Aurora Kinase
Les inhibiteurs des kinases Aurora ciblent les kinases Aurora, une famille de kinases sérine/thréonine qui jouent un rôle crucial dans la régulation de la mitose. Ces kinases sont essentielles pour l'alignement correct des chromosomes, leur ségrégation et la cytokinèse pendant la division cellulaire. Une activité anormale des kinases Aurora peut entraîner une prolifération cellulaire incontrôlée et le cancer. En inhibant les kinases Aurora, ces composés peuvent induire un arrêt du cycle cellulaire et l'apoptose dans les cellules cancéreuses, ce qui en fait des outils précieux pour la recherche et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de kinases Aurora de haute qualité pour soutenir vos recherches sur la régulation du cycle cellulaire, la mitose et l'oncologie.
109 produits trouvés pour "Aurora Kinase"
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TAK-901
CAS :<p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>Formule :C28H32N4O3SDegré de pureté :99.02% - 99.59%Couleur et forme :SolidMasse moléculaire :504.64dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formule :C52H53Cl2FN8O12Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :1071.93Centrinone
CAS :Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).Formule :C26H25F2N7O6S2Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :633.65NU6140
CAS :<p>NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).</p>Formule :C23H30N6O2Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :422.52Tinengotinib
CAS :Tinengotinib is a multikinase inhibitor that targets a series of kinases , including Aurora kinases A/B, JAK1/2, FGFR1/2/3, VEGFRs, and many other kinases.Formule :C20H19ClN6ODegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :394.86SK2187
CAS :SK2187 is a selective degrader of AURKAPROTAC with a DC50 of approximately 10 nM. It exhibits growth-inhibitory effects on NGP cells, with an IC50 value of 101.5 nM. SK2187 is utilized in studies of MYCN-amplified neuroblastoma.Formule :C45H49ClFN7O11SCouleur et forme :SolidMasse moléculaire :950.43dAurAB2
dAurAB2 is a bifunctional PROTAC capable of effectively degrading Aurora-A and Aurora-B, with DC50 values of 59 nM and 39 nM, respectively. It reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells and is valuable for neuroblastoma research.Couleur et forme :Odour SolidPROTAC MPS1 degrader 1
PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase)Formule :C41H46N12O7Couleur et forme :SolidMasse moléculaire :818.88PROTAC MPS1 degrader 2
PROTAC MPS1 Degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 values of 42.0, 2.1, and 154.0 nM respectively. It is utilized in the research of acute myeloid leukemia.Formule :C41H41N11O8SCouleur et forme :SolidMasse moléculaire :847.90CAM2602
<p>CAM2602 is an inhibitor of Aurora A-TPX2 interaction, demonstrating a binding affinity of 19 nM with Aurora A. This compound has been shown to inhibit the growth of pancreatic cancer cells. In solid tumor xenograft models, CAM2602 increases the proportion of PH3-positive cells while decreasing the ratio of P-Thr288Aurora A-positive cells, ultimately inhibiting tumor growth.</p>Couleur et forme :Odour SoliddAURK-4
CAS :dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formule :C52H52ClFN8O12Couleur et forme :SolidMasse moléculaire :1035.47Aurora A inhibitor 3
<p>Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-</p>Degré de pureté :98%Couleur et forme :Odour SolidRetreversine
CAS :Retreversine serves as an inactive control counterpart to Reversine, a pioneering class of ATP-competitive Aurora kinase inhibitor.Formule :C21H27N7OCouleur et forme :SolidMasse moléculaire :393.49AKI603
CAS :AKI603: Aurora A kinase blocker; IC50 12.3 nM; targets BCR-ABL-T315I resistance; halts leukemia cell growth.Formule :C19H23N9O2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :409.45AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61JB170
CAS :JB170 is a specific Aurora A degradator. Alisertib and Thalidomide, induces S-phase arrest in cell growth and inhibits the non-catalytic function.Formule :C48H44ClFN8O11Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :963.3611α-O-Tigloyl-12β-O-acetyltenacigenin B
CAS :11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphomaFormule :C28H40O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.61JB300
