Protéase du VIH
Les inhibiteurs de la protéase du VIH sont une classe de médicaments antirétroviraux qui ciblent spécifiquement l'enzyme protéase du virus de l'immunodéficience humaine (VIH). En inhibant cette enzyme, ces composés empêchent le virus de transformer ses polyprotéines en protéines matures et fonctionnelles, bloquant ainsi la production de nouveaux virions infectieux. Les inhibiteurs de la protéase du VIH constituent une pierre angulaire de la thérapie antirétrovirale hautement active (HAART) utilisée pour gérer le VIH/SIDA. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de la protéase du VIH pour soutenir votre recherche sur le traitement du VIH, la résistance médicamenteuse et la virologie.
496 produits trouvés pour "Protéase du VIH"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
BRN3OMe
CAS :BRN3OMe is an effective inhibitor of HIV-1 reverse transcriptase (HIV-1 reverse transcriptase), showing potential for antiviral drug research.
Formule :C7H13N3O4Couleur et forme :SolidMasse moléculaire :203.196Telinavir
CAS :Telinavir (SC-52151) is a potent and selective inhibitor of HIV protease. It effectively inhibits both HIV-1 and HIV-2, as well as lymphotropic, monocytotropic strains, and wild isolates of simian immunodeficiency viruses, with an EC50 of 26 ng/mL (43 nM). Telinavir shows high protein binding in human plasma and a low distribution rate in red blood cells.Formule :C33H44N6O5Couleur et forme :SolidMasse moléculaire :604.74L 702007
CAS :L 702007 is an inhibitor of HIV-1 reverse transcriptase.Formule :C18H25N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.41HIV-1 protease-IN-6
HIV-1 protease-IN-6 (17d) strongly inhibits HIV-1 protease (IC50: 21 pM, Ki: 4.7 pM) and effectively targets DRV-resistant mutants.Formule :C27H31FN2O6SCouleur et forme :SolidMasse moléculaire :530.61BMIM-TFSI
CAS :BMIM-TFSI (compound8) is an HIV-1 integrase inhibitor that effectively suppresses both the 3'-processing (3'-P) and strand transfer (ST) steps of the integration process. It is applicable in HIV-1 research.Formule :C10H15F6N3O4S2Couleur et forme :SolidMasse moléculaire :419.364(S)-Batylalcohol
CAS :(S)-Batylalcohol (1-O-Octadecyl-sn-glycerol) is an analogue of phosphonoformic acid (PFA) and demonstrates higher in vitro antiviral activity against human immunodeficiency virus type 1 (HIV-1) compared to PFA. This compound is applicable in antiretroviral research.Formule :C21H44O3Couleur et forme :SolidMasse moléculaire :344.572GS-9822
CAS :GS-9822 is a new LEDGIN inhibitor targeting LEDGF/p75 to alter HIV integration, showing a block-and-lock effect in cells.Formule :C36H39ClN4O4SCouleur et forme :SolidMasse moléculaire :659.24Methyl piperazine-2-carboxylate
CAS :Methyl piperazine-2-carboxylate (compound 4) is a potent activator of METTL3/METTL14/WTAP. It enhances the production of HIV-1p24 viral particles and increases the level of N6-methyladenosine in the viral RNA genome.Formule :C6H12N2O2Couleur et forme :SolidMasse moléculaire :144.172HIV-IN-3
HIV-IN-3 (Compound 22a) is a potent inhibitor of HIV (IC50: 1.5 μM). HIV-IN-3 has potential for the study of HIV-related diseases.Formule :C21H32ClN7O3Couleur et forme :SolidMasse moléculaire :465.98Saphenamycin
CAS :Saphenamycin is an antibiotic from a strain of Streptomyces.Formule :C23H18N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.40GSK3739936
CAS :GSK3739936 inhibits HIV-1 integrase (IC50: 11.1 nM, EC50: 1.7 nM), weak on CYP (IC50 >24.3 μM), rapid absorption, moderate clearance, high oral availability.Formule :C34H43FN2O4Couleur et forme :SolidMasse moléculaire :562.71Integrase-LEDGF/p75 allosteric inhibitor 1
