Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1431 produits trouvés pour "Autophagie"
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Rosiglitazone sodium
CAS :Rosiglitazone sodium is an effective and selective PPARγ activator, with EC50 values of 30 nM for PPARγ1, 100 nM for PPARγ2, and 60 nM for PPARγ. It also has an approximate Kd of 40 nM for PPARγ. Additionally, Rosiglitazone sodium acts as a regulator of TRP channels, inhibiting the activities of TRPM2 and TRPM3, while activating TRPC5.Formule :C18H18N3NaO3SCouleur et forme :SolidMasse moléculaire :379.41BRD1991
CAS :<p>BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.</p>Formule :C33H35Cl2N3O4Couleur et forme :SolidMasse moléculaire :608.55Autophagy activator-1
CAS :<p>Autophagyactivator-1 (Compound B2) is an autophagy activator that induces autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.</p>Formule :C25H32O8Couleur et forme :SolidMasse moléculaire :460.517SCH 563705
CAS :<p>SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.</p>Formule :C23H27N3O5Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :425.48BRD5631
CAS :BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway.Formule :C30H35N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.62Autophagy-lysosome activator-1
<p>Autophagy-lysosome Activator-1 (Compound F1) is an autophagy-lysosome stimulator that effectively induces the degradation of PD-L1 or VISTA in tumor cells.</p>Formule :C17H18N4O2Couleur et forme :SolidMasse moléculaire :310.35CXCR4 modulator-1
CAS :<p>CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.</p>Formule :C23H27N5O2Couleur et forme :SolidMasse moléculaire :405.49CXCR2 antagonist 6
<p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>Formule :C17H16F2N4OSCouleur et forme :SolidMasse moléculaire :362.4CXCR4 antagonist 3
<p>CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.</p>Formule :C22H31N5Couleur et forme :SolidMasse moléculaire :365.52SLW131
CAS :<p>SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.</p>Formule :C21H27N5O5SCouleur et forme :SolidMasse moléculaire :461.535Anle138b-F105
CAS :<p>Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) with a DC50 value of 3 nM. It targets tauP301L for lysosomal degradation.</p>Formule :C36H37FN4O5Couleur et forme :SolidMasse moléculaire :624.7EMU-116
CAS :<p>EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.</p>Formule :C25H35N5Couleur et forme :SolidMasse moléculaire :405.58SCH-900875
CAS :<p>SCH-900875 is an orally active, brain-penetrant, and selective inhibitor of the CXCR3 receptor, demonstrating significant selectivity towards CXCR1 and CXCR2 receptors as well. By binding to CXCR3, SCH-900875 blocks the ligands CXCL9, CXCL10, and CXCL11, thereby inhibiting downstream G protein and β-arrestin signaling pathways and reducing inflammation cell migration. This compound holds potential for research into autoimmune diseases (such as rheumatoid arthritis and multiple sclerosis) and inflammatory conditions (such as psoriasis and inflammatory bowel disease).</p>Formule :C28H37ClN8O2Couleur et forme :SolidMasse moléculaire :553.10Hesperadin hydrochloride
<p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12HDAC10-IN-2
<p>HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.</p>Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39YOK-1304
CAS :<p>YOK-1304, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62.</p>Formule :C28H35NO4Couleur et forme :SolidMasse moléculaire :449.58SH498
CAS :<p>SH498 is a novel Bmi-1-mediated anti-tumor agent with significant anti-proliferative effects.</p>Formule :C27H25F3N2O4Couleur et forme :SolidMasse moléculaire :498.49QW24
CAS :<p>QW24 down-regulates BMI-1, exhibits potent antitumour effects and is used as an effective therapeutic agent in the treatment of clinical colorectal cancer.</p>Formule :C27H28N2O4Couleur et forme :SolidMasse moléculaire :444.52LRRK2-IN-3
CAS :<p>LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.</p>Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99CXCR7 modulator 2
CAS :CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.Formule :C29H42N6O3Couleur et forme :SolidMasse moléculaire :522.68Acetylpepstatin
CAS :<p>Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease.</p>Formule :C33H61N5O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :703.875DCC-3116
CAS :<p>DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.</p>Formule :C26H36F3N7O2Degré de pureté :98.55%Couleur et forme :SoildMasse moléculaire :535.61Gepotidacin mesylate dihydrate
CAS :<p>Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.</p>Formule :C25H36N6O8SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :580.65VUF11207 trifluoroacetate salt
CAS :<p>VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.</p>Formule :C29H36F4N2O6Couleur et forme :SolidMasse moléculaire :584.609Dihydrocelastrol
CAS :<p>Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE co</p>Formule :C29H40O4Couleur et forme :SolidMasse moléculaire :452.63Pepstatin Ammonium
<p>Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM</p>Formule :C34H66N6O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :702.92Dusquetide
CAS :<p>Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.</p>Formule :C25H47N9O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.709EIPA hydrochloride
CAS :<p>EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.</p>Formule :C11H19Cl2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.22CXCR4-IN-1
CAS :<p>CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic</p>Formule :C23H32N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.54FR 167653
CAS :<p>FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.</p>Formule :C24H20FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.51VISTA-IN-2
CAS :<p>VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy,</p>Formule :C23H23N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.45
