Synthèse ADN/ARN
Les inhibiteurs de la synthèse de l'ADN et de l'ARN sont des composés qui interfèrent avec les processus de réplication et de transcription dans les cellules, empêchant ainsi la production de matériel génétique essentiel. Ces inhibiteurs peuvent cibler diverses enzymes et protéines impliquées dans la synthèse des acides nucléiques, ce qui en fait des outils précieux pour étudier les mécanismes de réplication, de transcription et de traduction. Ils sont également utilisés dans le développement de traitements contre les infections et le cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de la synthèse de l'ADN/ARN pour soutenir vos recherches en biologie moléculaire, virologie et développement thérapeutique.
774 produits trouvés pour "Synthèse ADN/ARN"
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UMPK ligand 1
CAS :<p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>Formule :C15H22N4O5SCouleur et forme :SolidMasse moléculaire :370.424PCNA-IN-1
CAS :PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.Formule :C19H18I3NO3Couleur et forme :SolidMasse moléculaire :689.065(R)-CSN5i-3
CAS :(R)-CSN5i-3 is CSN5i-3 of the R configuration.Formule :C28H29F2N5O2Degré de pureté :99.76% - 99.97%Couleur et forme :SolidMasse moléculaire :505.565-Methylcytosine hydrochloride
CAS :5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.Formule :C5H8ClN3OCouleur et forme :SolidMasse moléculaire :161.592-CEES
CAS :<p>2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.</p>Formule :C4H9ClSCouleur et forme :SolidMasse moléculaire :124.632AB25583
CAS :AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.Formule :C22H17ClN4O3SCouleur et forme :SolidMasse moléculaire :452.91KL-50
CAS :KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.Formule :C7H7FN6O2Couleur et forme :SolidMasse moléculaire :226.17And1 degrader 1
CAS :<p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>Formule :C26H27Cl2N3OCouleur et forme :SolidMasse moléculaire :468.42LN-439A
CAS :<p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>Formule :C24H26FN3O4Couleur et forme :SolidMasse moléculaire :439.48GR 122222X
CAS :GR 122222X is an inhibitor of topoisomerase II.Formule :C26H35N5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.65WRN inhibitor 11
CAS :WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Formule :C34H35ClF3N9O5Couleur et forme :SolidMasse moléculaire :742.15Polθ-IN-6
CAS :Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.Formule :C25H23N3O3SCouleur et forme :SolidMasse moléculaire :445.53WRN inhibitor 12
CAS :WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Formule :C33H33ClF3N9O5Couleur et forme :SolidMasse moléculaire :728.12Polθ-IN-5
CAS :Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.Formule :C23H18ClF2N7O3SCouleur et forme :SolidMasse moléculaire :545.9512(S)-HETE
CAS :<p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.47DHX9-IN-9
CAS :<p>DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].</p>Formule :C21H21ClFN5O3S2Couleur et forme :SolidMasse moléculaire :510Uridine 3',5'-diphosphate
CAS :<p>Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].</p>Formule :C9H14N2O12P2Couleur et forme :SolidMasse moléculaire :404.16WRN inhibitor 7
CAS :<p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>Formule :C27H23N3O6Couleur et forme :SolidMasse moléculaire :485.49iPAF1C
CAS :<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formule :C27H26BrFN4OCouleur et forme :SolidMasse moléculaire :521.42RAD51-IN-6
CAS :RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)Formule :C27H40N3O5PSCouleur et forme :SolidMasse moléculaire :549.66DENV-IN-6
CAS :<p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>Formule :C23H26ClFN4OSCouleur et forme :SolidMasse moléculaire :461CB 30900
CAS :CB30900 is a novel and effective thymidylate synthase inhibitor.Formule :C31H32FN5O9Couleur et forme :SolidMasse moléculaire :637.61Pol I-IN-1
Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibitionFormule :C23H22N4O2Couleur et forme :SolidMasse moléculaire :386.45PolQi1
CAS :<p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>Formule :C18H14ClF5N4O2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :448.77L-2'-Fd4C
CAS :L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].Formule :C9H10FN3O3Couleur et forme :SolidMasse moléculaire :227.19BAY-364
CAS :BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+Formule :C23H19N3O4Couleur et forme :SolidMasse moléculaire :401.41Antitumor agent-74
Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.Formule :C26H23FN6Couleur et forme :SolidMasse moléculaire :438.54,5'-Dimethylangelicin-NHS
NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.Formule :C21H19NO7SCouleur et forme :SolidMasse moléculaire :429.44Werner syndrome RecQ helicase-IN-2
CAS :Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Formule :C32H34F3N9O5Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :681.67D-G23
CAS :<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Formule :C19H22N4O3Couleur et forme :SolidMasse moléculaire :354.403Adafosbuvir
CAS :<p>Adafosbuvir has antiviral activity.</p>Formule :C22H29FN3O10PCouleur et forme :SolidMasse moléculaire :545.457RAD51-IN-5
CAS :<p>RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)</p>Formule :C26H38N4O5S2Couleur et forme :SolidMasse moléculaire :550.73EFdA-TP tetrasodium
CAS :EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.Formule :C12H11FN5Na4O12P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :621.12ddCTP trisodium
ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.Formule :C9H13N3Na3O12P3Couleur et forme :SolidMasse moléculaire :517.15-Iminodaunorubicin hydrochloride
CAS :<p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>Formule :C27H31ClN2O9Couleur et forme :SolidMasse moléculaire :563.00RAD51-IN-7