CAS :Oral HIV-1 allosteric integrase inhibitor, blocks DNA integration, antiviral, potent against NL432 (EC50: 3.9 nM).Formule :C33H41NO6SCouleur et forme :SolidMasse moléculaire :579.75Lamivudine, (+/-)-trans-
CAS :Lamivudine, a drug for HIV-1 and HBV, inhibits reverse transcriptase and resembles zalcitabine.Formule :C8H11N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :229.26Emtricitabine triphosphate
CAS :Emtricitabine triphosphate is an active metabolite of Emtricitabine, a drug for HIV/HBV that inhibits reverse transcriptase.Formule :C8H13FN3O12P3SCouleur et forme :SolidMasse moléculaire :487.19NBD-14189
CAS :NBD-14189: Potent HIV-1 entry blocker, binds gp120, IC50: 89 nM, strong antiviral (EC50 <200 nM).Formule :C18H16F4N4O2SCouleur et forme :SolidMasse moléculaire :428.40BRD-K98645985
CAS :BRD-K98645985: BAF inhibitor, binds ARID1A, reverses HIV-1 latency, EC50 ~2.37μM, alters nucleosome placement.Formule :C33H43N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.73ATPase-IN-6
CAS :ATPase-IN-6 is an inhibitor of H+/K+-ATPase (ATPase) and a derivative of imidazopyridine. It exhibits significant antiviral activity against various viruses, such as HIV-1 and SARS-CoV-2. ATPase-IN-6 is applicable in antiviral infection research.Formule :C29H25N3O4SCouleur et forme :SolidMasse moléculaire :511.59NNRT-IN-2
CAS :NNRT-IN-2 (compound 7w) is an orally administered non-nucleoside reverse transcriptase inhibitor (NNRTI) that effectively suppresses both wild-type HIV-1 and various mutant strains. It inhibits HIV-1 reverse transcriptase with an EC 50 value of 22 nM. Additionally, NNRT-IN-2 exhibits insensitivity to CYP and hERG, demonstrating favorable safety and pharmacokinetic profiles [1].Formule :C19H14F3N5O3Masse moléculaire :417.34Desthiazolylmethyl ritonavir
CAS :Desthiazolylmethyl ritonavir is an alkaline-catalyzed degradation product of the HIV protease inhibitor Ritonavir.Formule :C33H43N5O4SCouleur et forme :SolidMasse moléculaire :605.791HIV-1 inhibitor-44
HIV-1 inhibitor-44 (compound 11l) is an HIV-1 reverse transcriptase inhibitor that exhibits activity against wild-type HIV-1 strains (EC50: 0.209 μM).Formule :C23H26N2O4SCouleur et forme :SolidMasse moléculaire :426.53HIV-1-IN-86
CAS :HIV-1-IN-86 (compound 6m) is an HIV-1 inhibitor with an EC50 of 0.77 μM, exhibiting antiviral activity.Formule :C20H17N3O7SCouleur et forme :SolidMasse moléculaire :443.43Gardiquimod hydrochloride
CAS :Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.Formule :C17H24ClN5OCouleur et forme :SolidMasse moléculaire :349.858DPC 684
CAS :DPC 684 is a potent and selective HIV-1 protease inhibitor with an IC90 of 5.7-40 nM and a Ki of 0.021 nM. It competitively inhibits HIV-1 protease, preventing viral polyprotein cleavage. Compared to cellular proteases, DPC 684 shows high selectivity for retroviral proteases. The compound exhibits low protein binding and offers broad-spectrum inhibition against various wild-type and mutant HIV-1 proteases, with an IC90 of 1.9-6.3 nM. DPC 684 is significant for HIV research.Formule :C35H48FN5O5SCouleur et forme :SolidMasse moléculaire :669.85NBD-10007
CAS :NBD-10007 is an inhibitor of HIV-1 entry.Formule :C20H25ClN4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.96BMS-818251
CAS :BMS-818251 is a potent small-molecule inhibitor that targets HIV-1 entry, with an EC50 value of 0.019 nM. It exhibits over 10 times greater efficacy on the cross-subtype panels of the 208-HIV-1 strain compared to BMS-626529. BMS-818251 enhances potency through interactions with gp120 residues in the conserved β20-β21 hairpin.Formule :C29H26N6O5SCouleur et forme :SolidMasse moléculaire :570.619ZLM-66
ZLM-66: Doravirine analog, HIV-1 NNRTI inhibitor, IC50: 41nM, EC50: HIV-1 13nM, cIAP1 0.32nM; useful in AIDS research.Couleur et forme :SolidLentiginosine
