Synthèse ADN/ARN
Les inhibiteurs de la synthèse de l'ADN et de l'ARN sont des composés qui interfèrent avec les processus de réplication et de transcription dans les cellules, empêchant ainsi la production de matériel génétique essentiel. Ces inhibiteurs peuvent cibler diverses enzymes et protéines impliquées dans la synthèse des acides nucléiques, ce qui en fait des outils précieux pour étudier les mécanismes de réplication, de transcription et de traduction. Ils sont également utilisés dans le développement de traitements contre les infections et le cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de la synthèse de l'ADN/ARN pour soutenir vos recherches en biologie moléculaire, virologie et développement thérapeutique.
708 produits trouvés pour "Synthèse ADN/ARN"
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Plevitrexed
CAS :<p>Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.</p>Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53Methyl 3-oxodecanoate
CAS :<p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>Formule :C11H20O3Couleur et forme :SolidMasse moléculaire :200.275APE1-IN-3
CAS :<p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>Formule :C17H16O4Couleur et forme :SolidMasse moléculaire :284.31GTSE1-IN-1
CAS :<p>GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.</p>Formule :C21H24FN7Couleur et forme :SolidMasse moléculaire :393.46Polθ-IN-6
CAS :<p>Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.</p>Formule :C25H23N3O3SCouleur et forme :SolidMasse moléculaire :445.53WRN inhibitor 11
CAS :<p>WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.</p>Formule :C34H35ClF3N9O5Couleur et forme :SolidMasse moléculaire :742.152-CEES
CAS :<p>2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.</p>Formule :C4H9ClSCouleur et forme :SolidMasse moléculaire :124.632D-G23
CAS :<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Formule :C19H22N4O3Couleur et forme :SolidMasse moléculaire :354.403MTH1 activator-1
CAS :<p>MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.</p>Formule :C29H23F3N4O2Couleur et forme :SolidMasse moléculaire :516.5145-Fluorouridine 5'-phosphate
CAS :<p>5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.</p>Formule :C9H12FN2O9PCouleur et forme :SolidMasse moléculaire :342.17212(S)-HETE
CAS :<p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.47Werner syndrome RecQ helicase-IN-2
CAS :<p>Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.</p>Formule :C32H34F3N9O5Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :681.67Polθ-IN-5
CAS :<p>Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.</p>Formule :C23H18ClF2N7O3SCouleur et forme :SolidMasse moléculaire :545.95DNA ligase-IN-2
CAS :<p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is >64 μg/mL.</p>Formule :C13H8FN3O3Couleur et forme :SolidMasse moléculaire :273.219Bersiporocin
CAS :<p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>Formule :C15H19Cl2N3ODegré de pureté :98.88% - 99.79%Couleur et forme :SolidMasse moléculaire :328.24ATIC-IN-2
CAS :<p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>Formule :C4H4N4O3SCouleur et forme :SolidMasse moléculaire :188.165WRN inhibitor 12
CAS :WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Formule :C33H33ClF3N9O5Couleur et forme :SolidMasse moléculaire :728.12GSK_WRN4
CAS :<p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>Formule :C16H20N2O4SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :336.41Dencatistat
CAS :<p>Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.</p>Formule :C24H27N7O5SDegré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :525.58DIDS
CAS :<p>DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.</p>Formule :C16H10N2O6S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.52(R)-CSN5i-3
CAS :<p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>Formule :C28H29F2N5O2Degré de pureté :99.76% - 99.97%Couleur et forme :SolidMasse moléculaire :505.56L-2'-Fd4C
CAS :<p>L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].</p>Formule :C9H10FN3O3Couleur et forme :SolidMasse moléculaire :227.19DHX9-IN-19
CAS :<p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>Formule :C20H21ClN4O4S2Couleur et forme :SolidMasse moléculaire :480.988Pol I-IN-1
<p>Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition</p>Formule :C23H22N4O2Couleur et forme :SolidMasse moléculaire :386.455-Methylcytosine hydrochloride
CAS :<p>5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.</p>Formule :C5H8ClN3OCouleur et forme :SolidMasse moléculaire :161.59CB 30900
CAS :<p>CB30900 is a novel and effective thymidylate synthase inhibitor.</p>Formule :C31H32FN5O9Couleur et forme :SolidMasse moléculaire :637.61DENV-IN-6
CAS :<p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>Formule :C23H26ClFN4OSCouleur et forme :SolidMasse moléculaire :461Antiviral agent 67
CAS :<p>Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.</p>Formule :C19H19N3OCouleur et forme :SolidMasse moléculaire :305.374Ladirubicin
CAS :<p>Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.</p>Formule :C29H31NO11SCouleur et forme :SolidMasse moléculaire :601.62RAD51-IN-6
CAS :<p>RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)</p>Formule :C27H40N3O5PSCouleur et forme :SolidMasse moléculaire :549.662'-(2-Nitrobenzyl)-ATP
CAS :<p>2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.</p>Formule :C17H21N6O15P3Couleur et forme :SolidMasse moléculaire :642.30Polθ-IN-8
CAS :<p>Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.</p>Formule :C22H22ClN7O3SCouleur et forme :SolidMasse moléculaire :499.97(E)-Antiviral agent 67
CAS :<p>(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral compound that exhibits inhibitory activity against RNA-dependent RNA polymerase.</p>Formule :C19H19N3OCouleur et forme :SolidMasse moléculaire :305.374Polθ-IN-7
CAS :<p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>Formule :C28H35F3N6O2Couleur et forme :SolidMasse moléculaire :544.612AB25583
CAS :<p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>Formule :C22H17ClN4O3SCouleur et forme :SolidMasse moléculaire :452.91KL-50
CAS :<p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>Formule :C7H7FN6O2Couleur et forme :SolidMasse moléculaire :226.17And1 degrader 1
CAS :<p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>Formule :C26H27Cl2N3OCouleur et forme :SolidMasse moléculaire :468.42Uridine 3',5'-diphosphate
CAS :<p>Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].</p>Formule :C9H14N2O12P2Couleur et forme :SolidMasse moléculaire :404.16Xanthosine-5'-Triphosphate trisodium
CAS :<p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>Formule :C10H12N4Na3O15P3Couleur et forme :SolidMasse moléculaire :590.111LN-439A
CAS :<p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>Formule :C24H26FN3O4Couleur et forme :SolidMasse moléculaire :439.48N-Nitrosonornicotine
CAS :<p>N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.</p>Formule :C9H11N3OCouleur et forme :SolidMasse moléculaire :177.2GHP-88309
CAS :<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Formule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.27iPAF1C
CAS :<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formule :C27H26BrFN4OCouleur et forme :SolidMasse moléculaire :521.42RECTAS-2.0
CAS :<p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.</p>Formule :C18H17ClN4O4Couleur et forme :SolidMasse moléculaire :388.805GR 122222X
CAS :<p>GR 122222X is an inhibitor of topoisomerase II.</p>Formule :C26H35N5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.65PolQi1
CAS :<p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>Formule :C18H14ClF5N4O2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :448.77Epolactaene
CAS :<p>Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.</p>Formule :C21H27NO6Couleur et forme :SolidMasse moléculaire :389.44(Rac)-Plevitrexed
CAS :<p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53VPC-80051
CAS :<p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>Formule :C16H13F2N3OCouleur et forme :SolidMasse moléculaire :301.291CTPS1-IN-1
CAS :<p>CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.</p>Formule :C21H22N6O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :486.57