CAS :JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formule :C43H45ClFN7O10SCouleur et forme :SolidMasse moléculaire :906.375Barasertib
CAS :AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formule :C26H31FN7O6PDegré de pureté :99.92% - 99.97%Couleur et forme :SolidMasse moléculaire :587.54HLB-0532259
CAS :<p>HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)</p>Formule :C40H44N8O7Couleur et forme :SolidMasse moléculaire :748.827TAS-119
CAS :TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formule :C23H22Cl2FN5O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :506.36CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Couleur et forme :SolidSP-96
CAS :<p>SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.</p>Formule :C25H20FN7ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :453.47Aurora-A ligand 1
CAS :<p>Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.</p>Formule :C21H23N5O3Couleur et forme :SolidMasse moléculaire :393.439MS44
MS44 is a potent degrader of aurora kinase B (AURKBPROTAC) with a degradation concentration (DC50) of 103 nM. It effectively and selectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS)-dependent manner, showing specificity for AURKB over AURKA and AURKC. MS44 inhibits the proliferation of various cancer cell lines and strongly induces G2/M arrest. It is useful for studying AURKB-dependent tumors.Couleur et forme :Odour SolidGSK-1070916
CAS :GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formule :C30H33N7ODegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :507.637BIO
CAS :<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formule :C16H10BrN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :356.17PF 477736
CAS :PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formule :C22H25N7O2Degré de pureté :97.58% - 99.94%Couleur et forme :SolidMasse moléculaire :419.48Phthalazinone pyrazole
CAS :Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.Formule :C18H15N5ODegré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :317.34TCS7010
CAS :TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.Formule :C31H31ClFN7O2Degré de pureté :98.49% - 99.62%Couleur et forme :SolidMasse moléculaire :588.07Ilorasertib
CAS :Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).Formule :C25H21FN6O2SDegré de pureté :96.17% - 97.49%Couleur et forme :SolidMasse moléculaire :488.54Hesperadin
CAS :Hesperadin(IC50=250 nM) effectively inhibits Aurora B.Formule :C29H32N4O3SDegré de pureté :98.04% - 99.44%Couleur et forme :SolidMasse moléculaire :516.65CYC-116
CAS :CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not activeFormule :C18H20N6OSDegré de pureté :97.36% - 97.59%Couleur et forme :SolidMasse moléculaire :368.46SP-146
<p>SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).</p>Formule :C25H20FN7ODegré de pureté :97.82%Couleur et forme :SolidMasse moléculaire :453.47MK-8745
CAS :<p>MK-8745 is a potent and selective Aurora A inhibitor.</p>Formule :C20H19ClFN5OSDegré de pureté :99.09% - 99.79%Couleur et forme :SolidMasse moléculaire :431.91CCT 137690
CAS :CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).Formule :C26H31BrN8ODegré de pureté :98.51% - 99.89%Couleur et forme :SolidMasse moléculaire :551.48SNS-314 Mesylate
CAS :SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Formule :C18H15ClN6OS2·CH4O3SDegré de pureté :99.44% - 99.92%Couleur et forme :SolidMasse moléculaire :527.04AT9283
CAS :<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Formule :C19H23N7O2Degré de pureté :99.83% - 99.98%Couleur et forme :SolidMasse moléculaire :381.43SNS-314
CAS :<p>SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.</p>Formule :C18H15ClN6OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.93Reversine
CAS :Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formule :C21H27N7ODegré de pureté :98% - 99.45%Couleur et forme :SolidMasse moléculaire :393.49BI-847325
CAS :BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Formule :C29H28N4O2Degré de pureté :97.13% - 97.54%Couleur et forme :SolidMasse moléculaire :464.56Aurora kinase inhibitor-2
CAS :Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Formule :C23H20N4O3Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :400.43Protein kinase inhibitor 6
CAS :<p>Protein kinase inhibitor 6 is a protein kinase inhibitor.</p>Formule :C13H9FN2SDegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :244.29Alisertib
