PKA
La protéine kinase A (PKA) est une enzyme clé dans la cascade de signalisation des GPCR, activée par l'AMP cyclique (cAMP) en réponse à divers signaux extracellulaires. La PKA régule un large éventail de processus cellulaires, y compris le métabolisme, l'expression des gènes et la croissance cellulaire. La dérégulation de l'activité de la PKA est associée à diverses maladies, notamment le cancer, les troubles métaboliques et les affections cardiovasculaires. Les modulateurs de la PKA sont des outils précieux dans la recherche visant à comprendre les voies de signalisation des GPCR et à développer de nouvelles stratégies thérapeutiques. Chez CymitQuimica, nous offrons une sélection de modulateurs de PKA de haute qualité pour soutenir vos recherches en transduction de signal, régulation cellulaire et mécanismes des maladies.
57 produits trouvés pour "PKA".
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STAD 2
CAS :STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akapFormule :C102H182N24O22Couleur et forme :SolidMasse moléculaire :2096.724(2S,4R)-DS89002333
(2S,4R)-DS89002333 is an enantiomer of DS89002333 and functions as an orally active PRKACA inhibitor, exhibiting an IC50 of 0.3 nM.Formule :C22H20ClF2N3O3Masse moléculaire :447.11613PKA Inhibitor Fragment (6-22) amide TFA
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of cAMP-dependent protein kinase A (PKA).Formule :C82H131F3N28O26Degré de pureté :99.61% - 99.87%Couleur et forme :White SolidMasse moléculaire :1982.08Kemptide
CAS :Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).Formule :C32H61N13O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.91RI-STAD-2
RI-STAD-2 is a high-affinity peptide that interferes with the regulatory subunit RI of protein kinase A (PKA). It disrupts the binding between A-kinase anchoring proteins (AKAPs) and PKA-RI by mimicking the α-helical domain of AKAPs, interacting with the dimerization/docking (D/D) domain of PKA-RI. This disruption affects the activity and intracellular localization of PKA. RI-STAD-2 is utilized in studying the role of AKAPs and PKA-RI interactions in pathological processes such as cardiovascular diseases and cancer.Formule :C109H181N25O35Couleur et forme :SolidMasse moléculaire :2400.31519PKItide
CAS :PKItide demonstrates an inhibitory concentration 50 (IC50) of 0.2 μM against cAMP-dependent protein kinase (cAMP-PK) [1].Formule :C85H149N31O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1989.29PKA-IN-1
CAS :PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to studyFormule :C13H11N3ODegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :225.25AP-C2
CAS :AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.Formule :C18H16N4SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :320.41PKA/AKAP-IN-2
CAS :PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.Formule :C17H17NO3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :283.32DT-3 acetate
DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.Formule :C152H258N52O28S·xC2H4O2Couleur et forme :SolidMasse moléculaire :3294.07 (free acid)Bilobetin
CAS :Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.Formule :C31H20O10Degré de pureté :97% - 99.69%Couleur et forme :Yellow SolidMasse moléculaire :552.48Ref: TM-T4S2128
1mg44,00€2mg66,00€5mg137,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg403,00€50mg582,00€100mg800,00€PKA inhibitor fragment (6-22) amide Acetate
PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).Formule :C82H134N28O26Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :1928.11Ref: TM-T21674L
1mg90,00€2mg116,00€5mg166,00€10mg264,00€1mL*10mM (DMSO)432,00€25mg442,00€50mg645,00€100mg888,00€Daphnetin
CAS :Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Formule :C9H6O4Degré de pureté :97.47% - 99.95%Couleur et forme :SolidMasse moléculaire :178.14Fasudil dihydrochloride
CAS :Fasudil dihydrochloride inhibits ROCK1/2, PKA, PKC, PKG, and acts as a Ca²⁺ channel blocker and vasodilator, supporting vascular, cardiovascular, and signaling research.Formule :C14H19Cl2N3O2SDegré de pureté :99.86%Couleur et forme :White SolidMasse moléculaire :364.29Fasudil hydrochloride
CAS :Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formule :C14H18ClN3O2SDegré de pureté :99.54% - ≥95%Couleur et forme :White SolidMasse moléculaire :327.83H-89 dihydrochloride
CAS :H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Formule :C20H20BrN3O2S·2HClDegré de pureté :98.22% - >99.99%Couleur et forme :SolidMasse moléculaire :519.28Ref: TM-T6250
5mg37,00€1mL*10mM (DMSO)44,00€10mg55,00€25mg101,00€50mg192,00€100mg326,00€200mg485,00€500mg772,00€Staurosporine
CAS :Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFormule :C28H26N4O3Degré de pureté :99.24% - 99.82%Couleur et forme :SolidMasse moléculaire :466.53Ref: TM-T6680
1mg58,00€2mg82,00€5mg92,00€1mL*10mM (DMSO)103,00€10mg138,00€25mg234,00€50mg380,00€100mg565,00€500mg1.215,00€Metadoxine
CAS :Metadoxine (Metadoxil) is a neurotransmitter stimulant.Formule :C8H11NO3·C5H7NO3Degré de pureté :99.19%Couleur et forme :White SolidMasse moléculaire :298.298-Bromo-cAMP sodium salt
CAS :8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.Formule :C10H10BrN5NaO6PDegré de pureté :98% - 99.94%Couleur et forme :White SolidMasse moléculaire :430.08HA-100
CAS :HA-100 is an inhibitor of protein kinaseFormule :C13H15N3O2SDegré de pureté :99.44%Couleur et forme :White SolidMasse moléculaire :277.34
