Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1494 produits trouvés pour "Autophagie"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
SHS206
SHS206 (compound 6n) is an orally active mitochondrial uncoupler that decreases triglyceride levels in the liver. Demonstrating in vivo efficacy in a GAN mouse model, SHS206 also exhibits inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH).Formule :C14H7F6N3OCouleur et forme :SolidMasse moléculaire :347.22SH498
CAS :SH498 is a novel Bmi-1-mediated anti-tumor agent with significant anti-proliferative effects.
Formule :C27H25F3N2O4Couleur et forme :SolidMasse moléculaire :498.49SORT1-IN-2
CAS :SORT1-IN-2 (compound 6) is an inhibitor of SORT1.Formule :C21H29N3O4Couleur et forme :SolidMasse moléculaire :387.47QW24
CAS :QW24 down-regulates BMI-1, exhibits potent antitumour effects and is used as an effective therapeutic agent in the treatment of clinical colorectal cancer.Formule :C27H28N2O4Couleur et forme :SolidMasse moléculaire :444.52ATG12-IN-1
CAS :ATG12-IN-1 (compound 4) acts as an autophagy inhibitor targeting the ATG12-ATG3 protein-protein interaction (IC50= 9 μM), suitable for research in cancer studies.Formule :C23H15ClN4O2Couleur et forme :SolidMasse moléculaire :414.84SW063058
CAS :SW063058 is an autophagy inducer that specifically disrupts the interaction between Beclin 1 and Bcl-2 without affecting the interactions of Bcl-2 with pro-apoptotic members (such as Bax and BIM). By inhibiting the negative regulation of Beclin 1 (key to autophagy initiation) by Bcl-2, SW063058 enhances autophagic activity without inducing cytotoxicity, apoptosis, or other forms of cell death in vitro.Formule :C22H15BrFIN2O2Couleur et forme :SolidMasse moléculaire :565.17HDAC10-IN-2
HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39CXCR4 antagonist 3
CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.Formule :C22H31N5Couleur et forme :SolidMasse moléculaire :365.52Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12LRRK2-IN-4
CAS :LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99DQ661
CAS :DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.Formule :C41H47Cl2N5O2Couleur et forme :SolidMasse moléculaire :712.75Rosiglitazone sodium
CAS :Rosiglitazone sodium is an effective and selective PPARγ activator, with EC50 values of 30 nM for PPARγ1, 100 nM for PPARγ2, and 60 nM for PPARγ. It also has an approximate Kd of 40 nM for PPARγ. Additionally, Rosiglitazone sodium acts as a regulator of TRP channels, inhibiting the activities of TRPM2 and TRPM3, while activating TRPC5.Formule :C18H18N3NaO3SCouleur et forme :SolidMasse moléculaire :379.41ST-539
CAS :ST-539 is an inhibitor of the deubiquitinating enzyme USP30, with an IC50 of 0.37 μM. It enhances the ubiquitination of mitochondrial proteins and induces mitophagy (autophagy), thereby regulating mitochondrial homeostasis. ST-539 is applicable for research in neurodegenerative diseases.Formule :C30H31N3O4SCouleur et forme :SolidMasse moléculaire :529.65LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.Formule :C24H26F2N4O2SCouleur et forme :SolidMasse moléculaire :472.55SRI-31255
CAS :SRI-31255 is an orally active LRRK2 inhibitor, with IC50 values of 520 nM for human wild-type (WT) and 427 nM for the G2019S mutant. It inhibits kinase activity by binding to the ATP-binding pocket of LRRK2, providing neuroprotective effects. SRI-31255 serves as a lead compound for developing LRRK2-targeted therapies for Parkinson’s disease research.Formule :C15H14N4Couleur et forme :SolidMasse moléculaire :250.30CCX662
CAS :CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Formule :C28H37N5O4SCouleur et forme :SolidMasse moléculaire :539.69Anle138b-F105
CAS :Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) with a DC50 value of 3 nM. It targets tauP301L for lysosomal degradation.Formule :C36H37FN4O5Couleur et forme :SolidMasse moléculaire :624.7LC3B recruiter 1
CAS :LC3B recruiter 1 (compound 33R) is an LC3B recruiting fragment. It directly interacts with LC3B, exhibiting a Kd value of 2.87 µM.Formule :C14H10ClN3O2Couleur et forme :SolidMasse moléculaire :287.701ACT-672125