CAS :Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formule :C27H20ClFN4O4Degré de pureté :98.31% - >99.99%Couleur et forme :SolidMasse moléculaire :518.92MLN8054
CAS :MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Formule :C25H15ClF2N4O2Degré de pureté :98.07% - 98.26%Couleur et forme :SolidMasse moléculaire :476.86ZM-447439
CAS :ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Formule :C29H31N5O4Degré de pureté :99.11% - 99.59%Couleur et forme :Pale Yellow SolidMasse moléculaire :513.59AT-9283 HCl
CAS :AT-9283, a multi-targeted kinase inhibitor, is used potentially for the treatment of multiple myeloma.Formule :C19H24ClN7O2Couleur et forme :SolidMasse moléculaire :417.89TAK-632
CAS :TAK-632 is a potent pan-Raf inhibitor.Formule :C27H18F4N4O3SDegré de pureté :98% - 99.5%Couleur et forme :SolidMasse moléculaire :554.52VX-11e
CAS :VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Formule :C24H20Cl2FN5O2Degré de pureté :98.92% - ≥98%Couleur et forme :SolidMasse moléculaire :500.35Aurora kinase inhibitor-3
CAS :Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formule :C21H18F3N5ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :413.4URMC-099
CAS :URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formule :C27H27N5Degré de pureté :99.32% - 99.98%Couleur et forme :SolidMasse moléculaire :421.54MLN8054 sodium
CAS :MLN8054 sodium is an Aurora A inhibitor.Formule :C25H14ClF2N4NaO2Couleur et forme :SolidMasse moléculaire :498.84Danusertib
CAS :<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Formule :C26H30N6O3Degré de pureté :97.88% - 98.79%Couleur et forme :White PowderMasse moléculaire :474.55KW-2449
CAS :<p>KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.</p>Formule :C20H20N4ODegré de pureté :98.43% - 99.69%Couleur et forme :SolidMasse moléculaire :332.4JNJ-7706621
CAS :<p>JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.</p>Formule :C15H12F2N6O3SDegré de pureté :99.1% - 99.85%Couleur et forme :SolidMasse moléculaire :394.36Palmatine chloride
CAS :Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formule :C21H22ClNO4Degré de pureté :97.9% - 99.47%Couleur et forme :SolidMasse moléculaire :387.86Palmatine
CAS :<p>Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.</p>Formule :C21H22NO4Degré de pureté :96.28% - 99.49%Couleur et forme :SolidMasse moléculaire :352.4XL228
CAS :XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formule :C22H31N9ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :437.54Tozasertib
CAS :Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formule :C23H28N8OSDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :464.59PHA-680632
CAS :<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Formule :C28H35N7O2Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :501.62GW779439X
CAS :GW779439X is an inhibitor of CDK.Formule :C22H21F3N8Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :454.45AMG 900
CAS :<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Formule :C28H21N7OSDegré de pureté :98.4% - 99.51%Couleur et forme :SolidMasse moléculaire :503.58CCT241736
CAS :CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Formule :C22H23Cl2N7Degré de pureté :96.2% - 99.81%Couleur et forme :SolidMasse moléculaire :456.37ENMD-2076
CAS :ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formule :C21H25N7Degré de pureté :97.63% - ≥95%Couleur et forme :SolidMasse moléculaire :375.47Barasertib-HQPA
CAS :<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Formule :C26H30FN7O3Degré de pureté :98.43% - 99.29%Couleur et forme :SolidMasse moléculaire :507.56MK-5108
CAS :MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Formule :C22H21ClFN3O3SDegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :461.94SCH-1473759 hydrochloride
CAS :SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Formule :C20H27ClN8OSDegré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :463GW843682X
CAS :GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).Formule :C22H18F3N3O4SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :477.46BI-831266
CAS :BI-831266 is a potent and selective Aurora kinase B inhibitor.Formule :C27H38ClN7O2Couleur et forme :SolidMasse moléculaire :528.09Aurora kinase inhibitor-9
