Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1427 produits trouvés pour "Autophagie"
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4E2RCat
CAS :<p>4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expression</p>Formule :C22H14ClNO4S2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :455.93SAFit2
CAS :<p>SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51).Cost-effective and quality-assured</p>Formule :C46H62N2O10Degré de pureté :98.16% - >99.99%Couleur et forme :SolidMasse moléculaire :802.99AZ PFKFB3 26
CAS :<p>AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.</p>Formule :C24H26N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :402.49PHY34
CAS :<p>PHY34 inhibits autophagy at nanomolar potency, with anti-tumor effects on HGSOC in vivo.</p>Formule :C30H30O12Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :582.55CXCR2-IN-1
CAS :<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Formule :C19H20Cl2FN3O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :476.35GDC-0349
CAS :<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Formule :C24H32N6O3Degré de pureté :96.00% - 98.17%Couleur et forme :SolidMasse moléculaire :452.55SORT1-IN-2
CAS :<p>SORT1-IN-2 (compound 6) is an inhibitor of SORT1.</p>Formule :C21H29N3O4Couleur et forme :SolidMasse moléculaire :387.47Z-FY-CHO
CAS :<p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>Formule :C26H26N2O5Degré de pureté :95.88%Couleur et forme :SolidMasse moléculaire :446.5SW063058
CAS :<p>SW063058 is an autophagy inducer that specifically disrupts the interaction between Beclin 1 and Bcl-2 without affecting the interactions of Bcl-2 with pro-apoptotic members (such as Bax and BIM). By inhibiting the negative regulation of Beclin 1 (key to autophagy initiation) by Bcl-2, SW063058 enhances autophagic activity without inducing cytotoxicity, apoptosis, or other forms of cell death in vitro.</p>Formule :C22H15BrFIN2O2Couleur et forme :SolidMasse moléculaire :565.17LRRK2-IN-5
<p>LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.</p>Formule :C24H26F2N4O2SCouleur et forme :SolidMasse moléculaire :472.55Acetylpepstatin
CAS :<p>Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease.</p>Formule :C33H61N5O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :703.875SCH-900875
CAS :<p>SCH-900875 is an orally active, brain-penetrant, and selective inhibitor of the CXCR3 receptor, demonstrating significant selectivity towards CXCR1 and CXCR2 receptors as well. By binding to CXCR3, SCH-900875 blocks the ligands CXCL9, CXCL10, and CXCL11, thereby inhibiting downstream G protein and β-arrestin signaling pathways and reducing inflammation cell migration. This compound holds potential for research into autoimmune diseases (such as rheumatoid arthritis and multiple sclerosis) and inflammatory conditions (such as psoriasis and inflammatory bowel disease).</p>Formule :C28H37ClN8O2Couleur et forme :SolidMasse moléculaire :553.10LRRK2-IN-3
CAS :<p>LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.</p>Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99EMU-116
CAS :<p>EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.</p>Formule :C25H35N5Couleur et forme :SolidMasse moléculaire :405.58SLW131
CAS :<p>SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.</p>Formule :C21H27N5O5SCouleur et forme :SolidMasse moléculaire :461.535Autophagy-lysosome activator-1
<p>Autophagy-lysosome Activator-1 (Compound F1) is an autophagy-lysosome stimulator that effectively induces the degradation of PD-L1 or VISTA in tumor cells.</p>Formule :C17H18N4O2Couleur et forme :SolidMasse moléculaire :310.35BRD5631
CAS :<p>BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway.</p>Formule :C30H35N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.62Rosiglitazone sodium
CAS :<p>Rosiglitazone sodium is an effective and selective PPARγ activator, with EC50 values of 30 nM for PPARγ1, 100 nM for PPARγ2, and 60 nM for PPARγ. It also has an approximate Kd of 40 nM for PPARγ. Additionally, Rosiglitazone sodium acts as a regulator of TRP channels, inhibiting the activities of TRPM2 and TRPM3, while activating TRPC5.</p>Formule :C18H18N3NaO3SCouleur et forme :SolidMasse moléculaire :379.41CXCR7 modulator 2
CAS :<p>CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.</p>Formule :C29H42N6O3Couleur et forme :SolidMasse moléculaire :522.68CXCR4 modulator-1
CAS :<p>CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.</p>Formule :C23H27N5O2Couleur et forme :SolidMasse moléculaire :405.49
