Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1427 produits trouvés pour "Autophagie"
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Lamotrigine isethionate
CAS :<p>Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.</p>Formule :C11H13Cl2N5O4SCouleur et forme :SolidMasse moléculaire :382.22SR 3677 dihydrochloride
CAS :<p>Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).</p>Formule :C22H26Cl2N4O4Couleur et forme :SolidMasse moléculaire :481.37NSC 33994
CAS :<p>NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.</p>Formule :C28H42N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.65CXCR4 modulator-2
CAS :<p>CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.</p>Formule :C21H32N8O2Couleur et forme :SolidMasse moléculaire :428.53SMYD3-IN-2
<p>SMYD3-IN-2, a cancer research chemical, inhibits SMYD3 (IC50 0.81 μM) and BGC823 (IC50 0.75 μM), inducing fatal autophagy in gastric cancer.</p>Formule :C26H21BrN2O4Couleur et forme :SolidMasse moléculaire :505.36Antitumor agent-81
CAS :<p>Antitumor agent-81, a P62-RNF168 agonist, reduces H2A ubiquitination, hinders DNA repair, and inhibits tumor growth.</p>Formule :C19H19N7O3Couleur et forme :SolidMasse moléculaire :393.4ROC-325
CAS :<p>ROC-325: orally active autophagy inhibitor with anticancer effects, induces kidney cancer cell death; selective action.</p>Formule :C28H27ClN4OSDegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :503.06MPM-1
<p>MPM-1, a marine mimic, induces rapid necrotic-like death in cancer cells, disrupts autophagy, and causes lysosomal swelling.</p>Formule :C34H44F6N4O7Couleur et forme :SolidMasse moléculaire :734.73(Rac)-AZD 6482
CAS :<p>(Rac)-AZD 6482 is the racemate of AZD 6482. AZD 6482 is a potent and selective inhibitor of p110β (IC50 of 0.69 nM).</p>Formule :C22H24N4O4Couleur et forme :SolidMasse moléculaire :408.45K67
CAS :<p>K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.</p>Formule :C29H30N2O7S2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :582.69CCT128930
CAS :<p>'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'</p>Formule :C18H20ClN5Degré de pureté :99.07% - 99.18%Couleur et forme :SolidMasse moléculaire :341.84SR12418
CAS :<p>SR12418 is a specific synthetic ligand for REV-ERBα (IC50 = 68 nM) and REV-ERBβ (IC50 = 119 nM) in TR-FRET assays. inhibits IL-17A expression in EL4 cells.</p>Formule :C31H30FNO3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :483.57IT1t
CAS :<p>IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.</p>Formule :C21H34N4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.65CUR5g
CAS :<p>CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells.</p>Formule :C22H20N2O2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :344.41Amsacrine
CAS :<p>Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.</p>Formule :C21H19N3O3SDegré de pureté :99.2%Couleur et forme :Yellow Crystalline Powder SolidMasse moléculaire :393.46Autophagy inducer 3
CAS :<p>Autophagy Inducer 3 triggers selective cancer cell death via autophagy, sparing healthy cells.</p>Formule :C24H43NO2Couleur et forme :SolidMasse moléculaire :377.6Dinoprost
CAS :<p>Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient.</p>Formule :C20H34O5Degré de pureté :97.94% - 98.04%Couleur et forme :White To Off-White Crystalline SolidMasse moléculaire :354.48AMG 487 (S-enantiomer)
CAS :<p>AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.</p>Formule :C32H28F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.59Evogliptin
CAS :<p>Evogliptin (DA-1229) is an oral DPP4 inhibitor effective in reducing blood sugar and liver inflammation.</p>Formule :C19H26F3N3O3Couleur et forme :SolidMasse moléculaire :401.42ATG7-IN-3
CAS :<p>ATG7-IN-3, or compound 18, is an ATG7 inhibitor with a 0.048 μM IC50, blocking autophagy and LC3B puncta in H4 cells.</p>Formule :C11H16N6O5S2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :376.41Xantocillin
CAS :<p>Xanthocillin is a marine agent. Xanthocillin also induces autophagy through inhibition of the MEK/ERK pathway.</p>Formule :C18H12N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :288.3YM-155 hydrochloride
CAS :<p>Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant that inhibits survivin promoter with an IC 50 of 0.54 nM[1].</p>Formule :C20H19ClN4O3Couleur et forme :SolidMasse moléculaire :398.85OSU-53
CAS :<p>OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.</p>Formule :C25H24F3N3O6S2Couleur et forme :SolidMasse moléculaire :583.6ABTL-0812
CAS :<p>ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity.</p>Formule :C18H32O3Couleur et forme :SolidMasse moléculaire :296.44HF50731
CAS :<p>HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).</p>Formule :C26H46N4Couleur et forme :SolidMasse moléculaire :414.67(Rac)-BL-918