CAS :ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.Formule :C25H25F3N10O2SCouleur et forme :SolidMasse moléculaire :586.59PARL-IN-1
PARL-IN-1: Strong PARL blocker, IC50 28 nM, boosts PINK1/Parkin mitophagy.Formule :C40H58N6O7Couleur et forme :SolidMasse moléculaire :734.92ACT-777991
CAS :ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.Formule :C20H20F6N8O2SCouleur et forme :SolidMasse moléculaire :550.48CXCR2 antagonist 4
CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.Formule :C15H14F2N4OS2Couleur et forme :SolidMasse moléculaire :368.424-FPBUA
CAS :4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.Formule :C31H23FO7Couleur et forme :SolidMasse moléculaire :526.51LRRK2-IN-2
CAS :LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.Formule :C23H23Cl2F3N6O2Couleur et forme :SolidMasse moléculaire :543.37(R)-SCH 546738
CAS :(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Formule :C23H31Cl2N7OCouleur et forme :SolidMasse moléculaire :492.45CXCR7 antagonist-1 hydrochloride
CAS :CXCR7 antagonist-1 hydrochloride, Inhibits SDF-1 (CXCL12) or I-TAC binding to CXCR7, used for tumor and inflammation research.Formule :C21H20ClFN6ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :426.87HDAC10-IN-1
HDAC10-IN-1 is a potent, selective HDAC10 inhibitor (IC50=58 nM) affecting autophagy in FLT3-ITD+ acute myeloid leukemia cells.Formule :C18H23N3O2Couleur et forme :SolidMasse moléculaire :313.39CXCR4 antagonist 10
CAS :CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Formule :C18H18N4O4Couleur et forme :SolidMasse moléculaire :354.36Stauprimide
CAS :Stauprimide inhibits MYC by blocking NME2, reducing MYC transcription in ESCs.Formule :C35H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.62SCH 563705
CAS :SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formule :C23H27N3O5Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :425.48BRD1991
CAS :BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.Formule :C33H35Cl2N3O4Couleur et forme :SolidMasse moléculaire :608.55CXCR4 modulator-1
CAS :CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.Formule :C23H27N5O2Couleur et forme :SolidMasse moléculaire :405.49LRRK2-IN-3
CAS :LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99Gepotidacin mesylate dihydrate
CAS :Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.Formule :C25H36N6O8SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :580.65DCC-3116
CAS :DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.Formule :C26H36F3N7O2Degré de pureté :98.55%Couleur et forme :SoildMasse moléculaire :535.61VUF11207 trifluoroacetate salt
CAS :VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.Formule :C29H36F4N2O6Couleur et forme :SolidMasse moléculaire :584.609Dusquetide
CAS :Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.Formule :C25H47N9O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.709Pepstatin Ammonium
Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nMFormule :C34H66N6O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :702.92Dihydrocelastrol
CAS :Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE coFormule :C29H40O4Couleur et forme :SolidMasse moléculaire :452.63Salvianolic acid B
CAS :Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia miltiorrhiza extract with antiplatelet aggregation and antithrombotic effects.
Formule :C36H30O16Degré de pureté :99.75% - 99.86%Couleur et forme :Yellow SolidMasse moléculaire :718.61FR 167653
CAS :FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.Formule :C24H20FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.51EIPA hydrochloride
CAS :EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.Formule :C11H19Cl2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.22CXCR4-IN-1
CAS :CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic
Formule :C23H32N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.54VISTA-IN-2
CAS :VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy,
Formule :C23H23N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.45
