
DUB
Les inhibiteurs de déubiquitinases (DUB) ciblent les enzymes qui retirent les molécules d'ubiquitine des protéines, régulant ainsi la stabilité, la localisation et l'activité des protéines dans la cellule. Les déubiquitinases jouent un rôle essentiel dans divers processus cellulaires, notamment la régulation du cycle cellulaire, la réparation de l'ADN et les réponses immunitaires. La dérégulation de l'activité des DUB est liée au cancer, aux troubles neurodégénératifs et aux infections virales. Les inhibiteurs de DUB peuvent moduler ces processus, offrant des approches thérapeutiques potentielles pour ces conditions. Chez CymitQuimica, nous proposons des inhibiteurs de DUB pour soutenir vos recherches en homéostasie des protéines, en oncologie et en neurobiologie.
84 produits trouvés pour "DUB"
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HBX28258
CAS :<p>HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.</p>Formule :C26H30ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.99MF-095
CAS :<p>MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.</p>Formule :C27H31N3O4SCouleur et forme :SolidMasse moléculaire :493.62XL-188
CAS :<p>XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.</p>Formule :C32H42N6O4Couleur et forme :SolidMasse moléculaire :574.71Capzimin
CAS :<p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>Formule :C30H24N6O2S4Degré de pureté :98.31% - 99.32%Couleur et forme :SolidMasse moléculaire :628.81I-138
CAS :<p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>Formule :C26H23F3N6ODegré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :492.5USP28-IN-2
CAS :<p>USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.</p>Formule :C23H20Cl2N2O3SCouleur et forme :SolidMasse moléculaire :475.39GSK2643943A
CAS :<p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>Formule :C17H12FN3Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :277.3SJB3-019A
CAS :<p>SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times</p>Formule :C16H8N2O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :276.25USP30 inhibitor 11
CAS :<p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>Formule :C17H16N6O2SDegré de pureté :98.84% - 99.59%Couleur et forme :SolidMasse moléculaire :368.416RK73
CAS :<p>6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).</p>Formule :C13H17N5O2SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :307.37P22074
CAS :<p>P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.</p>Formule :C12H9NO3S2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :279.33USP22-IN-1
CAS :<p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>Formule :C22H18N4Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :338.41OTUB1/USP8-IN-1
CAS :<p>OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.</p>Formule :C22H16ClFN2O4Degré de pureté :98.59%Couleur et forme :SoildMasse moléculaire :426.83USP1-IN-3
CAS :<p>USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.</p>Formule :C27H24F3N7OCouleur et forme :SolidMasse moléculaire :519.52USP1-IN-5
CAS :<p>USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less than</p>Formule :C27H23F3N8OCouleur et forme :SolidMasse moléculaire :532.52USP7-IN-12
CAS :<p>USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].</p>Formule :C29H28ClFN4O2SCouleur et forme :SolidMasse moléculaire :551.07FT206
CAS :<p>FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].</p>Formule :C25H29N5OSCouleur et forme :SolidMasse moléculaire :447.6USP7-IN-1
CAS :<p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>Formule :C23H24ClN3O3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :425.91DUB-IN-7
CAS :<p>DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].</p>Formule :C17H19N5OCouleur et forme :SolidMasse moléculaire :309.37FT671
CAS :<p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>Formule :C24H23F4N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :533.48USP7-IN-3
CAS :<p>USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).</p>Formule :C29H31F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.59LDN-91946
CAS :<p>LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).</p>Formule :C15H10N2O4SDegré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :314.32USP30 inhibitor 18
CAS :<p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>Formule :C26H28FN3O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :497.58USP1-IN-6
CAS :<p>USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.</p>Formule :C29H27F3N8OCouleur et forme :SolidMasse moléculaire :560.57CT1113
CAS :<p>CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDX</p>Formule :C25H29N5O2SCouleur et forme :SolidMasse moléculaire :463.6USP7-IN-13
CAS :<p>USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].</p>Formule :C24H28N4O3Couleur et forme :SolidMasse moléculaire :420.5IMP-1710
CAS :<p>IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.</p>Formule :C23H19N5ODegré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :381.43USP7-IN-10
CAS :<p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>Formule :C26H29ClN4O3SCouleur et forme :SolidMasse moléculaire :513.05FT709
CAS :<p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>Formule :C23H22N4O7SCouleur et forme :SolidMasse moléculaire :498.51FT3967385
<p>FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.</p>Formule :C21H19N5O2Couleur et forme :SolidMasse moléculaire :373.41USP7-IN-6
CAS :<p>USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).</p>Formule :C41H43N7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :729.89USP7-797
CAS :<p>USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.</p>Formule :C27H28ClN3O3SDegré de pureté :95.90%Couleur et forme :SolidMasse moléculaire :510.05USP5-IN-1
<p>USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.</p>Formule :C19H20ClN3O5SDegré de pureté :99.76%Couleur et forme :SoildMasse moléculaire :437.9USP15-IN-1
CAS :<p>USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).</p>Formule :C22H23N3O3Degré de pureté :99.509% - 99.81%Couleur et forme :SolidMasse moléculaire :377.44