CAS :Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.Formule :C19H17Cl2N3O4SCouleur et forme :SolidMasse moléculaire :454.33Aurora kinase inhibitor-10
CAS :Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.Formule :C21H19F5N6O4SCouleur et forme :SolidMasse moléculaire :546.47Aurora Kinases-IN-2
CAS :Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.Formule :C22H18ClN5O3Couleur et forme :SolidMasse moléculaire :435.86Aurora A/PKC-IN-1
CAS :Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.Formule :C16H14N6OSe2Couleur et forme :SolidMasse moléculaire :464.24L 888607 Racemate
CAS :L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Formule :C19H15ClFNO2SCouleur et forme :SolidMasse moléculaire :375.84Ilorasertib hydrochloride
CAS :Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formule :C25H22ClFN6O2SDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :525OM-137
CAS :OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Formule :C13H14N4O3SCouleur et forme :SolidMasse moléculaire :306.34SAR156497
CAS :SAR156497: selective Aurora A/B/C inhibitor; IC50: 0.5 nM (A), 1 nM (B), 3 nM (C); good metabolic stability; anti-tumoral without genetic specificity.Formule :C27H24N4O4Couleur et forme :SolidMasse moléculaire :468.5FAK/aurora kinase-IN-1
CAS :FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].Formule :C23H24ClN7O3Couleur et forme :SolidMasse moléculaire :481.93VE-465
CAS :VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.Formule :C22H28N8OSCouleur et forme :SolidMasse moléculaire :452.58HOI-07
CAS :HOI-07 is a specific Aurora B inhibitor.Formule :C19H13NO4Couleur et forme :SolidMasse moléculaire :319.31Binucleine 2
CAS :Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.Formule :C13H11ClFN5Couleur et forme :SolidMasse moléculaire :291.71Aurora Kinases-IN-3
CAS :Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Formule :C20H16F3N3O4Couleur et forme :SolidMasse moléculaire :419.35RET-IN-19
CAS :<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Formule :C28H28N6O4SCouleur et forme :SolidMasse moléculaire :544.62Tripolin A
CAS :<p>Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)</p>Formule :C15H11NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :253.25Chiauranib
CAS :<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47GRK6-IN-1
CAS :GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Formule :C22H23ClN6O2Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :438.91CD532
CAS :CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Formule :C26H25F3N8ODegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :522.52Aurora kinase inhibitor-8
CAS :Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Formule :C30H29N7O3Couleur et forme :SolidMasse moléculaire :535.6GW814408X
CAS :GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formule :C19H16N6OMasse moléculaire :344.37TC-A 2317 hydrochloride
CAS :<p>TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.</p>Formule :C19H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.93Aurora Kinases-IN-4
CAS :<p>Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.</p>Formule :C26H28N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.55AAPK-25
CAS :AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formule :C21H13Cl2N3O2SDegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :442.32GRK2 Inhibitor 2
CAS :GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Formule :C19H16N4O2Couleur et forme :SolidMasse moléculaire :332.36GSK2646264
CAS :<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Formule :C24H26N2O2Couleur et forme :SolidMasse moléculaire :374.48LY3295668
CAS :<p>LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.</p>Formule :C24H26ClF2N5O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :489.95CCT129202
CAS :CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Formule :C23H25ClN8OSDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :497.02Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12Glycyl H-1152 hydrochloride
CAS :Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Formule :C18H26Cl2N4O3SCouleur et forme :SolidMasse moléculaire :449.39SCH-1473759
CAS :SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formule :C20H26N8OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.546K465
CAS :6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.Formule :C26H33ClFN9ODegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :542.05