CAS :Lentiginosine is a selective amyloglucosidase inhibitor.Formule :C8H15NO2Couleur et forme :SolidMasse moléculaire :157.21Fipravirimat
CAS :Fipravirimat is a potent inhibitor of HIV-1 with potential applications in HIV and AIDS research.Formule :C43H67FN2O4SCouleur et forme :SolidMasse moléculaire :727.07ZK-316
CAS :ZK-316 is a potent and broad-spectrum NNRTI inhibitor with an EC50 range of 0.99 to 75.1 nM. It is applicable for HIV research.Formule :C27H22D6N6O3S2Couleur et forme :SolidMasse moléculaire :554.72HIV-1 inhibitor-61
CAS :HIV-1 Inhibitor-61 (2c) serves as a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an EC50 value of 0.07 nM in NL4-3 wt MT-4 cells [1].Formule :C24H24F2N2O2SCouleur et forme :SolidMasse moléculaire :442.52BI 224436
CAS :BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.Formule :C27H26N2O4Couleur et forme :SolidMasse moléculaire :442.51MIV-150
CAS :MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50<1 nM against HIV-1/HIV-2MN).Formule :C19H17FN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :368.36HIV-1 inhibitor-14
HIV-1 inhibitor-14: potent, broad HIV-1 RT inhibitor. IC50=0.14μM. Effective against wild-type and resistant strains, EC50=5.79-28.3nM.Formule :C29H32N6O4SCouleur et forme :SolidMasse moléculaire :560.67HIV-1 inhibitor-13
HIV-1 inhibitor-13: oral NNRTI, IC50=0.14μM for HIV-1 RT, effective on resistant strains (EC50=2.85-18nM).Formule :C30H32N6O3Couleur et forme :SolidMasse moléculaire :524.61A 76889
CAS :A 76889 is an inhibitor of HIV-1 protease.Formule :C44H58N8O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :794.984'-Ethynyl-2'-deoxyadenosine
CAS :4'-E-dA is a potent nucleoside RT inhibitor for drug-resistant HIV (EC50: 98 nM in MT-4 cells).Formule :C12H13N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :275.26HIV-1 inhibitor-8
HIV-1 inhibitor-8: potent oral NNRTI, low toxicity, IC50: 0.081 μM, effective on multiple strains, EC50: 4.44-54.5 nM.Formule :C25H21N5OSCouleur et forme :SolidMasse moléculaire :439.53HIV-1 inhibitor-41
HIV-1 inhibitor-41 (B23): Oral non-nucleoside reverse transcriptase blocker, EC50 of 50 nM (E138K), 20.8 nM (WT), low hERG/CYP impact, non-toxic.Formule :C16H15F2N3OSCouleur et forme :SolidMasse moléculaire :335.37HIV-1 inhibitor-17
HIV-1 inhibitor-18 blocks HIV-1 capsid, acts on NL4-3 strain (EC50: 2.57 μM), has low cytotoxicity (MT-4 CC50: >8.55).Formule :C32H32N4O5SCouleur et forme :SolidMasse moléculaire :584.69PD 134922
CAS :PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.Formule :C37H61N5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :719.97HIV-1 inhibitor-82
CAS :HIV-1inhibitor-82 (Compound L14) is a small molecule inhibitor of HIV-1 entry with oral bioavailability, exhibiting an IC50 value of 0.39 μM. It holds potential for research in combating HIV-1 infection.Formule :C37H37ClN2O6S2Couleur et forme :SolidMasse moléculaire :705.283-Deazaadenosine
CAS :3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.Formule :C11H14N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :266.25BMS-378806
BMS-378806 is an HIV inhibitor with EC50: 0.85-26.5nM for various strains.
Formule :C22H22N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.43Aurothioglucose
CAS :Aurothioglucose is a active-site TrxR1 inhibitor.Formule :C6H11AuO5SDegré de pureté :98%Couleur et forme :Yellow Crystals SolidMasse moléculaire :392.18Oxindole
CAS :Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.
Formule :C8H7NODegré de pureté :99.34%Couleur et forme :Off-White Crystalline PowderMasse moléculaire :133.15HIV-1 integrase inhibitor
CAS :Hiv-1 integrase inhibitor is an effective anti-HIV drug.Formule :C11H9N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :247.21
