GPCR19
GPCR19, également connu sous le nom de GPR19, est un membre de la famille des récepteurs couplés aux protéines G dont les rôles sont encore en cours d'élucidation dans divers processus physiologiques. Bien que moins caractérisé que d'autres GPCR, GPCR19 suscite un intérêt particulier dans les recherches visant à découvrir de nouvelles cibles thérapeutiques pour les maladies métaboliques, le cancer et les troubles neurologiques. Chez CymitQuimica, nous offrons une sélection d'outils de recherche et de réactifs pour soutenir vos investigations sur les fonctions et les applications thérapeutiques potentielles de GPCR19.
37 produits trouvés pour "GPCR19".
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Deoxycholic acid
CAS :Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate.Formule :C24H40O4Degré de pureté :99.91% - 99.91%Couleur et forme :Crystals From Alc SolidMasse moléculaire :392.57Hyodeoxycholic acid
CAS :Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.Formule :C24H40O4Degré de pureté :97.29% - 98.82%Couleur et forme :SolidMasse moléculaire :392.57Ursodeoxycholic acid
CAS :Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!Formule :C24H40O4Degré de pureté :99.48% - ≥95%Couleur et forme :White - Almost White Solid PowderMasse moléculaire :392.57GPBAR-A
CAS :GPBAR-A is a synthetic small-molecule agonist of GPBAR1, also known as TGR5, that activates this G protein–coupled bile acid receptor involved in energy homeostasis, glucose metabolism, and immune regulation, GPBAR-A is extensively studied for its therapeutic potential in metabolic disorders such as type 2 diabetes, obesity, and inflammation-related diseases.Formule :C23H15F7N2O2Degré de pureté :99.99%Couleur et forme :White SolidMasse moléculaire :484.37TGR5 agonist 1
Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].Formule :C28H48NNaO6SCouleur et forme :SolidMasse moléculaire :549.74TGR5 agonist 4
TGR5 agonist 4 (compound 19), a derivative of cholic acid, selectively activates the TGR5 receptor with an effective concentration (EC50) of 4 μM [1].Formule :C24H38F2O5Couleur et forme :SolidMasse moléculaire :444.555-HT7R antagonist 1 free base
CAS :5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.Formule :C14H17ClN4Couleur et forme :SolidMasse moléculaire :276.77PEN (human)
CAS :PEN (human) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Formule :C97H159N27O32Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2215.49PEN (rat)
CAS :PEN (rat) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Formule :C102H169N27O33Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2301.62TGR5 agonist 2
TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].Formule :C29H50NNaO6SCouleur et forme :SolidMasse moléculaire :563.77TGR5 agonist 6
CAS :Compound 22b, also known as TGR5 agonist 6, is a non-systemic, intestine-targeted TGR5 agonist that demonstrates significant and sustained blood glucose-lowering effects with an acceptable safety profile.Formule :C42H48Cl2N6O6Couleur et forme :SolidMasse moléculaire :803.77TGR5 agonist 7
TGR5 agonist 7 (Compound 22-Na) is an intestine-restricted, orally active agonist of the G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 of less than 1 μM. In mouse models, it demonstrates blood glucose-lowering effects, making it useful for diabetes research.Formule :C37H59N2NaO9SCouleur et forme :SolidMasse moléculaire :730.93Neuromedin S (human)
CAS :Neuromedin S (human) is a 33-amino acid neuropeptide identified as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1, acting onCouleur et forme :SolidTriamterene
CAS :Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Formule :C12H11N7Degré de pureté :99.77%Couleur et forme :Yellow Yellow SolidMasse moléculaire :253.26Triamterene (Standard)
CAS :Triamterene (Standard) is the standard substance of Triamterene, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Formule :C12H11N7Couleur et forme :SolidMasse moléculaire :253.26BAR502
CAS :BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Formule :C25H44O3Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :392.62PEN (human) aceate
PEN (human) aceate, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.Formule :C99H163N27O34Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :2275.51SB756050
CAS :SB756050 is a specific TGR5 agonist.Formule :C21H28N2O8S2Degré de pureté :98.78% - >99.99%Couleur et forme :SolidMasse moléculaire :500.59SBI-115
CAS :SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5Formule :C14H13ClN2O4SDegré de pureté :99.53% - 99.78%Couleur et forme :SolidMasse moléculaire :340.78Ursodeoxycholic acid sodium
CAS :Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.Formule :C24H40NaO4Degré de pureté :99.66% - 99.96%Couleur et forme :SolidMasse moléculaire :415.56
