99.31%Couleur et forme :SolidMasse moléculaire :380.24Tezacaftor
CAS :<p>Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.</p>Formule :C26H27F3N2O6Degré de pureté :98.84% - >99.99%Couleur et forme :SolidMasse moléculaire :520.5PI-103
CAS :<p>PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).</p>Formule :C19H16N4O3Degré de pureté :97.79% - 99.3%Couleur et forme :SolidMasse moléculaire :348.36Genipin
CAS :<p>Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.</p>Formule :C11H14O5Degré de pureté :99.09% - 99.21%Couleur et forme :SolidMasse moléculaire :226.23Regorafenib monohydrate
CAS :<p>Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine</p>Formule :C21H17ClF4N4O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :500.83Purmorphamine
CAS :<p>Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo.</p>Formule :C31H32N6O2Degré de pureté :97.19% - 99.48%Couleur et forme :Light Tan SolidMasse moléculaire :520.62PATULIN
CAS :<p>Patulin (Claviform) is a mycotoxin produced by a variety of molds commonly found in rotting apples, including Aspergillus and Penicillium.</p>Formule :C7H6O4Degré de pureté :99.91% - 99.98%Couleur et forme :Compact Prisms Or Thick Plates From Ether Or Chloroform White CrystallineMasse moléculaire :154.12Sirtinol
CAS :<p>Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).</p>Formule :C26H22N2O2Degré de pureté :97.12% - 99.96%Couleur et forme :SolidMasse moléculaire :394.47Sertaconazole nitrate
CAS :<p>Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.</p>Formule :C20H15Cl3N2OS·HNO3Degré de pureté :98.66% - 99.65%Couleur et forme :SolidMasse moléculaire :500.78ULK-101
CAS :<p>ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.</p>Formule :C22H16F4N4OSDegré de pureté :97.55% - 99.94%Couleur et forme :SolidMasse moléculaire :460.45Nocodazole
CAS :<p>Nocodazole: synthetic microtubule polymerization blocker, also impedes Abl with low IC50; binds to beta-tubulin.</p>Formule :C14H11N3O3SDegré de pureté :98% - 99.91%Couleur et forme :Physical Description White Powder (Ntp 1992)Masse moléculaire :301.32Hesperadin
CAS :<p>Hesperadin(IC50=250 nM) effectively inhibits Aurora B.</p>Formule :C29H32N4O3SDegré de pureté :98.04% - 99.44%Couleur et forme :SolidMasse moléculaire :516.65PF-06447475
CAS :<p>PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.</p>Formule :C17H15N5ODegré de pureté :98.61% - 99.62%Couleur et forme :SolidMasse moléculaire :305.33Isosorbide Mononitrate
CAS :<p>Isosorbide Mononitrate (Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.</p>Formule :C6H9NO6Degré de pureté :98.16%Couleur et forme :Isosorbide-5-Mononitrate Is A Crystalline Solid It Is Very Flammable And May Be Toxic By IngestionMasse moléculaire :191.14Quizartinib
CAS :<p>Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.</p>Formule :C29H32N6O4SDegré de pureté :98% - 99.42%Couleur et forme :SolidMasse moléculaire :560.67Cediranib
CAS :<p>Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.</p>Formule :C25H27FN4O3Degré de pureté :97.21% - 99.94%Couleur et forme :SolidMasse moléculaire :450.51STO-609
CAS :<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Formule :C19H10N2O3Degré de pureté :97.14% - 98.8%Couleur et forme :SolidMasse moléculaire :314.29Tanespimycin
CAS :<p>Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!</p>Formule :C31H43N3O8Degré de pureté :99.07% - 99.83%Couleur et forme :Dark Purple SolidMasse moléculaire :585.69Embelin
CAS :<p>Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).</p>Formule :C17H26O4Degré de pureté :97.07% - 99.88%Couleur et forme :SolidMasse moléculaire :294.39Dynasore
CAS :<p>Dynasore, a cell-permeable dynamin inhibitor, blocks GTPase of dynamin 1/2 and Drp1 (IC50: 15 μM) without affecting other small GTPases.</p>Formule :C18H14N2O4Degré de pureté :95.85% - 99.22%Couleur et forme :SolidMasse moléculaire :322.31GNE-9605
CAS :<p>GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).</p>Formule :C17H20ClF4N7ODegré de pureté :98.55% - 98.75%Couleur et forme :SolidMasse moléculaire :449.83NH125
CAS :<p>NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.</p>Formule :C27H45IN2Degré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :524.56Sertindole
CAS :<p>Sertindole, atypical antipsychotic, targets D2, 5-HT1D, 5-HT2A, 5-HT2C receptors (Kds: 2.7, 20, 0.14, 6 nM).</p>Formule :C24H26ClFN4ODegré de pureté :99.87% - 99.92%Couleur et forme :Off-White To Pale Yellow SolidMasse moléculaire :440.94
