PKA
La protéine kinase A (PKA) est une enzyme clé dans la cascade de signalisation des GPCR, activée par l'AMP cyclique (cAMP) en réponse à divers signaux extracellulaires. La PKA régule un large éventail de processus cellulaires, y compris le métabolisme, l'expression des gènes et la croissance cellulaire. La dérégulation de l'activité de la PKA est associée à diverses maladies, notamment le cancer, les troubles métaboliques et les affections cardiovasculaires. Les modulateurs de la PKA sont des outils précieux dans la recherche visant à comprendre les voies de signalisation des GPCR et à développer de nouvelles stratégies thérapeutiques. Chez CymitQuimica, nous offrons une sélection de modulateurs de PKA de haute qualité pour soutenir vos recherches en transduction de signal, régulation cellulaire et mécanismes des maladies.
61 produits trouvés pour "PKA"
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Fasudil hydrochloride
CAS :Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formule :C14H18ClN3O2SDegré de pureté :99.54% - ≥95%Couleur et forme :White SolidMasse moléculaire :327.83PKG drug G1
CAS :PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.Formule :C13H11N3OSDegré de pureté :97.57% - 97.67%Couleur et forme :SolidMasse moléculaire :257.31CREBtide acetate(149155-45-3 free base)
CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).Formule :C75H133N29O21Degré de pureté :96.13%Couleur et forme :SolidMasse moléculaire :1777.07PKI 14-22 amide, myristoylated Acetate
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.Formule :C55H104N20O14Degré de pureté :96.34%Couleur et forme :SolidMasse moléculaire :1269.54Ref: TM-T21983L
1mg167,00€5mg363,00€10mg538,00€1mL*10mM (DMSO)695,00€25mg800,00€50mg1.071,00€100mg1.449,00€PKG inhibitor peptide TFA (82801-73-8 free base)
PKG inhibitor peptide TFA (82801-73-8 free base) is an inhibitor of ATP-competitive cGMP-dependent protein kinase (PKG).Formule :C40H75F3N18O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1057.13PKI (5-24) Acetate(99534-03-9 free base)
PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).Formule :C96H152N32O33Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :2282.43PKG Substrate acetate(81187-14-6 free base)
PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with aFormule :C37H71N17O13Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :962.08Hydroxyfasudil
CAS :Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Formule :C14H17N3O3SDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :307.37Malantide acetate(86555-35-3 free base)
Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptideFormule :C74H128N22O23Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :1693.97HA-100
CAS :HA-100 is an inhibitor of protein kinaseFormule :C13H15N3O2SDegré de pureté :99.44%Couleur et forme :Pale Yellow Crystalline SolidMasse moléculaire :277.34Metadoxine
CAS :Metadoxine (Metadoxil) is a neurotransmitter stimulant.Formule :C8H11NO3·C5H7NO3Degré de pureté :99.19%Couleur et forme :Off-White PowderMasse moléculaire :298.29H-8 hydrochloride
CAS :H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.Formule :C12H17Cl2N3O2SDegré de pureté :99.93%Couleur et forme :White To Off-White Crystalline SolidMasse moléculaire :338.256-Bn-cAMP
CAS :6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.Formule :C17H18N5O6PCouleur et forme :SolidMasse moléculaire :419.338-Chloro-cAMP sodium
CAS :8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.Formule :C10H10ClN5NaO6PCouleur et forme :SolidMasse moléculaire :385.638-MA-cAMP
CAS :8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.Formule :C11H15N6O6PCouleur et forme :SolidMasse moléculaire :358.25Rp-cAMPS triethylammonium salt
CAS :Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.Formule :C16H27N6O5PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.46BGC201531
CAS :BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.Formule :C26H28N2O6SDegré de pureté :98.51% - 99.33%Couleur et forme :SolidMasse moléculaire :496.58FMP-API-1
CAS :FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).Formule :C13H14N2O2Couleur et forme :SolidMasse moléculaire :230.2628-Br-cGMP-AM
CAS :8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.Formule :C13H15BrN5O9PCouleur et forme :SolidMasse moléculaire :496.16Protein kinase inhibitor 7
CAS :Protein kinase inhibitor 7 functions as an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). It impacts the autocrine motility factor (AMF) signaling pathway without affecting cell motility.Formule :C12H15N3O2SMasse moléculaire :265.33