CAS :RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)Formule :C25H31N5O4S2Couleur et forme :SolidMasse moléculaire :529.67T-2513 hydrochloride
CAS :T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.Formule :C25H28ClN3O5Couleur et forme :SolidMasse moléculaire :485.96Zorubicin
CAS :<p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>Formule :C34H35N3O10Couleur et forme :SolidMasse moléculaire :645.66Ladirubicin
CAS :Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.Formule :C29H31NO11SCouleur et forme :SolidMasse moléculaire :601.622'-(2-Nitrobenzyl)-ATP
CAS :<p>2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.</p>Formule :C17H21N6O15P3Couleur et forme :SolidMasse moléculaire :642.302,5-Di-tert-butyl-1,4-benzoquinone
CAS :<p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>Formule :C14H20O2Couleur et forme :SolidMasse moléculaire :220.31GHP-88309
CAS :<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Formule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.27VPC-80051
CAS :<p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>Formule :C16H13F2N3OCouleur et forme :SolidMasse moléculaire :301.291Xanthosine-5'-Triphosphate trisodium
CAS :<p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>Formule :C10H12N4Na3O15P3Couleur et forme :SolidMasse moléculaire :590.111Epolactaene
CAS :<p>Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.</p>Formule :C21H27NO6Couleur et forme :SolidMasse moléculaire :389.44(E)-Antiviral agent 67
CAS :<p>(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral compound that exhibits inhibitory activity against RNA-dependent RNA polymerase.</p>Formule :C19H19N3OCouleur et forme :SolidMasse moléculaire :305.374DNA ligase-IN-2
CAS :<p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is >64 μg/mL.</p>Formule :C13H8FN3O3Couleur et forme :SolidMasse moléculaire :273.219RECTAS-2.0
CAS :<p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.</p>Formule :C18H17ClN4O4Couleur et forme :SolidMasse moléculaire :388.805Polθ-IN-7
CAS :<p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>Formule :C28H35F3N6O2Couleur et forme :SolidMasse moléculaire :544.612Polθ-IN-8
CAS :Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.Formule :C22H22ClN7O3SCouleur et forme :SolidMasse moléculaire :499.97Antiviral agent 67
CAS :Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.Formule :C19H19N3OCouleur et forme :SolidMasse moléculaire :305.374DIDS
CAS :<p>DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.</p>Formule :C16H10N2O6S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.52Methyl 3-oxodecanoate
CAS :<p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>Formule :C11H20O3Couleur et forme :SolidMasse moléculaire :200.275CYP2C19-IN-1
CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.Formule :C26H26N2O6SCouleur et forme :SolidMasse moléculaire :494.56DNA polymerase-IN-6
CAS :DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.Formule :C26H28ClFN8O4Couleur et forme :SolidMasse moléculaire :571.003WRN inhibitor 13
CAS :WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.Formule :C16H20N2O5SCouleur et forme :SolidMasse moléculaire :352.405Metesind Glucuronate
CAS :Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.Formule :C29H34N4O10SCouleur et forme :SolidMasse moléculaire :630.67NSC 641396
CAS :NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.Formule :C18H13NO3Couleur et forme :SolidMasse moléculaire :291.301KWR095
CAS :<p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105TREX1-IN-3
CAS :<p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>Formule :C24H19ClN6O4Couleur et forme :SolidMasse moléculaire :490.898HPH-15
CAS :<p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>Formule :C19H31N3S4Couleur et forme :SolidMasse moléculaire :429.73TREX1-IN-4
CAS :<p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>Formule :C24H19ClN6O4Couleur et forme :SolidMasse moléculaire :490.898NRTT-IN-1
CAS :<p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>Formule :C28H24FN5O5Couleur et forme :SolidMasse moléculaire :529.519MTH1 activator-1
CAS :MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.Formule :C29H23F3N4O2Couleur et forme :SolidMasse moléculaire :516.5145-Fluorouridine 5'-phosphate
CAS :<p>5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.</p>Formule :C9H12FN2O9PCouleur et forme :SolidMasse moléculaire :342.172Deoxythymidine-5'-triphosphate-d15
CAS :Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.Formule :C10H15Li2N2O14P3Couleur et forme :SolidMasse moléculaire :509.13HRO761
CAS :HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Formule :C31H31ClF3N9O5Degré de pureté :98.74% - 99.62%Couleur et forme :SolidMasse moléculaire :702.08CTPS1-IN-1
CAS :CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Formule :C21H22N6O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :486.57SR 11302
CAS :SR 11302 is an inhibitor of activator protein-1 (AP-1).Formule :C26H32O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :376.535'-DMT-3'-TBDMS-ibu-rG
CAS :<p>5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.</p>Formule :C41H51N5O8SiCouleur et forme :SolidMasse moléculaire :769.965'-O-DMT-N6-ibu-dA
CAS :5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Formule :C35H37N5O6Couleur et forme :SolidMasse moléculaire :623.71Ethynylcytidine
CAS :<p>Ethynylcytidine is a nucleoside antimetabolite.</p>Formule :C11H13N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.24NSC639828
CAS :NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Formule :C18H13BrClN5O3Couleur et forme :SolidMasse moléculaire :462.69MitoE10
CAS :MitoE10 is an effective mitochondrial targeting antioxidant.Formule :C42H55O5PSCouleur et forme :SolidMasse moléculaire :702.92