CAS :<p>(Rac)-BL-918 is the racemic form of BL-918. BL-918 is an effective activator of UNC-51-like kinase 1 (ULK1) (EC₅₀ = 24.14 nM), Parkinson's disease.</p>Formule :C23H15F8N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :533.44FAAH inhibitor 1
CAS :<p>FAAH inhibitor 1 (Benzothiazole analog 3) is an effective FAAH inhibitor with an IC50 of 18 nM.</p>Formule :C24H23N3O3S3Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :497.65GSK3-IN-3
CAS :<p>GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.</p>Formule :C24H35N3O4Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :429.55MDK-6983
CAS :<p>MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.</p>Formule :C22H18Cl2N2O3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :429.3MRT-68601 HCl
CAS :<p>MRT-68601 HCl, a potent TBK1 (TANK-binding kinase-1), inhibits the formation of autophagosomes in lung cancer cells.</p>Formule :C25H34N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.58YOK-2204
CAS :<p>YOK-2204 is a ligand for the p62-ZZ domain and activates p62-dependent selective autophagy. It is also applicable in the design of AUTOTACs.</p>Formule :C28H35NO4Couleur et forme :SolidMasse moléculaire :449.58FC131
CAS :<p>CXCR4 antagonist</p>Formule :C36H47N11O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :729.83SA72
CAS :<p>SA72 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH).</p>Formule :C21H26N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.44SX-517
CAS :<p>SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.</p>Formule :C19H16BFN2O3SCouleur et forme :SolidMasse moléculaire :382.22TN-14003
CAS :<p>TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.</p>Formule :C90H141N33O18S2Couleur et forme :SolidMasse moléculaire :2037.42RNF5 inhibitor inh-02
CAS :<p>RNF5 inhibitor inh-02 is a selective inhibitor of the ubiquitin ligase RNF5/RMA1, which can significantly rescue F508del-CFTR cystic fibrosis (CF).</p>Formule :C23H20N4SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :384.5Evogliptin tartrate
CAS :<p>Evogliptin tartrate: Oral DPP-4 inhibitor, may treat atherosclerosis and diabetes.</p>Formule :C23H32F3N3O9Couleur et forme :SolidMasse moléculaire :551.51SR-17398
CAS :<p>SR-17398 is an inhibitor of Unc-51-Like Kinase 1 (ULK1) (IC50 = 22.4 uM).</p>Formule :C14H18N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.32(S)-Hydroxychloroquine
CAS :<p>(S)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine shows efficiently inhibits SARS-CoV-2 infection in vitro.</p>Formule :C18H26ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :335.87IZCZ-3
CAS :<p>IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.</p>Formule :C46H49N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :715.93KRH-1636
CAS :<p>KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.</p>Formule :C32H37N7O2Couleur et forme :SolidMasse moléculaire :551.68Autophagy inducer 4
CAS :<p>Autophagy inducer 4, a Magnolol-based Mannich derivative, is an anticancer agent that blocks cancer cell migration & is 76x more toxic to T47D cells.</p>Formule :C32H37NO6Couleur et forme :SolidMasse moléculaire :531.64PX20606 trans racemate
CAS :<p>PX20606 trans racemate is an agonist of FXR (EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively).</p>Formule :C29H22Cl3NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :554.85LRRK2-IN-7
CAS :<p>LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.</p>Formule :C24H26N6ODegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :414.5AZD8309
CAS :<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Formule :C15H14F2N4O2S2Degré de pureté :98.35% - 99.67%Couleur et forme :SolidMasse moléculaire :384.42ITX5061
CAS :<p>ITX5061 is a type II inhibitor of p38 MAPK and scavenger receptor B1 (SRB1) antagonist for the study of hepatitis C virus infection.</p>Formule :C30H38ClN3O7SDegré de pureté :98.35%Couleur et forme :SolidMasse moléculaire :620.16CCT020312
CAS :<p>CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB.Cost-effective and quality-assured.</p>Formule :C31H30Br2N4O2Degré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :650.4Atg4B-IN-2
CAS :<p>Atg4B-IN-2 is an Atg4B inhibitor with anticancer activity that inhibits Atg4B and PLA2 and resists the anticancer activity of resistant prostate cancer drugs.</p>Formule :C21H30O3Degré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :330.46NUCC-390
CAS :<p>NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.</p>Formule :C23H33N5ODegré de pureté :97.08%Couleur et forme :SolidMasse moléculaire :395.54MAPK13-IN-1
CAS :<p>MAPK13-IN-1 is a potent MAPK13 (p38δ) inhibitor (IC50: 620 nM).</p>Formule :C20H23N5O2Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :365.43
